Spatial transcriptomics iterative hierarchical clustering ('stIHC'), is a method for identifying spatial gene co-expression modules, defined as groups of genes with shared spatial expression patterns. The method is applicable across spatial transcriptomics technologies with differing spatial resolution, and provides a framework for investigating the spatial organisation of gene expression in tissues. For further details, see Higgins C., Li J.J., Carey M. <doi:10.1002/qub2.70011>.

The best ANN structure for time series data analysis is a demanding need in the present era. This package will find the best-fitted ANN model based on forecasting accuracy. The optimum size of the hidden layers was also determined after determining the number of lags to be included. This package has been developed using the algorithm of Paul and Garai (2021) <doi:10.1007/s00500-021-06087-4>.

Computes the solution path of the Terminating-LARS (T-LARS) algorithm. The T-LARS algorithm is a major building block of the T-Rex selector (see R package TRexSelector'). The package is based on the papers Machkour, Muma, and Palomar (2022) <arXiv:2110.06048>, Efron, Hastie, Johnstone, and Tibshirani (2004) <doi:10.1214/009053604000000067>, and Tibshirani (1996) <doi:10.1111/j.2517-6161.1996.tb02080.x>.

Gene-environment (GÃ E) interactions have important implications to elucidate the etiology of complex diseases beyond the main genetic and environmental effects. Outliers and data contamination in disease phenotypes of GÃ E studies have been commonly encountered, leading to the development of a broad spectrum of robust penalization methods. Nevertheless, within the Bayesian framework, the issue has not been taken care of in existing studies. We develop a robust Bayesian variable selection method for GÃ E interaction studies. The proposed Bayesian method can effectively accommodate heavy-tailed errors and outliers in the response variable while conducting variable selection by accounting for structural sparsity. In particular, the spike-and-slab priors have been imposed on both individual and group levels to identify important main and interaction effects. An efficient Gibbs sampler has been developed to facilitate fast computation. The Markov chain Monte Carlo algorithms of the proposed and alternative methods are efficiently implemented in C++.

tidyr is a reframing of the reshape2 package designed to accompany the tidy data framework, and to work hand-in-hand with magrittr and dplyr to build a solid pipeline for data analysis. It is designed specifically for tidying data, not the general reshaping that reshape2 does, or the general aggregation that reshape did. In particular, built-in methods only work for data frames, and tidyr provides no margins or aggregation.

SPAMS (SPArse Modeling Software) is an optimization toolbox for solving various sparse estimation problems. It includes tools for the following problems:

1. Dictionary learning and matrix factorization (NMF, sparse principle component analysis (PCA), ...)

2. Solving sparse decomposition problems with LARS, coordinate descent, OMP, SOMP, proximal methods

3. Solving structured sparse decomposition problems (l1/l2, l1/linf, sparse group lasso, tree-structured regularization, structured sparsity with overlapping groups,...).

This package implements the Butterworth-Induced Autoregressive ('BTWAR') model, where autoregressive coefficients are obtained from analog Butterworth filter prototypes mapped into the discrete-time domain using the Matched Z-Transform. The framework establishes a structured connection between frequency-domain filter design and time-domain autoregressive modeling. Model order selection is performed via nested rolling-origin cross-validation. Method described in Bras-Geraldes, Rocha and Martins (2026) <doi:10.3390/math14030479>.

This package provides a framework is provided to develop R packages using Rust <https://www.rust-lang.org/> with minimal overhead, and more wrappers are easily added. Help is provided to use Cargo <https://doc.rust-lang.org/cargo/> in a manner consistent with CRAN policies. Rust code can also be embedded directly in an R script. The package is not official, affiliated with, nor endorsed by the Rust project.

Features tools for exploring congruent phylogenetic birth-death models. It can construct the pulled speciation- and net-diversification rates from a reference model. Given alternative speciation- or extinction rates, it can construct new models that are congruent with the reference model. Functionality is included to sample new rate functions, and to visualize the distribution of one congruence class. See also Louca & Pennell (2020) <doi:10.1038/s41586-020-2176-1>.

R package to build and simulate deterministic compartmental models that can be non-Markovian. Length of stay in each compartment can be defined to follow a parametric distribution (d_exponential(), d_gamma(), d_weibull(), d_lognormal()) or a non-parametric distribution (nonparametric()). Other supported types of transition from one compartment to another includes fixed transition (constant()), multinomial (multinomial()), fixed transition probability (transprob()).

Gaussian mixture modeling of one- and two-dimensional data, provided in original or binned form, with an option to estimate the number of model components. The method uses Gaussian Mixture Models (GMM) with initial parameters determined by a dynamic programming algorithm, leading to stable and reproducible model fitting. For more details see Zyla, J., Szumala, K., Polanski, A., Polanska, J., & Marczyk, M. (2026) <doi:10.1016/j.jocs.2026.102811>.

This package provides time series regression models with one predictor using finite distributed lag models, polynomial (Almon) distributed lag models, geometric distributed lag models with Koyck transformation, and autoregressive distributed lag models. It also consists of functions for computation of h-step ahead forecasts from these models. See Demirhan (2020)(<doi:10.1371/journal.pone.0228812>) and Baltagi (2011)(<doi:10.1007/978-3-642-20059-5>) for more information.

As in music, a fugue statistic repeats a theme in small variations. Here, the psi-function that defines an m-statistic is slightly altered to maintain the same design sensitivity in matched sets of different sizes. The main functions in the package are sen() and senCI(). For sensitivity analyses for m-statistics, see Rosenbaum (2007) Biometrics 63 456-464 <doi:10.1111/j.1541-0420.2006.00717.x>.

This package provides a comprehensive suite of functions and RStudio Add-ins leveraging the capabilities of open-source Large Language Models (LLMs) to support R developers. These functions offer a range of utilities, including text rewriting, translation, and general query capabilities. Additionally, the programming-focused functions provide assistance with debugging, translating, commenting, documenting, and unit testing code, as well as suggesting variable and function names, thereby streamlining the development process.

This package implements an efficient algorithm for fitting the entire regularization path of support vector machine models with elastic-net penalties using a generalized coordinate descent scheme. The framework also supports SCAD and MCP penalties. It is designed for high-dimensional datasets and emphasizes numerical accuracy and computational efficiency. This package implements the algorithms proposed in Tang, Q., Zhang, Y., & Wang, B. (2022) <https://openreview.net/pdf?id=RvwMTDYTOb>.

This package provides function to read data from the Igor Pro data analysis program by Wavemetrics'. The data formats supported are Igor packed experiment format ('pxp') and Igor binary wave ('ibw'). See: <https://www.wavemetrics.com/> for details. Also includes functions to load special pxp files produced by the Igor Pro Neuromatic and Nclamp packages for recording and analysing neuronal data. See <https://github.com/SilverLabUCL/NeuroMatic> for details.

This package provides a systematic biology tool was developed to identify dysregulated miRNAs via a miRNA-miRNA interaction network. IDMIR first constructed a weighted miRNA interaction network through integrating miRNA-target interaction information, molecular function data from Gene Ontology (GO) database and gene transcriptomic data in specific-disease context, and then, it used a network propagation algorithm on the network to identify significantly dysregulated miRNAs.

Enables users to handle the dataset cleaning for conducting specific analyses with the log files from two international educational assessments: the Programme for International Student Assessment (PISA, <https://www.oecd.org/pisa/>) and the Programme for the International Assessment of Adult Competencies (PIAAC, <https://www.oecd.org/skills/piaac/>). An illustration of the analyses can be found on the LOGAN Shiny app (<https://loganpackage.shinyapps.io/shiny/>) on your browser.

The reference implementation of model equations and default parameters for the toxicokinetic-toxicodynamic (TKTD) model of the Lemna (duckweed) aquatic plant. Lemna is a standard test macrophyte used in ecotox effect studies. The model was described and published by the SETAC Europe Interest Group Effect Modeling. It is a refined description of the Lemna TKTD model published by Schmitt et al. (2013) <doi:10.1016/j.ecolmodel.2013.01.017>.

This package provides functionality to generate compound optimal designs for targeting the multiple experimental objectives directly, ensuring that the full set of research questions is answered as economically as possible. Designs can be found using point or coordinate exchange algorithms combining estimation, inference and lack-of-fit criteria that account for model inadequacy. Details and examples are given by Koutra et al. (2024) <doi:10.48550/arXiv.2412.17158>.

Fits latent Dirichlet allocation (LDA), supervised topic models, and multilevel supervised topic models for text data with multiple outcome variables. Core estimation routines are implemented in C++ using the Rcpp ecosystem. For topic models, see Blei et al. (2003) <https://www.jmlr.org/papers/volume3/blei03a/blei03a.pdf>. For supervised topic models, see Blei and McAuliffe (2007) <https://papers.nips.cc/paper_files/paper/2007/hash/d56b9fc4b0f1be8871f5e1c40c0067e7-Abstract.html>.

This package implements linear and generalized linear models for provider profiling, incorporating both fixed and random effects. For large-scale providers, the linear profiled-based method and the SerBIN method for binary data reduce the computational burden. Provides post-modeling features, such as indirect and direct standardization measures, hypothesis testing, confidence intervals, and post-estimation visualization. For more information, see Wu et al. (2022) <doi:10.1002/sim.9387>.

This package provides a meta-package that aims to make R easier for everyone, especially programmers who have a background in SAS® software. This set of packages brings many useful concepts to R', including data libraries, data dictionaries, formats and format catalogs, a data step, and a traceable log. The system also includes a package that replicates several commonly-used SAS® procedures, like PROC FREQ', PROC MEANS', and PROC REG'.

Fit, compare, and visualize Bayesian graphical vector autoregressive (GVAR) network models using Stan'. These models are commonly used in psychology to represent temporal and contemporaneous relationships between multiple variables in intensive longitudinal data. Fitted models can be compared with a test based on matrix norm differences of posterior point estimates to quantify the differences between two estimated networks. See also Siepe, Kloft & Heck (2024) <doi:10.31234/osf.io/uwfjc>.