Estimates Two-way Fixed Effects difference-in-differences/event-study models using the approach proposed by Gardner (2021) <doi:10.48550/arXiv.2207.05943>. To avoid the problems caused by OLS estimation of the Two-way Fixed Effects model, this function first estimates the fixed effects and covariates using untreated observations and then in a second stage, estimates the treatment effects.

Allows you to write queries that combine SQL (Structured Query Language) data retrieval with visualization specifications in a single, composable syntax. The ggsql package binds directly with the ggsql Rust library and allows you to set up readers and writers and execute queries against it. The package also offers knitr and shiny integration allowing the user to use ggsql in both frameworks.

This package provides a professional R interface to download and analyze spatial development indicators from the BBSR INKAR (Indicators and Maps for Spatial and Urban Development) database. Features a bilingual interactive wizard, fuzzy and normalized indicator search, multi-indicator downloads with automatic tidy merging (long/wide), guaranteed consistent output schema, robust disk caching with automatic retry, and ggplot2 themes for regional mapping.

This package implements the Clock of Regimes (KRONX) framework for regime-switching fragility analysis of financial time series. The package fits Gaussian and Student-t Hidden Markov Models (HMMs) to return data, constructs a hazard-adjusted transition operator Q, derives the associated generator K = Q - I, and computes the fundamental matrix N = -K inverse to characterize expected residence times under structural fragility.

Labeling, weighting, and plotting data following custom style guidelines for use in reports, presentations, and social media posts. The Center for Global Democracy (formerly the Latin American Public Opinion Project) at Vanderbilt University is a leader in public survey research, best known for the Americas Barometer project. The publicly available data can be downloaded from: <https://www.vanderbilt.edu/cgd/data-access/>.

This package provides a simple mechanism to specify a symmetric block diagonal matrices (often used for covariance matrices). This is based on the domain specific language implemented in nlmixr2 but expanded to create matrices in R generally instead of specifying parts of matrices to estimate. It has expanded to include some matrix manipulation functions that are generally useful for rxode2 and nlmixr2'.

Extracts decision rules from tree- and rule-based models fitted in R'. Rules are expressed as logical predicates that identify paths to terminal nodes, making model behavior more transparent and interpretable. Provides conversion methods to partykit party objects for a wide range of model types. The partykit infrastructure is described in Hothorn and Zeileis (2015) <https://jmlr.org/papers/v16/hothorn15a.html>.

Access to the Greek New Testament (27 books) and the Old Testament (39 books) and allow users to do textual analysis on the data. The New and Old Testament have been provided in their original languages, Greek and Hebrew, respectively. Additionally, the Revised American Standard Bible is also provided for users who'd rather use a wordâ forâ word modern English translation.

Model stability and variable inclusion plots [Mueller and Welsh (2010, <doi:10.1111/j.1751-5823.2010.00108.x>); Murray, Heritier and Mueller (2013, <doi:10.1002/sim.5855>)] as well as the adaptive fence [Jiang et al. (2008, <doi:10.1214/07-AOS517>); Jiang et al. (2009, <doi:10.1016/j.spl.2008.10.014>)] for linear and generalised linear models.

Renders rich inline text (bold, italic, code, links, images) in grid graphics and ggplot2', from markdown or flextable chunks. Provides grobs, theme elements, and geometry layers for styled text rendering. Only works with graphics devices that support systemfonts', such as those provided by ragg', svglite', or ggiraph'. The cairo_pdf device is also supported when fonts are installed at the system level.

Estimates average treatment effects at the cutoff based on sharp regression discontinuity designs (RDD) and multiple imputation regression discontinuity designs (MIRDD). It provides diagnostic tools for RDD by comparing results with those from MIRDD, as proposed in Takahashi (2023) <doi:10.1080/03610918.2021.1960374>. The package includes datasets from Takahashi (2023) and Takahashi (2026) <doi:10.1016/j.softx.2026.102707>.

This package provides functions for manipulating nested data frames in a list-column using dplyr <https://dplyr.tidyverse.org/> syntax. Rather than unnesting, then manipulating a data frame, nplyr allows users to manipulate each nested data frame directly. nplyr is a wrapper for dplyr functions that provide tools for common data manipulation steps: filtering rows, selecting columns, summarising grouped data, among others.

This package implements the Phylogeny-Guided Microbiome OTU-Specific Association Test method, which boosts the testing power by adaptively borrowing information from phylogenetically close OTUs (operational taxonomic units) of the target OTU. This method is built on a kernel machine regression framework and allows for flexible modeling of complex microbiome effects, adjustments for covariates, and can accommodate both continuous and binary outcomes.

Efficient implementations for Sorted L-One Penalized Estimation (SLOPE): generalized linear models regularized with the sorted L1-norm (Bogdan et al. 2015). Supported models include ordinary least-squares regression, binomial regression, multinomial regression, and Poisson regression. Both dense and sparse predictor matrices are supported. In addition, the package features predictor screening rules that enable fast and efficient solutions to high-dimensional problems.

This package implements statistical methods for detecting evolutionary shifts in both the optimal trait value (mean) and evolutionary diffusion variance. The method uses an L1-penalized optimization framework to identify branches where shifts occur, and the shift magnitudes. It also supports the inclusion of measurement error. For more details, see Zhang, Ho, and Kenney (2023) <doi:10.48550/arXiv.2312.17480>.

This package provides a pipeline for short tandem repeat instability analysis from fragment analysis data. Inputs of fsa files or peak tables, and a user supplied metadata data-frame. The package identifies ladders, calls peaks, identifies the modal peaks, calls repeats, then calculates repeat instability metrics (e.g. expansion index from Lee et al. (2010) <doi:10.1186/1752-0509-4-29>).

The Bayesian modelling of relative sea-level data using a comprehensive approach that incorporates various statistical models within a unifying framework. Details regarding each statistical models; linear regression (Ashe et al 2019) <doi:10.1016/j.quascirev.2018.10.032>, change point models (Cahill et al 2015) <doi:10.1088/1748-9326/10/8/084002>, integrated Gaussian process models (Cahill et al 2015) <doi:10.1214/15-AOAS824>, temporal splines (Upton et al 2025) <doi:10.32614/RJ-2024-018>, spatio-temporal splines (Upton et al 2025) <doi:10.32614/RJ-2024-018> and generalised additive models (Upton et al 2025) <doi:10.1093/jrsssc/qlae044>. This package facilitates data loading, model fitting and result summarisation. Notably, it accommodates the inherent measurement errors found in relative sea-level data across multiple dimensions, allowing for their inclusion in the statistical models.

Download, prepare and analyze data from large-scale assessments and surveys with complex sampling and assessment design (see Rutkowski', 2010 <doi:10.3102/0013189X10363170>). Such studies are, for example, international assessments like TIMSS', PIRLS and PISA'. A graphical interface is available for the non-technical user.The package includes functions to covert the original data from SPSS into R data sets keeping the user-defined missing values, merge data from different respondents and/or countries, generate variable dictionaries, modify data, produce descriptive statistics (percentages, means, percentiles, benchmarks) and multivariate statistics (correlations, linear regression, binary logistic regression). The number of supported studies and analysis types increases with every next release. For a general presentation of the package, see Mirazchiyski', 2021a (<doi:10.1186/s40536-021-00114-4>). For detailed technical aspects of the package, see Mirazchiyski', 2021b (<doi:10.3390/psych3020018>).

BLASE is a method for finding where bulk RNA-seq data lies on a single-cell pseudotime trajectory. It uses a fast and understandable approach based on Spearman correlation, with bootstrapping to provide confidence. BLASE can be used to "date" bulk RNA-seq data, annotate cell types in scRNA-seq, and help correct for developmental phenotype differences in bulk RNA-seq experiments.

Base-resolution copy number analysis of viral genome. Utilizes base-resolution read depth data over viral genome to find copy number segments with two-dimensional segmentation approach. Provides publish-ready figures, including histograms of read depths, coverage line plots over viral genome annotated with copy number change events and viral genes, and heatmaps showing multiple types of data with integrative clustering of samples.

An R package that tests for enrichment and depletion of user-defined pathways using a Fisher's exact test. The method is designed for versatile pathway annotation formats (eg. gmt, txt, xlsx) to allow the user to run pathway analysis on custom annotations. This package is also integrated with Cytoscape to provide network-based pathway visualization that enhances the interpretability of the results.

SimBu can be used to simulate bulk RNA-seq datasets with known cell type fractions. You can either use your own single-cell study for the simulation or the sfaira database. Different pre-defined simulation scenarios exist, as are options to run custom simulations. Additionally, expression values can be adapted by adding an mRNA bias, which produces more biologically relevant simulations.

This package defines interfaces from R to scvi-tools. A vignette works through the totalVI tutorial for analyzing CITE-seq data. Another vignette compares outputs of Chapter 12 of the OSCA book with analogous outputs based on totalVI quantifications. Future work will address other components of scvi-tools, with a focus on building understanding of probabilistic methods based on variational autoencoders.

The TMSig package contains tools to prepare, analyze, and visualize named lists of sets, with an emphasis on molecular signatures (such as gene or kinase sets). It includes fast, memory efficient functions to construct sparse incidence and similarity matrices and filter, cluster, invert, and decompose sets. Additionally, bubble heatmaps can be created to visualize the results of any differential or molecular signatures analysis.