This package provides tools to calculate functional similarities based on the pathways described on KEGG and REACTOME or in gene sets. These similarities can be calculated for pathways or gene sets, genes, or clusters and combined with other similarities. They can be used to improve networks, gene selection, testing relationships, and so on.

This package provides functions for Maximum Likelihood (ML) estimation, non-linear optimization, and related tools. It includes a unified way to call different optimizers, and classes and methods to handle the results from the Maximum Likelihood viewpoint. It also includes a number of convenience tools for testing and developing your own models.

Pure OCaml regular expressions with:

1. Perl-style regular expressions (module Re_perl)

2. Posix extended regular expressions (module Re_posix)

3. Emacs-style regular expressions (module Re_emacs)

4. Shell-style file globbing (module Re_glob)

5. Compatibility layer for OCaml's built-in Str module (module Re_str)

Coordinated Gene Activity in Pattern Sets (CoGAPS) implements a Bayesian MCMC matrix factorization algorithm, GAPS, and links it to gene set statistic methods to infer biological process activity. It can be used to perform sparse matrix factorization on any data, and when this data represents biomolecules, to do gene set analysis.

The package is an R wrapper for Progenetix REST API built upon the Beacon v2 protocol. Its purpose is to provide a seamless way for retrieving genomic data from Progenetix database—an open resource dedicated to curated oncogenomic profiles. Empowered by this package, users can effortlessly access and visualize data from Progenetix.

Deals with the braid groups. Includes creation of some specific braids, group operations, free reduction, and Bronfman polynomials. Braid theory has applications in fluid mechanics and quantum physics. The code is adapted from the Haskell library combinat', and is based on Birman and Brendle (2005) <doi:10.48550/arXiv.math/0409205>.

This package provides R routine for the so called two-sample Cramer-Test. This nonparametric two-sample-test on equality of the underlying distributions can be applied to multivariate data as well as univariate data. It offers two possibilities to approximate the critical value both of which are included in this package.

This package provides an implementation of Congruence Class Models for generating networks. It facilitates sampling networks based on specific topological properties and attribute mixing patterns using a Markov Chain Monte Carlo framework. The implementation builds upon code from the ergm package; see Handcock et al. (2008) <doi:10.18637/jss.v024.i01>.

R codes for distance based cell lineage reconstruction. Our methods won both sub-challenges 2 and 3 of the Allen Institute Cell Lineage Reconstruction DREAM Challenge in 2020. References: Gong et al. (2021) <doi:10.1016/j.cels.2021.05.008>, Gong et al. (2022) <doi:10.1186/s12859-022-04633-x>.

This package provides a tool to calculate the correlation boundary for the correlation between the response rate and the log-rank test statistic for the binary surrogate endpoint and the time-to-event primary endpoint, as well as conduct simulation studies to obtain design operating characteristics of the drop-the-losers design.

Fits Bayesian additive regression trees (BART; Chipman, George, and McCulloch (2010) <doi:10.1214/09-AOAS285>) while allowing the updating of predictors or response so that BART can be incorporated as a conditional model in a Gibbs/Metropolis-Hastings sampler. Also serves as a drop-in replacement for package BayesTree'.

The fastai <https://docs.fast.ai/index.html> library simplifies training fast and accurate neural networks using modern best practices. It is based on research in to deep learning best practices undertaken at fast.ai', including out of the box support for vision, text, tabular, audio, time series, and collaborative filtering models.

For supersonic aircraft, flying subsonic over land, find the best route between airports. Allow for coastal buffer and potentially closed regions. Use a minimal model of aircraft performance: the focus is on time saved versus subsonic flight, rather than on vertical flight profile. For modelling and forecasting, not for planning your flight!

This package provides tools for estimating uncertainty in individual polygenic risk scores (PRSs) using both sampling-based and analytical methods, as well as the Best Linear Unbiased Estimator (BLUE). These methods quantify variability in PRS estimates for both binary and quantitative traits. See Henderson (1975) <doi:10.2307/2529430> for more details.

This package implements the kK-NN algorithm, an adaptive k-nearest neighbor classifier that adjusts the neighborhood size based on local data curvature. The method estimates local Gaussian curvature by approximating the shape operator of the data manifold. This approach aims to improve classification performance, particularly in datasets with limited samples.

This package provides functions to simulate data from large-scale educational assessments, including background questionnaire data and cognitive item responses that adhere to a multiple-matrix sampled design. The theoretical foundation can be found on Matta, T.H., Rutkowski, L., Rutkowski, D. et al. (2018) <doi:10.1186/s40536-018-0068-8>.

Topological data analysis (TDA) is a method of data analysis that uses techniques from topology to analyze high-dimensional data. Here we implement Mapper, an algorithm from this area developed by Singh, Mémoli and Carlsson (2007) which generalizes the concept of a Reeb graph <https://en.wikipedia.org/wiki/Reeb_graph>.

Approximate node interaction parameters of Markov Random Fields graphical networks. Models can incorporate additional covariates, allowing users to estimate how interactions between nodes in the graph are predicted to change across covariate gradients. The general methods implemented in this package are described in Clark et al. (2018) <doi:10.1002/ecy.2221>.

Estimation of the survivor function for interval censored time-to-event data subject to misclassification using nonparametric maximum likelihood estimation, implementing the methods of Titman (2017) <doi:10.1007/s11222-016-9705-7>. Misclassification probabilities can either be specified as fixed or estimated. Models with time dependent misclassification may also be fitted.

Analysis of molecular marker data from model and non-model systems. For the later, it allows statistical analysis by simultaneously estimating linkage and linkage phases (genetic map construction) according to Wu and colleagues (2002) <doi:10.1006/tpbi.2002.1577>. All analysis are based on multi-point approaches using hidden Markov models.

This package provides general purpose tools for helping users to implement steepest gradient descent methods for function optimization; for details see Ruder (2016) <arXiv:1609.04747v2>. Currently, the Steepest 2-Groups Gradient Descent and the Adaptive Moment Estimation (Adam) are the methods implemented. Other methods will be implemented in the future.

Model selection for penalized graphical models using the Stability Approach to Regularization Selection ('StARS'), with options for speed-ups including Bounded StARS (B-StARS), batch computing, and other stability metrics (e.g., graphlet stability G-StARS). Christian L. Müller, Richard Bonneau, Zachary Kurtz (2016) <arXiv:1605.07072>.

Testing for Spatial Dependence of Qualitative Data in Cross Section. The list of functions includes join-count tests, Q test, spatial scan test, similarity test and spatial runs test. The methodology of these models can be found in <doi:10.1007/s10109-009-0100-1> and <doi:10.1080/13658816.2011.586327>.

Build custom Europe SpatialPolygonsDataFrame, if you don't know what is a SpatialPolygonsDataFrame see SpatialPolygons() in sp', by example for mapLayout() in antaresViz'. Antares is a powerful software developed by RTE to simulate and study electric power systems (more information about Antares here: <https://antares-simulator.org/>).