Rare Variant Sharing (RVS) implements tests of association and linkage between rare genetic variant genotypes and a dichotomous phenotype, e.g. a disease status, in family samples. The tests are based on probabilities of rare variant sharing by relatives under the null hypothesis of absence of linkage and association between the rare variants and the phenotype and apply to single variants or multiple variants in a region (e.g. gene-based test).

This package provides a transcriptional regulatory network (TRN) consists of a collection of transcription factors (TFs) and the regulated target genes. TFs are regulators that recognize specific DNA sequences and guide the expression of the genome, either activating or repressing the expression the target genes. The set of genes controlled by the same TF forms a regulon. This package provides classes and methods for the reconstruction of TRNs and analysis of regulons.

This package provides alternative implementations of some base R functions, including sort, order, and match. The functions are simplified but can be faster or have other advantages.

This package provides a menu-driven program and library of functions for carrying out convergence diagnostics and statistical and graphical analysis of Markov chain Monte Carlo (MCMC) sampling output.

Trigger animation effects on scroll on any HTML element of shiny and rmarkdown', such as any text or plot, thanks to the AOS Animate On Scroll jQuery library.

This package provides a suite for identifying causal models using relative concordances and identifying causal polymorphisms in case-control genetic association data, especially with large controls re-sequenced data.

Fits a double logistic function to NDVI time series and calculates instantaneous rate of green (IRG) according to methods described in Bischoff et al. (2012) <doi:10.1086/667590>.

Offers a variety of color palettes inspired by art, nature, and personal inspirations. Each palette is accompanied by a unique backstory, enriching the understanding and significance of the colors.

Maximum likelihood estimation and likelihood ratio test are essential for modern statistics. This package supports in calculating likelihood based inference. Reference: Pawitan Y. (2001, ISBN:0-19-850765-8).

Estimators for multivariate symmetrical uncertainty based on the work of Gustavo Sosa et al. (2016) <arXiv:1709.08730>, total correlation, information gain and symmetrical uncertainty of categorical variables.

Metric halfspace depth for object data, generalizing Tukey's depth for Euclidean data. Implementing the method described in Dai and Lopez-Pintado (2022) <doi:10.1080/01621459.2021.2011298>.

Policy evaluation using generalized Qini curves: Evaluate data-driven treatment targeting rules for one or more treatment arms over different budget constraints in experimental or observational settings under unconfoundedness.

Computes Strongest Neighbor Coherence (SNC), a structural diagnostic that replaces Cronbach's alpha using top-k correlation structure. For methodology, see Wells (2025) <https://github.com/TheotherDrWells/snc>.

Fit a regularized generalized linear model via penalized maximum likelihood. The model is fit for a path of values of the penalty parameter. Fits linear, logistic and Cox models.

This package provides an interface to the VK API <https://vk.com/dev/methods>. VK <https://vk.com/> is the largest European online social networking service, based in Russia.

This package provides a reference implementation of the Vertical Weighted Strips method explored by Raim, Livsey, and Irimata (2025) <doi:10.48550/arXiv.2401.09696> for rejection sampling.

Pretty fast implementation of the Ramer-Douglas-Peucker algorithm for reducing the number of points on a 2D curve. Urs Ramer (1972), "An iterative procedure for the polygonal approximation of plane curves" <doi:10.1016/S0146-664X(72)80017-0>. David H. Douglas and Thomas K. Peucker (1973), "Algorithms for the Reduction of the Number of Points Required to Represent a Digitized Line or its Caricature" <doi:10.3138/FM57-6770-U75U-7727>.

Feature Selection with Regularized Random Forest. This package is based on the randomForest package by Andy Liaw. The key difference is the RRF() function that builds a regularized random forest. Fortran original by Leo Breiman and Adele Cutler, R port by Andy Liaw and Matthew Wiener, Regularized random forest for classification by Houtao Deng, Regularized random forest for regression by Xin Guan. Reference: Houtao Deng (2013) <doi:10.48550/arXiv.1306.0237>.

This package implements state-of-the-art Random Graphical Models (RGMs) for multivariate data analysis across multiple environments, offering tools for exploring network interactions and structural relationships. Capabilities include joint inference across environments, integration of external covariates, and a Bayesian framework for uncertainty quantification. Applicable in various fields, including microbiome analysis. Methods based on Vinciotti, V., Wit, E., & Richter, F. (2023). "Random Graphical Model of Microbiome Interactions in Related Environments." <arXiv:2304.01956>.

This package provides a cross-platform Zip compression library for R. It is a replacement for the zip function, that does not require any additional external tools on any platform.

This package lets you determine the significance of pre-defined sets of genes with respect to an outcome variable, such as a group indicator, a quantitative variable or a survival time.

The Structural Topic Model (STM) allows researchers to estimate topic models with document-level covariates. The package also includes tools for model selection, visualization, and estimation of topic-covariate regressions.

This package computes standardized mean differences and confidence intervals for multiple data types based on Yang, D., & Dalton, J. E. (2012) <https://support.sas.com/resources/papers/proceedings12/335-2012.pdf>.

Rizin is a reverse engineering framework and a set of small command-line utilities, providing a complete binary analysis experience with features like disassembler, hexadecimal editor, emulation, binary inspection, debugger, and more.