Parse and read the files that comply with the brain imaging data structure, or BIDS format, see the publication from Gorgolewski, K., Auer, T., Calhoun, V. et al. (2016) <doi:10.1038/sdata.2016.44>. Provides query functions to extract and check the BIDS entity information (such as subject, session, task, etc.) from the file paths and suffixes according to the specification. The package is developed and used in the reproducible analysis and visualization of intracranial electroencephalography, or RAVE', see Magnotti, J. F., Wang, Z., and Beauchamp, M. S. (2020) <doi:10.1016/j.neuroimage.2020.117341>; see citation("bidsr") for details and attributions.

Applies the change-in-effect estimate method to assess confounding effects in medical and epidemiological research (Greenland & Pearce (2016) <doi:10.1146/annurev-publhealth-031914-122559> ). It starts with a crude model including only the outcome and exposure variables. At each of the subsequent steps, one variable which creates the largest change among the remaining variables is selected. This process is repeated until all variables have been entered into the model (Wang Z. Stata Journal 2007; 7, Number 2, pp. 183â 196). Currently, the chest package has functions for linear regression, logistic regression, negative binomial regression, Cox proportional hazards model and conditional logistic regression.

The user first provides design vectors n, a and b as well as null (p0) and alternative (p1) benchmark values for the probability of success. The key function "mv.plots.SM()" calculates mean values of exact upper and lower limits based on four different rank ordering methods. These plots form the basis of selecting a rank ordering. The function "inference()" calculates exact limits from a provided realisation and ordering choice. For more information, see "Exact confidence limits after a group sequential single arm binary trial" by Lloyd, C.J. (2020), Statistics in Medicine, Volume 38, 2389-2399, <doi:10.1002/sim.8909>.

Package computes and displays tables with support for SPSS'-style labels, multiple and nested banners, weights, multiple-response variables and significance testing. There are facilities for nice output of tables in knitr', Shiny', *.xlsx files, R and Jupyter notebooks. Methods for labelled variables add value labels support to base R functions and to some functions from other packages. Additionally, the package brings popular data transformation functions from SPSS Statistics and Excel': RECODE', COUNT', COUNTIF', VLOOKUP and etc. These functions are very useful for data processing in marketing research surveys. Package intended to help people to move data processing from Excel and SPSS to R.

An alternative to Exploratory Factor Analysis (EFA) for metrical data in R. Drawing on characteristics of classical test theory, Exploratory Likert Scaling (ELiS) supports the user exploring multiple one-dimensional data structures. In common research practice, however, EFA remains the go-to method to uncover the (underlying) structure of a data set. Orthogonal dimensions and the potential of overextraction are often accepted as side effects. As described in Müller-Schneider (2001) <doi:10.1515/zfsoz-2001-0404>), ELiS confronts these problems. As a result, elisr provides the platform to fully exploit the exploratory potential of the multiple scaling approach itself.

Useful functions to translate text for multiple languages using online translators. For example, by translating error messages and descriptive analysis results into a language familiar to the user, it enables a better understanding of the information, thereby reducing the barriers caused by language. It offers several helper functions to query gene information to help interpretation of interested genes (e.g., marker genes, differential expression genes), and provides utilities to translate ggplot graphics. This package is not affiliated with any of the online translators. The developers do not take responsibility for the invoice it incurs when using this package, especially for exceeding the free quota.

Latent group structures are a common challenge in panel data analysis. Disregarding group-level heterogeneity can introduce bias. Conversely, estimating individual coefficients for each cross-sectional unit is inefficient and may lead to high uncertainty. This package addresses the issue of unobservable group structures by implementing the pairwise adaptive group fused Lasso (PAGFL) by Mehrabani (2023) <doi:10.1016/j.jeconom.2022.12.002>. PAGFL identifies latent group structures and group-specific coefficients in a single step. On top of that, we extend the PAGFL to time-varying coefficient functions (FUSE-TIME), following Haimerl et al. (2025) <doi:10.48550/arXiv.2503.23165>.

Builds semantic topic models from Sentence-BERT embeddings (Reimers and Gurevych, 2019) <doi:10.18653/v1/D19-1410>. Sentence embeddings are computed in several modes with models run on the Open Neural Network Exchange ('ONNX') Runtime, including multilingual and long-context encoders and a fast static model. Topics are labeled with class-based term weighting that can be retuned without refitting. Candidate topic counts and document granularities (whole documents, sentences, clauses, or phrases) can be compared side by side, and fitted models assign topics to new documents, give soft memberships and per-document topic mixtures. The package offers coherence and diversity metrics and visualizations.

Build a constrained high quality Delaunay triangulation from simple features objects, applying constraints based on input line segments, and triangle properties including maximum area, minimum internal angle. The triangulation code in RTriangle uses the method of Cheng, Dey and Shewchuk (2012, ISBN:9781584887300). For a low-dependency alternative with low-quality path-based constrained triangulation see <https://CRAN.R-project.org/package=decido> and for high-quality configurable triangulation see <https://github.com/hypertidy/anglr>. Also consider comparison with the GEOS lib which since version 3.10.0 includes a low quality polygon triangulation method that starts with ear clipping and refines to Delaunay.

In fields such as ecology, microbiology, and genomics, non-Euclidean distances are widely applied to describe pairwise dissimilarity between samples. Given these pairwise distances, principal coordinates analysis (PCoA) is commonly used to construct a visualization of the data. However, confounding covariates can make patterns related to the scientific question of interest difficult to observe. We provide aPCoA as an easy-to-use tool to improve data visualization in this context, enabling enhanced presentation of the effects of interest. Details are described in Yushu Shi, Liangliang Zhang, Kim-Anh Do, Christine Peterson and Robert Jenq (2020) Bioinformatics, Volume 36, Issue 13, 4099-4101.

Description: Computes maximum likelihood estimates of general, zero-inflated, and zero-altered models for discrete and continuous distributions. It also performs Kolmogorov-Smirnov (KS) tests and likelihood ratio tests for general, zero-inflated, and zero-altered data. Additionally, it obtains the inverse of the Fisher information matrix and confidence intervals for the parameters of general, zero-inflated, and zero-altered models. The package simulates random deviates from zero-inflated or hurdle models to obtain maximum likelihood estimates. Based on the work of Aldirawi et al. (2022) <doi:10.1007/s42519-021-00230-y> and Dousti Mousavi et al. (2023) <doi:10.1080/00949655.2023.2207020>.

This package provides tools to model overdispersed immune cell frequencies using Beta-Binomial generalized linear models. Originally designed for memory B cells, the framework generalizes to evaluate rare cellular immune responses across vaccinology, immuno-oncology, and related fields. Includes method-of-moments dispersion estimation, likelihood ratio testing across experimental arms, and Monte Carlo simulation to calculate statistical power and Type I error rates. The methodologies are directly motivated by the analysis of immunology data in "Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial" (Parks et al. 2025) <doi:10.1126/scitranslmed.ady6831>.

This package provides functions and command-line user interface to generate allocation sequence by covariate-adaptive randomization for clinical trials. The package currently supports six covariate-adaptive randomization procedures. Three hypothesis testing methods that are valid and robust under covariate-adaptive randomization are also available in the package to facilitate the inference for treatment effect under the included randomization procedures. Additionally, the package provides comprehensive and efficient tools to allow one to evaluate and compare the performance of randomization procedures and tests based on various criteria. See Ma W, Ye X, Tu F, and Hu F (2023) <doi: 10.18637/jss.v107.i02> for details.

Shiny application that performs bifurcation and phaseplane analysis of systems of ordinary differential equations. The package allows for computation of equilibrium curves as a function of a single free parameter, detection of transcritical, saddle-node and hopf bifurcation points along these curves, and computation of curves representing these transcritical, saddle-node and hopf bifurcation points as a function of two free parameters. The shiny-based GUI allows visualization of the results in both 2D- and 3D-plots. The implemented methods for solution localisation and curve continuation are based on the book "Elements of applied bifurcation theory" (Kuznetsov, Y. A., 1995; ISBN: 0-387-94418-4).

This package contains utilities for the analysis of protein sequences in a phylogenetic context. Allows the generation of phylogenetic trees base on protein sequences in an alignment-independent way. Two different methods have been implemented. One approach is based on the frequency analysis of n-grams, previously described in Stuart et al. (2002) <doi:10.1093/bioinformatics/18.1.100>. The other approach is based on the species-specific neighborhood preference around amino acids. Features include the conversion of a protein set into a vector reflecting these neighborhood preferences, pairwise distances (dissimilarity) between these vectors, and the generation of trees based on these distance matrices.

This package provides a memory-efficient implementation for integrating gene expression data from single-cell RNA sequencing experiments. Uses a C++ backend with thin R wrappers to enable analysis of large-scale single-cell datasets. The package supports multiple data modalities including count matrices, paired data (splicing, RNA velocity, CITE-seq), and binary indicators. It implements a latent variable model with block coordinate descent optimization for dimensionality reduction and batch effect correction. The method is described in Mikaeili Namini et al. (2026) <doi:10.1093/bioinformatics/btag334>, building on the original GEDI model of Madrigal et al. (2024) <doi:10.1038/s41467-024-50963-0>.

This package implements estimation procedures for Autoregressive Distributed Lag (ARDL) and Nonlinear ARDL (NARDL) models, which allow researchers to investigate both short- and long-run relationships in time series data under mixed orders of integration. The package supports simultaneous modeling of symmetric and asymmetric regressors, flexible treatment of short-run and long-run asymmetries, and automated equation handling. It includes several cointegration testing approaches such as the Pesaran-Shin-Smith F and t bounds tests, and narayan test. Methodological foundations are provided in Pesaran, Shin, and Smith (2001) <doi:10.1016/S0304-4076(01)00049-5> and Shin, Yu, and Greenwood-Nimmo (2014, ISBN:9780123855079).

This package provides a reproducible workflow for importing, validating, classifying, summarizing, visualizing, and reporting responses to the 14-item Pragmatic Context Assessment Tool (pCAT). The package preserves the instrument's two-part response structure, supports original and updated Consolidated Framework for Implementation Research (CFIR) mappings, describes team agreement and disagreement, compares repeated assessments, and creates implementation action-planning outputs. It does not calculate or claim a validated total pCAT scale score. The instrument is described by Robinson and Damschroder (2023) <doi:10.1186/s43058-022-00380-5>; updated CFIR mappings are from Domlyn et al. (2026) <doi:10.1186/s43058-026-00956-5>.

Simulates judgments of frequency and duration based on the Probability Associator Time (PASS-T) model. PASS-T is a memory model based on a simple competitive artificial neural network. It can imitate human judgments of frequency and duration, which have been extensively studied in cognitive psychology (e.g. Hintzman (1970) <doi:10.1037/h0028865>, Betsch et al. (2010) <https://psycnet.apa.org/record/2010-18204-003>). The PASS-T model is an extension of the PASS model (Sedlmeier, 2002, ISBN:0198508638). The package provides an easy way to run simulations, which can then be compared with empirical data in human judgments of frequency and duration.

Calculations of an information criterion are proposed to check the quality of simulations results of Agent-based models (ABM/IBM) or other non-linear rule-based models. The POMDEV measure (Pattern Oriented Modelling DEViance) is based on the Kullback-Leibler divergence and likelihood theory. It basically indicates the deviance of simulation results from field observations. Once POMDEV scores and metropolis-hasting sampling on different model versions are effectuated, POMIC scores (Pattern Oriented Modelling Information Criterion) can be calculated. This method could be further developed to incorporate multiple patterns assessment. Piou C, U Berger and V Grimm (2009) <doi:10.1016/j.ecolmodel.2009.05.003>.

This package provides a high-level, object-oriented interface for Secure File Transfer Protocol (SFTP) operations built upon the curl package. The package implements an R6 class to manage persistent connections and provides tidyverse'-style functions for common file system tasks. Key features include recursive directory creation with idempotency support, "smart" local path resolution that distinguishes between files and directories, and the ability to download remote resources directly into memory as raw vectors for seamless integration into data processing pipelines. It is designed to handle common SFTP edge cases gracefully, providing informative error messages and robust path sanitization to ensure compatibility across different server configurations.

This is a modification of HDoutliers package. The HDoutliers algorithm is a powerful unsupervised algorithm for detecting anomalies in high-dimensional data, with a strong theoretical foundation. However, it suffers from some limitations that significantly hinder its performance level, under certain circumstances. This package implements the algorithm proposed in Talagala, Hyndman and Smith-Miles (2019) <arXiv:1908.04000> for detecting anomalies in high-dimensional data that addresses these limitations of HDoutliers algorithm. We define an anomaly as an observation that deviates markedly from the majority with a large distance gap. An approach based on extreme value theory is used for the anomalous threshold calculation.

This package is an implementation of a regularized regression prediction and empirical Bayes method to recover the true gene expression profile in noisy and sparse single-cell RNA-seq data. In single-cell RNA sequencing (scRNA-seq) studies, only a small fraction of the transcripts present in each cell are sequenced. This leads to unreliable quantification of genes with low or moderate expression, which hinders downstream analysis. This package single-cell analysis via expression recovery (SAVER) implements an expression recovery method for unique molecule index (UMI)-based scRNA-seq data that borrows information across genes and cells to provide accurate expression estimates for all genes.

Several cubic spline interpolation methods of H. Akima for irregular and regular gridded data are available through this package, both for the bivariate case (irregular data: ACM 761, regular data: ACM 760) and univariate case (ACM 433 and ACM 697). Linear interpolation of irregular gridded data is also covered by reusing D. J. Renkas triangulation code which is part of Akimas Fortran code. A bilinear interpolator for regular grids was also added for comparison with the bicubic interpolator on regular grids. Please note that most of the functions are now also covered in package interp, which is a re-implementation from scratch under a free license.