Calculates various intraclass correlation coefficients used to quantify inter-rater and intra-rater reliability. The assumption here is that the raters produced quantitative ratings. Most of the statistical procedures implemented in this package are described in details in Gwet, K.L. (2014, ISBN:978-0970806284): "Handbook of Inter-Rater Reliability," 4th edition, Advanced Analytics, LLC.

This package provides a new class of Bayesian meta-analysis models that incorporates a model for internal and external validity bias. In this way, it is possible to combine studies of diverse quality and different types. For example, we can combine the results of randomized control trials (RCTs) with the results of observational studies (OS).

This package provides a self-guided, weakly supervised learning algorithm for feature extraction from noisy and high-dimensional data. It facilitates the identification of patterns that reflect underlying group structures across all samples in a dataset. The method incorporates a novel strategy to integrate spatial information, improving the clarity of results in spatially resolved data.

Compute lifetime attributable risk of radiation-induced cancer reveals that it can be helpful with enhancement of the flexibility in research with fast calculation and various options. Important reference papers include Berrington de Gonzalez et al. (2012) <doi:10.1088/0952-4746/32/3/205>, National Research Council (2006, ISBN:978-0-309-09156-5).

This package provides functions for validating and normalizing bibliographic codes such as ISBN, ISSN, and LCCN. Also includes functions to communicate with the WorldCat API, translate Call numbers (Library of Congress and Dewey Decimal) to their subject classifications or subclassifications, and provides various loadable data files such call number / subject crosswalks and code tables.

Package for estimating the parameters of a nonlinear function using iterated linearization via Taylor series. Method is based on KubÃ¡Ä ek (2000) ISBN: 80-244-0093-6. The algorithm is a generalization of the procedure given in Köning, R., Wimmer, G. and Witkovský, V. (2014) <doi:10.1088/0957-0233/25/11/115001>.

To Simplify the time consuming and error prone task of assembling complex data sets for non-linear mixed effects modeling. Users are able to select from different absorption processes such as zero and first order, or a combination of both. Furthermore, data sets containing data from several entities, responses, and covariates can be simultaneously assembled.

Model selection for penalized graphical models using the Stability Approach to Regularization Selection ('StARS'), with options for speed-ups including Bounded StARS (B-StARS), batch computing, and other stability metrics (e.g., graphlet stability G-StARS). Christian L. Müller, Richard Bonneau, Zachary Kurtz (2016) <doi:10.48550/arXiv.1605.07072>.

The main goal of the psycho package is to provide tools for psychologists, neuropsychologists and neuroscientists, to facilitate and speed up the time spent on data analysis. It aims at supporting best practices and tools to format the output of statistical methods to directly paste them into a manuscript, ensuring statistical reporting standardization and conformity.

This package provides a profile boosting framework for feature selection in parametric models. It offers a unified interface pboost() and several wrapped models, including linear model, generalized linear models, quantile regression, Cox proportional hazards model, beta regression. An S3 interface EBIC() is provided as the stopping rule for the profile boosting by default.

This package provides a system that provides a streamlined way of generating publication ready plots for known Single-Cell transcriptomics data in a â publication readyâ format. This is, the goal is to automatically generate plots with the highest quality possible, that can be used right away or with minimal modifications for a research article.

This package provides a meta-package that loads the complete sitrep ecosystem for applied epidemiology analysis. This package provides report templates and automatically loads companion packages, including epitabulate (for epidemiological tables), epidict (for data dictionaries), epikit (for epidemiological utilities), and apyramid (for age-sex pyramids). Simply load sitrep to access all functions from the ecosystem.

This package performs Wasserstein projections from the predictive distributions of any model into the space of predictive distributions of linear models. We utilize L1 penalties to also reduce the complexity of the model space. This package employs the methods as described in Dunipace, Eric and Lorenzo Trippa (2020) <doi:10.48550/arXiv.2012.09999>.

Lets you temporarily execute an expression or a local block with a different here() root in the here package. This is useful for sourcing code in other projects which expect the root directory of here() to be the project directory of those projects. This may be the case with git submodules for example.

An implementation of calculating the R-squared measure as a total mediation effect size measure and its confidence interval for moderate- or high-dimensional mediator models. It gives an option to filter out non-mediators using variable selection methods. The original R package is directly related to the paper Yang et al (2021) "Estimation of mediation effect for high-dimensional omics mediators with application to the Framingham Heart Study" <doi:10.1101/774877>. The new version contains a choice of using cross-fitting, which is computationally faster. The details of the cross-fitting method are available in the paper Xu et al (2023) "Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting" <doi:10.1101/2023.02.06.527391>.

An R package for estimating conditional multivariate reference regions. The reference region is non parametrically estimated using a kernel density estimator. Covariates effects on the multivariate response means vector and variance-covariance matrix, thus on the region shape, are estimated by flexible additive predictors. Continuous covariates non linear effects might be estimated using penalized splines smoothers. Confidence intervals for the covariates estimated effects might be derived from bootstrap resampling. Kernel density bandwidth can be estimated with different methods, including a method that optimize the region coverage. Numerical, and graphical, summaries can be obtained by the user in order to evaluate reference region performance with real data. Full mathematical details can be found in <doi:10.1002/sim.9163> and <doi:10.1007/s00477-020-01901-1>.

This package is an R package designed for QC, analysis, and exploration of single cell RNA-seq data. It easily enables widely-used analytical techniques, including the identification of highly variable genes, dimensionality reduction; PCA, ICA, t-SNE, standard unsupervised clustering algorithms; density clustering, hierarchical clustering, k-means, and the discovery of differentially expressed genes and markers.

This is a Hi-C analysis package using a cumulative binomial test to detect interactions between distal genomic loci that have significantly more reads than expected by chance in Hi-C experiments. It takes mapped paired NGS reads as input and gives back the list of significant interactions for a given bin size in the genome.

Simple and efficient workflow for time-course gene expression data, built on publictly available open-source projects hosted on CRAN and bioconductor. moanin provides helper functions for all the steps required for analysing time-course data using functional data analysis: (1) functional modeling of the timecourse data; (2) differential expression analysis; (3) clustering; (4) downstream analysis.

Optimize one or two-arm, two-stage designs for clinical trials with respect to several implemented objective criteria or custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz et al. (2019) <doi:10.1002/sim.8291> and Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09> for details.

This package provides classes for storing and manipulating arbitrary-precision integer vectors and high-precision floating-point vectors. These extend the range and precision of the integer and double data types found in R. This package utilizes the Boost.Multiprecision C++ library. It is specifically designed to work well with the tidyverse collection of R packages.

Temporal Exponential Random Graph Models (TERGM) estimated by maximum pseudolikelihood with bootstrapped confidence intervals or Markov Chain Monte Carlo maximum likelihood. Goodness of fit assessment for ERGMs, TERGMs, and SAOMs. Micro-level interpretation of ERGMs and TERGMs. The methods are described in Leifeld, Cranmer and Desmarais (2018), JStatSoft <doi:10.18637/jss.v083.i06>.

Computes appropriate confidence intervals for the likelihood ratio tests commonly used in medicine/epidemiology, using the method of Marill et al. (2015) <doi:10.1177/0962280215592907>. It is particularly useful when the sensitivity or specificity in the sample is 100%. Note that this does not perform the test on nested models--for that, see epicalc::lrtest'.

Fetches the Cornell Lab of Ornithology Open Tree of Life (clootl) tree in a specified taxonomy. Optionally prune it to a given set of study taxa. Provide a recommended citation list for the studies that informed the extracted tree. Tree generated as described in McTavish et al. (2024) <doi:10.1101/2024.05.20.595017>.