The data consist of microarrays from 128 different individuals with acute lymphoblastic leukemia (ALL). A number of additional covariates are available. The data have been normalized (using rma) and it is the jointly normalized data that are available here. The data are presented in the form of an exprSet object.

This package provides a comprehensive implementation of dynamic time warping (DTW) algorithms in R. DTW computes the optimal (least cumulative distance) alignment between points of two time series. Common DTW variants covered include local (slope) and global (window) constraints, subsequence matches, arbitrary distance definitions, normalizations, minimum variance matching, and so on.

Fits a model to adjust and consider additional variations in three dimensions of age groups, time, and space on residuals excluded from a prediction model that have residual such as: linear regression, mixed model and so on. Details are given in Foreman et al. (2015) <doi:10.1186/1478-7954-10-1>.

Non-parametric test for equality of multivariate distributions. Trains a classifier to classify (multivariate) observations as coming from one of several distributions. If the classifier is able to classify the observations better than would be expected by chance (using permutation inference), then the null hypothesis that the distributions are equal is rejected.

This package provides functions for hit gene identification and quantification of sgRNA (single-guided RNA) abundances for CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) pooled screen data analysis. Details are in Jeong et al. (2019) <doi:10.1101/gr.245571.118> and Baggerly et al. (2003) <doi:10.1093/bioinformatics/btg173>.

An abstract DList class helps storing large list-type objects in a distributed manner. Corresponding high-level functions and methods for handling distributed storage (DStorage) and lists allows for processing such DLists on distributed systems efficiently. In doing so it uses a well defined storage backend implemented based on the DStorage class.

Providing access to the API for Gas Infrastructure Europe's natural gas transparency platforms <https://agsi.gie.eu/> and <https://alsi.gie.eu/>. Lets the user easily download metadata on companies and gas storage units covered by the API as well as the respective data on regional, country, company or facility level.

Mass-balance-adjusted Regression algorithm for streamflow reconstruction at sub-annual resolution (e.g., seasonal or monthly). The algorithm implements a penalty term to minimize the differences between the total sub-annual flows and the annual flow. The method is described in Nguyen et al (2020) <DOI:10.1002/essoar.10504791.1>.

This package provides access to the Native Status Resolver (NSR) <https://github.com/ojalaquellueva/nsr> API through R. The user supplies plant taxonomic names and political divisions and the package returns information about their likely native status (e.g., native, non-native,endemic), along with information on how those decisions were made.

Descriptive statistics (mean rank, pairwise frequencies, and marginal matrix), Analytic Hierarchy Process models (with Saaty's and Koczkodaj's inconsistencies), probability models (Luce models, distance-based models, and rank-ordered logit models) and visualization with multidimensional preference analysis for ranking data are provided. Current, only complete rankings are supported by this package.

This package provides an efficient framework for high-dimensional linear and diagonal discriminant analysis with variable selection. The classifier is trained using James-Stein-type shrinkage estimators and predictor variables are ranked using correlation-adjusted t-scores (CAT scores). Variable selection error is controlled using false non-discovery rates or higher criticism.

High dimensional interaction search by brute force requires a quadratic computational cost in the number of variables. The xyz algorithm provably finds strong interactions in almost linear time. For details of the algorithm see: G. Thanei, N. Meinshausen and R. Shah (2016). The xyz algorithm for fast interaction search in high-dimensional data.

It enables the identification of sequentialexperimentation orders for factorial designs that jointly reduce bias and the number of level changes. The method used is that presented by Conto et al. (2025), known as the Assignment-Expansion method, which consists of adapting the linear programming assignment problem to generate balanced experimentation orders. The properties identified are then generalized to designs with a larger number of factors and levels using the expansion method proposed by Correa et al. (2009) and later generalized by Bhowmik et al. (2017). For more details see Conto et al. (2025) <doi:10.1016/j.cie.2024.110844>, Correa et al. (2009) <doi:10.1080/02664760802499337> and Bhowmik et al. (2017) <doi:10.1080/03610926.2016.1152490>.

Estimates continuous time weights for performing causal survival analysis. For instance, weighted Nelson-Aalen or Kaplan-Meier estimates can be given a causal interpretation. See Ryalen, Stensrud, and Røysland (2019) <doi:10.1007/s10985-019-09468-y> and Ryalen (2019) <https://www.duo.uio.no/handle/10852/70353> for theory and examples.

Includes algorithms to assess alpha and beta diversity in all their dimensions (taxonomic, phylogenetic and functional). It allows performing a number of analyses based on species identities/abundances, phylogenetic/functional distances, trees, convex-hulls or kernel density n-dimensional hypervolumes depicting species relationships. Cardoso et al. (2015) <doi:10.1111/2041-210X.12310>.

Convert between Irish grid references and Irish Grid coordinates. Irish grid references can also be converted to or from an sf object in any coordinate reference system. Precisions from 1 m to 100 km including 2 km (tetrads) are supported, as are datasets with mixed precision. Conversion to sf polygons is precision-aware.

Measures real distances in pictures. With PDM() function, you can choose one *.jpg file, select the measure in mm of scale, starting and and finishing point in the graphical scale, the name of the measure, and starting and and finishing point of the measures. After, ask the user for a new measure.

This package provides functions for self-determination motivation theory (SDT) to compute measures of motivation internalization, motivation simplex structure, and of the original and adjusted self-determination or relative autonomy index. SDT was introduced by Deci and Ryan (1985) <doi:10.1007/978-1-4899-2271-7>. See package?SDT for an overview.

Computation of effects under linear, logistic and Poisson regression models with transformed variables. Logarithm and power transformations are allowed. Effects can be displayed both numerically and graphically in both the original and the transformed space of the variables. The methods are described in Barrera-Gomez and Basagana (2015) <doi:10.1097/EDE.0000000000000247>.

This package provides tools for denoising noisy signal and images via Total Variation Regularization. Reducing the total variation of the given signal is known to remove spurious detail while preserving essential structural details. For the seminal work on the topic, see Rudin et al (1992) <doi:10.1016/0167-2789(92)90242-F>.

This package provides efficient implementations of weighted dependence measures and related asymptotic tests for independence. Implemented measures are the Pearson correlation, Spearman's rho, Kendall's tau, Blomqvist's beta, and Hoeffding's D; see, e.g., Nelsen (2006) <doi:10.1007/0-387-28678-0> and Hollander et al. (2015, ISBN:9780470387375).

This package provides a high-level interface for creating and exporting summary tables to Excel'. Built on dplyr and openxlsx', it provides tools for generating one-way to n-way tables, and summarizing multiple response questions and question blocks. Tables are exported with native Excel formatting, including titles, footnotes, and basic styling options.

This package provides a set of functions to analyze overdispersed counts or proportions. Most of the methods are already available elsewhere but are scattered in different packages. The proposed functions should be considered as complements to more sophisticated methods such as generalized estimating equations (GEE) or generalized linear mixed effect models (GLMM).

Download and read US Census Bureau data relationship files. Provides support for cleaning and using block assignment files since 2010, as described in <https://www.census.gov/geographies/reference-files/time-series/geo/block-assignment-files.html>. Also includes support for working with block equivalency files, used for years outside of decennial census years.