This packages simulates spatial transcriptomics data with the mean- variance relationship using a Gaussian Process model per gene.

This package provides tools for spatial data analysis. Emphasis on kriging. Provides functions for prediction and simulation. Intended to be relatively straightforward, fast, and flexible.

Using spatial or bulk gene expression data, estimates abundance of mixed cell types within each observation. Based on "Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data", Danaher (2022). Designed for use with the NanoString GeoMx platform, but applicable to any gene expression data.

This package performs simulations of binary spatial raster data using the Ising model (Ising (1925) <doi:10.1007/BF02980577>; Onsager (1944) <doi:10.1103/PhysRev.65.117>). It allows to set a few parameters that represent internal and external pressures, and the number of simulations (Stepinski and Nowosad (2023) <doi:10.1098/rsos.231005>).

Provision of the S4 SpatialGraph class built on top of objects provided by igraph and sp packages, and associated utilities. See the documentation of the SpatialGraph-class within this package for further description. An example of how from a few points one can arrive to a SpatialGraph is provided in the function sl2sg().

This package provides robust estimation for spatial error model to presence of outliers in the residuals. The classical estimation methods can be influenced by the presence of outliers in the data. We proposed a robust estimation approach based on the robustified likelihood equations for spatial error model (Vural Yildirim & Yeliz Mert Kantar (2020): Robust estimation approach for spatial error model, Journal of Statistical Computation and Simulation, <doi:10.1080/00949655.2020.1740223>).

Many packages use htmlwidgets <https://CRAN.R-project.org/package=htmlwidgets> for interactive plotting of spatial data. This package provides functions for converting R objects, such as simple features, into structures suitable for use in htmlwidgets mapping libraries.

This package provides a collection of methods for the Bayesian estimation of Spatial Probit, Spatial Ordered Probit and Spatial Tobit Models. Original implementations from the works of LeSage and Pace (2009, ISBN: 1420064258) were ported and adjusted for R, as described in Wilhelm and de Matos (2013) <doi:10.32614/RJ-2013-013>.

This package provides functions and classes for spatial resampling to use with the rsample package, such as spatial cross-validation (Brenning, 2012) <doi:10.1109/IGARSS.2012.6352393>. The scope of rsample and spatialsample is to provide the basic building blocks for creating and analyzing resamples of a spatial data set, but neither package includes functions for modeling or computing statistics. The resampled spatial data sets created by spatialsample do not contain much overhead in memory.

The spatialHeatmap package offers the primary functionality for visualizing cell-, tissue- and organ-specific assay data in spatial anatomical images. Additionally, it provides extended functionalities for large-scale data mining routines and co-visualizing bulk and single-cell data. A description of the project is available here: https://spatialheatmap.org.

This package provides a collection of functions for estimating spatial regimes, aggregations of neighboring spatial units that are homogeneous in functional terms. The term spatial regime, therefore, should not be understood as a synonym for cluster. More precisely, the term cluster does not presuppose any functional relationship between the variables considered, while the term regime is linked to a regressive relationship underlying the spatial process.

This is a collection of publically available spatial omics datasets. Where possible we have curated these datasets as either SpatialExperiments, MoleculeExperiments or CytoImageLists and included annotations of the sample characteristics.

Computes spatial position models: the potential model as defined by Stewart (1941) <doi:10.1126/science.93.2404.89> and catchment areas as defined by Reilly (1931) or Huff (1964) <doi:10.2307/1249154>.

This package provides tools to compute and assess significance of early-warnings signals (EWS) of ecosystem degradation on raster data sets. EWS are spatial metrics derived from raster data -- e.g. spatial autocorrelation -- that increase before an ecosystem undergoes a non-linear transition (Genin et al. (2018) <doi:10.1111/2041-210X.13058>).

Spatial allelic expression counts from Combs & Fraser (2018), compiled into a SummarizedExperiment object. This package contains data of allelic expression counts of spatial slices of a fly embryo, a Drosophila melanogaster x Drosophila simulans cross. See the CITATION file for the data source, and the associated script for how the object was constructed from publicly available data.

This package provides tools for the statistical modelling of spatial extremes using max-stable processes, copula or Bayesian hierarchical models. More precisely, this package allows (conditional) simulations from various parametric max-stable models, analysis of the extremal spatial dependence, the fitting of such processes using composite likelihoods or least square (simple max-stable processes only), model checking and selection and prediction.

This package defines an S4 class for storing data from spatial -omics experiments. The class extends SingleCellExperiment to support storage and retrieval of additional information from spot-based and molecule-based platforms, including spatial coordinates, images, and image metadata. A specialized constructor function is included for data from the 10x Genomics Visium platform.

This package provides functions that compute the spatial covariance matrix for the matern and power classes of spatial models, for data that arise on rectangular units. This code can also be used for the change of support problem and for spatial data that arise on irregularly shaped regions like counties or zipcodes by laying a fine grid of rectangles and aggregating the integrals in a form of Riemann integration.

This package provides tools for NanoString Technologies GeoMx Technology. Package to easily graph on top of an OME-TIFF image. Plotting annotations can range from tissue segment to gene expression.

This package provides a new S4 class integrating Simple Features with the R package sf to bring geospatial data analysis methods based on vector data to spatial transcriptomics. Also implements management of spatial neighborhood graphs and geometric operations. This pakage builds upon SpatialExperiment and SingleCellExperiment, hence methods for these parent classes can still be used.