This package performs the colocalisation tests described in Giambartolomei et al (2013) <doi:10.1371/journal.pgen.1004383>, Wallace (2020) <doi:10.1371/journal.pgen.1008720>, Wallace (2021) <doi:10.1371/journal.pgen.1009440>.

This package provides functions for (1) ranking, selecting, and prioritising genes, proteins, and metabolites from high dimensional biology experiments, (2) multivariate hit calling in high content screens, and (3) combining data from diverse sources.

Manipulates date ('Date'), date time ('POSIXct') and time ('hms') vectors. Date/times are considered discrete and are floored whenever encountered. Times are wrapped and time zones are maintained unless explicitly altered by the user.

Functional denoising and functional ANOVA through wavelet-domain Markov groves. Fore more details see: Ma L. and Soriano J. (2018) Efficient functional ANOVA through wavelet-domain Markov groves. <arXiv:1602.03990v2 [stat.ME]>.

Bayesian nonlinear regression under a range of likelihood models using generalized Bayesian adaptive smoothing splines. Robust regression with Student's t likelihoods, quantile regression, and related latent-scale models are included as special cases.

Analyze small-sample clustered or longitudinal data using modified generalized estimating equations with bias-adjusted covariance estimator. The package provides any combination of three modified generalized estimating equations and 11 bias-adjusted covariance estimators.

Make it easy to create simplified trial summary (TS) domain based on FDA FDA guide <https://github.com/TuCai/phuse/blob/master/inst/examples/07_genTS/www/Simplified_TS_Creation_Guide_v2.pdf>.

This package provides a network-based gene weighting algorithm for pathway enrichment analysis, using either RNA-seq or microarray data. Zhaoyuan Fang, Weidong Tian and Hongbin Ji (2012) <doi:10.1038/cr.2011.149>.

This package provides a personalized dynamic latent factor model (Zhang et al. (2024) <doi:10.1093/biomet/asae015>) for irregular multi-resolution time series data, to interpolate unsampled measurements from low-resolution time series.

This package contains functions for converting existing HTML/JavaScript source into equivalent shiny functions. Bootstraps the process of making new shiny functions by allowing us to turn HTML snippets directly into R functions.

This package provides a macro language for R programs, which provides a macro facility similar to SAS®'. This package contains basic macro capabilities like defining macro variables, executing conditional logic, and defining macro functions.

This package provides a toolkit for medical records data analysis. The naryn package implements an efficient data structure for storing medical records, and provides a set of functions for data extraction, manipulation and analysis.

Empirically extrapolates recurring patterns in numeric and categorical time-feature sequences. Candidate windows are selected by similarity, validated with rolling-origin evaluation, and summarized as forecast distributions. The runtime package uses only base R.

Wrapper around the Open Source Routing Machine (OSRM) API <http://project-osrm.org/>. osrmr works with API versions 4 and 5 and can handle servers that run locally as well as the OSRM webserver.

Spatial estimation of a prevalence surface or a relative risks surface, using data from a Demographic and Health Survey (DHS) or an analog survey, see Larmarange et al. (2011) <doi:10.4000/cybergeo.24606>.

Fits Parametric Frailty Models by maximum marginal likelihood. Possible baseline hazards: exponential, Weibull, inverse Weibull (Fréchet), Gompertz, lognormal, log-skew-normal, and loglogistic. Possible Frailty distributions: gamma, positive stable, inverse Gaussian and lognormal.

User-friendly functions which parse output of command line programs used to query Slurm. Morris A. Jette and Tim Wickberg (2023) <doi:10.1007/978-3-031-43943-8_1> describe Slurm in detail.

Implementation of the Conditional Least Square (CLS) estimates and its covariance matrix for the first-order spatial integer-valued autoregressive model (SINAR(1,1)) proposed by Ghodsi (2012) <doi:10.1080/03610926.2011.560739>.

An implementation of interpreted string literals. Based on the glue package by Hester & Bryan (2024) <doi:10.32614/CRAN.package.glue> but with a focus on efficiency and simplicity at a cost of flexibility.

Sparse arrays interpreted as multivariate polynomials. Uses disordR discipline (Hankin, 2022, <doi:10.48550/ARXIV.2210.03856>). To cite the package in publications please use Hankin (2022) <doi:10.48550/ARXIV.2210.10848>.

Risk ratios and risk differences are estimated using regression models that allow for binary, categorical, and continuous exposures and confounders. Implemented are marginal standardization after fitting logistic models (g-computation) with delta-method and bootstrap standard errors, Miettinen's case-duplication approach (Schouten et al. 1993, <doi:10.1002/sim.4780121808>), log-binomial (Poisson) models with empirical variance (Zou 2004, <doi:10.1093/aje/kwh090>), binomial models with starting values from Poisson models (Spiegelman and Hertzmark 2005, <doi:10.1093/aje/kwi188>), and others.

This package contains functions for the SCENT algorithm. SCENT uses single-cell multimodal data and links ATAC-seq peaks to their target genes by modeling association between chromatin accessibility and gene expression across individual single cells.

The goal of anpan is to consolidate statistical methods for strain analysis. This includes automated filtering of metagenomic functional profiles, testing genetic elements for association with outcomes, phylogenetic association testing, and pathway-level random effects models.

The vegan package provides tools for descriptive community ecology. It has most basic functions of diversity analysis, community ordination and dissimilarity analysis. Most of its multivariate tools can be used for other data types as well.