HiCDOC normalizes intrachromosomal Hi-C matrices, uses unsupervised learning to predict A/B compartments from multiple replicates, and detects significant compartment changes between experiment conditions. It provides a collection of functions assembled into a pipeline to filter and normalize the data, predict the compartments and visualize the results. It accepts several type of data: tabular `.tsv` files, Cooler `.cool` or `.mcool` files, Juicer `.hic` files or HiC-Pro `.matrix` and `.bed` files.

This package provides R bindings for HiSpa, a hierarchical Bayesian model for inferring three-dimensional chromatin structures from Hi-C contact matrices using Markov Chain Monte Carlo (MCMC) sampling. The package implements a cluster-based hierarchical approach that efficiently handles large-scale Hi-C datasets. It uses Rcpp and RcppArmadillo for efficient C++ integration with the original HiSpa C++ implementation, enabling fast computation of chromatin structure inference through parallel MCMC sampling.

This package provides a collection of tools for regression analysis of non-negative data, including strictly positive and zero-inflated observations, based on the class of the Box-Cox symmetric (BCS) distributions and its zero-adjusted extension. The BCS distributions are a class of flexible probability models capable of describing different levels of skewness and tail-heaviness. The package offers a comprehensive regression modeling framework, including estimation and tools for evaluating goodness-of-fit.

Infrastructure for estimating probabilistic distributional regression models in a Bayesian framework. The distribution parameters may capture location, scale, shape, etc. and every parameter may depend on complex additive terms (fixed, random, smooth, spatial, etc.) similar to a generalized additive model. The conceptual and computational framework is introduced in Umlauf, Klein, Zeileis (2019) <doi:10.1080/10618600.2017.1407325> and the R package in Umlauf, Klein, Simon, Zeileis (2021) <doi:10.18637/jss.v100.i04>.

Prognostic Enrichment is a clinical trial strategy of evaluating an intervention in a patient population with a higher rate of the unwanted event than the broader patient population (R. Temple (2010) <DOI:10.1038/clpt.2010.233>). A higher event rate translates to a lower sample size for the clinical trial, which can have both practical and ethical advantages. This package is a tool to help evaluate biomarkers for prognostic enrichment of clinical trials.

Calculate various cardiovascular disease risk scores from the Framingham Heart Study (FHS), the American College of Cardiology (ACC), and the American Heart Association (AHA) as described in Dâ agostino, et al (2008) <doi:10.1161/circulationaha.107.699579>, Goff, et al (2013) <doi:10.1161/01.cir.0000437741.48606.98>, and Mclelland, et al (2015) <doi:10.1016/j.jacc.2015.08.035>, and Khan, et al (2024) <doi:10.1161/CIRCULATIONAHA.123.067626>.

This package provides methods for fitting nonstationary Gaussian process models by spatial deformation, as introduced by Sampson and Guttorp (1992) <doi:10.1080/01621459.1992.10475181>, and by dimension expansion, as introduced by Bornn et al. (2012) <doi:10.1080/01621459.2011.646919>. Low-rank thin-plate regression splines, as developed in Wood, S.N. (2003) <doi:10.1111/1467-9868.00374>, are used to either transform co-ordinates or create new latent dimensions.

An R API to MET Norway's Frost API <https://frost.met.no/index.html> to retrieve data as data frames. The Frost API, and the underlying data, is made available by the Norwegian Meteorological Institute (MET Norway). The data and products are distributed under the Norwegian License for Open Data 2.0 (NLOD) <https://data.norge.no/nlod/en/2.0> and Creative Commons 4.0 <https://creativecommons.org/licenses/by/4.0/>.

Quantify the serial correlation across lags of a given functional time series using the autocorrelation function and a partial autocorrelation function for functional time series proposed in Mestre et al. (2021) <doi:10.1016/j.csda.2020.107108>. The autocorrelation functions are based on the L2 norm of the lagged covariance operators of the series. Functions are available for estimating the distribution of the autocorrelation functions under the assumption of strong functional white noise.

Inspects ggplot objects by extracting their full declarative specification - layers, aesthetic mappings, scales, facets, coordinate systems, and labels - as tidy data frames. A second tier of functions enables structural comparison of two ggplot objects, supporting automated plot testing, auditing, and framework-agnostic grading workflows. Unlike ggcheck', which is designed exclusively for learnr'/'gradethis pipelines and returns ad-hoc objects, ggspec returns rectangular, pipeable output and does not require any grading framework as a dependency.

Easy wrangling and model-free analysis of microbial growth curve data, as commonly output by plate readers. Tools for reshaping common plate reader outputs into tidy formats and merging them with design information, making data easy to work with using gcplyr and other packages. Also streamlines common growth curve processing steps, like smoothing and calculating derivatives, and facilitates model-free characterization and analysis of growth data. See methods at <https://mikeblazanin.github.io/gcplyr/>.

Routines that allow the user to run goodness of fit tests based on empirical distribution functions for formal model evaluation in a general likelihood model. In addition, functions are provided to test if a sample follows Normal or Gamma distributions, validate the normality assumptions in a linear model, and examine the appropriateness of a Gamma distribution in generalized linear models with various link functions. Michael Arthur Stephens (1976) <http://www.jstor.org/stable/2958206>.

This package provides methods for processing spatial data for decision-making. This package is an R implementation of methods provided by the open source software GeoFIS <https://www.geofis.org> (Leroux et al. 2018) <doi:10.3390/agriculture8060073>. The main functionalities are the management zone delineation (Pedroso et al. 2010) <doi:10.1016/j.compag.2009.10.007> and data aggregation (Mora-Herrera et al. 2020) <doi:10.1016/j.compag.2020.105624>.

Organize a so-called ragged array as generalized arrays, which is simply an array with sub-dimensions denoting the subdivision of dimensions (grouping of members within dimensions). By the margins (names of dimensions and sub-dimensions) in generalized arrays, operators and utility functions provided in this package automatically match the margins, doing map-reduce style parallel computation along margins. Generalized arrays are also cooperative to R's native functions that work on simple arrays.

This package provides a user-friendly interface for the Hierarchical Data Format 5 ('HDF5') library designed to "just work." It bundles the necessary system libraries to ensure easy installation on all platforms. Features smart defaults that automatically map R objects (vectors, matrices, data frames) to efficient HDF5 types, removing the need to manage low-level details like dataspaces or property lists. Uses the HDF5 library developed by The HDF Group <https://www.hdfgroup.org/>.

The model is high-dimensional vector autoregression with measurement error, also known as linear gaussian state-space model. Provable sparse expectation-maximization algorithm is provided for the estimation of transition matrix and noise variances. Global and simultaneous testings are implemented for transition matrix with false discovery rate control. For more information, see the accompanying paper: Lyu, X., Kang, J., & Li, L. (2023). "Statistical inference for high-dimensional vector autoregression with measurement error", Statistica Sinica.

Calculates 3D lacunarity from voxel data. It is designed for use with point clouds generated from Light Detection And Ranging (LiDAR) scans in order to measure the spatial heterogeneity of 3-dimensional structures such as forest stands. It provides fast C++ functions to efficiently bin point cloud data into voxels and calculate lacunarity using different variants of the gliding-box algorithm originated by Allain & Cloitre (1991) <doi:10.1103/PhysRevA.44.3552>.

This package provides tools for Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA) for intersectional inequality research. Methods are described in Merlo (2018) <doi:10.1016/j.socscimed.2017.12.026> and Evans et al. (2018) <doi:10.1016/j.socscimed.2017.11.011>. The package creates intersectional strata, fits multilevel MAIHDA models, estimates variance partition coefficients, proportional change in variance, stratum effects, and discriminatory-accuracy summaries, and provides diagnostic and presentation plots.

Solve scalar-on-function linear models, including generalized linear mixed effect model and quantile linear regression model, and bias correction estimation methods due to measurement error. Details about the measurement error bias correction methods, see Luan et al. (2023) <doi:10.48550/arXiv.2305.12624>, Tekwe et al. (2022) <doi:10.1093/biostatistics/kxac017>, Zhang et al. (2023) <doi:10.5705/ss.202021.0246>, Tekwe et al. (2019) <doi:10.1002/sim.8179>.

Implementation of hypothesis testing procedures described in Hansen (1992) <doi:10.1002/jae.3950070506>, Carrasco, Hu, & Ploberger (2014) <doi:10.3982/ECTA8609>, Dufour & Luger (2017) <doi:10.1080/07474938.2017.1307548>, and Rodriguez-Rondon & Dufour (2026a) <doi:10.34989/swp-2026-23> that can be used to identify the number of regimes in Markov switching models. For a detailed description of the package, see Rodriguez-Rondon & Dufour (2026b) <doi:10.34989/swp-2026-7>.

This package provides a suite of diagnostic tools for univariate point processes. This includes tools for simulating and fitting both common and more complex temporal point processes. We also include functions to visualise these point processes and collect existing diagnostic tools of Brown et al. (2002) <doi:10.1162/08997660252741149> and Wu et al. (2021) <doi:10.1002/9781119821588.ch7>, which can be used to assess the fit of a chosen point process model.

Evaluation of the pdf and the cdf of the univariate, noncentral, p-generalized normal distribution. Sampling from the univariate, noncentral, p-generalized normal distribution using either the p-generalized polar method, the p-generalized rejecting polar method, the Monty Python method, the Ziggurat method or the method of Nardon and Pianca. The package also includes routines for the simulation of the bivariate, p-generalized uniform distribution and the simulation of the corresponding angular distribution.

This package provides a tidy interface to Pakistan's official administrative boundary data from the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Spatial data at country, province, district, and tehsil levels are embedded in the package as sf objects compatible with the tidyverse and geospatial ecosystem. Includes utilities for geographic dictionary lookup, coordinate reference system selection, spatial measurement, and neighbour structure construction for use with spdep', ggplot2', leaflet', and related packages.

This package creates classifier for binary outcomes using Adaptive Boosting (AdaBoost) algorithm on decision stumps with a fast C++ implementation. For a description of AdaBoost, see Freund and Schapire (1997) <doi:10.1006/jcss.1997.1504>. This type of classifier is nonlinear, but easy to interpret and visualize. Feature vectors may be a combination of continuous (numeric) and categorical (string, factor) elements. Methods for classifier assessment, predictions, and cross-validation also included.