Implementation of several goodness-of-fit tests for functional data. Currently, mostly related with the functional linear model with functional/scalar response and functional/scalar predictor. The package allows for the replication of the data applications considered in Garcà a-Portugués, à lvarez-Liébana, à lvarez-Pérez and González-Manteiga (2021) <doi:10.1111/sjos.12486>.

Generalized Linear Mixed Model (GLMM) for Binary Randomized Response Data. Includes Cauchit, Compl. Log-Log, Logistic, and Probit link functions for Bernoulli Distributed RR data. RR Designs: Warner, Forced Response, Unrelated Question, Kuk, Crosswise, and Triangular. Reference: Fox, J-P, Veen, D. and Klotzke, K. (2018). Generalized Linear Mixed Models for Randomized Responses. Methodology. <doi:10.1027/1614-2241/a000153>.

This package provides user-friendly tools for calibration in survey sampling. The package is production-oriented, and its interface is inspired by the famous popular macro Calmar for SAS, so that Calmar users can quickly get used to icarus'. In addition to calibration (with linear, raking and logit methods), icarus features functions for calibration on tight bounds and penalized calibration.

This package provides a computational method developed for model-based analysis of alternative polyadenylation (APA) using 3 end-linked reads. It accurately assigns 3 RNA-seq reads to polyA sites through statistical modeling, and generates multiple statistics for APA analysis. Please also see Li WV, Zheng D, Wang R, Tian B (2021) <doi:10.1186/s13059-021-02429-5>.

Set of functions that implement the PoDBAY method, described in the publication A method to estimate probability of disease and vaccine efficacy from clinical trial immunogenicity data by Julie Dudasova, Regina Laube, Chandni Valiathan, Matthew C. Wiener, Ferdous Gheyas, Pavel Fiser, Justina Ivanauskaite, Frank Liu and Jeffrey R. Sachs (NPJ Vaccines, 2021), <doi:10.1038/s41541-021-00377-6>.

Extends the functionality of R serialization by augmenting the built-in reference hook system. This enhanced implementation allows optimal, one-pass integrated serialization that combines R serialization with third-party serialization methods. Facilitates the serialization of even complex R objects, which contain non-system reference objects, such as those accessed via external pointers, for use in parallel and distributed computing.

This package provides a Bayesian semiparametric Dirichlet process mixtures to estimate correlated receiver operating characteristic (ROC) surfaces and the associated volume under the surface (VUS) with stochastic order constraints. The reference paper is:Zhen Chen, Beom Seuk Hwang, (2018) "A Bayesian semiparametric approach to correlated ROC surfaces with stochastic order constraints". Biometrics, 75, 539-550. <doi:10.1111/biom.12997>.

An ADMM implementation of SDP-1, a semidefinite programming relaxation of the maximum likelihood estimator for fitting a block model. SDP-1 has a tendency to produce equal-sized blocks and is ideal for producing a form of network histogram approximating a nonparametric graphon model. Alternatively, it can be used for community detection. (This is experimental code, proceed with caution.).

An easy way to examine archaeological count data. This package provides several tests and measures of diversity: heterogeneity and evenness (Brillouin, Shannon, Simpson, etc.), richness and rarefaction (Chao1, Chao2, ACE, ICE, etc.), turnover and similarity (Brainerd-Robinson, etc.). It allows to easily visualize count data and statistical thresholds: rank vs abundance plots, heatmaps, Ford (1962) and Bertin (1977) diagrams, etc.

This package provides a kernel of functions for programming time series methods in a way that is relatively independently of the representation of time. Also provides plotting, time windowing, and some other utility functions which are specifically intended for time series. See the Guide distributed as a vignette, or ?tframe.Intro for more details. (User utilities are in package tfplot.).

This package provides an interface to a HashiCorp vault server over its http API (typically these are self-hosted; see <https://www.vaultproject.io>). This allows for secure storage and retrieval of secrets over a network, such as tokens, passwords and certificates. Authentication with vault is supported through several backends including user name/password and authentication via GitHub'.

Performs brace expansions on strings. Made popular by Unix shells, brace expansion allows users to concisely generate certain character vectors by taking a single string and (recursively) expanding the comma-separated lists and double-period-separated integer and character sequences enclosed within braces in that string. The double-period-separated numeric integer expansion also supports padding the resulting numbers with zeros.

This package contain data sets and utilities from Project MOSAIC used to teach mathematics, statistics, computation and modeling. Project MOSAIC is a community of educators working to tie together aspects of quantitative work that students in science, technology, engineering and mathematics will need in their professional lives, but which are usually taught in isolation, if at all.

The tictoc package provides the timing functions tic and toc that can be nested. It provides an alternative to system.time() with a different syntax similar to that in another well-known software package. tic and toc are easy to use, and are especially useful when timing several sections in more than a few lines of code.

This package provides an implementation of an algorithm for general-purpose unconstrained non-linear optimization. The algorithm is of quasi-Newton type with BFGS updating of the inverse Hessian and soft line search with a trust region type monitoring of the input to the line search algorithm. The interface of ucminf is designed for easy interchange with the package optim.

This package contains two main functions. The first is fdr.ma which takes normalized expression data array, experimental design and computes adjusted p-values It returns the fdr adjusted p-values and plots, according to the methods described in (Reiner, Yekutieli and Benjamini 2002). The second, is fdr.gui() which creates a simple graphic user interface to access fdr.ma.

HubPub provides users with functionality to help with the Bioconductor Hub structures. The package provides the ability to create a skeleton of a Hub style package that the user can then populate with the necessary information. There are also functions to help add resources to the Hub package metadata files as well as publish data to the Bioconductor S3 bucket.

icetea (Integrating Cap Enrichment with Transcript Expression Analysis) provides functions for end-to-end analysis of multiple 5'-profiling methods such as CAGE, RAMPAGE and MAPCap, beginning from raw reads to detection of transcription start sites using replicates. It also allows performing differential TSS detection between group of samples, therefore, integrating the mRNA cap enrichment information with transcript expression analysis.

This package fits a model to the pattern of dropouts in single-cell RNASeq data. This model is used as a null to identify significantly variable (i.e. differentially expressed) genes for use in downstream analysis, such as clustering cells. Also includes an method for calculating exact Pearson residuals in UMI-tagged data using a library-size aware negative binomial model.

standR is an user-friendly R package providing functions to assist conducting good-practice analysis of Nanostring's GeoMX DSP data. All functions in the package are built based on the SpatialExperiment object, allowing integration into various spatial transcriptomics-related packages from Bioconductor. standR allows data inspection, quality control, normalization, batch correction and evaluation with informative visualizations.

The pattern of digestion and protection from DNA nucleases such as DNAse I, micrococcal nuclease, and Tn5 transposase can be used to infer the location of associated proteins. This package contains useful functions to analyze patterns of paired-end sequencing fragment density. VplotR facilitates the generation of V-plots and footprint profiles over single or aggregated genomic loci of interest.

Create, upload and run Acumos R models. Acumos (<https://www.acumos.org>) is a platform and open source framework intended to make it easy to build, share, and deploy AI apps. Acumos is part of the LF AI Foundation', an umbrella organization within The Linux Foundation'. With this package, user can create a component, and push it to an Acumos platform.

Fit various smoothing spline models. Includes an ssr() function for smoothing spline regression, an nnr() function for nonparametric nonlinear regression, an snr() function for semiparametric nonlinear regression, an slm() function for semiparametric linear mixed-effects models, and an snm() function for semiparametric nonlinear mixed-effects models. See Wang (2011) <doi:10.1201/b10954> for an overview.

This package implements Bayesian inference to detect signal from blinded clinical trial when total number of adverse events of special concerns and total risk exposures from all patients are available in the study. For more details see the article by Mukhopadhyay et. al. (2018) titled Bayesian Detection of Potential Risk Using Inference on Blinded Safety Data', in Pharmaceutical Statistics (to appear).