This package provides functionality to generate compound optimal designs for targeting the multiple experimental objectives directly, ensuring that the full set of research questions is answered as economically as possible. Designs can be found using point or coordinate exchange algorithms combining estimation, inference and lack-of-fit criteria that account for model inadequacy. Details and examples are given by Koutra et al. (2024) <doi:10.48550/arXiv.2412.17158>.

This package implements linear and generalized linear models for provider profiling, incorporating both fixed and random effects. For large-scale providers, the linear profiled-based method and the SerBIN method for binary data reduce the computational burden. Provides post-modeling features, such as indirect and direct standardization measures, hypothesis testing, confidence intervals, and post-estimation visualization. For more information, see Wu et al. (2022) <doi:10.1002/sim.9387>.

The Swash-Backwash Model for the Single Epidemic Wave was developed by Cliff and Haggett (2006) <doi:10.1007/s10109-006-0027-8> to model the velocity of spread of infectious diseases across space. This package enables the calculation of the Swash-Backwash Model for user-supplied panel data on regional infections. The package also provides additional functions for bootstrap confidence intervals, country comparison, visualization of results, and data management.

This package provides a meta-package that aims to make R easier for everyone, especially programmers who have a background in SAS® software. This set of packages brings many useful concepts to R', including data libraries, data dictionaries, formats and format catalogs, a data step, and a traceable log. The system also includes a package that replicates several commonly-used SAS® procedures, like PROC FREQ', PROC MEANS', and PROC REG'.

Fit, compare, and visualize Bayesian graphical vector autoregressive (GVAR) network models using Stan'. These models are commonly used in psychology to represent temporal and contemporaneous relationships between multiple variables in intensive longitudinal data. Fitted models can be compared with a test based on matrix norm differences of posterior point estimates to quantify the differences between two estimated networks. See also Siepe, Kloft & Heck (2024) <doi:10.31234/osf.io/uwfjc>.

The "Vertical and Horizontal Inheritance Consistence Analysis" method is described in the following publication: "VHICA: a new method to discriminate between vertical and horizontal transposon transfer: application to the mariner family within Drosophila" by G. Wallau. et al. (2016) <DOI:10.1093/molbev/msv341>. The purpose of the method is to detect horizontal transfers of transposable elements, by contrasting the divergence of transposable element sequences with that of regular genes.

Edit XMP metadata <https://en.wikipedia.org/wiki/Extensible_Metadata_Platform> in a variety of media file formats as well as edit bookmarks (aka outline aka table of contents) and documentation info entries in pdf files. Can detect and use a variety of command-line tools to perform these operations such as exiftool <https://exiftool.org/>, ghostscript <https://www.ghostscript.com/>, and/or pdftk <https://gitlab.com/pdftk-java/pdftk>.

tidyr is a reframing of the reshape2 package designed to accompany the tidy data framework, and to work hand-in-hand with magrittr and dplyr to build a solid pipeline for data analysis. It is designed specifically for tidying data, not the general reshaping that reshape2 does, or the general aggregation that reshape did. In particular, built-in methods only work for data frames, and tidyr provides no margins or aggregation.

SPAMS (SPArse Modeling Software) is an optimization toolbox for solving various sparse estimation problems. It includes tools for the following problems:

1. Dictionary learning and matrix factorization (NMF, sparse principle component analysis (PCA), ...)

2. Solving sparse decomposition problems with LARS, coordinate descent, OMP, SOMP, proximal methods

3. Solving structured sparse decomposition problems (l1/l2, l1/linf, sparse group lasso, tree-structured regularization, structured sparsity with overlapping groups,...).

This package provides functions to perform the fitting of an adaptive mixture of Student-t distributions to a target density through its kernel function as described in Ardia et al. (2009) <doi:10.18637/jss.v029.i03>. The mixture approximation can then be used as the importance density in importance sampling or as the candidate density in the Metropolis-Hastings algorithm to obtain quantities of interest for the target density itself.

Procedures include Phillips (1995) FMVAR <doi:10.2307/2171721>, Kitamura and Phillips (1997) FMGMM <doi:10.1016/S0304-4076(97)00004-3>, Park (1992) CCR <doi:10.2307/2951679>, and so on. Tests with 1 or 2 structural breaks include Gregory and Hansen (1996) <doi:10.1016/0304-4076(69)41685-7>, Zivot and Andrews (1992) <doi:10.2307/1391541>, and Kurozumi (2002) <doi:10.1016/S0304-4076(01)00106-3>.

Directed Dependence Coefficient (didec) is a measure of directed dependence. Multivariate Feature Ordering by Conditional Independence (MFOCI) is a variable selection algorithm based on didec. Hierarchical Variable Clustering (VarClustPartition) is a variable clustering method based on didec. For more information, see the paper by Ansari and Fuchs (2024, <doi:10.48550/arXiv.2212.01621>), and the paper by Fuchs and Wang (2024, <doi:10.1016/j.ijar.2024.109185>).

Estimate ecosystem metabolism in a Bayesian framework for individual water quality monitoring stations with continuous dissolved oxygen time series. A mass balance equation is used that provides estimates of parameters for gross primary production, respiration, and gas exchange. Methods adapted from Grace et al. (2015) <doi:10.1002/lom3.10011> and Wanninkhof (2014) <doi:10.4319/lom.2014.12.351>. Details in Beck et al. (2024) <doi:10.1002/lom3.10620>.

Computes maximum mean discrepancy two-sample test for univariate data using the Laplacian kernel, as described in Bodenham and Kawahara (2023) <doi:10.1007/s11222-023-10271-x>. The p-value is computed using permutations. Also includes implementation for computing the robust median difference statistic Q_n from Croux and Rousseeuw (1992) <doi:10.1007/978-3-662-26811-7_58> based on Johnson and Mizoguchi (1978) <doi:10.1137/0207013>.

This package performs hypothesis testing for general block designs with empirical likelihood. The core computational routines are implemented using the Eigen C++ library and RcppEigen interface, with OpenMP for parallel computation. Details of the methods are given in Kim, MacEachern, and Peruggia (2023) <doi:10.1080/10485252.2023.2206919>. This work was supported by the U.S. National Science Foundation under Grants No. SES-1921523 and DMS-2015552.

Estimation and inference using the Fractionally Cointegrated Vector Autoregressive (VAR) model. It includes functions for model specification, including lag selection and cointegration rank selection, as well as a comprehensive set of options for hypothesis testing, including tests of hypotheses on the cointegrating relations, the adjustment coefficients and the fractional differencing parameters. An article describing the FCVAR model with examples is available on the Webpage <https://sites.google.com/view/mortennielsen/software>.

Make 2D and 3D plots of linear programming (LP), integer linear programming (ILP), or mixed integer linear programming (MILP) models with up to three objectives. Plots of both the solution and criterion space are possible. For instance the non-dominated (Pareto) set for bi-objective LP/ILP/MILP programming models (see vignettes for an overview). The package also contains an function for checking if a point is inside the convex hull.

This package provides functions for processing, analysis and visualization of Hydrogen Deuterium eXchange monitored by Mass Spectrometry experiments (HDX-MS) (<doi:10.1093/bioinformatics/btaa587>). HaDeX introduces a new standardized and reproducible workflow for the analysis of the HDX-MS data, including novel uncertainty intervals. Additionally, it covers data exploration, quality control and generation of publication-quality figures. All functionalities are also available in the in-built Shiny app.

Generates valid HTML tag strings for HTML5 elements documented by Mozilla. Attributes are passed as named lists, with names being the attribute name and values being the attribute value. Attribute values are automatically double-quoted. To declare a DOCTYPE, wrap html() with function doctype(). Mozilla's documentation for HTML5 is available here: <https://developer.mozilla.org/en-US/docs/Web/HTML/Element>. Elements marked as obsolete are not included.

This package contains the MultiFractal Detrended Fluctuation Analysis (MFDFA), MultiFractal Detrended Cross-Correlation Analysis (MFXDFA), and the Multiscale Multifractal Analysis (MMA). The MFDFA() function proposed in this package was used in Laib et al. (<doi:10.1016/j.chaos.2018.02.024> and <doi:10.1063/1.5022737>). See references for more information. Interested users can find a parallel version of the MFDFA() function on GitHub.

Detection of multivariate outliers using robust estimates of location and scale. The Minimum Covariance Determinant (MCD) estimator is used to calculate robust estimates of the mean vector and covariance matrix. Outliers are determined based on robust Mahalanobis distances using either an unstructured covariance matrix, a principal components structured covariance matrix, or a factor analysis structured covariance matrix. Includes options for specifying the direction of interest for outlier detection for each variable.

This package provides a reproducible workflow for binning and visualizing NMR (nuclear magnetic resonance) spectra from environmental samples. The nmrrr package is intended for post-processing of NMR data, including importing, merging and, cleaning data from multiple files, visualizing NMR spectra, performing binning/integrations for compound classes, and relative abundance calculations. This package can be easily inserted into existing analysis workflows by users to help with analyzing and interpreting NMR data.

Constructs (non)additive genetic relationship matrices, and their inverses, from a pedigree to be used in linear mixed effect models (A.K.A. the animal model'). Also includes other functions to facilitate the use of animal models. Some functions have been created to be used in conjunction with the R package asreml for the ASReml software, which can be obtained upon purchase from VSN international (<https://vsni.co.uk/software/asreml>).

This package provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.