This software ADAM is a Gene set enrichment analysis (GSEA) package created to group a set of genes from comparative samples (control versus experiment) belonging to different species according to their respective functions. The corresponding roles are extracted from the default collections like Gene ontology and Kyoto encyclopedia of genes and genomes (KEGG). ADAM show their significance by calculating the p-values referring to gene diversity and activity. Each group of genes is called Group of functionally associated genes (GFAG).

This package creates complex autoregressive distributed lag (ARDL) models and constructs the underlying unrestricted and restricted error correction model (ECM) automatically, just by providing the order. It also performs the bounds-test for cointegration as described in Pesaran et al. (2001) <doi:10.1002/jae.616> and provides the multipliers and the cointegrating equation. The validity and the accuracy of this package have been verified by successfully replicating the results of Pesaran et al. (2001) in Natsiopoulos and Tzeremes (2022) <doi:10.1002/jae.2919>.

MCMC algorithms & processing functions for: 1. single response multiple regression, see Papageorgiou, G. (2018) <doi: 10.32614/RJ-2018-069>, 2. multivariate response multiple regression, with nonparametric models for the means, the variances and the correlation matrix, with variable selection, see Papageorgiou, G. and Marshall, B. C. (2020) <doi: 10.1080/10618600.2020.1739534>, 3. joint mean-covariance models for multivariate responses, see Papageorgiou, G. (2022) <doi: 10.1002/sim.9376>, and 4.Dirichlet process mixtures, see Papageorgiou, G. (2019) <doi: 10.1111/anzs.12273>.

Detects multiple changes in slope using the CPOP dynamic programming approach of Fearnhead, Maidstone, and Letchford (2019) <doi:10.1080/10618600.2018.1512868>. This method finds the best continuous piecewise linear fit to data under a criterion that measures fit to data using the residual sum of squares, but penalizes complexity based on an L0 penalty on changes in slope. Further information regarding the use of this package with detailed examples can be found in Fearnhead and Grose (2024) <doi:10.18637/jss.v109.i07>.

This package provides a set of functions to perform Raju, van der Linden and Fleer's (1995, <doi:10.1177/014662169501900405>) Differential Functioning of Items and Tests (DFIT) analyses. It includes functions to use the Monte Carlo Item Parameter Replication approach (Oshima, Raju, & Nanda, 2006, <doi:10.1111/j.1745-3984.2006.00001.x>) for obtaining the associated statistical significance tests cut-off points. They may also be used for a priori and post-hoc power calculations (Cervantes, 2017, <doi:10.18637/jss.v076.i05>).

Fits the space-time Epidemic Type Aftershock Sequence ('ETAS') model to earthquake catalogs using a stochastic declustering approach. The ETAS model is a spatio-temporal marked point process model and a special case of the Hawkes process. The package is based on a Fortran program by Jiancang Zhuang (available at <https://bemlar.ism.ac.jp/zhuang/software.html>), which is modified and translated into C++ and C such that it can be called from R. Parallel computing with OpenMP is possible on supported platforms.

User-friendly and fast set of functions for estimating parameters of hierarchical Bayesian species distribution models (Latimer and others 2006 <doi:10.1890/04-0609>). Such models allow interpreting the observations (occurrence and abundance of a species) as a result of several hierarchical processes including ecological processes (habitat suitability, spatial dependence and anthropogenic disturbance) and observation processes (species detectability). Hierarchical species distribution models are essential for accurately characterizing the environmental response of species, predicting their probability of occurrence, and assessing uncertainty in the model results.

Identify Cancer Dysfunctional Sub-pathway by integrating gene expression, DNA methylation and copy number variation, and pathway topological information. 1)We firstly calculate the gene risk scores by integrating three kinds of data: DNA methylation, copy number variation, and gene expression. 2)Secondly, we perform a greedy search algorithm to identify the key dysfunctional sub-pathways within the pathways for which the discriminative scores were locally maximal. 3)Finally, the permutation test was used to calculate statistical significance level for these key dysfunctional sub-pathways.

Interpretability of complex machine learning models is a growing concern. This package helps to understand key factors that drive the decision made by complicated predictive model (so called black box model). This is achieved through local approximations that are either based on additive regression like model or CART like model that allows for higher interactions. The methodology is based on Tulio Ribeiro, Singh, Guestrin (2016) <doi:10.1145/2939672.2939778>. More details can be found in Staniak, Biecek (2018) <doi:10.32614/RJ-2018-072>.

To determine the number of quantitative assays needed for a sample of data using pooled testing methods, which include mini-pooling (MP), MP with algorithm (MPA), and marker-assisted MPA (mMPA). To estimate the number of assays needed, the package also provides a tool to conduct Monte Carlo (MC) to simulate different orders in which the sample would be collected to form pools. Using MC avoids the dependence of the estimated number of assays on any specific ordering of the samples to form pools.

This is the R API for the nfer formalism (<http://nfer.io/>). nfer was developed to specify event stream abstractions for spacecraft telemetry such as the Mars Science Laboratory. Users write rules using a syntax that borrows heavily from Allen's Temporal Logic that, when applied to an event stream, construct a hierarchy of temporal intervals with data. The R API supports loading rules from a file or mining them from historical data. Traces of events or pools of intervals are provided as data frames.

This package provides functions for classifying sparseness in 2 x 2 categorical data where one or more cells have zero counts. The classification uses three widely applied summary measures: Risk Difference (RD), Relative Risk (RR), and Odds Ratio (OR). Helps in selecting suitable continuity corrections for zero cells in multi-centre or meta-analysis studies. Also supports sensitivity analysis and can detect phenomena such as Simpson's paradox. The methodology is based on Subbiah and Srinivasan (2008) <doi:10.1016/j.spl.2008.06.023>.

Functions, examples and data from the first and the second edition of "Numerical Methods and Optimization in Finance" by M. Gilli, D. Maringer and E. Schumann (2019, ISBN:978-0128150658). The package provides implementations of optimisation heuristics (Differential Evolution, Genetic Algorithms, Particle Swarm Optimisation, Simulated Annealing and Threshold Accepting), and other optimisation tools, such as grid search and greedy search. There are also functions for the valuation of financial instruments such as bonds and options, for portfolio selection and functions that help with stochastic simulations.

Accesses OpenWeatherMap's (owm) <https://openweathermap.org/> API. owm itself is a service providing weather data in the past, in the future and now. Furthermore, owm serves weather map layers usable in frameworks like leaflet'. In order to access the API, you need to sign up for an API key. There are free and paid plans. Beside functions for fetching weather data from owm', owmr supplies tools to tidy up fetched data (for fast and simple access) and to show it on leaflet maps.

We provide a toolbox to fit and simulate a univariate or multivariate damped random walk process that is also known as an Ornstein-Uhlenbeck process or a continuous-time autoregressive model of the first order, i.e., CAR(1) or CARMA(1, 0). This process is suitable for analyzing univariate or multivariate time series data with irregularly-spaced observation times and heteroscedastic measurement errors. When it comes to the multivariate case, the number of data points (measurements/observations) available at each observation time does not need to be the same, and the length of each time series can vary. The number of time series data sets that can be modeled simultaneously is limited to ten in this version of the package. We use Kalman-filtering to evaluate the resulting likelihood function, which leads to a scalable and efficient computation in finding maximum likelihood estimates of the model parameters or in drawing their posterior samples. Please pay attention to loading the data if this package is used for astronomical data analyses; see the details in the manual. Also see Hu and Tak (2020) <arXiv:2005.08049>.

How to fit a straight line through a set of points with errors in both coordinates? The bfsl package implements the York regression (York, 2004 <doi:10.1119/1.1632486>). It provides unbiased estimates of the intercept, slope and standard errors for the best-fit straight line to independent points with (possibly correlated) normally distributed errors in both x and y. Other commonly used errors-in-variables methods, such as orthogonal distance regression, geometric mean regression or Deming regression are special cases of the bfsl solution.

Efficient methods for Bayesian inference of state space models via Markov chain Monte Carlo (MCMC) based on parallel importance sampling type weighted estimators (Vihola, Helske, and Franks, 2020, <doi:10.1111/sjos.12492>), particle MCMC, and its delayed acceptance version. Gaussian, Poisson, binomial, negative binomial, and Gamma observation densities and basic stochastic volatility models with linear-Gaussian state dynamics, as well as general non-linear Gaussian models and discretised diffusion models are supported. See Helske and Vihola (2021, <doi:10.32614/RJ-2021-103>) for details.

Fitting (hierarchical) hidden Markov models to financial data via maximum likelihood estimation. See Oelschläger, L. and Adam, T. "Detecting Bearish and Bullish Markets in Financial Time Series Using Hierarchical Hidden Markov Models" (2021, Statistical Modelling) <doi:10.1177/1471082X211034048> for a reference on the method. A user guide is provided by the accompanying software paper "fHMM: Hidden Markov Models for Financial Time Series in R", Oelschläger, L., Adam, T., and Michels, R. (2024, Journal of Statistical Software) <doi:10.18637/jss.v109.i09>.

Multi modality data matrices are factorized conjointly into the multiplication of a shared sub-matrix and multiple modality specific sub-matrices, group sparse constraint is applied to the shared sub-matrix to capture the homogeneous and heterogeneous information, respectively. Then the samples are classified by clustering the shared sub-matrix with kmeanspp(), a new version of kmeans() developed here to obtain concordant results. The package also provides the cluster number estimation by rotation cost. Moreover, cluster specific features could be retrieved using hypergeometric tests.

This package provides an extension of the shadow-test approach to computerized adaptive testing (CAT) implemented in the TestDesign package for the assessment framework involving multiple tests administered periodically throughout the year. This framework is referred to as the Multiple Administrations Adaptive Testing (MAAT) and supports multiple item pools vertically scaled and multiple phases (stages) of CAT within each test. Between phases and tests, transitioning from one item pool (and associated constraints) to another is allowed as deemed necessary to enhance the quality of measurement.

Multivariate estimation and testing, currently a package for testing parametric data. To deal with parametric data, various multivariate normality tests and outlier detection are performed and visualized using the ggplot2 package. Homogeneity tests for covariance matrices are also possible, as well as the Hotelling's T-square test and the multivariate analysis of variance test. We are exploring additional tests and visualization techniques, such as profile analysis and randomized complete block design, to be made available in the future and making them easily accessible to users.

Calculates the Probability Plot Correlation Coefficient (PPCC) between a continuous variable X and a specified distribution. The corresponding composite hypothesis test that was first introduced by Filliben (1975) <doi: 10.1080/00401706.1975.10489279> can be performed to test whether the sample X is element of either the Normal, log-Normal, Exponential, Uniform, Cauchy, Logistic, Generalized Logistic, Gumbel (GEVI), Weibull, Generalized Extreme Value, Pearson III (Gamma 2), Mielke's Kappa, Rayleigh or Generalized Logistic Distribution. The PPCC test is performed with a fast Monte-Carlo simulation.

Create, transform, and summarize custom random variables with distribution functions (analogues of p*()', d*()', q*()', and r*() functions from base R). Two types of distributions are supported: "discrete" (random variable has finite number of output values) and "continuous" (infinite number of values in the form of continuous random variable). Functions for distribution transformations and summaries are available. Implemented approaches often emphasize approximate and numerical solutions: all distributions assume finite support and finite values of density function; some methods implemented with simulation techniques.

This package provides tools for the practical management of financial portfolios: backtesting investment and trading strategies, computing profit/loss and returns, analysing trades, handling lists of transactions, reporting, and more. The package provides a small set of reliable, efficient and convenient tools for processing and analysing trade/portfolio data. The manual provides all the details; it is available from <https://enricoschumann.net/R/packages/PMwR/manual/PMwR.html>. Examples and descriptions of new features are provided at <https://enricoschumann.net/notes/PMwR/>.