This package provides models to identify bimodally expressed genes from RNAseq data based on the Bimodality Index. SIBERG models the RNAseq data in the finite mixture modeling framework and incorporates mechanisms for dealing with RNAseq normalization. Three types of mixture models are implemented, namely, the mixture of log normal, negative binomial, or generalized Poisson distribution. See Tong et al. (2013) <doi:10.1093/bioinformatics/bts713>.

Predicts the occurrence times (in day-of-year) of spring phenological events. Three methods, including the accumulated degree days (ADD) method, the accumulated days transferred to a standardized temperature (ADTS) method, and the accumulated developmental progress (ADP) method, were used. See Shi et al. (2017a) <doi:10.1016/j.agrformet.2017.04.001> and Shi et al. (2017b) <doi:10.1093/aesa/sax063> for details.

Estimate vaccine efficacy (VE) using immunogenicity data. The inclusion of immunogenicity data in regression models can increase precision in VE. The methods are described in the publications "Elucidating vaccine efficacy using a correlate of protection, demographics, and logistic regression" and "Improving precision of vaccine efficacy evaluation using immune correlate data in time-to-event models" by Julie Dudasova, Zdenek Valenta, and Jeffrey R. Sachs (2024).

This package lets you carry out network-based gene set analysis by incorporating external information about interactions among genes, as well as novel interactions learned from data. It implements methods described in Shojaie A, Michailidis G (2010) <doi:10.1093/biomet/asq038>, Shojaie A, Michailidis G (2009) <doi:10.1089/cmb.2008.0081>, and Ma J, Shojaie A, Michailidis G (2016) <doi:10.1093/bioinformatics/btw410>.

The encoding of color can be handled in many different ways, using different color spaces. As different color spaces have different uses, efficient conversion between these representations are important. This package provides a set of functions that gives access to very fast color space conversion and comparisons implemented in C++, and offers 100-fold speed improvements over the convertColor function in the grDevices package.

Radicale is a CalDAV and CardDAV server for UNIX-like platforms. Calendars and address books are available for both local and remote access, possibly limited through authentication policies. They can be viewed and edited by calendar and contact clients on mobile phones or computers.

Radicale intentionally does not fully comply with the CalDAV and CardDAV RFCs. Instead, it supports the CalDAV and CardDAV implementations of popular clients.

Reprepro is a tool to manage a repository of Debian packages (.deb, .udeb, .dsc, ...). It stores files either being injected manually or downloaded from some other repository (partially) mirrored into one pool/ hierarchy. Managed packages and files are stored in a Berkeley DB, so no database server is needed. Checking signatures of mirrored repositories and creating signatures of the generated Package indices is supported.

The xvfb-run wrapper simplifies running commands and scripts within a virtual X server environment. It sets up an X authority file or uses an existing user-specified one, writes a cookie to it, and then starts the Xvfb X server as a background process. It also takes care of killing the server and cleaning up before returning the exit status of the command.

This package provides a collection of tools that support data splitting, predictive modeling, and model evaluation. A typical function is to split a dataset into a training dataset and a test dataset. Then compare the data distribution of the two datasets. Another feature is to support the development of predictive models and to compare the performance of several predictive models, helping to select the best model.

Developed for use by those tasked with the routine detection, characterisation and quantification of discrete changes in air quality time-series, such as identifying the impacts of air quality policy interventions. The main functions use signal isolation then break-point/segment (BP/S) methods based on strucchange and segmented methods to detect and quantify change events (Ropkins & Tate, 2021, <doi:10.1016/j.scitotenv.2020.142374>).

Provided are Computational methods for Immune Cell-type Subsets, including:(1) DCQ (Digital Cell Quantifier) to infer global dynamic changes in immune cell quantities within a complex tissue; and (2) VoCAL (Variation of Cell-type Abundance Loci) a deconvolution-based method that utilizes transcriptome data to infer the quantities of immune-cell types, and then uses these quantitative traits to uncover the underlying DNA loci.

Includes R functions for the estimation of tumor clones percentages for both snp data and (whole) genome sequencing data. See Cheng, Y., Dai, J. Y., Paulson, T. G., Wang, X., Li, X., Reid, B. J., & Kooperberg, C. (2017). Quantification of multiple tumor clones using gene array and sequencing data. The Annals of Applied Statistics, 11(2), 967-991, <doi:10.1214/17-AOAS1026> for more details.

Realize three approaches for Gene-Environment interaction analysis. All of them adopt Sparse Group Minimax Concave Penalty to identify important G variables and G-E interactions, and simultaneously respect the hierarchy between main G and G-E interaction effects. All the three approaches are available for Linear, Logistic, and Poisson regression. Also realize to mine and construct prior information for G variables and G-E interactions.

Implementation of two multi-criteria decision making methods (MCDM): Intuitionistic Fuzzy Synthetic Measure (IFSM) and Intuitionistic Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (IFTOPSIS) for intuitionistic fuzzy data sets for multi-criteria decision making problems. References describing the methods: JefmaÅ ski (2020) <doi:10.1007/978-3-030-52348-0_4>; JefmaÅ ski, Roszkowska, Kusterka-JefmaÅ ska (2021) <doi:10.3390/e23121636>.

General purpose TIFF file I/O for R users. Currently the only such package with read and write support for TIFF files with floating point (real-numbered) pixels, and the only package that can correctly import TIFF files that were saved from ImageJ and write TIFF files than can be correctly read by ImageJ <https://imagej.net/ij/>. Also supports text image I/O.

Linear Liu regression coefficient's estimation and testing with different Liu related measures such as MSE, R-squared etc. REFERENCES i. Akdeniz and Kaciranlar (1995) <doi:10.1080/03610929508831585> ii. Druilhet and Mom (2008) <doi:10.1016/j.jmva.2006.06.011> iii. Imdadullah, Aslam, and Saima (2017) iv. Liu (1993) <doi:10.1080/03610929308831027> v. Liu (2001) <doi:10.1016/j.jspi.2010.05.030>.

This package provides tools for creating and using lenses to simplify data manipulation. Lenses are composable getter/setter pairs for working with data in a purely functional way. Inspired by the Haskell library lens (Kmett, 2012) <https://hackage.haskell.org/package/lens>. For a fairly comprehensive (and highly technical) history of lenses please see the lens wiki <https://github.com/ekmett/lens/wiki/History-of-Lenses>.

This package provides functions for fitting various models to capture-recapture data including mixed-effects Cormack-Jolly-Seber(CJS) and multistate models and the multi-variate state model structure for survival estimation and POPAN structured Jolly-Seber models for abundance estimation. There are also Hidden Markov model (HMM) implementations of CJS and multistate models with and without state uncertainty and a simulation capability for HMM models.

This package provides methods for obtaining improved estimates of non-linear cross-validated risks are obtained using targeted minimum loss-based estimation, estimating equations, and one-step estimation (Benkeser, Petersen, van der Laan (2019), <doi:10.1080/01621459.2019.1668794>). Cross-validated area under the receiver operating characteristics curve (LeDell, Petersen, van der Laan (2015), <doi:10.1214/15-EJS1035>) and other metrics are included.

This package provides a client that grants access to the power of the ohsome API from R. It lets you analyze the rich data source of the OpenStreetMap (OSM) history. You can retrieve the geometry of OSM data at specific points in time, and you can get aggregated statistics on the evolution of OSM elements and specify your own temporal, spatial and/or thematic filters.

The online principal component regression method can process the online data set. OPCreg implements the online principal component regression method, which is specifically designed to process online datasets efficiently. This method is particularly useful for handling large-scale, streaming data where traditional batch processing methods may be computationally infeasible.The philosophy of the package is described in Guo (2025) <doi:10.1016/j.physa.2024.130308>.

This package provides functions for unconditional and conditional quantiles. These include methods for transformation-based quantile regression, quantile-based measures of location, scale and shape, methods for quantiles of discrete variables, quantile-based multiple imputation, restricted quantile regression, directional quantile classification, and quantile ratio regression. A vignette is given in Geraci (2016, The R Journal) <doi:10.32614/RJ-2016-037> and included in the package.

Semiparametric and parametric estimation of INAR models including a finite sample refinement (Faymonville et al. (2022) <doi:10.1007/s10260-022-00655-0>) for the semiparametric setting introduced in Drost et al. (2009) <doi:10.1111/j.1467-9868.2008.00687.x>, different procedures to bootstrap INAR data (Jentsch, C. and Weià , C.H. (2017) <doi:10.3150/18-BEJ1057>) and flexible simulation of INAR data.

Carries out analyses of two-way tables with one observation per cell, together with graphical displays for an additive fit and a diagnostic plot for removable non-additivity via a power transformation of the response. It implements Tukey's Exploratory Data Analysis (1973) <ISBN: 978-0201076165> methods, including a 1-degree-of-freedom test for row*column non-additivity', linear in the row and column effects.