This Rcpp-based package implements a highly efficient data structure and algorithm for performing alignment of short reads from CRISPR or shRNA screens to reference barcode library. Sequencing error are considered and matching qualities are evaluated based on Phred scores. A Bayes classifier is employed to predict the originating barcode of a read. The package supports provision of user-defined probability models for evaluating matching qualities. The package also supports multi-threading.

This package provides functions and classes for de novo prediction of transcription factor binding consensus by heuristic search.

Bindings to the blowfish password hashing algorithm <https://www.openbsd.org/papers/bcrypt-paper.pdf> derived from the OpenBSD implementation.

BCFtools is a set of utilities that manipulate variant calls in the Variant Call Format (VCF) and its binary counterpart BCF. All commands work transparently with both VCFs and BCFs, both uncompressed and BGZF-compressed.

BCFtools is a set of utilities that manipulate variant calls in the Variant Call Format (VCF) and its binary counterpart BCF. All commands work transparently with both VCFs and BCFs, both uncompressed and BGZF-compressed.

Implementation of the BC3NET algorithm for gene regulatory network inference (de Matos Simoes and Frank Emmert-Streib, Bagging Statistical Network Inference from Large-Scale Gene Expression Data, PLoS ONE 7(3): e33624, <doi:10.1371/journal.pone.0033624>).

Search, query, and download tabular and geospatial data from the British Columbia Data Catalogue (<https://catalogue.data.gov.bc.ca/>). Search catalogue data records based on keywords, data licence, sector, data format, and B.C. government organization. View metadata directly in R, download many data formats, and query geospatial data available via the B.C. government Web Feature Service ('WFS') using dplyr syntax.

This package provides a collection of tools for regression analysis of non-negative data, including strictly positive and zero-inflated observations, based on the class of the Box-Cox symmetric (BCS) distributions and its zero-adjusted extension. The BCS distributions are a class of flexible probability models capable of describing different levels of skewness and tail-heaviness. The package offers a comprehensive regression modeling framework, including estimation and tools for evaluating goodness-of-fit.

Various layers of B.C., including administrative boundaries, natural resource management boundaries, census boundaries etc. All layers are available in BC Albers (<https://spatialreference.org/ref/epsg/3005/>) equal-area projection, which is the B.C. government standard. The layers are sourced from the British Columbia and Canadian government under open licenses, including B.C. Data Catalogue (<https://data.gov.bc.ca>), the Government of Canada Open Data Portal (<https://open.canada.ca/en/using-open-data>), and Statistics Canada (<https://www.statcan.gc.ca/en/terms-conditions/open-licence>).

Enables quick calibration of radiocarbon dates under various calibration curves (including user generated ones); age-depth modelling as per the algorithm of Haslett and Parnell (2008) <DOI:10.1111/j.1467-9876.2008.00623.x>; Relative sea level rate estimation incorporating time uncertainty in polynomial regression models (Parnell and Gehrels 2015) <DOI:10.1002/9781118452547.ch32>; non-parametric phase modelling via Gaussian mixtures as a means to determine the activity of a site (and as an alternative to the Oxcal function SUM(); currently unpublished), and reverse calibration of dates from calibrated into 14C years (also unpublished).

Implementing the Block Coordinate Ascent with One-Step Generalized Rosen (BCA1SG) algorithm on the semiparametric models for panel count data, interval-censored survival data, and degradation data. A comprehensive description of the BCA1SG algorithm can be found in Wang et al. (2020) <https://github.com/yudongstat/BCA1SG/blob/master/BCA1SG.pdf>. For details of the semiparametric models for panel count data, interval-censored survival data, and degradation data, please see Wellner and Zhang (2007) <doi:10.1214/009053607000000181>, Huang and Wellner (1997) <ISBN:978-0-387-94992-5>, and Wang and Xu (2010) <doi:10.1198/TECH.2009.08197>, respectively.

Fully Bayesian Classification with a subset of high-dimensional features, such as expression levels of genes. The data are modeled with a hierarchical Bayesian models using heavy-tailed t distributions as priors. When a large number of features are available, one may like to select only a subset of features to use, typically those features strongly correlated with the response in training cases. Such a feature selection procedure is however invalid since the relationship between the response and the features has be exaggerated by feature selection. This package provides a way to avoid this bias and yield better-calibrated predictions for future cases when one uses F-statistic to select features.

BcToolBox is an utilities library used by Belledonne Communications software like belle-sip, mediastreamer2 and linphone.

Computation of bootstrap confidence intervals in an almost automatic fashion as described in Efron and Narasimhan (2020, <doi:10.1080/10618600.2020.1714633>).

Inference on the marginal model of the mixed effect model with the Box-Cox transformation and on the model median differences between treatment groups for longitudinal randomized clinical trials. These statistical methods are proposed by Maruo et al. (2017) <doi:10.1002/sim.7279>.

Calculates the prices of European options based on the universal solution provided by Bakshi, Cao and Chen (1997) <doi:10.1111/j.1540-6261.1997.tb02749.x>. This solution considers stochastic volatility, stochastic interest and random jumps. Please cite their work if this package is used.

This package performs inference for Bayesian conditional logistic regression with informative priors built from the concordant pair data. We include many options to build the priors. And we include many options during the inference step for estimation, testing and confidence set creation. For details, see Kapelner and Tennenbaum (2026) "Improved Conditional Logistic Regression using Information in Concordant Pairs with Software" <doi:10.48550/arXiv.2602.08212>.

It is very common nowadays for a study to collect multiple features and appropriately integrating multiple longitudinal features simultaneously for defining individual clusters becomes increasingly crucial to understanding population heterogeneity and predicting future outcomes. BCClong implements a Bayesian consensus clustering (BCC) model for multiple longitudinal features via a generalized linear mixed model. Compared to existing packages, several key features make the BCClong package appealing: (a) it allows simultaneous clustering of mixed-type (e.g., continuous, discrete and categorical) longitudinal features, (b) it allows each longitudinal feature to be collected from different sources with measurements taken at distinct sets of time points (known as irregularly sampled longitudinal data), (c) it relaxes the assumption that all features have the same clustering structure by estimating the feature-specific (local) clusterings and consensus (global) clustering.

This package provides tools for Dating Business Cycles using Harding-Pagan (Quarterly Bry-Boschan) method and various plotting features.

Fit semiparametric bivariate correlated frailty models.

This Ruby library provides a simple wrapper to bcrypt, a secure hash algorithm for hashing passwords.

BcMatroska is a free and open standard multi-media container format. It can hold an unlimited number of video, audio, picture, or subtitle tracks in one file. This project provides a convenient distribution of the Matroska multimedia container format.

This package provides functions to utilize a command line utility that does bulk inserts and exports from SQL Server databases.