This is a stochastic framework that combines biochemical reaction networks with extended Kalman filter and Rauch-Tung-Striebel smoothing. This framework allows to investigate the dynamics of cell differentiation from high-dimensional clonal tracking data subject to measurement noise, false negative errors, and systematically unobserved cell types. Our tool can provide statistical support to biologists in gene therapy clonal tracking studies for a deeper understanding of clonal reconstitution dynamics. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.07.08.499353>.

Data are partitioned (clustered) into k clusters "around medoids", which is a more robust version of K-means implemented in the function pam() in the cluster package. The PAM algorithm is described in Kaufman and Rousseeuw (1990) <doi:10.1002/9780470316801>. Please refer to the pam() function documentation for more references. Clustered data is plotted as a split heatmap allowing visualisation of representative "group-clusters" (medoids) in the data as separated fractions of the graph while those "sub-clusters" are visualised as a traditional heatmap based on hierarchical clustering.

Conduct dsep tests (piecewise SEM) of a directed, or mixed, acyclic graph without latent variables (but possibly with implicitly marginalized or conditioned latent variables that create dependent errors) based on linear, generalized linear, or additive modelswith or without a nesting structure for the data. Also included are functions to do desp tests step-by-step,exploratory path analysis, and Monte Carlo X2 probabilities. This package accompanies Shipley, B, (2026).Cause and Correlation in Biology: A User's Guide to Path Analysis, StructuralEquations and Causal Inference (3rd edition). Cambridge University Press.

Facilitate the management of data from knowledge resources that are frequently used alone or together in research environments. In TKCat', knowledge resources are manipulated as modeled database (MDB) objects. These objects provide access to the data tables along with a general description of the resource and a detail data model documenting the tables, their fields and their relationships. These MDBs are then gathered in catalogs that can be easily explored an shared. Finally, TKCat provides tools to easily subset, filter and combine MDBs and create new catalogs suited for specific needs.

Assess the significance of identified clusters and estimates the true number of clusters by comparing the explained variation due to the clustering from the original data to that produced by clustering a unimodal reference distribution which preserves the covariance structure in the data. The reference distribution is generated using kernel density estimation and a Gaussian copula framework. A dimension reduction strategy and sparse covariance estimation optimize this method for the high-dimensional, low-sample size setting. This method is described in Helgeson, Vock, and Bair (2021) <doi:10.1111/biom.13376>.

MIRit is an R package that provides several methods for investigating the relationships between miRNAs and genes in different biological conditions. In particular, MIRit allows to explore the functions of dysregulated miRNAs, and makes it possible to identify miRNA-gene regulatory axes that control biological pathways, thus enabling the users to unveil the complexity of miRNA biology. MIRit is an all-in-one framework that aims to help researchers in all the central aspects of an integrative miRNA-mRNA analyses, from differential expression analysis to network characterization.

OCTAD provides a platform for virtually screening compounds targeting precise cancer patient groups. The essential idea is to identify drugs that reverse the gene expression signature of disease by tamping down over-expressed genes and stimulating weakly expressed ones. The package offers deep-learning based reference tissue selection, disease gene expression signature creation, pathway enrichment analysis, drug reversal potency scoring, cancer cell line selection, drug enrichment analysis and in silico hit validation. It currently covers ~20,000 patient tissue samples covering 50 cancer types, and expression profiles for ~12,000 distinct compounds.

This package provides a collection of measures for measuring ecological diversity. Ecological diversity comes in two flavors: alpha diversity measures the diversity within a single site or sample, and beta diversity measures the diversity across two sites or samples. This package overlaps considerably with other R packages such as vegan', gUniFrac', betapart', and fossil'. We also include a wide range of functions that are implemented in software outside the R ecosystem, such as scipy', Mothur', and scikit-bio'. The implementations here are designed to be basic and clear to the reader.

An interface to the Briq API <https://briq.github.io>. Briq is a tool that aims to promote employee engagement by helping employees recognize and reward each other. Employees can praise and thank one another (for achieving a company goal, for example) by giving virtual credits (known as briqs or bqs') that can be redeemed for various rewards. The Briq API lets you create, read, update and delete users, user groups, transactions and messages. This package provides functions that simplify getting the users, user groups and transactions of your organization into R.

The goal of cvsem is to provide functions that allow for comparing Structural Equation Models (SEM) using cross-validation. Users can specify multiple SEMs using lavaan syntax. cvsem computes the Kullback Leibler (KL) Divergence between 1) the model implied covariance matrix estimated from the training data and 2) the sample covariance matrix estimated from the test data described in Cudeck, Robert & Browne (1983) <doi:10.18637/jss.v048.i02>. The KL Divergence is computed for each of the specified SEMs allowing for the models to be compared based on their prediction errors.

This package provides a facility to generate efficient designs for order-of-additions experiments under pair-wise-order model, see Dennis K. J. Lin and Jiayu Peng (2019)."Order-of-addition experiments: A review and some new thoughts". Quality Engineering, 31:1, 49-59, <doi:10.1080/08982112.2018.1548021>. It also provides a facility to generate component orthogonal arrays under component position model, see Jian-Feng Yang, Fasheng Sun & Hongquan Xu (2020): "A Component Position Model, Analysis and Design for Order-of-Addition Experiments". Technometrics, <doi:10.1080/00401706.2020.1764394>.

This package provides a specific and comprehensive framework for the analyses of time-to-event data in agriculture. Fit non-parametric and parametric time-to-event models. Compare time-to-event curves for different experimental groups. Plots and other displays. It is particularly tailored to the analyses of data from germination and emergence assays. The methods are described in Onofri et al. (2022) "A unified framework for the analysis of germination, emergence, and other time-to-event data in weed science", Weed Science, 70, 259-271 <doi:10.1017/wsc.2022.8>.

Automatic generation of exams based on exercises in Markdown or LaTeX format, possibly including R code for dynamic generation of exercise elements. Exercise types include single-choice and multiple-choice questions, arithmetic problems, string questions, and combinations thereof (cloze). Output formats include standalone files (PDF, HTML, Docx, ODT, ...), Moodle XML, QTI 1.2, QTI 2.1, Blackboard, Canvas, OpenOlat, ILIAS, TestVision, Particify, ARSnova, Kahoot!, Grasple, and TCExam. In addition to fully customizable PDF exams, a standardized PDF format (NOPS) is provided that can be printed, scanned, and automatically evaluated.

This package implements the Generalized Method of Wavelet Moments with Exogenous Inputs estimator (GMWMX) presented in Cucci, D. A., Voirol, L., Kermarrec, G., Montillet, J. P., and Guerrier, S. (2023) <doi:10.1007/s00190-023-01702-8>. The GMWMX estimator allows to estimate functional and stochastic parameters of linear models with correlated residuals. The gmwmx package provides functions to estimate, compare and analyze models, utilities to load and work with Global Navigation Satellite System (GNSS) data as well as methods to compare results with the Maximum Likelihood Estimator (MLE) implemented in Hector.

This package provides a guidance system for analysis with missing data. It incorporates expert, up-to-date methodology to help researchers choose the most appropriate analysis approach when some data are missing. You provide the available data and the assumed causal structure, including the likely causes of missing data. midoc will advise which analysis approaches can be used, and how best to perform them. midoc follows the framework for the treatment and reporting of missing data in observational studies (TARMOS). Lee et al (2021). <doi:10.1016/j.jclinepi.2021.01.008>.

This package implements scalable Markov chain Monte Carlo (Sca-MCMC) algorithms for Bayesian inference in dynamic generalized linear models (DGLMs). The package supports Pareto-type and Gamma-type DGLMs, which are suitable for modeling heavy-tailed phenomena such as wealth allocation and financial returns. It provides simulation tools for synthetic DGLM data, adaptive mutation-rate strategies (ScaI, ScaII, ScaIII), geometric temperature ladders for parallel tempering, and posterior predictive evaluation metrics (e.g., R2, RMSE). The methodology is based on the scalable MCMC framework described in Guo et al. (2025).

Enables the creation of Chain Event Graphs over spatial areas, with an optional Shiny user interface. Allows users to fully customise both the structure and underlying model of the Chain Event Graph, offering a high degree of flexibility for tailored analyses. For more details on Chain Event Graphs, see Freeman, G., & Smith, J. Q. (2011) <doi:10.1016/j.jmva.2011.03.008>, Collazo R. A., Görgen C. and Smith J. Q. (2018, ISBN:9781498729604) and Barclay, L. M., Hutton, J. L., & Smith, J. Q. (2014) <doi:10.1214/13-BA843>.

RtAudio is a set of C++ classes that provides a common API for real-time audio input/output. It was designed with the following objectives:

• object-oriented C++ design

• simple, common API across all supported platforms

• only one source and one header file for easy inclusion in programming projects

• allow simultaneous multi-api support

• support dynamic connection of devices

• provide extensive audio device parameter control

• allow audio device capability probing

• automatic internal conversion for data format, channel number compensation, (de)interleaving, and byte-swapping

This package offers classes and functions to contact web servers while enforcing scheduling rules required by the sites. The URL class makes it easy to construct a URL by providing parameters as a vector. The Request class allows to describe Simple Object Access Protocol (SOAP) or standard requests: URL, method (POST or GET), header, body. The Scheduler class controls the request frequency for each server address by means of rules (Rule class). The RequestResult class permits to get the request status to handle error cases and the content.

Package blima includes several algorithms for the preprocessing of Illumina microarray data. It focuses to the bead level analysis and provides novel approach to the quantile normalization of the vectors of unequal lengths. It provides variety of the methods for background correction including background subtraction, RMA like convolution and background outlier removal. It also implements variance stabilizing transformation on the bead level. There are also implemented methods for data summarization. It also provides the methods for performing T-tests on the detector (bead) level and on the probe level for differential expression testing.

The Iterative Proportional Fitting (IPF) algorithm operates on count data. This package offers implementations for several algorithms that extend this to nested structures: parent and child items for both of which constraints can be provided. The fitting algorithms include Iterative Proportional Updating <https://trid.trb.org/view/881554>, Hierarchical IPF <doi:10.3929/ethz-a-006620748>, Entropy Optimization <https://trid.trb.org/view/881144>, and Generalized Raking <doi:10.2307/2290793>. Additionally, a number of replication methods is also provided such as Truncate, replicate, sample <doi:10.1016/j.compenvurbsys.2013.03.004>.

The aim of nosoi (pronounced no.si) is to provide a flexible agent-based stochastic transmission chain/epidemic simulator (Lequime et al. Methods in Ecology and Evolution 11:1002-1007). It is named after the daimones of plague, sickness and disease that escaped Pandora's jar in the Greek mythology. nosoi is able to take into account the influence of multiple variable on the transmission process (e.g. dual-host systems (such as arboviruses), within-host viral dynamics, transportation, population structure), alone or taken together, to create complex but relatively intuitive epidemiological simulations.

This package provides methods for fitting bivariate lines in allometry using the major axis (MA) or standardised major axis (SMA), and for making inferences about such lines. The available methods of inference include confidence intervals and one-sample tests for slope and elevation, testing for a common slope or elevation amongst several allometric lines, constructing a confidence interval for a common slope or elevation, and testing for no shift along a common axis, amongst several samples. See Warton et al. 2012 <doi:10.1111/j.2041-210X.2011.00153.x> for methods description.

The current version of this package estimates spatial autoregressive models for binary dependent variables using GMM estimators <doi:10.18637/jss.v107.i08>. It supports one-step (Pinkse and Slade, 1998) <doi:10.1016/S0304-4076(97)00097-3> and two-step GMM estimator along with the linearized GMM estimator proposed by Klier and McMillen (2008) <doi:10.1198/073500107000000188>. It also allows for either Probit or Logit model and compute the average marginal effects. All these models are presented in Sarrias and Piras (2023) <doi:10.1016/j.jocm.2023.100432>.