This package provides functions for an Interactive Differential Expression AnaLysis of RNA-sequencing datasets, to extract quickly and effectively information downstream the step of differential expression. A Shiny application encapsulates the whole package. Support for reproducibility of the whole analysis is provided by means of a template report which gets automatically compiled and can be stored/shared.

sechm provides a simple interface between SummarizedExperiment objects and the ComplexHeatmap package. It enables plotting annotated heatmaps from SE objects, with easy access to rowData and colData columns, and implements a number of features to make the generation of heatmaps easier and more flexible. These functionalities used to be part of the SEtools package.

This package builds on the Epimods framework which facilitates finding weighted subnetworks ("modules") on Illumina Infinium 27k arrays using the SpinGlass algorithm, as implemented in the iGraph package. We have created a class of gene centric annotations associated with p-values and effect sizes and scores from any researchers prior statistical results to find functional modules.

This package provides a comprehensive library for date-time manipulations using a new family of orthogonal date-time classes (durations, time points, zoned-times, and calendars) that partition responsibilities so that the complexities of time zones are only considered when they are really needed. Capabilities include: date-time parsing, formatting, arithmetic, extraction and updating of components, and rounding.

Response surface designs with neighbour effects are suitable for experimental situations where it is expected that the treatment combination administered to one experimental unit may affect the response on neighboring units as well as the response on the unit to which it is applied. Integrating these effects in the response surface model improves the experiment's precision (Jaggi, S., Sarika and Sharma, V.K. (2010)<http://krishi.icar.gov.in/jspui/handle/123456789/4364>; Verma A., Jaggi S., Varghese, E.,Varghese, C.,Bhowmik, A., Datta, A. and Hemavathi M. (2021)<DOI: 10.1080/03610918.2021.1890123>). This package includes sym(), asym1(), asym2() functions that generates response surface designs which are rotatable under a polynomial model of a given order without interaction term incorporating neighbour effects.

Relative, generalized, and Erreygers corrected concentration index; plot Lorenz curves; and decompose health inequalities into contributing factors. The package currently works with (generalized) linear models, survival models, complex survey models, and marginal effects probit models. originally forked by Brecht Devleesschauwer from the decomp package (no longer on CRAN), rineq is now maintained by Kaspar Walter Meili. Compared to the earlier rineq version on github by Brecht Devleesschauwer (<https://github.com/brechtdv/rineq>), the regression tree functionality has been removed. Improvements compared to earlier versions include improved plotting of decomposition and concentration, added functionality to calculate the concentration index with different methods, calculation of robust standard errors, and support for the decomposition analysis using marginal effects probit regression models. The development version is available at <https://github.com/kdevkdev/rineq>.

This package provides functions to convert origin-destination data, represented as straight desire lines in the sf Simple Features class system, into JSON files that can be directly imported into A/B Street <https://www.abstreet.org>, a free and open source tool for simulating urban transport systems and scenarios of change <doi:10.1007/s10109-020-00342-2>.

Finds the k nearest neighbours in a dataset of specified points, adding the option to wrap certain variables on a torus. The user chooses the algorithm to use to find the nearest neighbours. Two such algorithms, provided by the packages RANN <https://cran.r-project.org/package=RANN>, and nabor <https://cran.r-project.org/package=nabor>, are suggested.

Upload, download, and edit internet maps with the Felt API (<https://feltmaps.notion.site/Felt-Public-API-reference-c01e0e6b0d954a678c608131b894e8e1>). Allows users to create new maps, edit existing maps, and extract data. Provides tools for working with layers, which represent geographic data, and elements, which are interactive annotations. Spatial data accessed from the API is transformed to work with sf'.

Generate commonly used plots in the field of design of experiments using ggplot2'. ggDoE currently supports the following plots: alias matrix, box cox transformation, boxplots, lambda plot, regression diagnostic plots, half normal plots, main and interaction effect plots for factorial designs, contour plots for response surface methodology, Pareto plot, and two dimensional projections of a latin hypercube design.

An EM algorithm, Karl et al. (2013) <doi:10.1016/j.csda.2012.10.004>, is used to estimate the generalized, variable, and complete persistence models, Mariano et al. (2010) <doi:10.3102/1076998609346967>. These are multiple-membership linear mixed models with teachers modeled as "G-side" effects and students modeled with either "G-side" or "R-side" effects.

Simulate an inhomogeneous self-exciting process (IHSEP), or Hawkes process, with a given (possibly time-varying) baseline intensity and an excitation function. Calculate the likelihood of an IHSEP with given baseline intensity and excitation functions for an (increasing) sequence of event times. Calculate the point process residuals (integral transforms of the original event times). Calculate the mean intensity process.

This package implements a nonparametric maximum likelihood method for assessing potentially time-varying vaccine efficacy (VE) against SARS-CoV-2 infection under staggered enrollment and time-varying community transmission, allowing crossover of placebo volunteers to the vaccine arm. Lin, D. Y., Gu, Y., Zeng, D., Janes, H. E., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab630>.

This package provides an efficient implementation of univariate local polynomial kernel density estimators that can handle bounded and discrete data. See Geenens (2014) <doi:10.48550/arXiv.1303.4121>, Geenens and Wang (2018) <doi:10.48550/arXiv.1602.04862>, Nagler (2018a) <doi:10.48550/arXiv.1704.07457>, Nagler (2018b) <doi:10.48550/arXiv.1705.05431>.

To decompose symmetric matrices such as brain connectivity matrices so that one can extract sparse latent component matrices and also estimate mixing coefficients, a blind source separation (BSS) method named LOCUS was proposed in Wang and Guo (2023) <arXiv:2008.08915>. For brain connectivity matrices, the outputs correspond to sparse latent connectivity traits and individual-level trait loadings.

Identifies the optimal number of clusters by calculating the similarity between two clustering methods at the same number of clusters using the corrected indices of Rand and Jaccard as described in Albatineh and Niewiadomska-Bugaj (2011). The number of clusters at which the index attain its maximum more frequently is a candidate for being the optimal number of clusters.

Fit Bayesian Dynamic Generalized Additive Models to multivariate observations. Users can build nonlinear State-Space models that can incorporate semiparametric effects in observation and process components, using a wide range of observation families. Estimation is performed using Markov Chain Monte Carlo with Hamiltonian Monte Carlo in the software Stan'. References: Clark & Wells (2023) <doi:10.1111/2041-210X.13974>.

The maybe type represents the possibility of some value or nothing. It is often used instead of throwing an error or returning `NULL`. The advantage of using a maybe type over `NULL` is that it is both composable and requires the developer to explicitly acknowledge the potential absence of a value, helping to avoid the existence of unexpected behaviour.

Imputation for both missing covariates and censored observations (optional) for survival data with missing covariates by the nearest neighbor based multiple imputation algorithm as described in Hsu et al. (2006) <doi:10.1002/sim.2452>, and Hsu and Yu (2018) <doi: 10.1177/0962280218772592>. Note that the current version can only impute for a situation with one missing covariate.

The purpose of this library is to to call different optimization solvers (such as Gonzalez Rodriguez et al. (2022) <doi:10.1007/s10898-022-01229-w>, Tawarmalani and Sahinidis (2005) <doi:10.1007/s10107-005-0581-8>, and Byrd et al. (2006) <doi:10.1007/0-387-30065-1_4>) to solve problems given by a standard nl file.

This package provides utility functions and objects for Extreme Value Analysis. These include probability functions with their exact derivatives w.r.t. the parameters that can be used for estimation and inference, even with censored observations. The transformations exchanging the two parameterizations of Peaks Over Threshold (POT) models: Poisson-GP and Point-Process are also provided with their derivatives.

Optimal group-sequential designs minimise some function of the expected and maximum sample size whilst controlling the type I error rate and power at a specified level. OptGS provides functions to quickly search for near-optimal group-sequential designs for normally distributed outcomes. The methods used are described in Wason, JMS (2015) <doi:10.18637/jss.v066.i02>.

Implementation of the modified skew discrete Laplace (SDL) regression model. The package provides a set of functions for a complete analysis of integer-valued data, where the dependent variable is assumed to follow a modified SDL distribution. This regression model is useful for the analysis of integer-valued data and experimental studies in which paired discrete observations are collected.

This package provides a toolbox to assist with statistical analysis of animal trajectories. It provides simple access to algorithms for calculating and assessing a variety of characteristics such as speed and acceleration, as well as multiple measures of straightness or tortuosity. Some support is provided for 3-dimensional trajectories. McLean & Skowron Volponi (2018) <doi:10.1111/eth.12739>.