This package provides functions for processing, analysis and visualization of Hydrogen Deuterium eXchange monitored by Mass Spectrometry experiments (HDX-MS) (<doi:10.1093/bioinformatics/btaa587>). HaDeX introduces a new standardized and reproducible workflow for the analysis of the HDX-MS data, including novel uncertainty intervals. Additionally, it covers data exploration, quality control and generation of publication-quality figures. All functionalities are also available in the in-built Shiny app.

Introductory statistics methods to accompany "Investigating Statistical Concepts, Applications, and Methods" (ISCAM) by Beth Chance & Allan Rossman (2024) <https://rossmanchance.com/iscam4/>. Tools to introduce statistical concepts with a focus on simulation approaches. Functions are verbose, designed to provide ample output for students to understand what each function does. Additionally, most functions are accompanied with plots. The package is designed to be used in an educational setting alongside the ISCAM textbook.

This package provides functions to download, clean, and structure open data from the Brazilian Federal Revenue (Receita Federal do Brasil - RFB) regarding Personal Income Tax (IRPF) statements. Includes a data dictionary and categorized metadata for several sections such as assets, rights, debts, and income brackets. More information about the data source can be found at <https://dados.gov.br/dados/conjuntos-dados/grandes-nmeros-do-imposto-de-renda-da-pessoa-fsica>.

This package provides a shiny application for forensic kinship testing, based on the pedsuite R packages. KLINK is closely aligned with the (non-R) software Familias and FamLink', but offers several unique features, including visualisations and automated report generation. The calculation of likelihood ratios supports pairs of linked markers, and all common mutation models. The program is described in Vigeland and Gilfillan (2026) <doi:10.1016/j.fsigen.2026.103578>.

Detection of multivariate outliers using robust estimates of location and scale. The Minimum Covariance Determinant (MCD) estimator is used to calculate robust estimates of the mean vector and covariance matrix. Outliers are determined based on robust Mahalanobis distances using either an unstructured covariance matrix, a principal components structured covariance matrix, or a factor analysis structured covariance matrix. Includes options for specifying the direction of interest for outlier detection for each variable.

This package contains the MultiFractal Detrended Fluctuation Analysis (MFDFA), MultiFractal Detrended Cross-Correlation Analysis (MFXDFA), and the Multiscale Multifractal Analysis (MMA). The MFDFA() function proposed in this package was used in Laib et al. (<doi:10.1016/j.chaos.2018.02.024> and <doi:10.1063/1.5022737>). See references for more information. Interested users can find a parallel version of the MFDFA() function on GitHub.

This package provides a reproducible workflow for binning and visualizing NMR (nuclear magnetic resonance) spectra from environmental samples. The nmrrr package is intended for post-processing of NMR data, including importing, merging and, cleaning data from multiple files, visualizing NMR spectra, performing binning/integrations for compound classes, and relative abundance calculations. This package can be easily inserted into existing analysis workflows by users to help with analyzing and interpreting NMR data.

Constructs (non)additive genetic relationship matrices, and their inverses, from a pedigree to be used in linear mixed effect models (A.K.A. the animal model'). Also includes other functions to facilitate the use of animal models. Some functions have been created to be used in conjunction with the R package asreml for the ASReml software, which can be obtained upon purchase from VSN international (<https://vsni.co.uk/software/asreml>).

This package provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Power analysis for AB testing. The calculations are based on the Welch's unequal variances t-test, which is generally preferred over the Student's t-test when sample sizes and variances of the two groups are unequal, which is frequently the case in AB testing. In such situations, the Student's t-test will give biased results due to using the pooled standard deviation, unlike the Welch's t-test.

This package provides an R interface to a Rust implementation of the Shuffled Complex Evolution - University of Arizona (SCE-UA) global optimization algorithm (Duan et al., 1992). SCE-UA combines simplex search, competitive evolution, and complex shuffling to solve nonlinear, non-convex, continuous parameter estimation problems. The method is commonly used for calibrating hydrological and environmental models and follows the algorithm proposed by Duan et al. (1992) <doi:10.1029/91WR02985>.

This package provides functions for hormesis screening by classifying the shapes of dose-response curves based on semiparametric tests. The shapes are indications of different potential toxicology effect. It also offers a scalable visualization scheme to present testing conclusions for large-scale dataset with a large number of dose-response curves. For more information, see Jin et al. (2026) <https://github.com/YinglJin-0203/shorm/blob/main/Manuscripts/BotanicalHormesisTestingFinalDraft.docx>.

The straightforward filtering index (SFINX) identifies true positive protein interactions in a fast, user-friendly, and highly accurate way. It is not only useful for the filtering of affinity purification - mass spectrometry (AP-MS) data, but also for similar types of data resulting from other co-complex interactomics technologies, such as TAP-MS, Virotrap and BioID. SFINX can also be used via the website interface at <http://sfinx.ugent.be>.

Models with skewâ normally distributed and thus asymmetric error terms, implementing the methods developed in Badunenko and Henderson (2023) "Production analysis with asymmetric noise" <doi:10.1007/s11123-023-00680-5>. The package provides tools to estimate regression models with skewâ normal error terms, allowing both the variance and skewness parameters to be heteroskedastic. It also includes a stochastic frontier framework that accommodates both i.i.d. and heteroskedastic inefficiency terms.

Utilities for rapidly loading specified rows and/or columns of data from large tab-separated value (tsv) files (large: e.g. 1 GB file of 10000 x 10000 matrix). tsvio is an R wrapper to C code that creates an index file for the rows of the tsv file, and uses that index file to collect rows and/or columns from the tsv file without reading the whole file into memory.

Interface to the TA-Lib (Technical Analysis Library) C library, providing access to 150+ indicators (e.g. Average Directional Movement Index (ADX), Moving Average Convergence Divergence (MACD), Relative Strength Index (RSI), Stochastic Oscillator, Bollinger Bands), candlestick pattern recognition, and rolling-window utilities. Core computations are implemented in C for fast Open-High-Low-Close-Volume (OHLCV) time-series feature engineering and rule-based signal generation, with optional interactive visualization via plotly'.

Edit XMP metadata <https://en.wikipedia.org/wiki/Extensible_Metadata_Platform> in a variety of media file formats as well as edit bookmarks (aka outline aka table of contents) and documentation info entries in pdf files. Can detect and use a variety of command-line tools to perform these operations such as exiftool <https://exiftool.sourceforge.net/>, ghostscript <https://www.ghostscript.com/>, and/or pdftk <https://gitlab.com/pdftk-java/pdftk>.

Download and read the public, non-identified microdata of the RAIS (Relação Anual de Informações Sociais), the annual census of formal employment relationships and establishments published by the Brazilian Ministry of Labour and Employment through the PDET FTP server <ftp://ftp.mtps.gov.br/pdet/microdados/RAIS/>. Lists the years and archives available on the server, resolves which regional or state archive holds a given state, downloads it with an idempotent local cache, and reads the 7z archives as a stream, filtering by state and selecting columns before anything is kept in memory, so that a single state can be extracted from a regional file of tens of millions of records. Handles the two header generations of the files (up to the RAIS 2022 and from the RAIS 2023 onwards) with the same normalized column names, provides the official record layout and a helper to consolidate the employment stock, admissions, separations and December payroll.

This package provides an implementation of the ACME estimator, described in Wolpert (2015), ACME: A Partially Periodic Estimator of Avian & Chiropteran Mortality at Wind Turbines. Unlike most other models, this estimator supports decreasing-hazard Weibull model for persistence; decreasing search proficiency as carcasses age; variable bleed-through at successive searches; and interval mortality estimates. The package provides, based on search data, functions for estimating the mortality inflation factor in Frequentist and Bayesian settings.

R comes with a suite of utilities for linear algebra with "numeric" (double precision) vectors/matrices. However, sometimes single precision (or less!) is more than enough for a particular task. This package extends R's linear algebra facilities to include 32-bit float (single precision) data. Float vectors/matrices have half the precision of their "numeric"-type counterparts but are generally faster to numerically operate on, for a performance vs accuracy trade-off.

This package provides an R wrapper for libnabo, an exact or approximate k nearest neighbour library which is optimised for low dimensional spaces (e.g. 3D). nabor includes a knn function that is designed as a drop-in replacement for the RANN function nn2. In addition, objects which include the k-d tree search structure can be returned to speed up repeated queries of the same set of target points.

This package provides a C++ header library for using the libsoda-cxx library with R. The C++ header reimplements the lsoda function from the ODEPACK library for solving initial value problems for first order ordinary differential equations. The C++ header can be used by other R packages by linking against this package. The C++ functions can be called inline using Rcpp. Finally, the package provides an ode function to call from R.

Celda is a suite of Bayesian hierarchical models for clustering single-cell RNA-sequencing (scRNA-seq) data. It is able to perform "bi-clustering" and simultaneously cluster genes into gene modules and cells into cell subpopulations. It also contains DecontX, a novel Bayesian method to computationally estimate and remove RNA contamination in individual cells without empty droplet information. A variety of scRNA-seq data visualization functions is also included.

scCB2 is an R package implementing CB2 for distinguishing real cells from empty droplets in droplet-based single cell RNA-seq experiments (especially for 10x Chromium). It is based on clustering similar barcodes and calculating Monte-Carlo p-value for each cluster to test against background distribution. This cluster-level test outperforms single-barcode-level tests in dealing with low count barcodes and homogeneous sequencing library, while keeping FDR well controlled.