This package provides a systematic biology tool was developed to identify dysregulated miRNAs via a miRNA-miRNA interaction network. IDMIR first constructed a weighted miRNA interaction network through integrating miRNA-target interaction information, molecular function data from Gene Ontology (GO) database and gene transcriptomic data in specific-disease context, and then, it used a network propagation algorithm on the network to identify significantly dysregulated miRNAs.

This package provides function to read data from the Igor Pro data analysis program by Wavemetrics'. The data formats supported are Igor packed experiment format ('pxp') and Igor binary wave ('ibw'). See: <https://www.wavemetrics.com/> for details. Also includes functions to load special pxp files produced by the Igor Pro Neuromatic and Nclamp packages for recording and analysing neuronal data. See <https://github.com/SilverLabUCL/NeuroMatic> for details.

The reference implementation of model equations and default parameters for the toxicokinetic-toxicodynamic (TKTD) model of the Lemna (duckweed) aquatic plant. Lemna is a standard test macrophyte used in ecotox effect studies. The model was described and published by the SETAC Europe Interest Group Effect Modeling. It is a refined description of the Lemna TKTD model published by Schmitt et al. (2013) <doi:10.1016/j.ecolmodel.2013.01.017>.

Enables users to handle the dataset cleaning for conducting specific analyses with the log files from two international educational assessments: the Programme for International Student Assessment (PISA, <https://www.oecd.org/pisa/>) and the Programme for the International Assessment of Adult Competencies (PIAAC, <https://www.oecd.org/skills/piaac/>). An illustration of the analyses can be found on the LOGAN Shiny app (<https://loganpackage.shinyapps.io/shiny/>) on your browser.

Fits latent Dirichlet allocation (LDA), supervised topic models, and multilevel supervised topic models for text data with multiple outcome variables. Core estimation routines are implemented in C++ using the Rcpp ecosystem. For topic models, see Blei et al. (2003) <https://www.jmlr.org/papers/volume3/blei03a/blei03a.pdf>. For supervised topic models, see Blei and McAuliffe (2007) <https://papers.nips.cc/paper_files/paper/2007/hash/d56b9fc4b0f1be8871f5e1c40c0067e7-Abstract.html>.

This package provides functionality to generate compound optimal designs for targeting the multiple experimental objectives directly, ensuring that the full set of research questions is answered as economically as possible. Designs can be found using point or coordinate exchange algorithms combining estimation, inference and lack-of-fit criteria that account for model inadequacy. Details and examples are given by Koutra et al. (2024) <doi:10.48550/arXiv.2412.17158>.

This package implements linear and generalized linear models for provider profiling, incorporating both fixed and random effects. For large-scale providers, the linear profiled-based method and the SerBIN method for binary data reduce the computational burden. Provides post-modeling features, such as indirect and direct standardization measures, hypothesis testing, confidence intervals, and post-estimation visualization. For more information, see Wu et al. (2022) <doi:10.1002/sim.9387>.

Fit, compare, and visualize Bayesian graphical vector autoregressive (GVAR) network models using Stan'. These models are commonly used in psychology to represent temporal and contemporaneous relationships between multiple variables in intensive longitudinal data. Fitted models can be compared with a test based on matrix norm differences of posterior point estimates to quantify the differences between two estimated networks. See also Siepe, Kloft & Heck (2024) <doi:10.31234/osf.io/uwfjc>.

The "Vertical and Horizontal Inheritance Consistence Analysis" method is described in the following publication: "VHICA: a new method to discriminate between vertical and horizontal transposon transfer: application to the mariner family within Drosophila" by G. Wallau. et al. (2016) <DOI:10.1093/molbev/msv341>. The purpose of the method is to detect horizontal transfers of transposable elements, by contrasting the divergence of transposable element sequences with that of regular genes.

Within-subject mediation analysis using structural equation modeling. Examine how changes in an outcome variable between two conditions are mediated through one or more variables. Supports within-subject mediation analysis using the lavaan package by Rosseel (2012) <doi:10.18637/jss.v048.i02>, and extends Monte Carlo confidence interval estimation to missing data scenarios using the semmcci package by Pesigan and Cheung (2023) <doi:10.3758/s13428-023-02114-4>.

The biodb package provides access to standard remote chemical and biological databases (ChEBI, KEGG, HMDB, ...), as well as to in-house local database files (CSV, SQLite), with easy retrieval of entries, access to web services, search of compounds by mass and/or name, and mass spectra matching for LCMS and MSMS. Its architecture as a development framework facilitates the development of new database connectors for local projects or inside separate published packages.

The development of high-throughput sequencing led to increased use of co-expression analysis to go beyong single feature (i.e. gene) focus. We propose GWENA (Gene Whole co-Expression Network Analysis) , a tool designed to perform gene co-expression network analysis and explore the results in a single pipeline. It includes functional enrichment of modules of co-expressed genes, phenotypcal association, topological analysis and comparison of networks configuration between conditions.

This package enables the interpretation and analysis of results from a gene set enrichment analysis using network-based and text-mining approaches. Most enrichment analyses result in large lists of significant gene sets that are difficult to interpret. Tools in this package help build a similarity-based network of significant gene sets from a gene set enrichment analysis that can then be investigated for their biological function using text-mining approaches.

This package provides functions to perform the fitting of an adaptive mixture of Student-t distributions to a target density through its kernel function as described in Ardia et al. (2009) <doi:10.18637/jss.v029.i03>. The mixture approximation can then be used as the importance density in importance sampling or as the candidate density in the Metropolis-Hastings algorithm to obtain quantities of interest for the target density itself.

Procedures include Phillips (1995) FMVAR <doi:10.2307/2171721>, Kitamura and Phillips (1997) FMGMM <doi:10.1016/S0304-4076(97)00004-3>, Park (1992) CCR <doi:10.2307/2951679>, and so on. Tests with 1 or 2 structural breaks include Gregory and Hansen (1996) <doi:10.1016/0304-4076(69)41685-7>, Zivot and Andrews (1992) <doi:10.2307/1391541>, and Kurozumi (2002) <doi:10.1016/S0304-4076(01)00106-3>.

Calculates the desparsified lasso as originally introduced in van de Geer et al. (2014) <doi:10.1214/14-AOS1221>, and provides inference suitable for high-dimensional time series, based on the long run covariance estimator in Adamek et al. (2020) <doi:10.48550/arXiv.2007.10952>. Also estimates high-dimensional local projections by the desparsified lasso, as described in Adamek et al. (2022) <doi:10.48550/arXiv.2209.03218>.

Directed Dependence Coefficient (didec) is a measure of functional dependence. Multivariate Feature Ordering by Conditional Independence (MFOCI) is a variable selection algorithm based on didec. Hierarchical Variable Clustering (VarClustPartition) is a variable clustering method based on didec. For more information, see the paper by Ansari and Fuchs (2025, <doi:10.48550/arXiv.2212.01621>), and the paper by Fuchs and Wang (2024, <doi:10.1016/j.ijar.2024.109185>).

Estimate ecosystem metabolism in a Bayesian framework for individual water quality monitoring stations with continuous dissolved oxygen time series. A mass balance equation is used that provides estimates of parameters for gross primary production, respiration, and gas exchange. Methods adapted from Grace et al. (2015) <doi:10.1002/lom3.10011> and Wanninkhof (2014) <doi:10.4319/lom.2014.12.351>. Details in Beck et al. (2024) <doi:10.1002/lom3.10620>.

This package performs hypothesis testing for general block designs with empirical likelihood. The core computational routines are implemented using the Eigen C++ library and RcppEigen interface, with OpenMP for parallel computation. Details of the methods are given in Kim, MacEachern, and Peruggia (2023) <doi:10.1080/10485252.2023.2206919>. This work was supported by the U.S. National Science Foundation under Grants No. SES-1921523 and DMS-2015552.

Maximum likelihood estimation of an extended class of row-column (RC) association models for two-dimensional contingency tables, which are formulated by a condition of reduced rank on a matrix of extended association parameters; see Forcina (2019) <doi:10.48550/arXiv.1910.13848>. These parameters are defined by choosing the logit type for the row and column variables among four different options and a transformation derived from suitable divergence measures.

This package provides a plotting package for climate science and services. Provides a set of functions for visualizing climate data, including maps, time series, scorecards and other diagnostics. Some functions are adapted and extended from the s2dv and CSTools packages (Manubens et al. (2018) <doi:10.1016/j.envsoft.2018.01.018>; Pérez-Zanón et al. (2022) <doi:10.5194/gmd-15-6115-2022>), with more consistent and integrated functionalities.

Estimation and inference using the Fractionally Cointegrated Vector Autoregressive (VAR) model. It includes functions for model specification, including lag selection and cointegration rank selection, as well as a comprehensive set of options for hypothesis testing, including tests of hypotheses on the cointegrating relations, the adjustment coefficients and the fractional differencing parameters. An article describing the FCVAR model with examples is available on the Webpage <https://sites.google.com/view/mortennielsen/software>.

Make 2D and 3D plots of linear programming (LP), integer linear programming (ILP), or mixed integer linear programming (MILP) models with up to three objectives. Plots of both the solution and criterion space are possible. For instance the non-dominated (Pareto) set for bi-objective LP/ILP/MILP programming models (see vignettes for an overview). The package also contains an function for checking if a point is inside the convex hull.

Generates valid HTML tag strings for HTML5 elements documented by Mozilla. Attributes are passed as named lists, with names being the attribute name and values being the attribute value. Attribute values are automatically double-quoted. To declare a DOCTYPE, wrap html() with function doctype(). Mozilla's documentation for HTML5 is available here: <https://developer.mozilla.org/en-US/docs/Web/HTML/Element>. Elements marked as obsolete are not included.