This package provides a robust and powerful empirical Bayesian approach is developed for replicability analysis of two large-scale experimental studies. The method controls the false discovery rate by using the joint local false discovery rate based on the replicability null as the test statistic. An EM algorithm combined with a shape constraint nonparametric method is used to estimate unknown parameters and functions. [Li, Y. et al., (2024), <doi:10.1371/journal.pgen.1011423>].

Separate a data frame in two based on key columns. The function unjoin() provides an inside-out version of a nested data frame. This is used to identify duplication and normalize it (in the database sense) by linking two tables with the redundancy removed. This is a basic requirement for detecting topology within spatial structures that has motivated the need for this package as a building block for workflows within more applied projects.

This package provides a toolbox of common robust statistical tests, including robust descriptives, robust t-tests, and robust ANOVA. It is also available as a module for jamovi (see <https://www.jamovi.org> for more information). Walrus is based on the WRS2 package by Patrick Mair, which is in turn based on the scripts and work of Rand Wilcox. These analyses are described in depth in the book Introduction to Robust Estimation & Hypothesis Testing'.

Allows to provide live interpretations and explanations of statistical functions in R. These interpretations and explanations are shown when the explained function is called by the user. They can interact with the values of the explained function's actual results to offer relevant, meaningful insights. The xplain interpretations and explanations are based on an easy-to-use XML format that allows to include R code to interact with the returns of the explained function.

This package lets you fit a Gaussian process model to data. Gaussian processes are commonly used in computer experiments to fit an interpolating model. The model is stored as an R6 object and can be easily updated with new data. There are options to run in parallel, and Rcpp has been used to speed up calculations. For more info about Gaussian process software, see Erickson et al. (2018) <doi:10.1016/j.ejor.2017.10.002>.

ASSIGN is a computational tool to evaluate the pathway deregulation/activation status in individual patient samples. ASSIGN employs a flexible Bayesian factor analysis approach that adapts predetermined pathway signatures derived either from knowledge-based literature or from perturbation experiments to the cell-/tissue-specific pathway signatures. The deregulation/activation level of each context-specific pathway is quantified to a score, which represents the extent to which a patient sample encompasses the pathway deregulation/activation signature.

Banksy is an R package that incorporates spatial information to cluster cells in a feature space (e.g. gene expression). To incorporate spatial information, BANKSY computes the mean neighborhood expression and azimuthal Gabor filters that capture gene expression gradients. These features are combined with the cell's own expression to embed cells in a neighbor-augmented product space which can then be clustered, allowing for accurate and spatially-aware cell typing and tissue domain segmentation.

This package provides functionality for untargeted LC-MS metabolomics research as specified in the associated protocol article in the Metabolomics Data Processing and Data Analysis—Current Best Practices special issue of the Metabolites journal (2020). This includes tabular data preprocessing and quality control, uni- and multivariate analysis as well as quality control visualizations, feature-wise visualizations and results visualizations. Raw data preprocessing and functionality related to biological context, such as pathway analysis, is not included.

The spicyR package provides a framework for performing inference on changes in spatial relationships between pairs of cell types for cell-resolution spatial omics technologies. spicyR consists of three primary steps: (i) summarizing the degree of spatial localization between pairs of cell types for each image; (ii) modelling the variability in localization summary statistics as a function of cell counts and (iii) testing for changes in spatial localizations associated with a response variable.

The goal is to print an "aperçu", a short view of a vector, a matrix, a data.frame, a list or an array. By default, it prints the first 5 elements of each dimension. By default, the number of columns is equal to the number of lines. If you want to control the selection of the elements, you can pass a list, with each element being a vector giving the selection for each dimension.

Developed for use by those tasked with the routine detection, characterisation and quantification of discrete changes in air quality time-series, such as identifying the impacts of air quality policy interventions. The main functions use signal isolation then break-point/segment (BP/S) methods based on strucchange and segmented methods to detect and quantify change events (Ropkins & Tate, 2021, <doi:10.1016/j.scitotenv.2020.142374>; Ropkins et al., 2026, <doi:10.21105/joss.08839>).

Implementation of Graph Signal Processing (GSP) methods including Spectral Graph Wavelet Transform (SGWT) for analyzing spatial patterns in biological data. Based on Hammond, Vandergheynst, and Gribonval (2011) <doi:10.1016/j.acha.2010.04.005>. Provides tools for multi-scale analysis of biology spatial signals, including forward and inverse transforms, energy analysis, and visualization functions tailored for biological applications. Biological application example is on Stephanie, Yao, Yuzhou (2024) <doi:10.1101/2024.12.20.629650>.

Searches for, accesses, and retrieves Statistics Canada data tables, as well as individual vectors, as tidy data frames. This package enriches the tables with metadata, deals with encoding issues, allows for bilingual English or French language data retrieval, and bundles convenience functions to make it easier to work with retrieved table data. For more efficient data access the package allows for caching data in a local database and database level filtering, data manipulation and summarizing.

For identifying, estimating, and plotting descriptive multidimensional item response theory models, restricted to 2D and 3D and dichotomous or polytomous data that fit the two-parameter logistic model or the graded response model. The method is primarily exploratory and centered on the plot function, which exposes item characteristics and constructs, represented by vector arrows, within a three-dimensional interactive latent space. The results can be useful for item-level analysis as well as test development.

The summation notation suggested by Einstein (1916) <doi:10.1002/andp.19163540702> is a concise mathematical notation that implicitly sums over repeated indices of n-dimensional arrays. Many ordinary matrix operations (e.g. transpose, matrix multiplication, scalar product, diag()', trace etc.) can be written using Einstein notation. The notation is particularly convenient for expressing operations on arrays with more than two dimensions because the respective operators ('tensor products') might not have a standardized name.

This package contains methods for observed-score linking and equating under the single-group, equivalent-groups, and nonequivalent-groups with anchor test(s) designs. Equating types include identity, mean, linear, general linear, equipercentile, circle-arc, and composites of these. Equating methods include synthetic, nominal weights, Tucker, Levine observed score, Levine true score, Braun/Holland, frequency estimation, and chained equating. Plotting and summary methods, and methods for multivariate presmoothing and bootstrap error estimation are also provided.

This package provides a toolset for generating Ecological Limit Function (ELF) models and evaluating potential species loss resulting from flow change, based on the elfgen framework. ELFs describe the relation between aquatic species richness (fish or benthic macroinvertebrates) and stream size characteristics (streamflow or drainage area). Journal publications are available outlining framework methodology (Kleiner et al. (2020) <doi:10.1111/1752-1688.12876>) and application (Rapp et al. (2020) <doi:10.1111/1752-1688.12877>).

This package provides a ggplot2 extension that creates publication-quality forest and funnel plots from meta package objects or tidy data frames. Provides custom ggproto geometries for study-level confidence intervals with weight-proportional squares, summary effect diamonds, prediction intervals, null-effect reference lines, and funnel-plot contours. Supports subgroup analysis, back-transformation of summary measures, on-the-fly effect pooling, effect and weight table columns, and journal-specific layout presets (JAMA, BMJ, RevMan5).

This package provides a function that uses a genetic algorithm to search for a subset of size k from the integers 1:n, such that a user-supplied objective function is minimized at that subset. The selection step is done by tournament selection based on ranks, and elitism may be used to retain a portion of the best solutions from one generation to the next. Population objective function values may optionally be evaluated in parallel.

L1 estimation for linear regression using Barrodale and Roberts method <doi:10.1145/355616.361024> and the EM algorithm <doi:10.1023/A:1020759012226>. Estimation of mean and covariance matrix using the multivariate Laplace distribution, density, distribution function, quantile function and random number generation for univariate and multivariate Laplace distribution <doi:10.1080/03610929808832115>. Implementation of Naik and Plungpongpun <doi:10.1007/0-8176-4487-3_7> for the Generalized spatial median estimator is included.

Analyze molecular dynamics (MD) simulation data using structural alphabets. Protein local conformations from molecular simulations are encoded in a compressed string representation. Residue-level UniProt annotations can be directly retrieved. Comparative analysis tools are available to investigate conformational variability, coordinated motions, and differences between systems (e.g. wild-type vs mutant; bound vs unbound). Methodological details for the structural alphabet analysis can be found in Pandini et al. (2013) <doi:10.1093/bioinformatics/btt326>.

This package provides a set of functions for some multivariate analyses utilizing a structural equation modeling (SEM) approach through the OpenMx package. These analyses include canonical correlation analysis (CANCORR), redundancy analysis (RDA), and multivariate principal component regression (MPCR). It implements procedures discussed in Gu and Cheung (2023) <doi:10.1111/bmsp.12301>, Gu, Yung, and Cheung (2019) <doi:10.1080/00273171.2018.1512847>, and Gu et al. (2023) <doi:10.1080/00273171.2022.2141675>.

This package provides different interval estimates of a location parameter when the sample size is one or more. These include classical methods when n=1, new Bayesian analogues of these classical methods, and extensions of these methods to larger sample sizes in the normal case. Other functions calculate Bayes factors based on t-statistics, and implement the (generalized) inverse normal distribution. These methods are described in Gerard (2026) <doi:10.48550/arXiv.2607.25007>.

This package provides a tidyverse'-friendly toolkit, inspired by the OSMnx Python library, to download, model, simplify, analyze and visualize street networks and other geospatial features from OpenStreetMap'. Build routable graphs from a place name, address, point or bounding box; simplify topology; compute shortest paths, isochrones and urban metrics (intersection density, circuity, street-orientation entropy, centrality); and export to sf', sfnetworks and MapLibre'. Heavy graph computation is performed by a bundled Rust core.