This package provides a pipeline which processes single cell RNA-seq (scRNA-seq) reads from CEL-seq and CEL-seq2 protocols. Demultiplex scRNA-seq FASTQ files, align reads to reference genome using Rsubread, and generate UMI filtered count matrix. Also provide visualizations of read alignments and pre- and post-alignment QC metrics.

This package serves as an upstream pipeline for pre-processing sequencing-based spatial transcriptomics data. Functions includes FASTQ trimming, BAM file reformatting, index building, spatial barcode detection, demultiplexing, gene count matrix generation with UMI deduplication, QC, and revelant visualization. Config is an essential input for most of the functions which aims to improve reproducibility.

This package provides a suite of functions for simulating spatial patterns of cells in tissue images. Output images are multitype point data in SingleCellExperiment format. Each point represents a cell, with its 2D locations and cell type. Potential cell patterns include background cells, tumour/immune cell clusters, immune rings, and blood/lymphatic vessels.

Simulates, fits, and predicts long-memory and anti-persistent time series, possibly mixed with ARMA, regression, transfer-function components. Exact methods (MLE, forecasting, simulation) are used. Bug reports should be done via GitHub (at <https://github.com/JQVeenstra/arfima>), where the development version of this package lives; it can be installed using devtools.

Allows the user to connect with the World Spider Catalogue (WSC; <https://wsc.nmbe.ch/>) and the World Spider Trait (WST; <https://arachnidatraits.sci.muni.cz/araneae/) databases. Also performs several basic functions such as checking names validity, retrieving coordinate data from the Global Biodiversity Information Facility (GBIF; <https://www.gbif.org/>), and mapping.

This package provides functions for exploring and visualising estimation results obtained with BayesX, a free software for estimating structured additive regression models (<https://www.uni-goettingen.de/de/bayesx/550513.html>). In addition, functions that allow to read, write and manipulate map objects that are required in spatial analyses performed with BayesX.

Many modern C/C++ development tools in the clang toolchain, such as clang-tidy or clangd', rely on the presence of a compilation database in JSON format <https://clang.llvm.org/docs/JSONCompilationDatabase.html>. This package temporarily injects additional build flags into the R build process to generate such a compilation database.

Estimation, prediction, and simulation of nonstationary Gaussian process with modular covariate-based covariance functions. Sources of nonstationarity, such as spatial mean, variance, geometric anisotropy, smoothness, and nugget, can be considered based on spatial characteristics. An induced compact-supported nonstationary covariance function is provided, enabling fast and memory-efficient computations when handling densely sampled domains.

This package provides a spatially-aware cell clustering algorithm is provided with cluster significance assessment. It comprises four key modules: spatially-aware cell-gene co-embedding, cell clustering, signature gene identification, and cluster significant assessment. More details can be referred to Peng Xie, et al. (2025) <doi:10.1016/j.cell.2025.05.035>.

Draws stylized choropleth maps -- hexagonal maps and triangular multiclass hex maps -- for New Zealand District Health Boards and Regional Council areas. These allow faceted, coloured displays of quantitative information for comparison across District Health Boards or Regional Councils. The preprint Lumley (2019) <arXiv:1912.04435> is based on the methods in this package.

This package provides a port of the python diffcp package. Computes the derivative of the optimal solution map of a convex cone program, treating the program as an implicit function of its data (constraint matrix, offset, objective coefficients, and optionally a quadratic), mirroring Agrawal et al. (2019) <doi:10.48550/arXiv.1904.09043>.

Populate data from an R environment into .doc and .docx templates. Create a template document in a program such as Word', and add strings encased in guillemet characters to create flags («example»). Use getDictionary() to create a dictionary of flags and replacement values, then call docket() to generate a populated document.

The Explainable Ensemble Trees e2tree approach has been proposed by Aria et al. (2024) <doi:10.1007/s00180-022-01312-6>. It aims to explain and interpret decision tree ensemble models using a single tree-like structure. e2tree is a new way of explaining an ensemble tree trained through randomForest or xgboost packages.

This package provides tools for simulating draws from continuous time processes with well-defined exponential family random graph (ERGM) equilibria, i.e. ERGM generating processes (EGPs). A number of EGPs are supported, including the families identified in Butts (2023) <doi:10.1080/0022250X.2023.2180001>, as are functions for hazard calculation and timing calibration.

Fast reverse complement of DNA and RNA sequences using a C++ lookup table for O(1) per-base complement mapping. Supports full IUPAC ambiguity codes, DNA and RNA modes, case preservation, and NA handling. Much faster than other packages for computing reverse complements of many short sequences such as primers, probes, and, k-mers.

This package provides an interface to HDFql <https://www.hdfql.com/> and helper functions for reading data from and writing data to HDF5 files. HDFql provides a high-level language for managing HDF5 data that is platform independent. For more information, see the reference manual <https://www.hdfql.com/resources/HDFqlReferenceManual.pdf>.

Calculates intraclass correlation coefficient (ICC) for assessing reproducibility of interval-censored data with two repeated measurements (Kovacic and Varnai (2014) <doi:10.1097/EDE.0000000000000139>). ICC is estimated by maximum likelihood from model with one fixed and one random effect (both intercepts). Help in model checking (normality of subjects means and residuals) is provided.

This package contains functions for fitting a joinpoint proportional hazards model to relative survival or cause-specific survival data, including estimates of joinpoint years at which survival trends have changed and trend measures in the hazard and cumulative survival scale. See Yu et al.(2009) <doi:10.1111/j.1467-985X.2009.00580.x>.

This package provides the tables from the Sean Lahman Baseball Database as a set of R data.frames. It uses the data on pitching, hitting and fielding performance and other tables from 1871 through 2024, as recorded in the 2025 version of the database. Documentation examples show how many baseball questions can be investigated.

Simulation and estimation of univariate and multivariate log-GARCH models. The main functions of the package are: lgarchSim(), mlgarchSim(), lgarch() and mlgarch(). The first two functions simulate from a univariate and a multivariate log-GARCH model, respectively, whereas the latter two estimate a univariate and multivariate log-GARCH model, respectively.

This package provides R bindings to llama.cpp for running large language models locally, with optional GPU acceleration via ggmlR'. Supports text generation, embeddings, chat-based workflows, tool calling, and multimodal (vision) inference. Includes OpenAI'- and Anthropic'-compatible HTTP servers for serving local models, along with device selection and multi-GPU support.

Supports visual interpretation of hierarchical composite endpoints (HCEs). HCEs are complex constructs used as primary endpoints in clinical trials, combining outcomes of different types into ordinal endpoints, in which each patient contributes the most clinically important event (one and only one) to the analysis. See Karpefors M et al. (2022) <doi:10.1177/17407745221134949>.

This package implements an interface to the legacy Fortran code from O'Connell and Dobson (1984) <DOI:10.2307/2531148>. Implements Fortran 77 code for the methods developed by Schouten (1982) <DOI:10.1111/j.1467-9574.1982.tb00774.x>. Includes estimates of average agreement for each observer and average agreement for each subject.

This package provides tools for analyzing metabolic pathway completeness, abundance, and transcripts using KEGG Orthology (KO) data from (meta)genomic and (meta)transcriptomic studies. Supports both completeness (presence/absence) and abundance-weighted analyses. Includes built-in KEGG reference datasets. For more details see Li et al. (2023) <doi:10.1038/s41467-023-42193-7>.