Constraint-based causal discovery using the PC algorithm while accounting for a partial node ordering, for example a partial temporal ordering when the data were collected in different waves of a cohort study. Andrews RM, Foraita R, Didelez V, Witte J (2021) <arXiv:2108.13395> provide a guide how to use tpc to analyse cohort data.

This package provides functions for uniform sampling of the environmental space, designed to assist species distribution modellers in gathering ecologically relevant pseudo-absence data. The method ensures balanced representation of environmental conditions and helps reduce sampling bias in model calibration. Based on the framework described by Da Re et al. (2023) <doi:10.1111/2041-210X.14209>.

This is a package for regression modeling, testing, estimation, validation, graphics, prediction, and typesetting by storing enhanced model design attributes in the fit. The rms package is a collection of functions that assist with and streamline modeling. It also contains functions for binary and ordinal logistic regression models, ordinal models for continuous Y with a variety of distribution families, and the Buckley-James multiple regression model for right-censored responses, and implements penalized maximum likelihood estimation for logistic and ordinary linear models. The package works with almost any regression model, but it was especially written to work with binary or ordinal regression models, Cox regression, accelerated failure time models, ordinary linear models, the Buckley-James model, generalized least squares for serially or spatially correlated observations, generalized linear models, and quantile regression.

R/qtl is an extension library for the R statistics system. It is used to analyze experimental crosses for identifying genes contributing to variation in quantitative traits (so-called quantitative trait loci, QTLs).

Using a hidden Markov model, R/qtl estimates genetic maps, to identify genotyping errors, and to perform single-QTL and two-QTL, two-dimensional genome scans.

Ren'Py is a visual novel engine that helps you use words, images, and sounds to tell interactive stories that run on computers and mobile devices. These can be both visual novels and life simulation games. The easy to learn script language allows anyone to efficiently write large visual novels, while its Python scripting is enough for complex simulation games.

This package contains most of the popular internal and external cluster validation methods ready to use for the most of the outputs produced by functions coming from package "cluster". Package contains also functions and examples of usage for cluster stability approach that might be applied to algorithms implemented in "cluster" package as well as user defined clustering algorithms.

The FAS package implements the bootstrap method for the tuning parameter selection and tuning-free inference on sparse regression coefficient vectors. Currently, the test could be applied to linear and factor-augmented sparse regressions, see Lederer & Vogt (2021, JMLR) <https://www.jmlr.org/papers/volume22/20-539/20-539.pdf> and Beyhum & Striaukas (2023) <arXiv:2307.13364>.

Implemented are the Wald-type statistic, a permuted version thereof as well as the ANOVA-type statistic for general factorial designs, even with non-normal error terms and/or heteroscedastic variances, for crossed designs with an arbitrary number of factors and nested designs with up to three factors. Friedrich et al. (2017) <doi:10.18637/jss.v079.c01>.

Identifying latent genetic interactions in genome-wide association studies using the Latent Interaction Testing (LIT) framework. LIT is a flexible kernel-based approach that leverages information across multiple traits to detect latent genetic interactions without specifying or observing the interacting variable (e.g., environment). LIT accepts standard PLINK files as inputs to analyze large genome-wide association studies.

Primarily, the qcv package computes key indices related to the Quantifying Construct Validity procedure (QCV; Westen & Rosenthal, 2003 <doi:10.1037/0022-3514.84.3.608>; see also Furr & Heuckeroth, in press). The qcv() function is the heart of the qcv package, but additional functions in the package provide useful ancillary information related to the QCV procedure.

Convert a time series of observations to a time series of standardised indices that can be used to monitor variables on a common and probabilistically interpretable scale. The indices can be aggregated and rescaled to different time scales, visualised using plot capabilities, and calculated using a range of distributions. This includes flexible non-parametric and non-stationary methods.

This package provides functions for point and interval estimation in error-in-variables models via total least squares or generalized total least squares method. See Golub and Van Loan (1980) <doi:10.1137/0717073>, Gleser (1981) <https://www.jstor.org/stable/2240867>, Ivan Markovsky and Huffel (2007) <doi:10.1016/j.sigpro.2007.04.004> for more information.

This package provides a robust computational framework for analyzing complex multimodal data. Extends existing state-dependent models to account for diverse data streams, addressing challenges such as varying temporal scales and learner characteristics to improve the robustness and interpretability of findings. For methodological details, see Shaffer, Wang, and Ruis (2025) "Transmodal Analysis" <doi:10.18608/jla.2025.8423>.

Quickly create, run, and report structural equation models, and twin models. See ?umx for help, and umx_open_CRAN_page("umx") for NEWS. Timothy C. Bates, Michael C. Neale, Hermine H. Maes, (2019). umx: A library for Structural Equation and Twin Modelling in R. Twin Research and Human Genetics, 22, 27-41. <doi:10.1017/thg.2019.2>.

This package provides a flexible method for modeling cumulative effects of time-varying exposures, weighted according to their relative proximity in time, and represented by time-dependent covariates. The current implementation estimates the weight function in the Cox proportional hazards model. The function that assigns weights to doses taken in the past is estimated using cubic regression splines.

The Parallel Mixed Model (PMM) approach is suitable for hit selection and cross-comparison of RNAi screens generated in experiments that are performed in parallel under several conditions. For example, we could think of the measurements or readouts from cells under RNAi knock-down, which are infected with several pathogens or which are grown from different cell lines.

Assists in the whole process of designing and evaluating Randomized Control Trials. Robust treatment assignment by strata/blocks, that handles misfits; Power calculations of the minimum detectable treatment effect or minimum populations; Balance tables of T-test of covariates; Balance Regression: (treatment ~ all x variables) with F-test of null model; Impact_evaluation: Impact evaluation regressions. This function gives you the option to include control_vars, fixed effect variables, cluster variables (for robust SE), multiple endogenous variables and multiple heterogeneous variables (to test treatment effect heterogeneity) summary_statistics: Function that creates a summary statistics table with statistics rank observations in n groups: Creates a factor variable with n groups. Each group has a min and max label attach to each category. Athey, Susan, and Guido W. Imbens (2017) <arXiv:1607.00698>.

This package solves convex cone programs via operator splitting. It can solve: linear programs, second-order cone programs, semidefinite programs, exponential cone programs, and power cone programs, or problems with any combination of those cones. SCS uses AMD (a set of routines for permuting sparse matrices prior to factorization) and LDL (a sparse LDL factorization and solve package) from SuiteSparse.

This package implements a self-organizing map which has application in gene clustering. It provides functions like:

• filtering data by certain floor, ceiling, max/min ratio, and max - min difference;

• normalization of the data;

• get the average distortion measure;

• train a self-organizing map;

• summarize a som object;

• yeast cell cycle.

R is a language and environment for statistical computing and graphics. It provides a variety of statistical techniques, such as linear and nonlinear modeling, classical statistical tests, time-series analysis, classification and clustering. It also provides robust support for producing publication-quality data plots. A large amount of 3rd-party packages are available, greatly increasing its breadth and scope.

This package provides functions to specify and fit generalized nonlinear models, including models with multiplicative interaction terms such as the UNIDIFF model from sociology and the AMMI model from crop science, and many others. Over-parameterized representations of models are used throughout; functions are provided for inference on estimable parameter combinations, as well as standard methods for diagnostics etc.

Hierarchical community detection on networks by a recursive spectral partitioning strategy, which is shown to be effective and efficient in Li, Lei, Bhattacharyya, Sarkar, Bickel, and Levina (2018) <arXiv:1810.01509>. The package also includes a data generating function for a binary tree stochastic block model, a special case of stochastic block model that admits hierarchy between communities.

This package provides functions to estimate the probability to receive the observed treatment, based on individual characteristics. The inverse of these probabilities can be used as weights when estimating causal effects from observational data via marginal structural models. Both point treatment situations and longitudinal studies can be analysed. The same functions can be used to correct for informative censoring.

Designed for association studies in nested association mapping (NAM) panels, experimental and random panels. The method is described by Xavier et al. (2015) <doi:10.1093/bioinformatics/btv448>. It includes tools for genome-wide associations of multiple populations, marker quality control, population genetics analysis, genome-wide prediction, solving mixed models and finding variance components through likelihood and Bayesian methods.