Power logit regression models for bounded continuous data, in which the density generator may be normal, Student-t, power exponential, slash, hyperbolic, sinh-normal, or type II logistic. Diagnostic tools associated with the fitted model, such as the residuals, local influence measures, leverage measures, and goodness-of-fit statistics, are implemented. The estimation process follows the maximum likelihood approach and, currently, the package supports two types of estimators: the usual maximum likelihood estimator and the penalized maximum likelihood estimator. More details about power logit regression models are described in Queiroz and Ferrari (2022) <arXiv:2202.01697>.

In the situation when multiple alternative treatments or interventions available, different population groups may respond differently to different treatments. This package implements a method that discovers the population subgroups in which a certain treatment has a better effect than the other alternative treatments. This is done by first estimating the treatment effect for a given treatment and its uncertainty by computing random forests, and the resulting model is summarized by a decision tree in which the probabilities that the given treatment is best for a given subgroup is shown in the corresponding terminal node of the tree.

An efficient tool for fitting the nested common and shared atoms models using variational Bayes approximate inference for fast computation. Specifically, the package implements the common atoms model (Denti et al., 2023), its finite version (D'Angelo et al., 2023), and a hybrid finite-infinite model. All models use Gaussian mixtures with a normal-inverse-gamma prior distribution on the parameters. Additional functions are provided to help analyze the results of the fitting procedure. References: Denti, Camerlenghi, Guindani, Mira (2023) <doi:10.1080/01621459.2021.1933499>, Dâ Angelo, Canale, Yu, Guindani (2023) <doi:10.1111/biom.13626>.

This package provides functions for Bayesian Predictive Stacking within the Bayesian transfer learning framework for geospatial artificial systems, as introduced in "Bayesian Transfer Learning for Artificially Intelligent Geospatial Systems: A Predictive Stacking Approach" (Presicce and Banerjee, 2025) <doi:10.48550/arXiv.2410.09504>. This methodology enables efficient Bayesian geostatistical modeling, utilizing predictive stacking to improve inference across spatial datasets. The core functions leverage C++ for high-performance computation, making the framework well-suited for large-scale spatial data analysis in parallel and distributed computing environments. Designed for scalability, it allows seamless application in computationally demanding scenarios.

Analyzes and models data subject to sampling biases. Provides functions to estimate the density and cumulative distribution functions from biased samples of continuous distributions. Includes the estimators proposed by Bhattacharyya et al. (1988) <doi:10.1080/03610928808829825> and Jones (1991) <doi:10.2307/2337020> for density, and by Cox (2005, ISBN:052184939X) and Bose and Dutta (2022) <doi:10.1007/s00184-021-00824-3> for distribution, with different bandwidth selectors. Also includes a real length-biased dataset on shrub width from Muttlak (1988) <https://www.proquest.com/openview/3dd74592e623cdbcfa6176e85bd3d390/1?cbl=18750&diss=y&pq-origsite=gscholar>.

Wrapper and plotting utilities for the spatial population genetics tool EEMS (Estimated Effective Migration Surfaces) for SNP (Single Nucleotide Polymorphism) data, originally provided as a command-line tool written in C++ together with an accompanying R package for plotting the output of the EEMS tool itself (<https://github.com/dipetkov/eems/>). There are four main motivations for offering this to R users as a package. Firstly, to remove the installation and configuration burden for the EEMS command-line tool, which relies on manually installed Boost and Eigen system libraries and configuring their location; secondly, to streamline the workflow by having a singe environment (the R system) for the entire analysis rather than a file-based command-line executable whose output files are then to be imported and analysed by a separate R script; thirdly, to make the input formats compatible with other, R'-based spatial population genetics tools such as the ConStruct package; and lastly, to allow for easily running several chains in parallel and combining them for plotting and further analysis. The package also adds more intuitive, streamlined tooling around creating more complex habitats. The method of estimating effective migration surfaces was first described by Petkova, D., Novembre, J. & Stephens, M. (2016) <doi:10.1038/ng.3464>.

Radare2 is a complete framework for reverse-engineering, debugging, and analyzing binaries. It is composed of a set of small utilities that can be used together or independently from the command line.

Radare2 is built around a scriptable disassembler and hexadecimal editor that support a variety of executable formats for different processors and operating systems, through multiple back ends for local and remote files and disk images.

It can also compare (diff) binaries with graphs and extract information like relocation symbols. It is able to deal with malformed binaries, making it suitable for security research and analysis.

Radare2 is a complete framework for reverse-engineering, debugging, and analyzing binaries. It is composed of a set of small utilities that can be used together or independently from the command line.

Radare2 is built around a scriptable disassembler and hexadecimal editor that support a variety of executable formats for different processors and operating systems, through multiple back ends for local and remote files and disk images.

It can also compare (diff) binaries with graphs and extract information like relocation symbols. It is able to deal with malformed binaries, making it suitable for security research and analysis.

This package provides simulation methods for the evolution of antibody repertoires. The heavy and light chain variable region of both human and C57BL/6 mice can be simulated in a time-dependent fashion. Both single lineages using one set of V-, D-, and J-genes or full repertoires can be simulated. The algorithm begins with an initial V-D-J recombination event, starting the first phylogenetic tree. Upon completion, the main loop of the algorithm begins, with each iteration representing one simulated time step. Various mutation events are possible at each time step, contributing to a diverse final repertoire.

GLDEX offers fitting algorithms corresponding to two major objectives. One is to provide a smoothing device to fit distributions to data using the weighted and unweighted discretised approach based on the bin width of the histogram. The other is to provide a definitive fit to the data set using the maximum likelihood and quantile matching estimation. Other methods such as moment matching, starship method, and L moment matching are also provided. Diagnostics on goodness of fit can be done via qqplots, KS-resample tests and comparing mean, variance, skewness and kurtosis of the data with the fitted distribution.

Designed for studies where animals tagged with acoustic tags are expected to move through receiver arrays. This package combines the advantages of automatic sorting and checking of animal movements with the possibility for user intervention on tags that deviate from expected behaviour. The three analysis functions (explore(), migration() and residency()) allow the users to analyse their data in a systematic way, making it easy to compare results from different studies. CJS calculations are based on Perry et al. (2012) <https://www.researchgate.net/publication/256443823_Using_mark-recapture_models_to_estimate_survival_from_telemetry_data>.

The Pritchard-Stephens-Donnelly (PSD) admixture model has k intermediate subpopulations from which n individuals draw their alleles dictated by their individual-specific admixture proportions. The BN-PSD model additionally imposes the Balding-Nichols (BN) allele frequency model to the intermediate populations, which therefore evolved independently from a common ancestral population T with subpopulation-specific FST (Wright's fixation index) parameters. The BN-PSD model can be used to yield complex population structures. This simulation approach is now extended to subpopulations related by a tree. Method described in Ochoa and Storey (2021) <doi:10.1371/journal.pgen.1009241>.

This package provides a header only, C++ interface to R with enhancements over cpp11'. Enforces copy-on-write semantics consistent with R behavior. Offers native support for ALTREP objects, UTF-8 string handling, modern C++ features and idioms, and reduced memory requirements. Allows for vendoring, making it useful for restricted environments. Compared to cpp11', it adds support for converting C++ maps to R lists, Roxygen documentation directly in C++ code, proper handling of matrix attributes, support for nullable external pointers, bidirectional copy of complex number types, flexibility in type conversions, use of nullable pointers, and various performance optimizations.

Estimates the conditional association between an exposure and an outcome given covariates. Three methods are implemented: O-estimation, where a nuisance model for the association between the covariates and the outcome is used; E-estimation where a nuisance model for the association between the covariates and the exposure is used, and doubly robust (DR) estimation where both nuisance models are used. In DR-estimation, the estimates will be consistent when at least one of the nuisance models is correctly specified, not necessarily both. For more information, see Zetterqvist and Sjölander (2015) <doi:10.1515/em-2014-0021>.

This package provides feedback about data.table operations. dtlog redefines the subsetting method for data tables as well as several functions exported by data.table so that each operation prints a short message describing what it did: how many rows were removed, which columns were added, updated or dropped, how many groups an aggregation produced, and so on. The operations themselves are left untouched, including modification by reference. It also provides dttable(), which describes the variables a single data table holds and passes every other call on to base::table() unchanged. Inspired by the tidylog package.

This package implements the approximate Bayesian method for bandwidth selection in multivariate kernel density estimation (KDE) proposed in Filippone & Sanguinetti (2011) <doi:10.1016/j.csda.2011.05.023>. The method uses the Expectation Propagation (EP) algorithm to approximate the posterior distribution of the inverse bandwidth (precision matrix) under a leave-one-out cross-validated likelihood. Three covariance structures are supported: isotropic (scalar precision), diagonal, and full precision matrix. Online Bayesian updating is supported for the isotropic case. The approximate posterior can be used for bandwidth selection, model comparison (via the model evidence / Bayes factor), and online learning.

High-throughput single-cell measurements of DNA methylomes can quantify methylation heterogeneity and uncover its role in gene regulation. However, technical limitations and sparse coverage can preclude this task. scMET is a hierarchical Bayesian model which overcomes sparsity, sharing information across cells and genomic features to robustly quantify genuine biological heterogeneity. scMET can identify highly variable features that drive epigenetic heterogeneity, and perform differential methylation and variability analyses. We illustrate how scMET facilitates the characterization of epigenetically distinct cell populations and how it enables the formulation of novel hypotheses on the epigenetic regulation of gene expression.

This package provides a comprehensive statistical analysis of the accuracy of blood pressure devices based on the method of AAMI/ANSI SP10 standards developed by the AAMI Sphygmomanometer Committee for indirect measurement of blood pressure, incorporated into IS0 81060-2. The bpAcc package gives the exact probability of accepting a device D derived from the join distribution of the sample standard deviation and a non-linear transformation of the sample mean for a specified sample size introduced by Chandel et al. (2024) and by the Association for the Advancement of Medical Instrumentation (2003, ISBN:1-57020-183-8).

Computes the D', Wn, and conditional asymmetric linkage disequilibrium (ALD) measures for pairs of genetic loci. Performs these linkage disequilibrium (LD) calculations on phased genotype data recorded using Genotype List (GL) String or columnar formats. Alternatively, generates expectation-maximization (EM) estimated haplotypes from phased data, or performs LD calculations on EM estimated haplotypes. Performs sign tests comparing LD values for phased and unphased datasets, and generates heat-maps for each LD measure. Described by Osoegawa et al. (2019a) <doi:10.1016/j.humimm.2019.01.010>, and Osoegawa et. al. (2019b) <doi:10.1016/j.humimm.2019.05.018>.

In the era of big data, data redundancy and distributed characteristics present novel challenges to data analysis. This package introduces a method for estimating optimal subsets of redundant distributed data, based on PPCDT (Conjunction of Power and P-value in Distributed Settings). Leveraging PPC technology, this approach can efficiently extract valuable information from redundant distributed data and determine the optimal subset. Experimental results demonstrate that this method not only enhances data quality and utilization efficiency but also assesses its performance effectively. The philosophy of the package is described in Guo G. (2020) <doi:10.1007/s00180-020-00974-4>.

High-throughput analysis of growth curves and fluorescence data using three methods: linear regression, growth model fitting, and smooth spline fit. Analysis of dose-response relationships via smoothing splines or dose-response models. Complete data analysis workflows can be executed in a single step via user-friendly wrapper functions. The results of these workflows are summarized in detailed reports as well as intuitively navigable R data containers. A shiny application provides access to all features without requiring any programming knowledge. The package is described in further detail in Wirth et al. (2023) <doi:10.1038/s41596-023-00850-7>.

Detect sample-provenance inconsistencies and potential mix-ups in mass-spectrometry-based plasma-proteome cohorts. Provides a clustering-based approach (build a nearest-neighbour graph in a dimensionality-reduced space and iteratively split large components by edge weight), a threshold-based approach (classify sample pairs as belonging or not-belonging from a pairwise distance cutoff), parameter optimization over distance metrics and cutoffs, and a pairwise random-forest classifier for protein importance ranking. This is a native R port of the author's Python package spqrp (<https://github.com/fhradilak/spqrp>), implementing methods from an associated manuscript currently in preparation.

Rapidly build accurate genetic prediction models for genome-wide association or whole-genome sequencing study data by smooth-threshold multivariate genetic prediction (STMGP) method. Variable selection is performed using marginal association test p-values with an optimal p-value cutoff selected by Cp-type criterion. Quantitative and binary traits are modeled respectively via linear and logistic regression models. A function that works through PLINK software (Purcell et al. 2007 <DOI:10.1086/519795>, Chang et al. 2015 <DOI:10.1186/s13742-015-0047-8>) <https://www.cog-genomics.org/plink2> is provided. Covariates can be included in regression model.

Pleiotropy-informed significance analysis of genome-wide association studies with surrogate functional false discovery rates (sfFDR). The sfFDR framework adapts the fFDR to leverage informative data from multiple sets of GWAS summary statistics to increase power in study while accommodating for linkage disequilibrium. sfFDR provides estimates of key FDR quantities in a significance analysis such as the functional local FDR and $q$-value, and uses these estimates to derive a functional $p$-value for type I error rate control and a functional local Bayes factor for post-GWAS analyses (e.g., fine mapping and colocalization).