Allows to calculate the probabilities of occurrences of an event in a great number of repetitions of Bernoulli experiment, through the application of the local and the integral theorem of De Moivre Laplace, and the theorem of Poisson. Gives the possibility to show the results graphically and analytically, and to compare the results obtained by the application of the above theorems with those calculated by the direct application of the Binomial formula. Is basically useful for educational purposes.

Empirical Bayes ranking applicable to parallel-estimation settings where the estimated parameters are asymptotically unbiased and normal, with known standard errors. A mixture normal prior for each parameter is estimated using Empirical Bayes methods, subsequentially ranks for each parameter are simulated from the resulting joint posterior over all parameters (The marginal posterior densities for each parameter are assumed independent). Finally, experiments are ordered by expected posterior rank, although computations minimizing other plausible rank-loss functions are also given.

This package provides a population genetic simulator, which is able to generate synthetic datasets for single-nucleotide polymorphisms (SNP) for multiple populations. The genetic distances among populations can be set according to the Fixation Index (Fst) as explained in Balding and Nichols (1995) <doi:10.1007/BF01441146>. This tool is able to simulate outlying individuals and missing SNPs can be specified. For Genome-wide association study (GWAS), disease status can be set in desired level according risk ratio.

Quantitative genetics tool supporting the modelling of multivariate genetic variance structures in quantitative data. It allows fitting different models through multivariate genetic-relationship-matrix (GRM) structural equation modelling (SEM) in unrelated individuals, using a maximum likelihood approach. Specifically, it combines genome-wide genotyping information, as captured by GRMs, with twin-research-based SEM techniques, St Pourcain et al. (2017) <doi:10.1016/j.biopsych.2017.09.020>, Shapland et al. (2020) <doi:10.1101/2020.08.14.251199>.

Functions, data sets, analyses and examples from the second edition of the book A Handbook of Statistical Analyses Using R (Brian S. Everitt and Torsten Hothorn, Chapman & Hall/CRC, 2008). The first chapter of the book, which is entitled An Introduction to R'', is completely included in this package, for all other chapters, a vignette containing all data analyses is available. In addition, the package contains Sweave code for producing slides for selected chapters (see HSAUR2/inst/slides).

Linear and logistic regression models penalized with hierarchical shrinkage priors for selection of biomarkers (or more general variable selection), which can be fitted using Stan (Carpenter et al. (2017) <doi:10.18637/jss.v076.i01>). It implements the horseshoe and regularized horseshoe priors (Piironen and Vehtari (2017) <doi:10.1214/17-EJS1337SI>), as well as the projection predictive selection approach to recover a sparse set of predictive biomarkers (Piironen, Paasiniemi and Vehtari (2020) <doi:10.1214/20-EJS1711>).

Short for linear binning', the linbin package provides functions for manipulating, binning, and plotting linearly referenced data. Although developed for data collected on river networks, it can be used with any interval or point data referenced to a 1-dimensional coordinate system. Flexible bin generation and batch processing makes it easy to compute and visualize variables at multiple scales, useful for identifying patterns within and between variables and investigating the influence of scale of observation on data interpretation.

The main function, plot_mm(), is used for (gg)plotting output from mixture models, including both densities and overlaying mixture weight component curves from the fit models in line with the tidy principles. The package includes several additional functions for added plot customization. Supported model objects include: mixtools', EMCluster', and flexmix', with more from each in active dev. Supported mixture model specifications include mixtures of univariate Gaussians, multivariate Gaussians, Gammas, logistic regressions, linear regressions, and Poisson regressions.

An implementation of a phylogenetic comparative method. It can fit univariate among-species Ornstein-Uhlenbeck models of phenotypic trait evolution, where the trait evolves towards a primary optimum. The optimum can be modelled as a single parameter, as multiple discrete regimes on the phylogenetic tree, and/or with continuous covariates. See also Hansen (1997) <doi:10.2307/2411186>, Butler & King (2004) <doi:10.1086/426002>, Hansen et al. (2008) <doi:10.1111/j.1558-5646.2008.00412.x>.

Generates region-specific Suess and Laws corrections for stable carbon isotope data from marine organisms collected between 1850 and 2025. Version 0.1.7 of SuessR contains four built-in regions: the Bering Sea ('Bering Sea'), the Aleutian archipelago ('Aleutian Islands'), the Gulf of Alaska ('Gulf of Alaska'), and the subpolar North Atlantic ('Subpolar North Atlantic'). Users can supply their own environmental data for regions currently not built into the package to generate corrections for those regions.

Kataegis is a localized hypermutation occurring when a region is enriched in somatic SNVs. Kataegis can result from multiple cytosine deaminations catalyzed by the AID/APOBEC family of proteins. This package contains functions to detect kataegis from SNVs in BED format. This package reports two scores per kataegic event, a hypermutation score and an APOBEC mediated kataegic score. Yousif, F. et al.; The Origins and Consequences of Localized and Global Somatic Hypermutation; Biorxiv 2018 <doi:10.1101/287839>.

This package provides functions to build interactive dashboards combining the Tabler UI Kit with Shiny', making it easy to create professional-looking web applications. Tabler is fully responsive and compatible with all modern browsers. Offers customizable layouts and components built with HTML5 and CSS3'. The underlying Tabler (<https://github.com/tabler/tabler>) and Tabler Icons (<https://github.com/tabler/tabler-icons>) were pre-built from source to eliminate the need for Node.js and NPM on package installation.

Helper functions for MASCOTNUM / RT-UQ <https://uq.math.cnrs.fr/> algorithm template, for design of numerical experiments practice: algorithm template parser to support MASCOTNUM specification <https://github.com/MASCOTNUM/algorithms>, ask & tell decoupling injection (inspired by <https://search.r-project.org/CRAN/refmans/sensitivity/html/decoupling.html>) to use "crimped" algorithms (like uniroot(), optim(), ...) from outside R, basic template examples: Brent algorithm for 1 dim root finding and L-BFGS-B from base optim().

STARMA (Space-Time Autoregressive Moving Average) models are commonly utilized in modeling and forecasting spatiotemporal time series data. However, the intricate nonlinear dynamics observed in many space-time rainfall patterns often exceed the capabilities of conventional STARMA models. This R package enables the fitting of Time Delay Spatio-Temporal Neural Networks, which are adept at handling such complex nonlinear dynamics efficiently. For detailed methodology, please refer to Saha et al. (2020) <doi:10.1007/s00704-020-03374-2>.

Converts coefficients, standard errors, significance stars, and goodness-of-fit statistics of statistical models into LaTeX tables or HTML tables/MS Word documents or to nicely formatted screen output for the R console for easy model comparison. A list of several models can be combined in a single table. The output is highly customizable. New model types can be easily implemented. Details can be found in Leifeld (2013), JStatSoft <doi:10.18637/jss.v055.i08>.).

Allows forecasting time series using nearest neighbors regression Francisco Martinez, Maria P. Frias, Maria D. Perez-Godoy and Antonio J. Rivera (2019) <doi:10.1007/s10462-017-9593-z>. When the forecasting horizon is higher than 1, two multi-step ahead forecasting strategies can be used. The model built is univariate and autoregressive, that is, it is only based on the observations of the time series. The nearest neighbors used in a prediction can be consulted and plotted.

This package provides a simple XML tree parser/generator. It includes functions to read XML files into R objects, get information out of and into nodes, and write R objects back to XML code. It's not as powerful as the XML package and doesn't aim to be, but for simple XML handling it could be useful. It was originally developed for the R GUI and IDE RKWard <https://rkward.kde.org>, to make plugin development easier.

This package provides an R interface to the C-TOOL soil carbon turnover model for simulating soil organic carbon dynamics in agricultural systems. The package supports the definition of carbon inputs, management schedules, soil parameters, and temperature forcing, and includes tools for scenario analysis and calibration of selected model parameters against observed soil organic carbon stocks. The C-TOOL model and related modelling framework are described by Petersen et al. (2002) <doi:10.1016/S0304-3800(02)00034-0>, Petersen et al. (2005) <doi:10.1016/j.soilbio.2004.08.006>, Petersen et al. (2013) <doi:10.1016/j.jclepro.2013.03.007>, and Taghizadeh-Toosi et al. (2014) <doi:10.1016/j.ecolmodel.2014.08.016>. Further applications and developments are described by Taghizadeh-Toosi et al. (2016) <doi:10.1016/j.agsy.2016.03.004>, Keel et al. (2017) <doi:10.1111/ejss.12454>, Taghizadeh-Toosi et al. (2020) <doi:10.1007/s11104-020-04500-9>, and Taghizadeh-Toosi and Christensen (2021) <doi:10.1038/s41598-021-97744-z>.

This package provides a daemon for checking running and not running processes. It reads the /proc directory every n seconds and does a POSIX regexp on the process names. The daemon runs a user-provided script when it detects a program in the running processes, or an alternate script if it doesn't detect the program. The daemon can only be called by the root user, but can use sudo -u user in the process called if needed.

Oscope is a oscillatory genes identifier in unsynchronized single cell RNA-seq. This statistical pipeline has been developed to identify and recover the base cycle profiles of oscillating genes in an unsynchronized single cell RNA-seq experiment. The Oscope pipeline includes three modules: a sine model module to search for candidate oscillator pairs; a K-medoids clustering module to cluster candidate oscillators into groups; and an extended nearest insertion module to recover the base cycle order for each oscillator group.

This package provides an optimization method based on sequential quadratic programming for maximum likelihood estimation of the mixture proportions in a finite mixture model where the component densities are known. The algorithm is expected to obtain solutions that are at least as accurate as the state-of-the-art MOSEK interior-point solver, and they are expected to arrive at solutions more quickly when the number of samples is large and the number of mixture components is not too large.

Exact nearest-neighbour and radius-search routines that operate directly on bigmemory::big.matrix objects. The package streams row blocks through BLAS kernels, supports self-search and external-query search, exposes prepared references for repeated queries, and can build exact k-nearest-neighbour, radius, mutual k-nearest-neighbour, and shared-nearest-neighbour graphs. Version 0.3.0 adds execution plans, serializable prepared caches, resumable streamed graph jobs, coercion helpers, exact candidate reranking, and recall summaries for evaluating approximate neighbours.

This package provides classes and functions to work with biological sequences (DNA, RNA and amino acid sequences). Implements S3 infrastructure to work with biological sequences as described in Keck (2020) <doi:10.1111/2041-210X.13490>. Provides a collection of functions to perform biological conversion among classes (transcription, translation) and basic operations on sequences (detection, selection and replacement based on positions or patterns). The package also provides functions to import and export sequences from and to other package formats.

Working with reproducible reports or any other similar projects often require to run the script that builds the output file in a specified way. buildr can help you organize, modify and comfortably run those scripts. The package provides a set of functions that interactively guides you through the process and that are available as RStudio Addin, meaning you can set up the keyboard shortcuts, enabling you to choose and run the desired build script with one keystroke anywhere anytime.