Identifying latent genetic interactions in genome-wide association studies using the Latent Interaction Testing (LIT) framework. LIT is a flexible kernel-based approach that leverages information across multiple traits to detect latent genetic interactions without specifying or observing the interacting variable (e.g., environment). LIT accepts standard PLINK files as inputs to analyze large genome-wide association studies.

Primarily, the qcv package computes key indices related to the Quantifying Construct Validity procedure (QCV; Westen & Rosenthal, 2003 <doi:10.1037/0022-3514.84.3.608>; see also Furr & Heuckeroth, in press). The qcv() function is the heart of the qcv package, but additional functions in the package provide useful ancillary information related to the QCV procedure.

Convert a time series of observations to a time series of standardised indices that can be used to monitor variables on a common and probabilistically interpretable scale. The indices can be aggregated and rescaled to different time scales, visualised using plot capabilities, and calculated using a range of distributions. This includes flexible non-parametric and non-stationary methods.

This package provides functions for point and interval estimation in error-in-variables models via total least squares or generalized total least squares method. See Golub and Van Loan (1980) <doi:10.1137/0717073>, Gleser (1981) <https://www.jstor.org/stable/2240867>, Ivan Markovsky and Huffel (2007) <doi:10.1016/j.sigpro.2007.04.004> for more information.

Quickly create, run, and report structural equation models, and twin models. See ?umx for help, and umx_open_CRAN_page("umx") for NEWS. Timothy C. Bates, Michael C. Neale, Hermine H. Maes, (2019). umx: A library for Structural Equation and Twin Modelling in R. Twin Research and Human Genetics, 22, 27-41. <doi:10.1017/thg.2019.2>.

This package provides a flexible method for modeling cumulative effects of time-varying exposures, weighted according to their relative proximity in time, and represented by time-dependent covariates. The current implementation estimates the weight function in the Cox proportional hazards model. The function that assigns weights to doses taken in the past is estimated using cubic regression splines.

R/qtl is an extension library for the R statistics system. It is used to analyze experimental crosses for identifying genes contributing to variation in quantitative traits (so-called quantitative trait loci, QTLs).

Using a hidden Markov model, R/qtl estimates genetic maps, to identify genotyping errors, and to perform single-QTL and two-QTL, two-dimensional genome scans.

Ren'Py is a visual novel engine that helps you use words, images, and sounds to tell interactive stories that run on computers and mobile devices. These can be both visual novels and life simulation games. The easy to learn script language allows anyone to efficiently write large visual novels, while its Python scripting is enough for complex simulation games.

Assists in the whole process of designing and evaluating Randomized Control Trials. Robust treatment assignment by strata/blocks, that handles misfits; Power calculations of the minimum detectable treatment effect or minimum populations; Balance tables of T-test of covariates; Balance Regression: (treatment ~ all x variables) with F-test of null model; Impact_evaluation: Impact evaluation regressions. This function gives you the option to include control_vars, fixed effect variables, cluster variables (for robust SE), multiple endogenous variables and multiple heterogeneous variables (to test treatment effect heterogeneity) summary_statistics: Function that creates a summary statistics table with statistics rank observations in n groups: Creates a factor variable with n groups. Each group has a min and max label attach to each category. Athey, Susan, and Guido W. Imbens (2017) <arXiv:1607.00698>.

R is a language and environment for statistical computing and graphics. It provides a variety of statistical techniques, such as linear and nonlinear modeling, classical statistical tests, time-series analysis, classification and clustering. It also provides robust support for producing publication-quality data plots. A large amount of 3rd-party packages are available, greatly increasing its breadth and scope.

This package provides functions to specify and fit generalized nonlinear models, including models with multiplicative interaction terms such as the UNIDIFF model from sociology and the AMMI model from crop science, and many others. Over-parameterized representations of models are used throughout; functions are provided for inference on estimable parameter combinations, as well as standard methods for diagnostics etc.

Hierarchical community detection on networks by a recursive spectral partitioning strategy, which is shown to be effective and efficient in Li, Lei, Bhattacharyya, Sarkar, Bickel, and Levina (2018) <arXiv:1810.01509>. The package also includes a data generating function for a binary tree stochastic block model, a special case of stochastic block model that admits hierarchy between communities.

This package provides functions to estimate the probability to receive the observed treatment, based on individual characteristics. The inverse of these probabilities can be used as weights when estimating causal effects from observational data via marginal structural models. Both point treatment situations and longitudinal studies can be analysed. The same functions can be used to correct for informative censoring.

Designed for association studies in nested association mapping (NAM) panels, experimental and random panels. The method is described by Xavier et al. (2015) <doi:10.1093/bioinformatics/btv448>. It includes tools for genome-wide associations of multiple populations, marker quality control, population genetics analysis, genome-wide prediction, solving mixed models and finding variance components through likelihood and Bayesian methods.

This package implements partition-assisted clustering and multiple alignments of networks. It 1) utilizes partition-assisted clustering to find robust and accurate clusters and 2) discovers coherent relationships of clusters across multiple samples. It is particularly useful for analyzing single-cell data set. Please see Li et al. (2017) <doi:10.1371/journal.pcbi.1005875> for detail method description.

Cluster data without specifying the number of clusters using the Table Invitation Prior (TIP) introduced in the paper "Clustering Gene Expression Using the Table Invitation Prior" by Charles W. Harrison, Qing He, and Hsin-Hsiung Huang (2022) <doi:10.3390/genes13112036>. TIP is a Bayesian prior that uses pairwise distance and similarity information to cluster vectors, matrices, or tensors.

Run a Gibbs sampler for hurdle models to analyze data showing an excess of zeros, which is common in zero-inflated count and semi-continuous models. The package includes the hurdle model under Gaussian, Gamma, inverse Gaussian, Weibull, Exponential, Beta, Poisson, negative binomial, logarithmic, Bell, generalized Poisson, and binomial distributional assumptions. The models described in Ganjali et al. (2024).

Retrieval the leaf area index (LAI) and soil moisture (SM) from microwave backscattering data using water cloud model (WCM) model . The WCM algorithm attributed to Pervot et al.(1993) <doi:10.1016/0034-4257(93)90053-Z>. The authors are grateful to SAC, ISRO, Ahmedabad for providing financial support to Dr. Prashant K Srivastava to conduct this research work.

This package solves convex cone programs via operator splitting. It can solve: linear programs, second-order cone programs, semidefinite programs, exponential cone programs, and power cone programs, or problems with any combination of those cones. SCS uses AMD (a set of routines for permuting sparse matrices prior to factorization) and LDL (a sparse LDL factorization and solve package) from SuiteSparse.

This package implements a self-organizing map which has application in gene clustering. It provides functions like:

• filtering data by certain floor, ceiling, max/min ratio, and max - min difference;

• normalization of the data;

• get the average distortion measure;

• train a self-organizing map;

• summarize a som object;

• yeast cell cycle.

Extend Rasch and Item Response Theory (IRT) analyses by providing tools for post-processing the output from five major IRT packages (i.e., eRm', psychotools', ltm', mirt', and TAM'). The current version provides the plotPIccc() function, which extracts from the return object of the originating package all information required to draw an extended Person-Item-Map (PIccc), showing any combination of * category characteristic curves (CCCs), * threshold characteristic curves (TCCs), * item characteristic curves (ICCs), * category information functions (CIFs), * item information functions (IIFs), * test information function (TIF), and the * standard error curve (S.E.). for uni- and multidimensional models (as far as supported by each package). It allows for selecting dimensions, items, and categories to plot and offers numerous options to adapt the output. The return object contains all calculated values for further processing.

Redox is a C++ interface to the Redis key-value store that makes it easy to write applications that are both elegant and high-performance. Communication should be a means to an end, not something we spend a lot of time worrying about. Redox takes care of the details so you can move on to the interesting part of your project.

An interface to the Bayesian Weighted Sums model implemented in RStan'. It estimates the summed effect of multiple, often moderately to highly correlated, continuous predictors. Its applications can be found in analysis of exposure mixtures. The model was proposed by Hamra, Maclehose, Croen, Kauffman, and Newschaffer (2021) <doi:10.3390/ijerph18041373>. This implementation includes an extension to model binary outcome.

Solves ordinary and delay differential equations, where the objective function is written in either R or C. Suitable only for non-stiff equations, the solver uses a Dormand-Prince method that allows interpolation of the solution at any point. This approach is as described by Hairer, Norsett and Wanner (1993) <ISBN:3540604529>. Support is also included for iterating difference equations.