R based Genetic algorithm for gene expression optimization by considering both mRNA secondary structure and codon usage bias, GeneGA includes the information of highly expressed genes of almost 200 genomes. Meanwhile, Vienna RNA Package is needed to ensure GeneGA to function properly.

The package provide RNA-seq count for 2 strains of mus musclus; Wild type and Ob/Ob. Each strain was divided into two groups, and each group received either chow diet or high fat diet. RNA expression was measured after 20 weeks in 7 tissues.

Implement the BETA algorithm for infering direct target genes from DNA-binding and perturbation expression data Wang et al. (2013) <doi: 10.1038/nprot.2013.150>. Extend the algorithm to predict the combined function of two DNA-binding elements from comprable binding and expression data.

Provides: (1) Tools to infer dominance hierarchies based on calculating Elo scores, but with custom functions to improve estimates in animals with relatively stable dominance ranks. (2) Tools to plot the shape of the dominance hierarchy and estimate the uncertainty of a given data set.

This package implements cubic regularization methods (ARC) for local optimization problems common in statistics and applied research. Provides robust handling of ill-conditioned, nonconvex, and indefinite Hessian problems with automatic saddle point escape. Supports box constraints; linear equality constraints are planned for a future release.

This package provides tools working with data from ACLED (Armed Conflict Location and Event Data). Functions include simplified access to ACLED's API (<https://apidocs.acleddata.com/>), methods for keeping local versions of ACLED data up-to-date, and functions for common ACLED data transformations.

This package implements methods for estimating latent Gaussian processes from categorical functional data using binomial, probit, or multinomial GAM-based approaches, and for clustering individuals via multivariate functional principal component scores. Methods are described in Champon et al. (2026) <doi:10.1080/01621459.2026.2672226>.

Complex hypothesis testing through conditional cumulative distribution function estimation. Method is detailed in: Gauthier M, Agniel D, Thiébaut R & Hejblum BP (2021). "Distribution-free complex hypothesis testing for single-cell RNA-seq differential expression analysis", bioRxiv <doi:10.1101/2021.05.21.445165>.

Modeling associations between covariates and power spectra of replicated time series using a cepstral-based semiparametric framework. Implements a fast two-stage estimation procedure via Whittle likelihood and multivariate regression.The methodology is based on Li and Dong (2025) <doi:10.1080/10618600.2025.2473936>.

This package implements the DAAREM method for accelerating the convergence of slow, monotone sequences from smooth, fixed-point iterations such as the EM algorithm. For further details about the DAAREM method, see Henderson, N.C. and Varadhan, R. (2019) <doi:10.1080/10618600.2019.1594835>.

Computes various effect sizes of the difference, their variance, and confidence interval. This package treats Cohen's d, Hedges d, biased/unbiased c (an effect size between a mean and a constant) and e (an effect size between means without assuming the variance equality).

This package provides tools for automatic model selection and diagnostics for Climate and Environmental data. In particular the envcpt() function does automatic model selection between a variety of trend, changepoint and autocorrelation models. The envcpt() function should be your first port of call.

Estimates item and person parameters for the Continuous Response Model (CRM; Samejima, 1973, <doi:10.1007/BF02291114>), computes item fit residual statistics, draws empirical 3D item category response curves, draws theoretical 3D item category response curves, and generates data under the CRM for simulation studies.

Calculates, inspects, tabulates, and visualises changes in rankings across two to four ordered states. Creates ggplot2'-based rank-transition charts that retain categories entering or leaving a selected top-rank boundary. Supports ranks calculated from numeric values as well as authoritative ranks supplied without values.

This package provides a function that generates a customized correlation matrix based on limit values and proportions for intervals composed by its limits. It can also generate random matrices with low, medium, and high correlations, in which low, medium, and high thresholds are user-defined.

Seamless integration between R and Goose AI capabilities including memory management, visualization enhancements, and workflow automation. Save R objects to Goose memory, apply Block branding to visualizations, and manage data science project workflows. For more information about Goose AI, see <https://github.com/block/goose>.

Lightweight way to read NumPy .npy and .npz files in R. All data types supported by NumPy', with all sizes (converted internally to R native size), both C and Fortran order, and any shape, up to an arbitrary number of dimensions, are supported.

The gap encodes the distance between clusters and improves interpretation of cluster heatmaps. The gaps can be of the same distance based on a height threshold to cut the dendrogram. Another option is to vary the size of gaps based on the distance between clusters.

Offers methods for visualising, modelling, and forecasting high-dimensional functional time series, also known as functional panel data. Documentation about hdftsa is initially provided via the paper by Cristian F. Jimenez-Varon, Ying Sun and Han Lin Shang (2024, Journal of Computational and Graphical Statistics).

Various functions and algorithms are provided here for solving optimal matching tasks in the context of preclinical cancer studies. Further, various helper and plotting functions are provided for unsupervised and supervised machine learning as well as longitudinal mixed-effects modeling of tumor growth response patterns.

Suite of tools for managing cached files, targeting use in other R packages. Uses rappdirs for cross-platform paths. Provides utilities to manage cache directories, including targeting files by path or by key; cached directories can be compressed and uncompressed easily to save disk space.

Estimates the density of a spatially distributed animal population sampled with an array of passive detectors, such as traps. Models incorporating distance-dependent detection are fitted by simulation and inverse prediction as proposed by Efford (2004) <doi:10.1111/j.0030-1299.2004.13043.x>.

This is a collection of tools for more efficiently understanding and sharing the results of (primarily) regression analyses. There are also a number of miscellaneous functions for statistical and programming purposes. Support for models produced by the survey and lme4 packages are points of emphasis.

This package provides functions to estimate and visualize linear as well as nonlinear impulse responses based on local projections by Jordà (2005) <doi:10.1257/0002828053828518>. The methods and the package are explained in detail in Adämmer (2019) <doi:10.32614/RJ-2019-052>.