The BACON algorithms are methods for multivariate outlier nomination (detection) and robust linear regression by Billor, Hadi, and Velleman (2000) <doi:10.1016/S0167-9473(99)00101-2>. The extension to weighted problems is due to Beguin and Hulliger (2008) <https://www150.statcan.gc.ca/n1/en/catalogue/12-001-X200800110616>; see also <doi:10.21105/joss.03238>.

This package provides a complete toolset for methylome-wide association studies (MWAS). It is specifically designed for data from enrichment based methylation assays, but can be applied to other data as well. The analysis pipeline includes seven steps: (1) scanning aligned reads from BAM files, (2) calculation of quality control measures, (3) creation of methylation score (coverage) matrix, (4) principal component analysis for capturing batch effects and detection of outliers, (5) association analysis with respect to phenotypes of interest while correcting for top PCs and known covariates, (6) annotation of significant findings, and (7) multi-marker analysis (methylation risk score) using elastic net. Additionally, RaMWAS include tools for joint analysis of methlyation and genotype data. This work is published in Bioinformatics, Shabalin et al. (2018) <doi:10.1093/bioinformatics/bty069>.

The Resource Description Framework, or RDF is a widely used data representation model that forms the cornerstone of the Semantic Web. RDF represents data as a graph rather than the familiar data table or rectangle of relational databases. The rdflib package provides a friendly and concise user interface for performing common tasks on RDF data, such as reading, writing and converting between the various serializations of RDF data, including rdfxml', turtle', nquads', ntriples', and json-ld'; creating new RDF graphs, and performing graph queries using SPARQL'. This package wraps the low level redland R package which provides direct bindings to the redland C library. Additionally, the package supports the newer and more developer friendly JSON-LD format through the jsonld package. The package interface takes inspiration from the Python rdflib library.

Data exploration and prediction with focus on high dimensional data and chemometrics. The package was initially designed about partial least squares regression and discrimination models and variants, in particular locally weighted PLS models (LWPLS). Then, it has been expanded to many other methods for analyzing high dimensional data. The name rchemo comes from the fact that the package is orientated to chemometrics, but most of the provided methods are fully generic to other domains. Functions such as transform(), predict(), coef() and summary() are available. Tuning the predictive models is facilitated by generic functions gridscore() (validation dataset) and gridcv() (cross-validation). Faster versions are also available for models based on latent variables (LVs) (gridscorelv() and gridcvlv()) and ridge regularization (gridscorelb() and gridcvlb()).

Allows the user to learn Bayesian networks from datasets containing thousands of variables. It focuses on score-based learning, mainly the BIC and the BDeu score functions. It provides state-of-the-art algorithms for the following tasks: (1) parent set identification - Mauro Scanagatta (2015) <http://papers.nips.cc/paper/5803-learning-bayesian-networks-with-thousands-of-variables>; (2) general structure optimization - Mauro Scanagatta (2018) <doi:10.1007/s10994-018-5701-9>, Mauro Scanagatta (2018) <http://proceedings.mlr.press/v73/scanagatta17a.html>; (3) bounded treewidth structure optimization - Mauro Scanagatta (2016) <http://papers.nips.cc/paper/6232-learning-treewidth-bounded-bayesian-networks-with-thousands-of-variables>; (4) structure learning on incomplete data sets - Mauro Scanagatta (2018) <doi:10.1016/j.ijar.2018.02.004>. Distributed under the LGPL-3 by IDSIA.

SCUDO (Signature-based Clustering for Diagnostic Purposes) is a rank-based method for the analysis of gene expression profiles for diagnostic and classification purposes. It is based on the identification of sample-specific gene signatures composed of the most up- and down-regulated genes for that sample. Starting from gene expression data, functions in this package identify sample-specific gene signatures and use them to build a graph of samples. In this graph samples are joined by edges if they have a similar expression profile, according to a pre-computed similarity matrix. The similarity between the expression profiles of two samples is computed using a method similar to GSEA. The graph of samples can then be used to perform community clustering or to perform supervised classification of samples in a testing set.

This is an R package to make it easier to import and store phylogenetic trees with associated data; and to link external data from different sources to phylogeny. It also supports exporting phylogenetic trees with heterogeneous associated data to a single tree file and can be served as a platform for merging tree with associated data and converting file formats.

This package is a flexible and comprehensive R toolbox for model-based optimization. It implements Efficient Global Optimization Algorithm for single- and multi-objective optimization. It supports mixed parameters. The machine learning toolbox mlr offers regression learners. It provides various infill criteria and features batch proposal, parallel execution, visualization, and logging. Its modular implementation allows easy customization by the user.

The R package ggplot2 is a plotting system based on the grammar of graphics. GGally extends ggplot2 by adding several functions to reduce the complexity of combining geometric objects with transformed data. Some of these functions include a pairwise plot matrix, a two group pairwise plot matrix, a parallel coordinates plot, a survival plot, and several functions to plot networks.

MEDIPS was developed for analyzing data derived from methylated DNA immunoprecipitation (MeDIP) experiments followed by sequencing (MeDIP-seq). However, MEDIPS provides functionalities for the analysis of any kind of quantitative sequencing data (e.g. ChIP-seq, MBD-seq, CMS-seq and others) including calculation of differential coverage between groups of samples and saturation and correlation analysis.

This package implements a kernel-based association test for copy number variation (CNV) aggregate analysis in a certain genomic region (e.g., gene set, chromosome, or genome) that is robust to the within-locus and across-locus etiological heterogeneity, and bypass the need to define a "locus" unit for CNVs. Brucker, A., et al. (2020) <doi:10.1101/666875>.

Interact with Condor from R via SSH connection. Files are first uploaded from user machine to submitter machine, and the job is then submitted from the submitter machine to Condor'. Functions are provided to submit, list, and download Condor jobs from R. Condor is an open source high-throughput computing software framework for distributed parallelization of computationally intensive tasks.

This package contains tools for working with data during statistical analysis, promoting flexible, intuitive, and reproducible workflows. There are functions designated for specific statistical tasks such building a custom univariate descriptive table, computing pairwise association statistics, etc. These are built on a collection of data manipulation tools designed for general use that are motivated by the functional programming concept.

This package provides a Shiny'-based toolkit for item/test analysis. It is designed for multiple-choice, true-false, and open-ended questions. The toolkit is usable with datasets in 1-0 or other formats. Key analyses include difficulty, discrimination, response-option analysis, reports. The classical test theory methods used are described in Ebel & Frisbie (1991, ISBN:978-0132892314).

This Rcpp'-based package implements highly efficient functions for the calculation of the Jonckheere-Terpstra statistic. It can be used for a variety of applications, including feature selection in machine learning problems, or to conduct genome-wide association studies (GWAS) with multiple quantitative phenotypes. The code leverages OpenMP directives for multi-core computing to reduce overall processing time.

This package contains Rcpp and RcppEigen implementations of matrix operations useful for Gaussian process models, such as the inversion of a symmetric Toeplitz matrix, sampling from multivariate normal distributions, evaluation of the log-density of a multivariate normal vector, and Bayesian inference for latent variable Gaussian process models with elliptical slice sampling (Murray, Adams, and MacKay 2010).

This package contains functions for operations with fuzzy cognitive maps using t-norm and s-norm operators. T-norms and S-norms are described by Dov M. Gabbay and George Metcalfe (2007) <doi:10.1007/s00153-007-0047-1>. System indicators are described by Cox, Earl D. (1995) <isbn:1886801010>. Executable examples are provided in the "inst/examples" folder.

Approximate frequentist inference for generalized linear mixed model analysis with expectation propagation used to circumvent the need for multivariate integration. In this version, the random effects can be any reasonable dimension. However, only probit mixed models with one level of nesting are supported. The methodology is described in Hall, Johnstone, Ormerod, Wand and Yu (2018) <arXiv:1805.08423v1>.

Extends the capabilities of ggplot2 by providing grammatical elements and plot helpers designed for visualizing temporal patterns. The package implements a grammar of temporal graphics, which leverages calendar structures to highlight changes over time. The package also provides plot helper functions to quickly produce commonly used time series graphics, including time plots, season plots, and seasonal sub-series plots.

H-index and h-alpha are a bibliometric indicators. This package provides functions to simulate how these indicators may develop over time for a given set of researchers and to visualize the simulation data. The implementation is based on the STATA ado h-index and is described in more detail in Bornmann et al. (2019) <arXiv:1905.11052>.

An RStudio Addin for Hippie Expand (AKA Hippie Code Completion or Cyclic Expand Word). This type of completion searches for matching tokens within the user's current source editor file, regardless of file type. By searching only within the current source file, hippie offers a fast way to identify and insert completions that appear around the user's cursor.

This package provides a set of streamlined functions that allow easy generation of linear regression diagnostic plots necessarily for checking linear model assumptions. This package is meant for easy scheming of linear regression diagnostics, while preserving merits of "The Grammar of Graphics" as implemented in ggplot2'. See the ggplot2 website for more information regarding the specific capability of graphics.

This package provides a way to estimate and test marginal mediation effects for zero-inflated compositional mediators. Estimates of Natural Indirect Effect (NIE), Natural Direct Effect (NDE) of each taxon, as well as their standard errors and confident intervals, were provided as outputs. Zeros will not be imputed during analysis. See Wu et al. (2022) <doi:10.3390/genes13061049>.

Maximum a posteriori (MAP) estimation for topic models (i.e., Latent Dirichlet Allocation) in text analysis, as described in Taddy (2012) On estimation and selection for topic models'. Previous versions of this code were included as part of the textir package. If you want to take advantage of openmp parallelization, uncomment the relevant flags in src/MAKEVARS before compiling.