This package provides functions and routines useful in the analysis of somatic signatures (cf. L. Alexandrov et al., Nature 2013). In particular, functions to perform a signature analysis with known signatures and a signature analysis on stratified mutational catalogue (SMC) are provided.

This package provides a collection of functions to create spatial weights matrix objects from polygon contiguities, from point patterns by distance and tessellations, for summarizing these objects, and for permitting their use in spatial data analysis, including regional aggregation by minimum spanning tree.

This package provides tools for depth functions methodology applied to multivariate analysis. Besides allowing calculation of depth values and depth-based location estimators, the package includes functions or drawing contour plots and perspective plots of depth functions. Euclidean and spherical depths are supported.

This package provides tools for creating and modifying HTTP requests, then performing them and processing the results. httr2 is a re-imagining of httr that uses a pipe-based interface and solves more of the problems that API wrapping packages face.

This package estimates conditional Akaike information in mixed-effect models. These models are fitted using (g)lmer() from lme4, lme() from nlme, and gamm() from mgcv. The provided functions facilitate the computation of the conditional Akaike information for model evaluation.

Tools for performing model selection and model averaging. Automated model selection through subsetting the maximum model, with optional constraints for model inclusion. Model parameter and prediction averaging based on model weights derived from information criteria (AICc and alike) or custom model weighting schemes.

Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation. The HiBED deconvolution estimates proportions up to 7 cell types (GABAergic neurons, glutamatergic neurons, astrocytes, microglial cells, oligodendrocytes, endothelial cells, and stromal cells) in bulk brain tissues.

This package provides functions for Accurate and Speedy linkage map construction, manipulation and diagnosis of Doubled Haploid, Backcross and Recombinant Inbred R/qtl objects. This includes extremely fast linkage map clustering and optimal marker ordering using MSTmap (see Wu et al.,2008).

Random variate generation, density, CDF and quantile function for the Argus distribution. Especially, it includes for random variate generation a flexible inversion method that is also fast in the varying parameter case. A Ratio-of-Uniforms method is provided as second alternative.

This package provides alternatives to the normal adjusted R-squared estimator for the estimation of the multiple squared correlation in regression models, as fitted by the lm() function. The alternative estimators are described in Karch (2020) <DOI:10.1525/collabra.343>.

This package implements life tables, fertility and mortality indicators, decomposition methods, Lee-Carter mortality forecasting, Leslie matrices, and population pyramids for demographic analysis. Methods are described in Preston et al. (2001, ISBN:1557864519) and Ustyuzhanin (2025) <doi:10.17323/demreview.v12i4.30415>.

Facilitates univariate and multivariate analysis of evolutionary sequences of phenotypic change. The package extends the modeling framework available in the paleoTS package. Please see <https://klvoje.github.io/evoTS/index.html> for information about the package and the implemented models.

Find all hierarchical models of specified generalized linear model with information criterion (AIC, BIC, or AICc) within specified cutoff of minimum value. Alternatively, find all such graphical models. Use branch and bound algorithm so we do not have to fit all models.

Fitting hidden Markov models of learning under the cognitive diagnosis framework. The estimation of the hidden Markov diagnostic classification model, the first order hidden Markov model, the reduced-reparameterized unified learning model, and the joint learning model for responses and response times.

We provide the collection of data-sets used in the book An Introduction to Statistical Learning with Applications in R, Second Edition'. These include many data-sets that we used in the first edition (some with minor changes), and some new datasets.

Convert irregularly spaced longitudinal data into regular intervals for further analysis, and perform clustering using advanced machine learning techniques. The package is designed for handling complex longitudinal datasets, optimizing them for research in healthcare, demography, and other fields requiring temporal data modeling.

Density, distribution function, quantile function and random generation for the K-distribution. A plotting function that plots data on Weibull paper and another function to draw additional lines. See results from package in T Lamont-Smith (2018), submitted J. R. Stat. Soc.

Routines to perform large scale regression. Linear, logistic, and Poisson regressions are supported. Large scale regression efficiently fits models where a small number of covariates are changing and the subjects have complete data. A genome wide association study would be an example.

This package provides a new approach to detect change points based on smoothing and multiple testing, which is for long data sequence modeled as piecewise constant functions plus stationary Gaussian noise, see Dan Cheng and Armin Schwartzman (2015) <arXiv:1504.06384>.

Handles and formats author information in scientific writing in R Markdown and Quarto'. plume provides easy-to-use and flexible tools for inserting author data in YAML as well as generating author and contribution lists (among others) as strings from tabular data.

Estimate coefficient of variation percent (CV%) for any arbitrary distribution, including some built-in estimates for commonly-used transformations in pharmacometrics. Methods are described in various sources, but applied here as summarized in: Prybylski, (2024) <doi:10.1007/s40262-023-01343-2>.

Fits single- and multiple-group penalized factor analysis models via a trust-region algorithm with integrated automatic multiple tuning parameter selection (Geminiani et al., 2021 <doi:10.1007/s11336-021-09751-8>). Available penalties include lasso, adaptive lasso, scad, mcp, and ridge.

Implementations self-normalization (SN) based algorithms for change-points estimation in time series data. This comprises nested local-window algorithms for detecting changes in both univariate and multivariate time series developed in Zhao, Jiang and Shao (2022) <doi:10.1111/rssb.12552>.

Hierarchical models for the analysis of species-area relationships (SARs) by combining several data sets and covariates; with a global data set combining individual SAR studies; as described in Solymos and Lele (2012) <doi:10.1111/j.1466-8238.2011.00655.x>.