Simply and efficiently simulates (i) variants from reference genomes and (ii) reads from both Illumina <https://www.illumina.com/> and Pacific Biosciences (PacBio) <https://www.pacb.com/> platforms. It can either read reference genomes from FASTA files or simulate new ones. Genomic variants can be simulated using summary statistics, phylogenies, Variant Call Format (VCF) files, and coalescent simulationsâ the latter of which can include selection, recombination, and demographic fluctuations. jackalope can simulate single, paired-end, or mate-pair Illumina reads, as well as PacBio reads. These simulations include sequencing errors, mapping qualities, multiplexing, and optical/polymerase chain reaction (PCR) duplicates. Simulating Illumina sequencing is based on ART by Huang et al. (2012) <doi:10.1093/bioinformatics/btr708>. PacBio sequencing simulation is based on SimLoRD by Stöcker et al. (2016) <doi:10.1093/bioinformatics/btw286>. All outputs can be written to standard file formats.

Download and post process the infectious disease case data from Japan Institute for Health Security. Also the package included ready-to-analyse datasets. See the data source website for further details <https://id-info.jihs.go.jp/>.

This package provides a set of functions to compute the Hodrick-Prescott (HP) filter with automatically selected jumps. The original HP filter extracts a smooth trend from a time series, and our version allows for a small number of automatically identified jumps. See Maranzano and Pelagatti (2024) <doi:10.2139/ssrn.4896170> for details.

Different algorithms to perform approximate joint diagonalization of a finite set of square matrices. Depending on the algorithm, orthogonal or non-orthogonal diagonalizer is found. These algorithms are particularly useful in the context of blind source separation. Original publications of the algorithms can be found in Ziehe et al. (2004), Pham and Cardoso (2001) <doi:10.1109/78.942614>, Souloumiac (2009) <doi:10.1109/TSP.2009.2016997>, Vollgraff and Obermayer <doi:10.1109/TSP.2006.877673>. An example of application in the context of Brain-Computer Interfaces EEG denoising can be found in Gouy-Pailler et al (2010) <doi:10.1109/TBME.2009.2032162>.

Allows to import functions and whole packages from Julia in R. Imported Julia functions can directly be called as R functions. Data structures can be translated between Julia and R. More details can also be found in the corresponding article <doi:10.18637/jss.v101.i06>.

Reproducible work requires a record of where every statistic originated. When writing reports, some data is too big to load in the same environment and some statistics take a while to compute. This package offers a way to keep notes on statistics, simple functions, and small objects. Notepads can be locked to avoid accidental updates. Notepads keep track of who added the notes and when the notes were added. A simple text representation is used to allow for clear version histories.

Fit joint models for longitudinal and time-to-event data under the Bayesian approach. Multiple longitudinal outcomes of mixed type (continuous/categorical) and multiple event times (competing risks and multi-state processes) are accommodated. Rizopoulos (2012, ISBN:9781439872864).

This package provides a gridded classification of weather types by applying the Jenkinson and Collison classification. For a given region (it can be either local region or the whole map),it computes at each grid the 11 weather types during the period considered for the analysis. See Otero et al., (2017) <doi:10.1007/s00382-017-3705-y> for more information.

Computes the Jackknife Mutual Information (JMI) between two random vectors and provides the p-value for dependence tests. See Zeng, X., Xia, Y. and Tong, H. (2018) <doi:10.1073/pnas.1715593115>.

This package provides an interface to Jamendo API <https://developer.jamendo.com/v3.0>. Pull audio, features and other information for a given Jamendo user (including yourself!) or enter an artist's -, album's -, or track's name and retrieve the available information in seconds.

Automatic disaggregation of small-area population estimates by demographic groups (e.g., age, sex, race, marital status, educational level, etc) along with the estimates of uncertainty, using advanced Bayesian statistical modelling approaches based on integrated nested Laplace approximation (INLA) Rue et al. (2009) <doi:10.1111/j.1467-9868.2008.00700.x> and stochastic partial differential equation (SPDE) methods Lindgren et al. (2011) <doi:10.1111/j.1467-9868.2011.00777.x>. The package implements hierarchical Bayesian modeling frameworks for small area estimation as described in Leasure et al. (2020) <doi:10.1073/pnas.1913050117> and Nnanatu et al. (2025) <doi:10.1038/s41467-025-59862-4>.

This package provides methods for fast segmentation of multivariate signals into piecewise constant profiles and for generating realistic copy-number profiles. A typical application is the joint segmentation of total DNA copy numbers and allelic ratios obtained from Single Nucleotide Polymorphism (SNP) microarrays in cancer studies. The methods are described in Pierre-Jean, Rigaill and Neuvial (2015) <doi:10.1093/bib/bbu026>.

Leverages the yum package to implement a YAML ('YAML Ain't Markup Language', a human friendly standard for data serialization; see <https://yaml.org>) standard for documenting justifications, such as for decisions taken during the planning, execution and analysis of a study or during the development of a behavior change intervention as illustrated by Marques & Peters (2019) <doi:10.17605/osf.io/ndxha>. These justifications are both human- and machine-readable, facilitating efficient extraction and organisation.

Aids in the calculation and visualization of regions of non-significance using the Johnson-Neyman technique and its extensions as described by Bauer and Curran (2005) <doi:10.1207/s15327906mbr4003_5> to assess the influence of categorical and continuous moderators. Allows correcting for phylogenetic relatedness.

Solves kernel ridge regression, within the the mixed model framework, for the linear, polynomial, Gaussian, Laplacian and ANOVA kernels. The model components (i.e. fixed and random effects) and variance parameters are estimated using the expectation-maximization (EM) algorithm. All the estimated components and parameters, e.g. BLUP of dual variables and BLUP of random predictor effects for the linear kernel (also known as RR-BLUP), are available. The kernel ridge mixed model (KRMM) is described in Jacquin L, Cao T-V and Ahmadi N (2016) A Unified and Comprehensible View of Parametric and Kernel Methods for Genomic Prediction with Application to Rice. Front. Genet. 7:145. <doi:10.3389/fgene.2016.00145>.

Predicts any variable in any categorical dataset for given values of predictor variables. If a dataset contains 4 variables, then any variable can be predicted based on the values of the other three variables given by the user. The user can upload their own datasets and select what variable they want to predict. A handsontable is provided to enter the predictor values and also accuracy of the prediction is also shown.

Cubic spline fitting along with knot selection, includes support for additional variables.

Offers a graphical user interface for the evaluation of inter-rater agreement with Cohen's and Fleiss Kappa. The calculation of kappa statistics is done using the R package irr', so that KappaGUI is essentially a Shiny front-end for irr'.

Uses Bessel functions to calculate the fundamental and complementary analytic solutions to the Kelvin differential equation.

Selection of k in k-means clustering based on Pham et al. paper ``Selection of k in k-means clustering''.

K Quantiles Medoids (KQM) clustering applies quantiles to divide data of each dimension into K mean intervals. Combining quantiles of all the dimensions of the data and fully permuting quantiles on each dimension is the strategy to determine a pool of candidate initial cluster centers. To find the best initial cluster centers from the pool of candidate initial cluster centers, two methods based on quantile strategy and PAM strategy respectively are proposed. During a clustering process, medoids of clusters are used to update cluster centers in each iteration. Comparison between KQM and the method of randomly selecting initial cluster centers shows that KQM is almost always getting clustering results with smaller total sum squares of distances.

This package provides methods to extract information on pathways, genes and various single-nucleotid polymorphisms (SNPs) from online databases. It provides functions for data preparation and evaluation of genetic influence on a binary outcome using the logistic kernel machine test (LKMT). Three different kernel functions are offered to analyze genotype information in this variance component test: A linear kernel, a size-adjusted kernel and a network-based kernel).

Assists researchers in choosing Key Opinion Leaders (KOLs) in a network to help disseminate or encourage adoption of an innovation by other network members. Potential KOL teams are evaluated using the ABCDE framework (Neal et al., 2025 <doi:10.31219/osf.io/3vxy9_v1>). This framework which considers: (1) the team members Availability, (2) the Breadth of the team's network coverage, (3) the Cost of recruiting a team of a given size, and (4) the Diversity of the team's members, (5) which are pooled into a single Evaluation score.

In self-reported or anonymised data the user often encounters heaped data, i.e. data which are rounded (to a possibly different degree of coarseness). While this is mostly a minor problem in parametric density estimation the bias can be very large for non-parametric methods such as kernel density estimation. This package implements a partly Bayesian algorithm treating the true unknown values as additional parameters and estimates the rounding parameters to give a corrected kernel density estimate. It supports various standard bandwidth selection methods. Varying rounding probabilities (depending on the true value) and asymmetric rounding is estimable as well: Gross, M. and Rendtel, U. (2016) (<doi:10.1093/jssam/smw011>). Additionally, bivariate non-parametric density estimation for rounded data, Gross, M. et al. (2016) (<doi:10.1111/rssa.12179>), as well as data aggregated on areas is supported.