Imputation for both missing covariates and censored observations (optional) for survival data with missing covariates by the nearest neighbor based multiple imputation algorithm as described in Hsu et al. (2006) <doi:10.1002/sim.2452>, and Hsu and Yu (2018) <doi: 10.1177/0962280218772592>. Note that the current version can only impute for a situation with one missing covariate.

The purpose of this library is to to call different optimization solvers (such as Gonzalez Rodriguez et al. (2022) <doi:10.1007/s10898-022-01229-w>, Tawarmalani and Sahinidis (2005) <doi:10.1007/s10107-005-0581-8>, and Byrd et al. (2006) <doi:10.1007/0-387-30065-1_4>) to solve problems given by a standard nl file.

Optimal group-sequential designs minimise some function of the expected and maximum sample size whilst controlling the type I error rate and power at a specified level. OptGS provides functions to quickly search for near-optimal group-sequential designs for normally distributed outcomes. The methods used are described in Wason, JMS (2015) <doi:10.18637/jss.v066.i02>.

Package for learning and evaluating (subgroup) policies via doubly robust loss functions. Policy learning methods include doubly robust blip/conditional average treatment effect learning and sequential policy tree learning. Methods for (subgroup) policy evaluation include doubly robust cross-fitting and online estimation/sequential validation. See Nordland and Holst (2026) <doi:10.18637/jss.v116.i04> for documentation and references.

Implementation of the modified skew discrete Laplace (SDL) regression model. The package provides a set of functions for a complete analysis of integer-valued data, where the dependent variable is assumed to follow a modified SDL distribution. This regression model is useful for the analysis of integer-valued data and experimental studies in which paired discrete observations are collected.

This package provides crop yield and meteorological data for Ontario, Canada. Includes functions for fitting and predicting data using spatio-temporal models, as well as tools for visualizing the results. The package builds upon existing R packages, including copula (Hofert et al., 2025) <doi:10.32614/CRAN.package.copula>, and bsts (Scott, 2024) <doi:10.32614/CRAN.package.bsts>.

Spatial components offer tools for dimension reduction and spatially variable gene detection for high dimensional spatial transcriptomics data. Construction of a projection onto low-dimensional feature space of spatially dependent metagenes offers pre-processing to clustering, testing for spatial variability and denoising of spatial expression patterns. For more details, see Koehler et al. (2026) <doi:10.1093/bioinformatics/btag052>.

This package provides a toolbox to assist with statistical analysis of animal trajectories. It provides simple access to algorithms for calculating and assessing a variety of characteristics such as speed and acceleration, as well as multiple measures of straightness or tortuosity. Some support is provided for 3-dimensional trajectories. McLean & Skowron Volponi (2018) <doi:10.1111/eth.12739>.

An integrated set of extensions to the ergm package to analyze and simulate network evolution based on exponential-family random graph models (ERGM). tergm is a part of the statnet suite of packages for network analysis. See Krivitsky and Handcock (2014) <doi:10.1111/rssb.12014> and Carnegie, Krivitsky, Hunter, and Goodreau (2015) <doi:10.1080/10618600.2014.903087>.

Bayesian variable selection using shrinkage priors to identify significant variables in high-dimensional datasets. The package includes methods for determining the number of significant variables through innovative clustering techniques of posterior distributions, specifically utilizing the 2-Means and Sequential 2-Means (S2M) approaches. The package aims to simplify the variable selection process with minimal tuning required in statistical analysis.

Access and analyze the World Bank's World Development Indicators (WDI) using the corresponding API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392-about-the-indicators-api-documentation>. WDI provides more than 24,000 country or region-level indicators for various contexts. wbwdi enables users to download, process and work with WDI series across multiple countries, aggregates, and time periods.

Statistical models and utilities for the analysis of word frequency distributions. The utilities include functions for loading, manipulating and visualizing word frequency data and vocabulary growth curves. The package also implements several statistical models for the distribution of word frequencies in a population. (The name of this package derives from the most famous word frequency distribution, Zipf's law.).

Calculate RNNI distance between and manipulate with ranked trees. RNNI stands for Ranked Nearest Neighbour Interchange and is an extension of the classical NNI space (space of trees created by the NNI moves) to ranked trees, where internal nodes are ordered according to their heights (usually assumed to be times). The RNNI distance takes the tree topology into account, as standard NNI does, but also penalizes changes in the order of internal nodes, i.e. changes in the order of times of evolutionary events. For more information about the RNNI space see: Gavryushkin et al. (2018) <doi:10.1007/s00285-017-1167-9>, Collienne & Gavryushkin (2021) <doi:10.1007/s00285-021-01567-5>, Collienne et al. (2021) <doi:10.1007/s00285-021-01685-0>, and Collienne (2021) <http://hdl.handle.net/10523/12606>.

This package provides a comprehensive collection of practical and easy-to-use tools for regression analysis of recurrent events, with or without the presence of a (possibly) informative terminal event described in Chiou et al. (2023) <doi:10.18637/jss.v105.i05>. The modeling framework is based on a joint frailty scale-change model, that includes models described in Wang et al. (2001) <doi:10.1198/016214501753209031>, Huang and Wang (2004) <doi:10.1198/016214504000001033>, Xu et al. (2017) <doi:10.1080/01621459.2016.1173557>, and Xu et al. (2019) <doi:10.5705/SS.202018.0224> as special cases. The implemented estimating procedure does not require any parametric assumption on the frailty distribution. The package also allows the users to specify different model forms for both the recurrent event process and the terminal event.

The r-mhsmm package implements estimation and prediction methods for hidden Markov and semi-Markov models for multiple observation sequences. Such techniques are of interest when observed data is thought to be dependent on some unobserved (or hidden) state. Also, this package is suitable for equidistant time series data, with multivariate and/or missing data. Allows user defined emission distributions.

The prebs package aims at making RNA-sequencing (RNA-seq) data more comparable to microarray data. The comparability is achieved by summarizing sequencing-based expressions of probe regions using a modified version of RMA algorithm. The pipeline takes mapped reads in BAM format as an input and produces either gene expressions or original microarray probe set expressions as an output.

Estimate the causal treatment effect for subjects that can adhere to one or both of the treatments. Given longitudinal data with missing observations, consistent causal effects are calculated. Unobserved potential outcomes are estimated through direct integration as described in: Qu et al., (2019) <doi:10.1080/19466315.2019.1700157> and Zhang et. al., (2021) <doi:10.1080/19466315.2021.1891965>.

This package performs goodness of fit test for the Birnbaum-Saunders distribution and provides the maximum likelihood estimate and the method-of-moments estimate. For more details, see Park and Wang (2013) <arXiv:2308.10150>. This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) (No. 2022R1A2C1091319, RS-2023-00242528).

Use three methods to estimate parameters from a mediation analysis with a binary misclassified mediator. These methods correct for the problem of "label switching" using Youden's J criteria. A detailed description of the analysis methods is available in Webb and Wells (2024), "Effect estimation in the presence of a misclassified binary mediator" <doi:10.48550/arXiv.2407.06970>.

Fit of a double additive location-scale model with a nonparametric error distribution from possibly right- or interval censored data. The additive terms in the location and dispersion submodels, as well as the unknown error distribution in the location-scale model, are estimated using Laplace P-splines. For more details, see Lambert (2021) <doi:10.1016/j.csda.2021.107250>.

This package provides statistical and visualization tools for the analysis of demographic indicators, and spatio-temporal behavior and characterization of outbreaks of vector-borne diseases (VBDs) in Colombia. It implements travel times estimated in Bravo-Vega C., Santos-Vega M., & Cordovez J.M. (2022), and the endemic channel method (Bortman, M. (1999) <https://iris.paho.org/handle/10665.2/8562>).

This package provides a framework to simulate ecosystem dynamics through ordinary differential equations (ODEs). You create an ODE model, tells ecode to explore its behaviour, and perform numerical simulations on the model. ecode also allows you to fit model parameters by machine learning algorithms. Potential users include researchers who are interested in the dynamics of ecological community and biogeochemical cycles.

Fast, numerically robust computation of weighted moments via Rcpp'. Supports computation on vectors and matrices, and Monoidal append of moments. Moments and cumulants over running fixed length windows can be computed, as well as over time-based windows. Moment computations are via a generalization of Welford's method, as described by Bennett et. (2009) <doi:10.1109/CLUSTR.2009.5289161>.

This package implements methods for network estimation and forecasting of high-dimensional time series exhibiting strong serial and cross-sectional correlations under a factor-adjusted vector autoregressive model. See Barigozzi, Cho and Owens (2024+) <doi:10.1080/07350015.2023.2257270> for further descriptions of FNETS methodology and Owens, Cho and Barigozzi (2024+) <arXiv:2301.11675> accompanying the R package.