This package provides an R interface for the Bureau of Economic Analysis (BEA) API (see <http://www.bea.gov/API/bea_web_service_api_user_guide.htm> for more information) that serves two core purposes - 1. To Extract/Transform/Load data [beaGet()] from the BEA API as R-friendly formats in the user's work space [transformation done by default in beaGet() can be modified using optional parameters; see, too, bea2List(), bea2Tab()]. 2. To enable the search of descriptive meta data [beaSearch()]. Other features of the library exist mainly as intermediate methods or are in early stages of development. Important Note - You must have an API key to use this library. Register for a key at <http://www.bea.gov/API/signup/index.cfm> .

Numerous functions for cohort-based analyses, either for prediction or causal inference. For causal inference, it includes Inverse Probability Weighting and G-computation for marginal estimation of an exposure effect when confounders are expected. We deal with binary outcomes, times-to-events, competing events, and multi-state data. For multistate data, semi-Markov model with interval censoring may be considered, and we propose the possibility to consider the excess of mortality related to the disease compared to reference lifetime tables. For predictive studies, we propose a set of functions to estimate time-dependent receiver operating characteristic (ROC) curves with the possible consideration of right-censoring times-to-events or the presence of confounders. Finally, several functions are available to assess time-dependent ROC curves or survival curves from aggregated data.

The package is focused on the detection of correlation between expressed genes and selected epigenomic signals (i.e. enhancers obtained from ChIP-seq data) either within topologically associated domains (TADs) or between chromatin contact loop anchors. Various parameters can be controlled to investigate the influence of external factors and visualization plots are available for each analysis step.

This package provides functions for an Interactive Differential Expression AnaLysis of RNA-sequencing datasets, to extract quickly and effectively information downstream the step of differential expression. A Shiny application encapsulates the whole package. Support for reproducibility of the whole analysis is provided by means of a template report which gets automatically compiled and can be stored/shared.

sechm provides a simple interface between SummarizedExperiment objects and the ComplexHeatmap package. It enables plotting annotated heatmaps from SE objects, with easy access to rowData and colData columns, and implements a number of features to make the generation of heatmaps easier and more flexible. These functionalities used to be part of the SEtools package.

This package builds on the Epimods framework which facilitates finding weighted subnetworks ("modules") on Illumina Infinium 27k arrays using the SpinGlass algorithm, as implemented in the iGraph package. We have created a class of gene centric annotations associated with p-values and effect sizes and scores from any researchers prior statistical results to find functional modules.

This package provides tools to download and extract data from the OzButterflies Database <doi:10.5281/zenodo.19019034>, which contains reflectance spectra, calibrated photographs, and cytochrome c oxidase subunit I (COI) sequences of Australian butterflies. The main function get_Oz_butterflies() downloads the database and extracts selected files to a specified directory using user-defined filters.

Extension of cmprsk to Stratified and Clustered data. A goodness of fit test for Fine-Gray model is also provided. Methods are detailed in the following articles: Zhou et al. (2011) <doi:10.1111/j.1541-0420.2010.01493.x>, Zhou et al. (2012) <doi:10.1093/biostatistics/kxr032>, Zhou et al. (2013) <doi: 10.1002/sim.5815>.

Enables simultaneous statistical inference for the accuracy of multiple classifiers in multiple subgroups (strata). For instance, allows to perform multiple comparisons in diagnostic accuracy studies with co-primary endpoints sensitivity and specificity (Westphal M, Zapf A. Statistical inference for diagnostic test accuracy studies with multiple comparisons. Statistical Methods in Medical Research. 2024;0(0). <doi:10.1177/09622802241236933>).

Piecewise linear segmentation of ordered data by a dynamic programming algorithm. The algorithm was developed for time series data, e.g. growth curves, and for genome-wide read-count data from next generation sequencing, but is broadly applicable. Generic implementations of dynamic programming routines allow to scan for optimal segmentation parameters and test custom segmentation criteria ("scoring functions").

This package provides functions to facilitate access to the DKAN API (<https://dkan.readthedocs.io/en/latest/apis/index.html>), including the DKAN REST API (metadata), and the DKAN datastore API (data). Includes functions to list, create, retrieve, update, and delete datasets and resources nodes. It also includes functions to search and retrieve data from the DKAN datastore.

Create list comprehensions (and other types of comprehension) similar to those in python', haskell', and other languages. List comprehension in R converts a regular for() loop into a vectorized lapply() function. Support for looping with multiple variables, parallelization, and across non-standard objects included. Package also contains a variety of functions to help with list comprehension.

Upload, download, and edit internet maps with the Felt API (<https://developers.felt.com/rest-api/getting-started>). Allows users to create new maps, edit existing maps, and extract data. Provides tools for working with layers, which represent geographic data, and elements, which are interactive annotations. Spatial data accessed from the API is transformed to work with sf'.

This package provides functions to implement the Flexible cFDR (Hutchinson et al. (2021) <doi:10.1371/journal.pgen.1009853>) and Binary cFDR (Hutchinson et al. (2021) <doi:10.1101/2021.10.21.465274>) methodologies to leverage auxiliary data from arbitrary distributions, for example functional genomic data, with GWAS p-values to generate re-weighted p-values.

Likelihood-free inference method for stochastic models. Uses a deterministic optimizer on simple simulations of the model that are performed with a prior drawn randomness by applying the inverse transform method. Is designed to work on its own and also by using the Julia package Jflimo available on the git page of the project: <https://metabarcoding.org/flimo>.

Generalized Entropy Calibration produces calibration weights using generalized entropy as the objective function for optimization. This approach, as implemented in the GECal package, is based on Kwon, Kim, and Qiu (2024) <doi:10.48550/arXiv.2404.01076>. GECal incorporates design weights into the constraints to maintain design consistency, rather than including them in the objective function itself.

Solves goal programming problems of the weighted and lexicographic type, as well as combinations of the two, as described by Ignizio (1983) <doi:10.1016/0305-0548(83)90003-5>. Allows for a simple human-readable input describing the problem as a series of equations. Relies on the lpSolve package to solve the underlying linear optimisation problem.

Estimates networks of conditional dependencies (Gaussian graphical models) from multiple classes of data (similar but not exactly, i.e. measurements on different equipment, in different locations or for various sub-types). Package also allows to generate simulation data and evaluate the performance. Implementation of the method described in Angelini, De Canditiis and Plaksienko (2022) <doi:10.3390/math10213983>.

Estimation of Latent Order Logistic (LOLOG) Models for Networks. LOLOGs are a flexible and fully general class of statistical graph models. This package provides functions for performing MOM, GMM and variational inference. Visual diagnostics and goodness of fit metrics are provided. See Fellows (2018) <doi:10.48550/arXiv.1804.04583> for a detailed description of the methods.

Random Forest Spatial Interpolation (RFSI, SekuliÄ et al. (2020) <doi:10.3390/rs12101687>) and spatio-temporal geostatistical (spatio-temporal regression Kriging (STRK)) interpolation for meteorological (Kilibarda et al. (2014) <doi:10.1002/2013JD020803>, SekuliÄ et al. (2020) <doi:10.1007/s00704-019-03077-3>) and other environmental variables. Contains global spatio-temporal models calculated using publicly available data.

Calculation of molecular number and brightness from fluorescence microscopy image series. The software was published in a 2016 paper <doi:10.1093/bioinformatics/btx434>. The seminal paper for the technique is Digman et al. 2008 <doi:10.1529/biophysj.107.114645>. A review of the technique was published in 2017 <doi:10.1016/j.ymeth.2017.12.001>.

Statistical methods for estimating preferential attachment and node fitness generative mechanisms in temporal complex networks are provided. Thong Pham et al. (2015) <doi:10.1371/journal.pone.0137796>. Thong Pham et al. (2016) <doi:10.1038/srep32558>. Thong Pham et al. (2020) <doi:10.18637/jss.v092.i03>. Thong Pham et al. (2021) <doi:10.1093/comnet/cnab024>.

Allows you to make clean, good-looking scatter plots with the option to easily add marginal density or box plots on the axes. It is also available as a module for jamovi (see <https://www.jamovi.org> for more information). Scatr is based on the cowplot package by Claus O. Wilke and the ggplot2 package by Hadley Wickham.

An implementation of Lind and Mehlum's (2010) <doi:10.1111/j.1468-0084.2009.00569.x> Utest to test for the presence of a U shaped or inverted U shaped relationship between variables in (generalized) linear models. It also implements a test of upward/downward sloping relationships at the lower and upper boundary of the data range.