lipidr an easy-to-use R package implementing a complete workflow for downstream analysis of targeted and untargeted lipidomics data. lipidomics results can be imported into lipidr as a numerical matrix or a Skyline export, allowing integration into current analysis frameworks. Data mining of lipidomics datasets is enabled through integration with Metabolomics Workbench API. lipidr allows data inspection, normalization, univariate and multivariate analysis, displaying informative visualizations. lipidr also implements a novel Lipid Set Enrichment Analysis (LSEA), harnessing molecular information such as lipid class, total chain length and unsaturation.

This package provides tools to compute ordinal, statistics and effect sizes as an alternative to mean comparison: Cliff's delta or success rate difference (SRD), Vargha and Delaney's A or the Area Under a Receiver Operating Characteristic Curve (AUC), the discrete type of McGraw & Wong's Common Language Effect Size (CLES) or Grissom & Kim's Probability of Superiority (PS), and the Number needed to treat (NNT) effect size. Moreover, comparisons to Cohen's d are offered based on Huberty & Lowman's Percentage of Group (Non-)Overlap considerations.

The goal of the package aldvmm is to fit adjusted limited dependent variable mixture models of health state utilities. Adjusted limited dependent variable mixture models are finite mixtures of normal distributions with an accumulation of density mass at the limits, and a gap between 100% quality of life and the next smaller utility value. The package aldvmm uses the likelihood and expected value functions proposed by Hernandez Alava and Wailoo (2015) <doi:10.1177/1536867X1501500307> using normal component distributions and a multinomial logit model of probabilities of component membership.

This package provides functions for behavior genetics analysis, including variance component model identification [Hunter et al. (2021) <doi:10.1007/s10519-021-10055-x>], calculation of relatedness coefficients using path-tracing methods [Wright (1922) <doi:10.1086/279872>; McArdle & McDonald (1984) <doi:10.1111/j.2044-8317.1984.tb00802.x>], inference of relatedness, pedigree conversion, and simulation of multi-generational family data [Lyu et al. (2024) <doi:10.1101/2024.12.19.629449>]. For a full overview, see [Garrison et al. (2024) <doi:10.21105/joss.06203>].

This package provides a Bayesian regression model for discrete response, where the conditional distribution is modelled via a discrete Weibull distribution. This package provides an implementation of Metropolis-Hastings and Reversible-Jumps algorithms to draw samples from the posterior. It covers a wide range of regularizations through any two parameter prior. Examples are Laplace (Lasso), Gaussian (ridge), Uniform, Cauchy and customized priors like a mixture of priors. An extensive visual toolbox is included to check the validity of the results as well as several measures of goodness-of-fit.

CliFlo is a web portal to the New Zealand National Climate Database and provides public access (via subscription) to around 6,500 various climate stations (see <https://cliflo.niwa.co.nz/> for more information). Collating and manipulating data from CliFlo (hence clifro) and importing into R for further analysis, exploration and visualisation is now straightforward and coherent. The user is required to have an internet connection, and a current CliFlo subscription (free) if data from stations, other than the public Reefton electronic weather station, is sought.

Implementation of some Deep Learning methods. Includes multilayer perceptron, different activation functions, regularisation strategies, stochastic gradient descent and dropout. Thanks go to the following references for helping to inspire and develop the package: Ian Goodfellow, Yoshua Bengio, Aaron Courville, Francis Bach (2016, ISBN:978-0262035613) Deep Learning. Terrence J. Sejnowski (2018, ISBN:978-0262038034) The Deep Learning Revolution. Grant Sanderson (3brown1blue) <https://www.youtube.com/playlist?list=PLZHQObOWTQDNU6R1_67000Dx_ZCJB-3pi> Neural Networks YouTube playlist. Michael A. Nielsen <http://neuralnetworksanddeeplearning.com/> Neural Networks and Deep Learning.

An interactive image editing tool that can be added as part of the HTML in Shiny, R markdown or any type of HTML document. Often times, plots, photos are embedded in the web application/file. drawer can take screenshots of these image-like elements, or any part of the HTML document and send to an image editing space called canvas to allow users immediately edit the screenshot(s) within the same document. Users can quickly combine, compare different screenshots, upload their own images and maybe make a scientific figure.

An estimation method that can use computer simulations to approximate maximum-likelihood estimates even when the likelihood function can not be evaluated directly. It can be applied whenever it is feasible to conduct many simulations, but works best when the data is approximately Poisson distributed. It was originally designed for demographic inference in evolutionary biology (Naduvilezhath et al., 2011 <doi:10.1111/j.1365-294X.2011.05131.x>, Mathew et al., 2013 <doi:10.1002/ece3.722>). It has optional support for conducting coalescent simulation using the coala package.

Multiple moderation analysis for two-instance repeated measures designs, with up to three simultaneous moderators (dichotomous and/or continuous) with additive or multiplicative relationship. Includes analyses of simple slopes and conditional effects at (automatically determined or manually set) values of the moderator(s), as well as an implementation of the Johnson-Neyman procedure for determining regions of significance in single moderator models. Based on Montoya, A. K. (2018) "Moderation analysis in two-instance repeated measures designs: Probing methods and multiple moderator models" <doi:10.3758/s13428-018-1088-6> .

This package provides a central decision in a parametric regression is how to specify the relation between an dependent variable and each explanatory variable. This package provides a semi-parametric tool for comparing different transformations of an explanatory variables in a parametric regression. The functions is relevant in a situation, where you would use a box-cox or Box-Tidwell transformations. In contrast to the classic power-transformations, the methods in this package allows for theoretical driven user input and the possibility to compare with a non-parametric transformation.

An R interface to pikchr (<https://pikchr.org>, pronounced â pictureâ ), a PIC'-like markup language for creating diagrams within technical documentation. Originally developed by Brian Kernighan, PIC has been adapted into pikchr by D. Richard Hipp, the creator of SQLite'. pikchr is designed to be embedded in fenced code blocks of Markdown or other documentation markup languages, making it ideal for generating diagrams in text-based formats. This package allows R users to seamlessly integrate the descriptive syntax of pikchr for diagram creation directly within the R environment.

Computes the effective range of a smoothing matrix, which is a measure of the distance to which smoothing occurs. This is motivated by the application of spatial splines for adjusting for unmeasured spatial confounding in regression models, but the calculation of effective range can be applied to smoothing matrices in other contexts. For algorithmic details, see Rainey and Keller (2024) "spconfShiny: an R Shiny application..." <doi:10.1371/journal.pone.0311440> and Keller and Szpiro (2020) "Selecting a Scale for Spatial Confounding Adjustment" <doi:10.1111/rssa.12556>.

Smoothing signals and computing their derivatives is a common requirement in signal processing workflows. Savitzky-Golay filters are a established method able to do both (Savitzky and Golay, 1964 <doi:10.1021/ac60214a047>). This package implements one dimensional Savitzky-Golay filters that can be applied to vectors and matrices (either row-wise or column-wise). Vectorization and memory allocations have been profiled to reduce computational fingerprint. Short filter lengths are implemented in the direct space, while longer filters are implemented in frequency space, using a Fast Fourier Transform (FFT).

Visualize Variance is an intuitive shiny applications tailored for agricultural research data analysis, including one-way and two-way analysis of variance, correlation, and other essential statistical tools. Users can easily upload their datasets, perform analyses, and download the results as a well-formatted document, streamlining the process of data analysis and reporting in agricultural research.The experimental design methods are based on classical work by Fisher (1925) and Scheffe (1959). The correlation visualization approaches follow methods developed by Wei & Simko (2021) and Friendly (2002) <doi:10.1198/000313002533>.

Efficient Bayesian generalized linear models with time-varying coefficients as in Helske (2022, <doi:10.1016/j.softx.2022.101016>). Gaussian, Poisson, and binomial observations are supported. The Markov chain Monte Carlo (MCMC) computations are done using Hamiltonian Monte Carlo provided by Stan, using a state space representation of the model in order to marginalise over the coefficients for efficient sampling. For non-Gaussian models, the package uses the importance sampling type estimators based on approximate marginal MCMC as in Vihola, Helske, Franks (2020, <doi:10.1111/sjos.12492>).

LegATo is a suite of open-source software tools for longitudinal microbiome analysis. It is extendable to several different study forms with optimal ease-of-use for researchers. Microbiome time-series data presents distinct challenges including complex covariate dependencies and variety of longitudinal study designs. This toolkit will allow researchers to determine which microbial taxa are affected over time by perturbations such as onset of disease or lifestyle choices, and to predict the effects of these perturbations over time, including changes in composition or stability of commensal bacteria.

Performance analysis workflow that combines the power of the R language (and the tidyverse realm) and many auxiliary tools to provide a consistent, flexible, extensible, fast, and versatile framework for the performance analysis of task-based applications that run on top of the StarPU runtime (with its MPI (Message Passing Interface) layer for multi-node support). Its goal is to provide a fruitful prototypical environment to conduct performance analysis hypothesis-checking for task-based applications that run on heterogeneous (multi-GPU, multi-core) multi-node HPC (High-performance computing) platforms.

Experience studies are used by actuaries to explore historical experience across blocks of business and to inform assumption setting activities. This package provides functions for preparing data, creating studies, visualizing results, and beginning assumption development. Experience study methods, including exposure calculations, are described in: Atkinson & McGarry (2016) "Experience Study Calculations" <https://www.soa.org/49378a/globalassets/assets/files/research/experience-study-calculations.pdf>. The limited fluctuation credibility method used by the exp_stats() function is described in: Herzog (1999, ISBN:1-56698-374-6) "Introduction to Credibility Theory".

Count transformation models featuring parameters interpretable as discrete hazard ratios, odds ratios, reverse-time discrete hazard ratios, or transformed expectations. An appropriate data transformation for a count outcome and regression coefficients are simultaneously estimated by maximising the exact discrete log-likelihood using the computational framework provided in package mlt', technical details are given in Siegfried & Hothorn (2020) <DOI:10.1111/2041-210X.13383>. The package also contains an experimental implementation of multivariate count transformation models with an application to multi-species distribution models <DOI:10.48550/arXiv.2201.13095>.

Collection of ancillary functions and utilities for Partial Linear Single Index Models for Environmental mixture analyses, which currently provides functions for scalar outcomes. The outputs of these functions include the single index function, single index coefficients, partial linear coefficients, mixture overall effect, exposure main and interaction effects, and differences of quartile effects. In the future, we will add functions for binary, ordinal, Poisson, survival, and longitudinal outcomes, as well as models for time-dependent exposures. See Wang et al (2020) <doi:10.1186/s12940-020-00644-4> for an overview.

This package provides an implementation of two-dimensional functional principal component analysis (FPCA), Marginal FPCA, and Product FPCA for repeated functional data. Marginal and Product FPCA implementations are done for both dense and sparsely observed functional data. References: Chen, K., Delicado, P., & Müller, H. G. (2017) <doi:10.1111/rssb.12160>. Chen, K., & Müller, H. G. (2012) <doi:10.1080/01621459.2012.734196>. Hall, P., Müller, H.G. and Wang, J.L. (2006) <doi:10.1214/009053606000000272>. Yao, F., Müller, H. G., & Wang, J. L. (2005) <doi:10.1198/016214504000001745>.

Fast, model-agnostic implementation of different H-statistics introduced by Jerome H. Friedman and Bogdan E. Popescu (2008) <doi:10.1214/07-AOAS148>. These statistics quantify interaction strength per feature, feature pair, and feature triple. The package supports multi-output predictions and can account for case weights. In addition, several variants of the original statistics are provided. The shape of the interactions can be explored through partial dependence plots or individual conditional expectation plots. DALEX explainers, meta learners ('mlr3', tidymodels', caret') and most other models work out-of-the-box.

Rank-based tests for enrichment of KOG (euKaryotic Orthologous Groups) classes with up- or down-regulated genes based on a continuous measure. The meta-analysis is based on correlation of KOG delta-ranks across datasets (delta-rank is the difference between mean rank of genes belonging to a KOG class and mean rank of all other genes). With binary measure (1 or 0 to indicate significant and non-significant genes), one-tailed Fisher's exact test for over-representation of each KOG class among significant genes will be performed.