The aim of the package is to provide some basic functions for doing statistics with one dimensional Fuzzy Data (in the form of polygonal fuzzy numbers). In particular, the package contains functions for the basic operations on the class of fuzzy numbers (sum, scalar product, mean, median, Hukuhara difference) as well as for calculating (Bertoluzza) distance and sample variance. Moreover a function to simulate fuzzy random variables and bootstrap tests for the equality of means is included. Version 2.1 fixes some bugs of previous versions.

The TEQR package contains software to calculate the operating characteristics for the TEQR and the ACT designs.The TEQR (toxicity equivalence range) design is a toxicity based cumulative cohort design with added safety rules. The ACT (Activity constrained for toxicity) design is also a cumulative cohort design with additional safety rules. The unique feature of this design is that dose is escalated based on lack of activity rather than on lack of toxicity and is de-escalated only if an unacceptable level of toxicity is experienced.

Implementation of the tree-guided feature selection and logic aggregation approach introduced in Chen et al. (2024) <doi:10.1080/01621459.2024.2326621>. The method enables the selection and aggregation of large-scale rare binary features with a known hierarchical structure using a convex, linearly-constrained regularized regression framework. The package facilitates the application of this method to both linear regression and binary classification problems by solving the optimization problem via the smoothing proximal gradient descent algorithm (Chen et al. (2012) <doi:10.1214/11-AOAS514>).

Specialized toolkit for processing biological and fisheries data from Peru's anchovy (Engraulis ringens) fishery. Provides functions to analyze fishing logbooks, calculate biological indicators (length-weight relationships, juvenile percentages), generate spatial fishing indicators, and visualize regulatory measures from Peru's Ministry of Production. Features automated data processing from multiple file formats, coordinate validation, spatial analysis of fishing zones, and tools for analyzing fishing closure announcements and regulatory compliance. Includes built-in datasets of Peruvian coastal coordinates and parallel lines for analyzing fishing activities within regulatory zones.

Genome-wide association studies (GWAS) is a widely used tool for identification of genetic variants associated with phenotypes and diseases, though complex diseases featuring many genetic variants with small effects present difficulties for traditional these studies. By leveraging pleiotropy, the statistical power of a single GWAS can be increased. This package provides functions for fitting graph-GPA, a statistical framework to prioritize GWAS results by integrating pleiotropy. GGPA package provides user-friendly interface to fit graph-GPA models, implement association mapping, and generate a phenotype graph.

This package provides smooth additive quantile regression models, fitted using the methods of Fasiolo et al. (2017). Differently from quantreg, the smoothing parameters are estimated automatically by marginal loss minimization, while the regression coefficients are estimated using either PIRLS or Newton algorithm. The learning rate is determined so that the Bayesian credible intervals of the estimated effects have approximately the correct coverage. The main function is qgam() which is similar to gam() in the mgcv package, but fits non-parametric quantile regression models.

Rasqal is a C library that handles Resource Description Framework (RDF) query language syntaxes, query construction and execution of queries returning results as bindings, boolean, RDF graphs/triples or syntaxes. The supported query languages are SPARQL Query 1.0, SPARQL Query 1.1, SPARQL Update 1.1 (no executing) and the Experimental SPARQL extensions (LAQRS). Rasqal can write binding query results in the SPARQL XML, SPARQL JSON, CSV, TSV, HTML, ASCII tables, RDF/XML and Turtle/N3 and read them in SPARQL XML, RDF/XML and Turtle/N3.

This package provides tools to fit Bayesian state-space models to animal tracking data. Models are provided for location filtering, location filtering and behavioural state estimation, and their hierarchical versions. The models are primarily intended for fitting to ARGOS satellite tracking data but options exist to fit to other tracking data types. For Global Positioning System data, consider the moveHMM package. Simplified Markov Chain Monte Carlo convergence diagnostic plotting is provided but users are encouraged to explore tools available in packages such as coda and boa'.

This package performs regression analysis for longitudinal count data, allowing for serial dependence among observations from a given individual and two dimensional random effects on the linear predictor. Estimation is via maximization of the exact likelihood of a suitably defined model. Missing values and unbalanced data are allowed. Details can be found in the accompanying scientific papers: Goncalves & Cabral (2021, Journal of Statistical Software, <doi:10.18637/jss.v099.i03>) and Goncalves et al. (2007, Computational Statistics & Data Analysis, <doi:10.1016/j.csda.2007.03.002>).

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a 3+3/PC dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.

To help you access, transform, analyze, and visualize ForestGEO data, we developed a collection of R packages (<https://forestgeo.github.io/fgeo/>). This package, in particular, helps you to install and load the entire package-collection with a single R command, and provides convenient ways to find relevant documentation. Most commonly, you should not worry about the individual packages that make up the package-collection as you can access all features via this package. To learn more about ForestGEO visit <http://www.forestgeo.si.edu/>.

This package provides methods to "add" two R tables; also an alternative interpretation of named vectors as generalized R tables, so that c(a=1,b=2,c=3) + c(b=3,a=-1) will return c(b=5,c=3). Uses disordR discipline (Hankin, 2022, <doi:10.48550/arXiv.2210.03856>). Extraction and replacement methods are provided. The underlying mathematical structure is the Free Abelian group, hence the name. To cite in publications please use Hankin (2023) <doi:10.48550/arXiv.2307.13184>.

Fit a full or subsampling bagging survival tree on a mixture of population (susceptible and nonsusceptible) using either a pseudo R2 criterion or an adjusted Logrank criterion. The predictor is evaluated using the Out Of Bag Integrated Brier Score (IBS) and several scores of importance are computed for variable selection. The thresholds values for variable selection are computed using a nonparametric permutation test. See Cyprien Mbogning and Philippe Broet (2016)<doi:10.1186/s12859-016-1090-x> for an overview about the methods implemented in this package.

This package contains model-based treatment of missing data for regression models with missing values in covariates or the dependent variable using maximum likelihood or Bayesian estimation (Ibrahim et al., 2005; <doi:10.1198/016214504000001844>; Luedtke, Robitzsch, & West, 2020a, 2020b; <doi:10.1080/00273171.2019.1640104><doi:10.1037/met0000233>). The regression model can be nonlinear (e.g., interaction effects, quadratic effects or B-spline functions). Multilevel models with missing data in predictors are available for Bayesian estimation. Substantive-model compatible multiple imputation can be also conducted.

We consider the network structure detection for variables Y with auxiliary variables X accommodated, which are possibly subject to measurement error. The following three functions are designed to address various structures by different methods : one is NP_Graph() that is used for handling the nonlinear relationship between the responses and the covariates, another is Joint_Gaussian() that is used for correction in linear regression models via the Gaussian maximum likelihood, and the other Cond_Gaussian() is for linear regression models via conditional likelihood function.

Implementation of prediction and inference procedures for Synthetic Control methods using least square, lasso, ridge, or simplex-type constraints. Uncertainty is quantified with prediction intervals as developed in Cattaneo, Feng, and Titiunik (2021) <doi:10.1080/01621459.2021.1979561> for a single treated unit and in Cattaneo, Feng, Palomba, and Titiunik (2025) <doi:10.1162/rest_a_01588> for multiple treated units and staggered adoption. More details about the software implementation can be found in Cattaneo, Feng, Palomba, and Titiunik (2025) <doi:10.18637/jss.v113.i01>.

Access and manipulate spatial tracking data, with straightforward coercion from and to other formats. Filter for speed and create time spent maps from tracking data. There are coercion methods to convert between trip and ltraj from adehabitatLT', and between trip and psp and ppp from spatstat'. Trip objects can be created from raw or grouped data frames, and from types in the sp', sf', amt', trackeR', mousetrap', and other packages, Sumner, MD (2011) <https://figshare.utas.edu.au/articles/thesis/The_tag_location_problem/23209538>.

HPiP (Host-Pathogen Interaction Prediction) uses an ensemble learning algorithm for prediction of host-pathogen protein-protein interactions (HP-PPIs) using structural and physicochemical descriptors computed from amino acid-composition of host and pathogen proteins.The proposed package can effectively address data shortages and data unavailability for HP-PPI network reconstructions. Moreover, establishing computational frameworks in that regard will reveal mechanistic insights into infectious diseases and suggest potential HP-PPI targets, thus narrowing down the range of possible candidates for subsequent wet-lab experimental validations.

RNA abundance and cell size parameters could improve RNA-seq deconvolution algorithms to more accurately estimate cell type proportions given the different cell type transcription activity levels. A Total RNA Expression Gene (TREG) can facilitate estimating total RNA content using single molecule fluorescent in situ hybridization (smFISH). We developed a data-driven approach using a measure of expression invariance to find candidate TREGs in postmortem human brain single nucleus RNA-seq. This R package implements the method for identifying candidate TREGs from snRNA-seq data.

The main purpose of this package is to provide the algorithmic complexity for short strings, an approximation of the Kolmogorov Complexity of a short string using the coding theorem method. While the database containing the complexity is provided in the data only package acss.data, this package provides functions accessing the data such as prob_random returning the posterior probability that a given string was produced by a random process. In addition, two traditional (but problematic) measures of complexity are also provided: entropy and change complexity.

This package provides functions for the Bayesian analysis of some simple commonly-used models, without using Markov Chain Monte Carlo (MCMC) methods such as Gibbs sampling. The rust package <https://cran.r-project.org/package=rust> is used to simulate a random sample from the required posterior distribution, using the generalized ratio-of-uniforms method. See Wakefield, Gelfand and Smith (1991) <DOI:10.1007/BF01889987> for details. At the moment three conjugate hierarchical models are available: beta-binomial, gamma-Poisson and a 1-way analysis of variance (ANOVA).

This package implements multiple change searching algorithms for a variety of frequently considered parametric change-point models. In particular, it integrates a criterion proposed by Zou, Wang and Li (2020) <doi:10.1214/19-AOS1814> to select the number of change-points in a data-driven fashion. Moreover, it also provides interfaces for user-customized change-point models with one's own cost function and parameter estimation routine. It is easy to get started with the cpss.* set of functions by accessing their documentation pages (e.g., ?cpss).

Access chemical, hazard, bioactivity, and exposure data from the Computational Toxicology and Exposure ('CTX') APIs <https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis>. ctxR was developed to streamline the process of accessing the information available through the CTX APIs without requiring prior knowledge of how to use APIs. Most data is also available on the CompTox Chemical Dashboard ('CCD') <https://comptox.epa.gov/dashboard/> and other resources found at the EPA Computational Toxicology and Exposure Online Resources <https://www.epa.gov/comptox-tools>.

Compares distributions with one another in terms of their fit to each sample in a dataset that contains multiple samples, as described in Joo, Aguinis, and Bradley (in press). Users can examine the fit of seven distributions per sample: pure power law, lognormal, exponential, power law with an exponential cutoff, normal, Poisson, and Weibull. Automation features allow the user to compare all distributions for all samples with a single command line, which creates a separate row containing results for each sample until the entire dataset has been analyzed.