This package provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Power analysis for AB testing. The calculations are based on the Welch's unequal variances t-test, which is generally preferred over the Student's t-test when sample sizes and variances of the two groups are unequal, which is frequently the case in AB testing. In such situations, the Student's t-test will give biased results due to using the pooled standard deviation, unlike the Welch's t-test.

Models with skewâ normally distributed and thus asymmetric error terms, implementing the methods developed in Badunenko and Henderson (2023) "Production analysis with asymmetric noise" <doi:10.1007/s11123-023-00680-5>. The package provides tools to estimate regression models with skewâ normal error terms, allowing both the variance and skewness parameters to be heteroskedastic. It also includes a stochastic frontier framework that accommodates both i.i.d. and heteroskedastic inefficiency terms.

This package provides functions for hormesis screening by classifying the shapes of dose-response curves based on semiparametric tests. The shapes are indications of different potential toxicology effect. It also offers a scalable visualization scheme to present testing conclusions for large-scale dataset with a large number of dose-response curves. For more information, see Jin et al. (2026) <https://github.com/YinglJin-0203/shorm/blob/main/Manuscripts/BotanicalHormesisTestingFinalDraft.docx>.

The straightforward filtering index (SFINX) identifies true positive protein interactions in a fast, user-friendly, and highly accurate way. It is not only useful for the filtering of affinity purification - mass spectrometry (AP-MS) data, but also for similar types of data resulting from other co-complex interactomics technologies, such as TAP-MS, Virotrap and BioID. SFINX can also be used via the website interface at <http://sfinx.ugent.be>.

This package provides an R interface to a Rust implementation of the Shuffled Complex Evolution - University of Arizona (SCE-UA) global optimization algorithm (Duan et al., 1992). SCE-UA combines simplex search, competitive evolution, and complex shuffling to solve nonlinear, non-convex, continuous parameter estimation problems. The method is commonly used for calibrating hydrological and environmental models and follows the algorithm proposed by Duan et al. (1992) <doi:10.1029/91WR02985>.

Utilities for rapidly loading specified rows and/or columns of data from large tab-separated value (tsv) files (large: e.g. 1 GB file of 10000 x 10000 matrix). tsvio is an R wrapper to C code that creates an index file for the rows of the tsv file, and uses that index file to collect rows and/or columns from the tsv file without reading the whole file into memory.

Interface to the TA-Lib (Technical Analysis Library) C library, providing access to 150+ indicators (e.g. Average Directional Movement Index (ADX), Moving Average Convergence Divergence (MACD), Relative Strength Index (RSI), Stochastic Oscillator, Bollinger Bands), candlestick pattern recognition, and rolling-window utilities. Core computations are implemented in C for fast Open-High-Low-Close-Volume (OHLCV) time-series feature engineering and rule-based signal generation, with optional interactive visualization via plotly'.

Edit XMP metadata <https://en.wikipedia.org/wiki/Extensible_Metadata_Platform> in a variety of media file formats as well as edit bookmarks (aka outline aka table of contents) and documentation info entries in pdf files. Can detect and use a variety of command-line tools to perform these operations such as exiftool <https://exiftool.sourceforge.net/>, ghostscript <https://www.ghostscript.com/>, and/or pdftk <https://gitlab.com/pdftk-java/pdftk>.

This package provides an implementation of the ACME estimator, described in Wolpert (2015), ACME: A Partially Periodic Estimator of Avian & Chiropteran Mortality at Wind Turbines. Unlike most other models, this estimator supports decreasing-hazard Weibull model for persistence; decreasing search proficiency as carcasses age; variable bleed-through at successive searches; and interval mortality estimates. The package provides, based on search data, functions for estimating the mortality inflation factor in Frequentist and Bayesian settings.

This package provides a C++ header library for using the libsoda-cxx library with R. The C++ header reimplements the lsoda function from the ODEPACK library for solving initial value problems for first order ordinary differential equations. The C++ header can be used by other R packages by linking against this package. The C++ functions can be called inline using Rcpp. Finally, the package provides an ode function to call from R.

R comes with a suite of utilities for linear algebra with "numeric" (double precision) vectors/matrices. However, sometimes single precision (or less!) is more than enough for a particular task. This package extends R's linear algebra facilities to include 32-bit float (single precision) data. Float vectors/matrices have half the precision of their "numeric"-type counterparts but are generally faster to numerically operate on, for a performance vs accuracy trade-off.

This package provides an R wrapper for libnabo, an exact or approximate k nearest neighbour library which is optimised for low dimensional spaces (e.g. 3D). nabor includes a knn function that is designed as a drop-in replacement for the RANN function nn2. In addition, objects which include the k-d tree search structure can be returned to speed up repeated queries of the same set of target points.

Celda is a suite of Bayesian hierarchical models for clustering single-cell RNA-sequencing (scRNA-seq) data. It is able to perform "bi-clustering" and simultaneously cluster genes into gene modules and cells into cell subpopulations. It also contains DecontX, a novel Bayesian method to computationally estimate and remove RNA contamination in individual cells without empty droplet information. A variety of scRNA-seq data visualization functions is also included.

scCB2 is an R package implementing CB2 for distinguishing real cells from empty droplets in droplet-based single cell RNA-seq experiments (especially for 10x Chromium). It is based on clustering similar barcodes and calculating Monte-Carlo p-value for each cluster to test against background distribution. This cluster-level test outperforms single-barcode-level tests in dealing with low count barcodes and homogeneous sequencing library, while keeping FDR well controlled.

Stan based functions to estimate CAR-MM models. These models allow to estimate Generalised Linear Models with CAR (conditional autoregressive) spatial random effects for spatially and temporally misaligned data, provided a suitable Multiple Membership matrix. The main references are Gramatica, Liverani and Congdon (2023) <doi:10.1214/23-BA1370>, Petrof, Neyens, Nuyts, Nackaerts, Nemery and Faes (2020) <doi:10.1002/sim.8697> and Gramatica, Congdon and Liverani <doi:10.1111/rssc.12480>.

Supplies higher-order coordinatized data specification and fluid transform operators that include pivot and anti-pivot as special cases. The methodology is describe in Zumel', 2018, "Fluid data reshaping with cdata'", <https://winvector.github.io/FluidData/FluidDataReshapingWithCdata.html> , <DOI:10.5281/zenodo.1173299> . This package introduces the idea of explicit control table specification of data transforms. Works on in-memory data or on remote data using rquery and SQL database interfaces.

Generally, most of the packages specify the probability density function, cumulative distribution function, quantile function, and random numbers generation of the probability distributions. The present package allows to compute some important distributional properties, including the first four ordinary and central moments, Pearson's coefficient of skewness and kurtosis, the mean and variance, coefficient of variation, median, and quartile deviation at some parametric values of several well-known and extensively used probability distributions.

Interface to the python package dgpsi for Gaussian process, deep Gaussian process, and linked deep Gaussian process emulations of computer models and networks using stochastic imputation (SI). The implementations follow Ming & Guillas (2021) <doi:10.1137/20M1323771> and Ming, Williamson, & Guillas (2023) <doi:10.1080/00401706.2022.2124311> and Ming & Williamson (2023) <doi:10.48550/arXiv.2306.01212>. To get started with the package, see <https://mingdeyu.github.io/dgpsi-R/>.

The official implementation of the Global Livestock Environmental Assessment Model (GLEAM) of the Food and Agriculture Organization of the United Nations (FAO) in R. GLEAM-X provides a modular, transparent framework for simulating livestock production systems and quantifying their environmental impacts. Methodological background: MacLeod et al. (2017) "Invited review: A position on the Global Livestock Environmental Assessment Model (GLEAM)" <doi:10.1017/S1751731117001847>. Further information: <https://www.fao.org/gleam/en/>.

This package provides functions and methods for: splitting large raster objects into smaller chunks, transferring images from a binary format into raster layers, transferring raster layers into an RData file, calculating the maximum gap (amount of consecutive missing values) of a numeric vector, and fitting harmonic regression models to periodic time series. The homoscedastic harmonic regression model is based on G. Roerink, M. Menenti and W. Verhoef (2000) <doi:10.1080/014311600209814>.

Statistical testing procedures for detecting GxE (gene-environment) interactions. The main focus lies on GRSxE interaction tests that aim at detecting GxE interactions through GRS (genetic risk scores). Moreover, a novel testing procedure based on bagging and OOB (out-of-bag) predictions is implemented for incorporating all available observations at both GRS construction and GxE testing (Lau et al., 2023, <doi:10.1038/s41598-023-28172-4>).

Designed to simplify geospatial data access from the Statistics Finland Web Feature Service API <https://geo.stat.fi/geoserver/index.html>, the geofi package offers researchers and analysts a set of tools to obtain and harmonize administrative spatial data for a wide range of applications, from urban planning to environmental research. The package contains annually updated time series of municipality key datasets that can be used for data aggregation and language translations.

This package provides tools to estimate, compare, and visualize healthcare resource utilization using data derived from electronic health records or real-world evidence sources. The package supports pre index and post index analysis, patient cohort comparison, and customizable summaries and visualizations for clinical and health economics research. Methods implemented are based on Scott et al. (2022) <doi:10.1080/13696998.2022.2037917> and Xia et al. (2024) <doi:10.14309/ajg.0000000000002901>.