Non-parametric estimators for casual effects based on longitudinal modified treatment policies as described in Diaz, Williams, Hoffman, and Schenck <doi:10.1080/01621459.2021.1955691>, traditional point treatment, and traditional longitudinal effects. Continuous, binary, categorical treatments, and multivariate treatments are allowed as well are censored outcomes. The treatment mechanism is estimated via a density ratio classification procedure irrespective of treatment variable type. For both continuous and binary outcomes, additive treatment effects can be calculated and relative risks and odds ratios may be calculated for binary outcomes. Supports survival outcomes with competing risks (Diaz, Hoffman, and Hejazi; <doi:10.1007/s10985-023-09606-7>).

In addition to modeling the expectation (location) of an outcome, mixed effects location scale models (MELSMs) include submodels on the variance components (scales) directly. This allows models on the within-group variance with mixed effects, and between-group variances with fixed effects. The MELSM can be used to model volatility, intraindividual variance, uncertainty, measurement error variance, and more. Multivariate MELSMs (MMELSMs) extend the model to include multiple correlated outcomes, and therefore multiple locations and scales. The latent multivariate MELSM (LMMELSM) further includes multiple correlated latent variables as outcomes. This package implements two-level mixed effects location scale models on multiple observed or latent outcomes, and between-group variance modeling. Williams, Martin, Liu, and Rast (2020) <doi:10.1027/1015-5759/a000624>. Hedeker, Mermelstein, and Demirtas (2008) <doi:10.1111/j.1541-0420.2007.00924.x>.

The Bayesian estimation of mixture models (and more general hidden Markov models) suffers from the label switching phenomenon, making the MCMC output non-identifiable. This package can be used in order to deal with this problem using various relabelling algorithms.

Probabilistic record linkage without direct identifiers using only diagnosis codes. Method is detailed in: Hejblum, Weber, Liao, Palmer, Churchill, Szolovits, Murphy, Kohane & Cai (2019) <doi: 10.1038/sdata.2018.298> ; Zhang, Hejblum, Weber, Palmer, Churchill, Szolovits, Murphy, Liao, Kohane & Cai (2021) <doi: 10.1093/jamia/ocab187>.

The programs were developed for estimation of parameters and testing exponential versus Pareto distribution during our work on hydrologic extremes. See Kozubowski, T.J., A.K. Panorska, F. Qeadan, and A. Gershunov (2007) <doi:10.1080/03610910802439121>, and Panorska, A.K., A. Gershunov, and T.J. Kozubowski (2007) <doi:10.1007/978-0-387-34918-3_26>.

Implementation of several phenotype-based family genetic risk scores with unified input data and data preparation functions to help facilitate the required data preparation and management. The implemented family genetic risk scores are the extended liability threshold model conditional on family history from Pedersen (2022) <doi:10.1016/j.ajhg.2022.01.009> and Pedersen (2023) <https://www.nature.com/articles/s41467-023-41210-z>, Pearson-Aitken Family Genetic Risk Scores from Krebs (2024) <doi:10.1016/j.ajhg.2024.09.009>, and family genetic risk score from Kendler (2021) <doi:10.1001/jamapsychiatry.2021.0336>.

This package provides drill down functionality for leaflet choropleths in shiny apps.

Fit linear models based on periodic splines, moderate model coefficients using multivariate adaptive shrinkage, then compute properties of the moderated curves.

Computations related to group sequential boundaries. Includes calculation of bounds using the Lan-DeMets alpha spending function approach. Based on FORTRAN program ld98 implemented by Reboussin, et al. (2000) <doi:10.1016/s0197-2456(00)00057-x>.

Calculate point estimates of and valid confidence intervals for longitudinal summaries of nonparametric, algorithm-agnostic variable importance measures. For more details, see Williamson et al. (2024) <doi:10.48550/arXiv.2311.01638>.

Alternate font rendering is useful when rendering text to novel graphics outputs where modern font rendering is not available or where bespoke text positioning is required. Bitmap and vector fonts allow for custom layout and rendering using pixel coordinates and line drawing. Formatted text is created as a data.frame of pixel coordinates (for bitmap fonts) or stroke coordinates (for vector fonts). All text can be easily previewed as a matrix or raster image. A selection of fonts is included with this package.

This package implements the kK-NN algorithm, an adaptive k-nearest neighbor classifier that adjusts the neighborhood size based on local data curvature. The method estimates local Gaussian curvature by approximating the shape operator of the data manifold. This approach aims to improve classification performance, particularly in datasets with limited samples.

Quickly generate lorem ipsum placeholder text. Easy to integrate in RMarkdown documents. Includes an RStudio addin to insert lorem ipsum into the current document.

Linear ridge regression coefficient's estimation and testing with different ridge related measures such as MSE, R-squared etc. REFERENCES i. Hoerl and Kennard (1970) <doi:10.1080/00401706.1970.10488634>, ii. Halawa and El-Bassiouni (2000) <doi:10.1080/00949650008812006>, iii. Imdadullah, Aslam, and Saima (2017), iv. Marquardt (1970) <doi:10.2307/1267205>.

Lipid annotation in untargeted LC-MS lipidomics based on fragmentation rules. Alcoriza-Balaguer MI, Garcia-Canaveras JC, Lopez A, Conde I, Juan O, Carretero J, Lahoz A (2019) <doi:10.1021/acs.analchem.8b03409>.

This package implements a local indicator of stratified power to analyze local spatial stratified association and demonstrate how spatial stratified association changes spatially and in local regions, as outlined in Hu et al. (2024) <doi:10.1080/13658816.2024.2437811>.

Estimate the slope and intercept of a bivariate linear relationship by calculating a posterior density that is invariant to interchange and scaling of the coordinates.

An implementation of a computational framework for performing robust structured regression with the L2 criterion from Chi and Chi (2021+). Improvements using the majorization-minimization (MM) principle from Liu, Chi, and Lange (2022+) added in Version 2.0.

Create maps made of lines. The package contains one function: linemap(). linemap() displays a map made of lines using a raster or gridded data.

Determining consensus seriations for binary incidence matrices, using a two-step process of Procrustes-fit correspondence analysis for heuristic selection of partial seriations and iterative regression to establish a single consensus. Contains the Lakhesis Calculator, a graphical platform for identifying seriated sequences. Collins-Elliott (2024) <https://volweb.utk.edu/~scolli46/sceLakhesis.pdf>.

This package provides tools to teach students elemental statistics. The main topics covered are descriptive statistics, probability models (discrete and continuous variables) and statistical inference (confidence intervals and hypothesis tests). One of the main advantages of this package is that allows the user to read quite a variety of types of data files with one unique command. Moreover it includes shortcuts to simple but up-to-now not in R descriptive features such a complete frequency table or an histogram with the optimal number of intervals. Related to model distributions (both discrete and continuous), the package allows the student to easy plot the mass/density function, distribution function and quantile function just detailing as input arguments the known population parameters. The inference related tools are basically confidence interval and hypothesis testing. Having defined independent commands for these two tools makes it easier for the student to understand what the software is performing, and it also helps the student to have a better knowledge on which specific tool they need to use in each situation. Moreover, the hypothesis testing commands provide not only the numeric result on the screen but also a very intuitive graph (which includes the statistic distribution, the observed value of the statistic, the rejection area and the p-value) that is very useful for the student to visualise the process. The regression section includes up to now, a simple linear model, with one single command the student can obtain the numeric summary as well as the corresponding diagram with the adjusted regression model and a legend with basic information (formula of the adjusted model and R-squared).

Evaluates whether the relationship between two vectors is linear or nonlinear. Performs a test to determine how well a linear model fits the data compared to higher order polynomial models. Jhang et al. (2004) <doi:10.1043/1543-2165(2004)128%3C44:EOLITC%3E2.0.CO;2>.

This package provides histograms, boxplots and dotplots as alternatives to scatterplots of data when plotting fitted logistic regressions.

It implements Expectation/Conditional Maximization Either (ECME) and rapidly converging algorithms as well as Bayesian inference for linear mixed models, which is described in Schafer, J.L. (1998) "Some improved procedures for linear mixed models". Dept. of Statistics, The Pennsylvania State University.