Analysis of DNA mixtures involving relatives by computation of likelihood ratios that account for dropout and drop-in, mutations, silent alleles and population substructure. This is useful in kinship cases, like non-invasive prenatal paternity testing, where deductions about individuals relationships rely on DNA mixtures, and in criminal cases where the contributors to a mixed DNA stain may be related. Relationships are represented by pedigrees and can include kinship between more than two individuals. The main function is relMix() and its graphical user interface relMixGUI(). The implementation and method is described in Dorum et al. (2017) <doi:10.1007/s00414-016-1526-x>, Hernandis et al. (2019) <doi:10.1016/j.fsigss.2019.09.085> and Kaur et al. (2016) <doi:10.1007/s00414-015-1276-1>.

Helps users in quickly visualizing risk-of-bias assessments performed as part of a systematic review. It allows users to create weighted bar-plots of the distribution of risk-of-bias judgments within each bias domain, in addition to traffic-light plots of the specific domain-level judgments for each study. The resulting figures are of publication quality and are formatted according the risk-of-bias assessment tool use to perform the assessments. Currently, the supported tools are ROB2.0 (for randomized controlled trials; Sterne et al (2019) <doi:10.1136/bmj.l4898>), ROBINS-I (for non-randomised studies of interventions; Sterne et al (2016) <doi:10.1136/bmj.i4919>), and QUADAS-2 (for diagnostic accuracy studies; Whiting et al (2011) <doi:10.7326/0003-4819-155-8-201110180-00009>).

This method identifies topological domains in genomes from Hi-C sequence data. The authors published an implementation of their method as an R script. This package originates from those original TopDom R scripts and provides help pages adopted from the original TopDom PDF documentation. It also provides a small number of bug fixes to the original code.

Missing values are ubiquitous in data and need to be explored and handled in the initial stages of analysis. The package provides data structures and functions that facilitate the plotting of missing values and examination of imputations. This allows missing data dependencies to be explored with minimal deviation from the common work patterns of ggplot2 and tidy data.

This package provides the exponential integrals E_1(x), E_2(x), E_n(x) and Ei(x), and the incomplete gamma function G(a, x) defined for negative values of its first argument. The package also gives easy access to the underlying C routines through an API; see the package vignette for details.

This package provides utilities to help set and record the setting of the seed and the uniform and normal generators used when a random experiment is run. The utilities can be used in other functions that do random experiments to simplify recording and/or setting all the necessary information for reproducibility. See the vignette and reference manual for examples.

This package is a model building aid for nonlinear mixed-effects (population) model analysis using NONMEM, facilitating data set checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison. The methods are described in Keizer et al. (2013) <doi:10.1038/psp.2013.24>, and Jonsson et al. (1999) <doi:10.1016/s0169-2607(98)00067-4>.

MEIGOR provides a comprehensive environment for performing global optimization tasks in bioinformatics and systems biology. It leverages advanced metaheuristic algorithms to efficiently search the solution space and is specifically tailored to handle the complexity and high-dimensionality of biological datasets. This package supports various optimization routines and is integrated with Bioconductor's infrastructure for a seamless analysis workflow.

An R package for multiple-group comparison to detect tissue/cell-specific marker genes among subtypes. It provides functions to compute OVESEG-test statistics, derive component weights in the mixture null distribution model and estimate p-values from weightedly aggregated permutations. Obtained posterior probabilities of component null hypotheses can also portrait all kinds of upregulation patterns among subtypes.

Implementation of the technique of Lleonart et al. (2000) <doi:10.1006/jtbi.2000.2043> to scale body measurements that exhibit an allometric growth. This procedure is a theoretical generalization of the technique used by Thorpe (1975) <doi:10.1111/j.1095-8312.1975.tb00732.x> and Thorpe (1976) <doi:10.1111/j.1469-185X.1976.tb01063.x>.

Typically, models in R exist in memory and can be saved via regular R serialization. However, some models store information in locations that cannot be saved using R serialization alone. The goal of bundle is to provide a common interface to capture this information, situate it within a portable object, and restore it for use in new settings.

Bayesian analysis of luminescence data and C-14 age estimates. Bayesian models are based on the following publications: Combes, B. & Philippe, A. (2017) <doi:10.1016/j.quageo.2017.02.003> and Combes et al. (2015) <doi:10.1016/j.quageo.2015.04.001>. This includes, amongst others, data import, export, application of age models and palaeodose model.

Convert text into synthesized speech and get a list of supported voices for a region. Microsoft's Cognitive Services Text to Speech REST API <https://learn.microsoft.com/en-us/azure/cognitive-services/speech-service/rest-text-to-speech?tabs=streaming> supports neural text to speech voices, which support specific languages and dialects that are identified by locale.

The Crunch.io service <https://crunch.io/> provides a cloud-based data store and analytic engine, as well as an intuitive web interface. Using this package, analysts can interact with and manipulate Crunch datasets from within R. Importantly, this allows technical researchers to collaborate naturally with team members, managers, and clients who prefer a point-and-click interface.

Create and customize interactive collapsible D3 trees using the D3 JavaScript library and the htmlwidgets package. These trees can be used directly from the R console, from RStudio', in Shiny apps and R Markdown documents. When in Shiny the tree layout is observed by the server and can be used as a reactive filter of structured data.

Tool to print out the value of R objects/expressions while running an R script. Outputs can be made dependent on user-defined conditions/criteria. Debug messages only appear when a global option for debugging is set. This way, debugr code can even remain in the debugged code for later use without any negative effects during normal runtime.

Allows to perform the dynamic mixture estimation with state-space components and normal regression components, and clustering with normal mixture. Quasi-Bayesian estimation, as well as, that based on the Kerridge inaccuracy approximation are implemented. Main references: Nagy and Suzdaleva (2013) <doi:10.1016/j.apm.2013.05.038>; Nagy et al. (2011) <doi:10.1002/acs.1239>.

Allows humanitarian community, academia, media, government, and non-governmental organizations to utilize the data collected by the Displacement Tracking Matrix (<https://dtm.iom.int>), a unit in the International Organization for Migration. This also provides non-sensitive Internally Displaced Person figures, aggregated at the country, Admin 1 (states, provinces, or equivalent), and Admin 2 (smaller administrative areas) levels.

This package performs test procedures for general hypothesis testing problems for four multivariate coefficients of variation (Ditzhaus and Smaga, 2023 <arXiv:2301.12009>). We can verify the global hypothesis about equality as well as the particular hypotheses defined by contrasts, e.g., we can conduct post hoc tests. We also provide the simultaneous confidence intervals for contrasts.

This package provides a suite of routines for the hyperdirichlet distribution and reified Bradley-Terry; supersedes the hyperdirichlet package; uses disordR discipline <doi:10.48550/ARXIV.2210.03856>. To cite in publications please use Hankin 2017 <doi:10.32614/rj-2017-061>, and for Generalized Plackett-Luce likelihoods use Hankin 2024 <doi:10.18637/jss.v109.i08>.

This package provides functions for genome-wide association studies (GWAS)/gene-environment-wide interaction studies (GEWIS) with longitudinal outcomes and exposures. He et al. (2017) "Set-Based Tests for Gene-Environment Interaction in Longitudinal Studies" and He et al. (2017) "Rare-variant association tests in longitudinal studies, with an application to the Multi-Ethnic Study of Atherosclerosis (MESA)".

Simulation, analysis and sampling of spatial biodiversity data (May, Gerstner, McGlinn, Xiao & Chase 2017) <doi:10.1111/2041-210x.12986>. In the simulation tools user define the numbers of species and individuals, the species abundance distribution and species aggregation. Functions for analysis include species rarefaction and accumulation curves, species-area relationships and the distance decay of similarity.

Fits community site occupancy models to environmental DNA metabarcoding data collected using spatially-replicated survey design. Model fitting results can be used to evaluate and compare the effectiveness of species detection to find an efficient survey design. Reference: Fukaya et al. (2022) <doi:10.1111/2041-210X.13732>, Fukaya and Hasebe (2025) <doi:10.1002/1438-390X.12219>.

Useful functions and workflows for proteomics quality control and data analysis of both limited proteolysis-coupled mass spectrometry (LiP-MS) (Feng et. al. (2014) <doi:10.1038/nbt.2999>) and regular bottom-up proteomics experiments. Data generated with search tools such as Spectronaut', MaxQuant and Proteome Discover can be easily used due to flexibility of functions.