leapR is a package that identifies pathways that are enriched across diverse omics experiments. It leverages any tabular expression data (proteomics, transcriptomics) using the `SummarizedExperiment` object. It works with any pathway in the .gct file format.

Find an upper bound for the total amount of overstatement of assets in a set of accounts, or estimate the amount of sales tax owed on a collection of transactions (Meeden and Sargent, 2007, <doi:10.1080/03610920701386802>).

This package provides a minimalist web framework for developing application programming interfaces in R that provides a flexible framework for handling common HTTP-requests, errors, logging, and an ability to integrate any R code as server middle-ware.

This package implements the Changepoints for a Range of Penalties (CROPS) algorithm of Haynes et al. (2017) <doi:10.1080/10618600.2015.1116445> for finding all of the optimal segmentations for multiple penalty values over a continuous range.

Fits constrained groupwise additive index models and provides functions for inference and interpretation of these models. The method is described in Masselot, Chebana, Campagna, Lavigne, Ouarda, Gosselin (2022) "Constrained groupwise additive index models" <doi:10.1093/biostatistics/kxac023>.

The COSSO regularization method automatically estimates and selects important function components by a soft-thresholding penalty in the context of smoothing spline ANOVA models. Implemented models include mean regression, quantile regression, logistic regression and the Cox regression models.

This package contains the normalizing and variance stabilizing Data-Driven Haar-Fisz algorithm. Also contains related algorithms for simulating from certain microarray gene intensity models and evaluation of certain transformations. Contains cDNA and shipping credit flow data.

Fast fitting of generalised linear models on moderately large datasets, by taking an initial sample, fitting in memory, then evaluating the score function for the full data in the database. Thomas Lumley <doi:10.1080/10618600.2019.1610312>.

You can load a schema from a DTR (data type registry) as an R object. Use this schema to write your data in JSON-LD (JavaScript Object Notation for Linked Data) format to make it machine readable.

Computing Global Sensitivity Indices from given data using Optimal Transport, as defined in Borgonovo et al (2024) <doi:10.1287/mnsc.2023.01796>. You provide an input sample, an output sample, decide the algorithm, and compute the indices.

Analysis of multivariate data using generalized linear latent variable models (gllvm). Estimation is performed using either the Laplace method, variational approximations, or extended variational approximations, implemented via TMB (Kristensen et al. (2016), <doi:10.18637/jss.v070.i05>).

Ridge regression provide biased estimators of the regression parameters with lower variance. The HDBRR ("High Dimensional Bayesian Ridge Regression") function fits Bayesian Ridge regression without MCMC, this one uses the SVD or QR decomposition for the posterior computation.

Several procedures for the hierarchical kernel extreme value process of Reich and Shaby (2012) <DOI:10.1214/12-AOAS591>, including simulation, estimation and spatial extrapolation. The spatial latent variable model <DOI:10.1214/11-STS376> is also included.

Implementation for kernel functional partial least squares (KFPLS) method. KFPLS method is developed for functional nonlinear models, and the method does not require strict constraints for the nonlinear structures. The crucial function of this package is KFPLS().

Framework for adding authentication to shiny applications. Provides flexibility as compared to other options for where user credentials are saved, allows users to create their own accounts, and password reset functionality. Bryer (2024) <doi:10.5281/zenodo.10987876>.

Maximum likelihood Gaussian process modeling for univariate and multi-dimensional outputs with diagnostic plots following Santner et al (2003) <doi:10.1007/978-1-4757-3799-8>. Contact the maintainer for a package version that includes sensitivity analysis.

Estimation of relatively complex nonlinear mixed-effects models, including the Sigmoidal Mixed Model and the Piecewise Linear Mixed Model with abrupt or smooth transition, through a single intuitive line of code and with automated generation of starting values.

This package provides tools for 4D nucleome imaging. Quantitative analysis of the 3D nuclear landscape recorded with super-resolved fluorescence microscopy. See Volker J. Schmid, Marion Cremer, Thomas Cremer (2017) <doi:10.1016/j.ymeth.2017.03.013>.

This package implements the Univariate Bootstrap and the Traditional (Naive) Bootstrap for resampling multivariate data while preserving covariance structure. Also provides functions for DeFries-Fulker behavioral genetics models, including the Rodgers-Kohler formulation with robust standard errors.

Perform flexible and quick calculations for Demand and Supply Planning, such as projected inventories and coverages, as well as replenishment plan. For any time bucket, daily, weekly or monthly, and any granularity level, product or group of products.

Fits the Piecewise Exponential distribution with random time grids using the clustering structure of the Product Partition Models. Details of the implemented model can be found in Demarqui et al. (2008) <doi:10.1007/s10985-008-9086-0>.

To calculate the standard error of measurement (SEM) to assess the observer variability (inter- and intra-observer variation). The methods used in this package are referenced from Zoran B. PopoviÄ (2017) <doi:10.21037/cdt.2017.03.12>.

Computes clustering by fitting Gaussian mixture models (GMM) via stochastic approximation following the methods of Nguyen and Jones (2018) <doi:10.1201/9780429446177>. It also provides some test data generation and plotting functionality to assist with this process.

Fits Gaussian, Binomial, and Negative-Binomial varying-coefficient mixture-of-experts models with local-linear estimation, explicit label alignment, bandwidth selection, diagnostics, bootstrap inference, analytic-style confidence bands, and coefficient-specific analytic GLRT diagnostics with optional bootstrap calibration.