This package provides an expectation maximization (EM) algorithm to fit a mixture of continuous time Markov models for use with clickstream or other sequence type data. Gallaugher, M.P.B and McNicholas, P.D. (2018) <arXiv:1802.04849>.

ClickHouse (<https://clickhouse.com/>) is an open-source, high performance columnar OLAP (online analytical processing of queries) database management system for real-time analytics using SQL. This DBI backend relies on the ClickHouse HTTP interface and support HTTPS protocol.

Creation of interactive tables, listings and figures ('TLFs') and associated report for exploratory analysis of data in a clinical trial, e.g. for clinical oversight activities. Interactive figures include sunburst, treemap, scatterplot, line plot and barplot of counts data. Interactive tables include table of summary statistics (as counts of adverse events, enrollment table) and listings. Possibility to compare data (summary table or listing) across two data batches/sets. A clinical data review report is created via study-specific configuration files and template R Markdown reports contained in the package.

This package provides measures of effect sizes for summarized continuous variables as well as diagnostic accuracy statistics for 2x2 table data. Includes functions for Cohen's d, robust effect size, Cohen's q, partial eta-squared, coefficient of variation, odds ratio, likelihood ratios, sensitivity, specificity, positive and negative predictive values, Youden index, number needed to treat, number needed to diagnose, and predictive summary index.

This package provides an interface to the ClinicalOmicsDB API, allowing for easy data downloading and importing. ClinicalOmicsDB is a database of clinical and omics data from cancer patients. The database is accessible at <http://trials.linkedomics.org>.

Climate stability measures are not formalized in the literature and tools for generating stability metrics from existing data are nascent. This package provides tools for calculating climate stability from raster data encapsulating climate change as a series of time slices. The methods follow Owens and Guralnick <doi:10.17161/bi.v14i0.9786> Biodiversity Informatics.

Predict the course of clinical trial with a time-to-event endpoint for both two-arm and single-arm design. Each of the four primary study design parameters (the expected number of observed events, the number of subjects enrolled, the observation time, and the censoring parameter) can be derived analytically given the other three parameters. And the simulation datasets can be generated based on the design settings.

Clique percolation community detection for weighted and unweighted networks as well as threshold and plotting functions. For more information see Farkas et al. (2007) <doi:10.1088/1367-2630/9/6/180> and Palla et al. (2005) <doi:10.1038/nature03607>.

Implement tableGrob object as a clickable image map. The clickableImageMap package is designed to be more convenient and more configurable than the edit() function. Limitations that I have encountered with edit() are cannot control (1) positioning (2) size (3) appearance and formatting of fonts In contrast, when the table is implemented as a tableGrob', all of these features are controllable. In particular, the ggplot2 grid system allows exact positioning of the table relative to other graphics etc.

This package provides a clinical significance analysis can be used to determine if an intervention has a meaningful or practical effect for patients. You provide a tidy data set plus a few more metrics and this package will take care of it to make your results publication ready. Accompanying package to Claus et al. <doi:10.18637/jss.v111.i01>.

Recalibrate risk scores (predicting binary outcomes) to improve clinical utility of risk score using weighted logistic or constrained logistic recalibration methods. Additionally, produces plots to assess the potential for recalibration to improve the clinical utility of a risk model. Methods are described in detail in Mishra, A. (2019) "Methods for Risk Markers that Incorporate Clinical Utility" <http://hdl.handle.net/1773/44068>.

This package provides estimates of several summary measures for clinical trials including the average hazard ratio, the weighted average hazard ratio, the restricted superiority probability ratio, the restricted mean survival difference and the ratio of restricted mean times lost, based on the short-term and long-term hazard ratio model (Yang, 2005 <doi:10.1093/biomet/92.1.1>) which accommodates various non-proportional hazards scenarios. The inference procedures and the asymptotic results for the summary measures are discussed in Yang (2018, <doi:10.1002/sim.7676>).