This package implements a metabolic network analysis pipeline to identify an active metabolic module based on high throughput data. The pipeline takes as input transcriptional and/or metabolic data and finds a metabolic subnetwork (module) most regulated between the two conditions of interest. The package further provides functions for module post-processing, annotation and visualization.

This package provides a seamless interface to the MEME Suite family of tools for motif analysis. memes provides data aware utilities for using GRanges objects as entrypoints to motif analysis, data structures for examining & editing motif lists, and novel data visualizations. memes functions and data structures are amenable to both base R and tidyverse workflows.

This package implements a general purpose gene set analysis method called PADOG that downplays the importance of genes that apear often accross the sets of genes to be analyzed. The package provides also a benchmark for gene set analysis methods in terms of sensitivity and ranking using 24 public datasets from KEGGdzPathwaysGEO package.

The package offers statistical tests based on the 2-Wasserstein distance for detecting and characterizing differences between two distributions given in the form of samples. Functions for calculating the 2-Wasserstein distance and testing for differential distributions are provided, as well as a specifically tailored test for differential expression in single-cell RNA sequencing data.

This R package is for multi-sample transcript discovery and quantification using long read RNA-Seq data. You can use bambu after read alignment to obtain expression estimates for known and novel transcripts and genes. The output from bambu can directly be used for visualisation and downstream analysis, such as differential gene expression or transcript usage.

This package provides methods for spatial data analysis, especially raster data. The included methods allow for low-level data manipulation as well as high-level global, local, zonal, and focal computation. The predict and interpolate methods facilitate the use of regression type (interpolation, machine learning) models for spatial prediction. Processing of very large files is supported.

This package performs both classical and robust panel clustering by applying Principal Component Analysis (PCA) for dimensionality reduction and clustering via standard K-Means or Trimmed K-Means. The method is designed to ensure stable and reliable clustering, even in the presence of outliers. Suitable for analyzing panel data in domains such as economic research, financial time-series, healthcare analytics, and social sciences. The package allows users to choose between classical K-Means for standard clustering and Trimmed K-Means for robust clustering, making it a flexible tool for various applications. For this package, we have benefited from the studies Rencher (2003), Wang and Lu (2021) <DOI:10.25236/AJBM.2021.031018>, Cuesta-Albertos et al. (1997) <https://www.jstor.org/stable/2242558?seq=1>.

Response surface designs with neighbour effects are suitable for experimental situations where it is expected that the treatment combination administered to one experimental unit may affect the response on neighboring units as well as the response on the unit to which it is applied (Dalal et al.,2025 <doi: 10.57805/revstat.v23i2.513>). Integrating these effects in the response surface model improves the experiment's precision Verma A., Jaggi S., Varghese, E.,Varghese, C.,Bhowmik, A., Datta, A. and Hemavathi M. (2021)<doi: 10.1080/03610918.2021.1890123>). This package includes sym(), asym1(), asym2(), asym3() and asym4() functions that generates response surface designs which are rotatable under a polynomial model of a given order without interaction term incorporating neighbour effects.

The method models RNA-seq reads using a mixture of 3 beta-binomial distributions to generate posterior probabilities for genotyping bi-allelic single nucleotide polymorphisms. Elena Vigorito, Anne Barton, Costantino Pitzalis, Myles J. Lewis and Chris Wallace (2023) <doi:10.1093/bioinformatics/btad393> "BBmix: a Bayesian beta-binomial mixture model for accurate genotyping from RNA-sequencing.".

This package provides functions for cobin and micobin regression models, a new family of generalized linear models for continuous proportional data (Y in the closed unit interval [0, 1]). It also includes an exact, efficient sampler for the Kolmogorov-Gamma random variable. For details, see Lee et al. (2025+) <doi:10.48550/arXiv.2504.15269>.

Este pacote traduz os seguintes conjuntos de dados: airlines', airports', ames_raw', AwardsManagers', babynames', Batting', diamonds', faithful', fueleconomy', Fielding', flights', gapminder', gss_cat', iris', Managers', mpg', mtcars', atmos', penguins', People, Pitching', pixarfilms','planes', presidential', table1', table2', table3', table4a', table4b', table5', vehicles', weather', who'. English: It provides a Portuguese translated version of the datasets listed above.

This package provides functions to compute state-specific and marginal life expectancies. The computation is based on a fitted continuous-time multi-state model that includes an absorbing death state; see Van den Hout (2017, ISBN:9781466568402). The fitted multi-state model model should be estimated using the msm package using age as the time-scale.

Wrapper for computing parameters for univariate distributions using MLE. It creates an object that stores d, p, q, r functions as well as parameters and statistics for diagnostics. Currently supports automated fitting from base and actuar packages. A manually fitting distribution fitting function is included to support directly specifying parameters for any distribution from ancillary packages.

Given a set of parameters describing model dynamics and a corresponding cost function, FAMoS performs a dynamic forward-backward model selection on a specified selection criterion. It also applies a non-local swap search method. Works on any cost function. For detailed information see Gabel et al. (2019) <doi:10.1371/journal.pcbi.1007230>.

Analysis of Bayesian adaptive enrichment clinical trial using Free-Knot Bayesian Model Averaging (FK-BMA) method of Maleyeff et al. (2024) for Gaussian data. Maleyeff, L., Golchi, S., Moodie, E. E. M., & Hudson, M. (2024) "An adaptive enrichment design using Bayesian model averaging for selection and threshold-identification of predictive variables" <doi:10.1093/biomtc/ujae141>.

This package provides optimized C++ code for computing the partial Receiver Operating Characteristic (ROC) test used in niche and species distribution modeling. The implementation follows Peterson et al. (2008) <doi:10.1016/j.ecolmodel.2007.11.008>. Parallelization via OpenMP was implemented with assistance from the DeepSeek Artificial Intelligence Assistant (<https://www.deepseek.com/>).

Utilizing Generative Artificial Intelligence models like GPT-4 and Gemini Pro as coding and writing assistants for R users. Through these models, GenAI offers a variety of functions, encompassing text generation, code optimization, natural language processing, chat, and image interpretation. The goal is to aid R users in streamlining laborious coding and language processing tasks.

Apply an adaptation of the SuperFastHash algorithm to any R object. Hash whole R objects or, for vectors or lists, hash R objects to obtain a set of hash values that is stored in a structure equivalent to the input. See <http://www.azillionmonkeys.com/qed/hash.html> for a description of the hash algorithm.

These are data and functions to support quantitative peace science research. The data are important state-year information on democracy and wealth, which require periodic updates and regular maintenance. The functions permit some exploratory and diagnostic assessment of the kinds of data in demand by the community, but do not impose many dependencies on the user.

This package provides tools for data analysis with multivariate Bayesian structural time series (MBSTS) models. Specifically, the package provides facilities for implementing general structural time series models, flexibly adding on different time series components (trend, season, cycle, and regression), simulating them, fitting them to multivariate correlated time series data, conducting feature selection on the regression component.

Multiple imputation using XGBoost', subsampling, and predictive mean matching as described in Deng and Lumley (2023) <doi:10.1080/10618600.2023.2252501>. The package supports various types of variables, offers flexible settings, and enables saving an imputation model to impute new data. Data processing and memory usage have been optimised to speed up the imputation process.

This package provides tools for analysing multivariate time series with wavelets. This includes: simulation of a multivariate locally stationary wavelet (mvLSW) process from a multivariate evolutionary wavelet spectrum (mvEWS); estimation of the mvEWS, local coherence and local partial coherence. See Park, Eckley and Ombao (2014) <doi:10.1109/TSP.2014.2343937> for details.

An S4 implementation of the unbiased extension of the model- assisted synthetic-regression estimator proposed by Mandallaz (2013) <DOI:10.1139/cjfr-2012-0381>, Mandallaz et al. (2013) <DOI:10.1139/cjfr-2013-0181> and Mandallaz (2014) <DOI:10.1139/cjfr-2013-0449>. It yields smaller variances than the standard bias correction, the generalised regression estimator.

Permutation based non-parametric analysis of CRISPR screen data. Details about this algorithm are published in the following paper published on BMC genomics, Jia et al. (2017) <doi:10.1186/s12864-017-3938-5>: A permutation-based non-parametric analysis of CRISPR screen data. Please cite this paper if you use this algorithm for your paper.