Implement the Tariff algorithm for coding cause-of-death from verbal autopsies. The Tariff method was originally proposed in James et al (2011) <DOI:10.1186/1478-7954-9-31> and later refined as Tariff 2.0 in Serina, et al. (2015) <DOI:10.1186/s12916-015-0527-9>. Note that this package was not developed by authors affiliated with the Institute for Health Metrics and Evaluation and thus unintentional discrepancies may exist between the this implementation and the implementation available from IHME.

Fast algorithms for fitting Bayesian variable selection models and computing Bayes factors, in which the outcome (or response variable) is modeled using a linear regression or a logistic regression. The algorithms are based on the variational approximations described in "Scalable variational inference for Bayesian variable selection in regression, and its accuracy in genetic association studies" (P. Carbonetto & M. Stephens, 2012, <DOI:10.1214/12-BA703>). This software has been applied to large data sets with over a million variables and thousands of samples.

Traces information spread through interactions between features, utilising information theory measures and a higher-order generalisation of the concept of widest paths in graphs. In particular, vistla can be used to better understand the results of high-throughput biomedical experiments, by organising the effects of the investigated intervention in a tree-like hierarchy from direct to indirect ones, following the plausible information relay circuits. Due to its higher-order nature, vistla can handle multi-modality and assign multiple roles to a single feature.

Imports WhatsApp chat logs and parses them into a usable dataframe object. The parser works on chats exported from Android or iOS phones and on Linux, macOS and Windows. The parser has multiple options for extracting smileys and emojis from the messages, extracting URLs and domains from the messages, extracting names and types of sent media files from the messages, extracting timestamps from messages, extracting and anonymizing author names from messages. Can be used to create anonymized versions of data.

This package provides a general routine, envMU, which allows estimation of the M envelope of span(U) given root n consistent estimators of M and U. The routine envMU does not presume a model. This package implements response envelopes, partial response envelopes, envelopes in the predictor space, heteroscedastic envelopes, simultaneous envelopes, scaled response envelopes, scaled envelopes in the predictor space, groupwise envelopes, weighted envelopes, envelopes in logistic regression, envelopes in Poisson regression envelopes in function-on-function linear regression, envelope-based Partial Partial Least Squares, envelopes with non-constant error covariance, envelopes with t-distributed errors, reduced rank envelopes and reduced rank envelopes with non-constant error covariance. For each of these model-based routines the package provides inference tools including bootstrap, cross validation, estimation and prediction, hypothesis testing on coefficients are included except for weighted envelopes. Tools for selection of dimension include AIC, BIC and likelihood ratio testing. Background is available at Cook, R. D., Forzani, L. and Su, Z. (2016) <doi:10.1016/j.jmva.2016.05.006>. Optimization is based on a clockwise coordinate descent algorithm.

Differential open reading frame (ORF) translation analysis framework for ribosome profiling (Ribo-seq) with matched RNA-seq. Implements (i) Differential ORF Usage (DOU), a beta-binomial generalized linear model that models the expected proportion of Ribo-seq versus RNA-seq reads mapping to each ORF within a gene, and (ii) ORF-level Differential Translation Efficiency (DTE), a negative binomial GLM that capture changes in translation efficiency of individual ORFs across experimental conditions. Supports ORF-level read summarization for bulk and single-cell Ribo-seq.

MesKit provides commonly used analysis and visualization modules based on mutational data generated by multi-region sequencing (MRS). This package allows to depict mutational profiles, measure heterogeneity within or between tumors from the same patient, track evolutionary dynamics, as well as characterize mutational patterns on different levels. Shiny application was also developed for a need of GUI-based analysis. As a handy tool, MesKit can facilitate the interpretation of tumor heterogeneity and the understanding of evolutionary relationship between regions in MRS study.

This package provides an association test that is capable of dealing with very rare and even private variants. This is accomplished by a kernel-based approach that takes the positions of the variants into account. The test can be used for pre-processed matrix data, but also directly for variant data stored in VCF files. Association testing can be performed whole-genome, whole-exome, or restricted to pre-defined regions of interest. The test is complemented by tools for analyzing and visualizing the results.

Vulcan (VirtUaL ChIP-Seq Analysis through Networks) is a package that interrogates gene regulatory networks to infer cofactors significantly enriched in a differential binding signature coming from ChIP-Seq data. In order to do so, our package combines strategies from different BioConductor packages: DESeq for data normalization, ChIPpeakAnno and DiffBind for annotation and definition of ChIP-Seq genomic peaks, csaw to define optimal peak width and viper for applying a regulatory network over a differential binding signature.

Laplace approximations and penalized B-splines are combined for fast Bayesian inference in latent Gaussian models. The routines can be used to fit survival models, especially proportional hazards and promotion time cure models (Gressani, O. and Lambert, P. (2018) <doi:10.1016/j.csda.2018.02.007>). The Laplace-P-spline methodology can also be implemented for inference in (generalized) additive models (Gressani, O. and Lambert, P. (2021) <doi:10.1016/j.csda.2020.107088>). See the associated website for more information and examples.

Consider an at-most-K-stage group sequential design with only an upper bound for the last analysis and non-binding lower bounds.With binary endpoint, two kinds of test can be applied, asymptotic test based on normal distribution and exact test based on binomial distribution. This package supports the computation of boundaries and conditional power for single-arm group sequential test with binary endpoint, via either asymptotic or exact test. The package also provides functions to obtain boundary crossing probabilities given the design.

This package provides high-performance R bindings for ONNX Runtime <https://onnxruntime.ai/>, enabling efficient machine learning model inference. Written in Rust for memory safety and speed, the package supports cross-platform model execution with multiple execution providers. Includes comprehensive error handling and validation, with bundled MNIST example model for immediate testing and prototyping. Designed for production use with support for macOS (arm64), Linux (x64/arm64), and Windows (x64). Runtime libraries are downloaded on explicit request from <https://github.com/microsoft/onnxruntime/releases>.

Makes univariate, multivariate, or random fields simulations precise and simple. Just select the desired time series or random fieldsâ properties and it will do the rest. CoSMoS is based on the framework described in Papalexiou (2018, <doi:10.1016/j.advwatres.2018.02.013>), extended for random fields in Papalexiou and Serinaldi (2020, <doi:10.1029/2019WR026331>), and further advanced in Papalexiou et al. (2021, <doi:10.1029/2020WR029466>) to allow fine-scale space-time simulation of storms (or even cyclone-mimicking fields).

This package provides a set of functions for inferring, visualizing, and analyzing B cell phylogenetic trees. Provides methods to 1) reconstruct unmutated ancestral sequences, 2) build B cell phylogenetic trees using multiple methods, 3) visualize trees with metadata at the tips, 4) reconstruct intermediate sequences, 5) detect biased ancestor-descendant relationships among metadata types Workflow examples available at documentation site (see URL). Citations: Hoehn et al (2022) <doi:10.1371/journal.pcbi.1009885>, Hoehn et al (2021) <doi:10.1101/2021.01.06.425648>.

This package provides a wrapper on top of the Domino Command-Line Client'. It lets you run Domino commands (e.g., "run", "upload", "download") directly from your R environment. Under the hood, it uses R's system function to run the Domino executable, which must be installed as a prerequisite. Domino is a service that makes it easy to run your code on scalable hardware, with integrated version control and collaboration features designed for analytical workflows (see <http://www.dominodatalab.com> for more information).

Differential geometric least angle regression method for fitting sparse generalized linear models. In this version of the package, the user can fit models specifying Gaussian, Poisson, Binomial, Gamma and Inverse Gaussian family. Furthermore, several link functions can be used to model the relationship between the conditional expected value of the response variable and the linear predictor. The solution curve can be computed using an efficient predictor-corrector or a cyclic coordinate descent algorithm, as described in the paper linked to via the URL below.

This package provides a source-traceable computational implementation of the ERBio method for occupational biological risk assessment. It provides deterministic risk calculation, versioned questionnaires, a scientifically audited regulatory biological-agent registry, workplace-level assessment, preventive planning outputs, bilingual Spanish-English functionality and reproducible reports. The software preserves a single language-neutral calculation core and keeps method-faithful components distinct from explicit computational extensions. The underlying ERBio method was developed by Aguilar-Elena and is described in Aguilar-Elena (2015) <doi:10.5281/zenodo.22107465>.

Detects classical candlestick patterns and structure-based chart patterns from open, high, low, close, and volume (OHLCV) time series and provides reusable stock-screening workflows. Built-in detectors include single- and multi-candle patterns, trend structures such as double bottoms and ascending triangles, and a configurable "golden pit" recovery setup. Includes a unified API to run pattern scans across one or many symbols. Methods are informed by Nison (2001, ISBN:9780735201811) "Japanese Candlestick Charting Techniques" and Bulkowski (2021, ISBN:9781119739685) "Encyclopedia of Chart Patterns".

This package provides pipe-style interface for data.table'. Package preserves all data.table features without significant impact on performance. let and take functions are simplified interfaces for most common data manipulation tasks. For example, you can write take(mtcars, mean(mpg), by = am) for aggregation or let(mtcars, hp_wt = hp/wt, hp_wt_mpg = hp_wt/mpg) for modification. Use take_if/let_if for conditional aggregation/modification. Additionally there are some conveniences such as automatic data.frame conversion to data.table'.

This package provides methods for constructing and maintaining a database of presentations in R. The presentations are either ones that the user gives or gave or presentations at a particular event or event series. The package also provides a plot method for the interactive mapping of the presentations using leaflet by grouping them according to country, city, year and other presentation attributes. The markers on the map come with popups providing presentation details (title, institution, event, links to materials and events, and so on).

Computes the probability of a set of species abundances of a single or multiple samples of individuals with one or more guilds under a mainland-island model. One must specify the mainland (metacommunity) model and the island (local) community model. It assumes that species fluctuate independently. The package also contains functions to simulate under this model. See Haegeman, B. & R.S. Etienne (2017). A general sampling formula for community structure data. Methods in Ecology & Evolution 8: 1506-1519 <doi:10.1111/2041-210X.12807>.

Generates cell-level cytokine activity estimates using relevant information from gene sets constructed with the CytoSig and the Reactome databases and scored using the modified Variance-adjusted Mahalanobis (VAM) framework for single-cell RNA-sequencing (scRNA-seq) data. CytoSig database is described in: Jiang at al., (2021) <doi:10.1038/s41592-021-01274-5>. Reactome database is described in: Gillespie et al., (2021) <doi:10.1093/nar/gkab1028>. The VAM method is outlined in: Frost (2020) <doi:10.1093/nar/gkaa582>.

This package provides tools for processing and evaluating seasonal weather forecasts, with an emphasis on tercile forecasts. We follow the World Meteorological Organization's "Guidance on Verification of Operational Seasonal Climate Forecasts", S.J.Mason (2018, ISBN: 978-92-63-11220-0, URL: <https://library.wmo.int/idurl/4/56227>). The development was supported by the European Unionâ s Horizon 2020 research and innovation programme under grant agreement no. 869730 (CONFER). A comprehensive online tutorial is available at <https://seasonalforecastingengine.github.io/SeaValDoc/>.

Establishes and maintains vertex pool topology for geometry handled by wk'. Segments are the atomic unit, vertices are shared via integer references into a pool. Topology is made discoverable via coincident vertex detection while not requiring modification of the input data. Topological data models follow principles described in Worboys and Duckham (2004, ISBN:978-0415283755). The edge-based topology geometry decomposed into vertices and directed edge pairs is a simplification of the quad-edge case in Guibas & Stolfi (1985) <doi:10.1145/282918.282923>.