Computes Bayesian A- and D-optimal block designs under the linear mixed effects model settings using block/array exchange algorithm of Debusho, Gemechu and Haines (2018) <doi:10.1080/03610918.2018.1429617> and Gemechu, Debusho and Haines (2025) <doi:10.5539/ijsp.v14n1p50> where the interest is in a comparison of all possible elementary treatment contrasts. The package also provides an optional method of using the graphical user interface (GUI) R package tcltk to ensure that it is user friendly.

This package provides pathwise estimation of regularized logistic propensity score models using covariate balancing loss functions rather than maximum likelihood. Regularization paths are fit via the adelie elastic-net solver with a glmnet'-like interface, yielding balancing weights that target covariate balance for the ATE and ATT. Under lasso penalization, lambda bounds the maximum covariate imbalance, so the regularization path traces a sequence of decreasing imbalance tolerances. For details, see Sverdrup & Hastie (2026) <doi:10.48550/arXiv.2602.18577>.

Utility functions that help with common base-R problems relating to lists. Lists in base-R are very flexible. This package provides functions to quickly and easily characterize types of lists. That is, to identify if all elements in a list are null, data.frames, lists, or fully named lists. Other functionality is provided for the handling of lists, such as the easy splitting of lists into equally sized groups, and the unnesting of data.frames within fully named lists.

Core visualizations and summaries for the CRAN package database. The package provides comprehensive methods for cleaning up and organizing the information in the CRAN package database, for building package directives networks (depends, imports, suggests, enhances, linking to) and collaboration networks, producing package dependence trees, and for computing useful summaries and producing interactive visualizations from the resulting networks and summaries. The resulting networks can be coerced to igraph <https://CRAN.R-project.org/package=igraph> objects for further analyses and modelling.

Best subset selection in generalised linear models via continuous optimisation. Reformulates the NP-hard discrete subset selection problem as a continuous optimisation over the hypercube [0,1]^p, solved via a Frank-Wolfe homotopy algorithm with closed-form ridge inner solves. Supports linear (Gaussian), binary logistic, and multinomial regression. For methodological details see Moka, Liquet, Zhu and Muller (2024) <doi:10.1007/s11222-024-10387-8> and Mathur, Liquet, Muller and Moka (2026) <doi:10.48550/arXiv.2603.21952>.

Based on fishery Catch Dynamics instead of fish Population Dynamics (hence CatDyn) and using high-frequency or medium-frequency catch in biomass or numbers, fishing nominal effort, and mean fish body weight by time step, from one or two fishing fleets, estimate stock abundance, natural mortality rate, and fishing operational parameters. It includes methods for data organization, plotting standard exploratory and analytical plots, predictions, for 100 types of models of increasing complexity, and 72 likelihood models for the data.

Defines window or bin boundaries for the analysis of genomic data. Boundaries are based on the inflection points of a cubic smoothing spline fitted to the raw data. Along with defining boundaries, a technique to evaluate results obtained from unequally-sized windows is provided. Applications are particularly pertinent for, though not limited to, genome scans for selection based on variability between populations (e.g. using Wright's fixations index, Fst, which measures variability in subpopulations relative to the total population).

This package provides the standard operations for signal processing on graphs: graph Fourier transform, spectral graph wavelet transform, visualization tools. It also implements a data driven method for graph signal denoising/regression, for details see De Loynes, Navarro, Olivier (2021) <doi:10.1016/j.cam.2020.113319>. The package also provides an interface to the SuiteSparse Matrix Collection, <https://sparse.tamu.edu/>, a large and widely used set of sparse matrix benchmarks collected from a wide range of applications.

Perform two linear combination methods for biomarkers: (1) Empirical performance optimization for specificity (or sensitivity) at a controlled sensitivity (or specificity) level of Huang and Sanda (2022) <doi:10.1214/22-aos2210>, and (2) weighted maximum score estimator with empirical minimization of averaged false positive rate and false negative rate. Both adopt the algorithms of Huang and Sanda (2022) <doi:10.1214/22-aos2210>. MOSEK solver is used and needs to be installed; an academic license for MOSEK is free.

High dimensional longitudinal data analysis with Markov Chain Monte Carlo(MCMC). Currently support mixed effect regression with or without missing observations by considering covariance structures. It provides estimates by missing at random and missing not at random assumptions. In this R package, we present Bayesian approaches that statisticians and clinical researchers can easily use. The functions methodology is based on the book "Bayesian Approaches in Oncology Using R and OpenBUGS" by Bhattacharjee A (2020) <doi:10.1201/9780429329449-14>.

This package provides tools for the analysis of population differences using the Major Histocompatibility Complex (MHC) genotypes of samples having a variable number of alleles (1-4) recorded for each individual. A hierarchical Dirichlet-Multinomial model on the genotype counts is used to pool small samples from multiple populations for pairwise tests of equality. Bayesian inference is implemented via the rstan package. Bootstrapped and posterior p-values are provided for chi-squared and likelihood ratio tests of equal genotype probabilities.

Handling the microclimatic data in R. The myClim workflow begins at the reading data primary from microclimatic dataloggers, but can be also reading of meteorological station data from files. Cleaning time step, time zone settings and metadata collecting is the next step of the work flow. With myClim tools one can crop, join, downscale, and convert microclimatic data formats, sort them into localities, request descriptive characteristics and compute microclimatic variables. Handy plotting functions are provided with smart defaults.

NEON observational data are provided via the NEON Data Portal <https://www.neonscience.org> and NEON API, and can be downloaded and reformatted by the neonUtilities package. NEON observational data (human-observed measurements, and analyses derived from human-collected samples, such as tree diameters and algal chemistry) are published in a format consisting of one or more tabular data files. This package provides tools for performing common operations on NEON observational data, including checking for duplicates and joining tables.

This package provides a comprehensive set of indexes and tests for social segregation analysis, as described in Tivadar (2019) - OasisR': An R Package to Bring Some Order to the World of Segregation Measurement <doi:10.18637/jss.v089.i07>. The package is the most complete existing tool and it clarifies many ambiguities and errors regarding the definition of segregation indices. Additionally, OasisR introduces several resampling methods that enable testing their statistical significance (randomization tests, bootstrapping, and jackknife methods).

We provide an R interface to OpenML.org which is an online machine learning platform where researchers can access open data, download and upload data sets, share their machine learning tasks and experiments and organize them online to work and collaborate with other researchers. The R interface allows to query for data sets with specific properties, and allows the downloading and uploading of data sets, tasks, flows and runs. See <https://www.openml.org/guide/api> for more information.

This package provides functions to Simultaneously Infer Causal Graphs and Genetic Architecture. Includes acyclic and cyclic graphs for data from an experimental cross with a modest number (<10) of phenotypes driven by a few genetic loci (QTL). Chaibub Neto E, Keller MP, Attie AD, Yandell BS (2010) Causal Graphical Models in Systems Genetics: a unified framework for joint inference of causal network and genetic architecture for correlated phenotypes. Annals of Applied Statistics 4: 320-339. <doi:10.1214/09-AOAS288>.

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

Calculates the slope (longitudinal gradient or steepness) of linear geographic features such as roads (for more details, see Ariza-López et al. (2019) <doi:10.1038/s41597-019-0147-x>) and rivers (for more details, see Cohen et al. (2018) <doi:10.1016/j.jhydrol.2018.06.066>). It can use local Digital Elevation Model (DEM) data or download DEM data via the ceramic package. The package also provides functions to add elevation data to linestrings and visualize elevation profiles.

This package provides functions for estimation (parametric, semi-parametric and non-parametric) of copula-based dependence coefficients between a finite collection of random vectors, including phi-dependence measures and Bures-Wasserstein dependence measures. An algorithm for agglomerative hierarchical variable clustering is also implemented. Following the articles De Keyser & Gijbels (2024) <doi:10.1016/j.jmva.2024.105336>, De Keyser & Gijbels (2024) <doi:10.1016/j.ijar.2023.109090>, and De Keyser & Gijbels (2024) <doi:10.48550/arXiv.2404.07141>.

This package provides a single-function pipeline for automated collapsing and visualization of large phylogenetic trees with geological timescales. Automatically parses taxonomic labels from multiple formats (GTDB, Silva, NCBI, embedded, custom), identifies Most Recent Common Ancestors (MRCAs), assigns color-blind-safe palettes, executes batch collapsing with automatic nesting-aware ordering, integrates deeptime geologic time scales with adaptive time breaks and unit switching, and manages smart legend layout. Supports special ancestral node identifiers (LUCA, LACA, LBCA) for highlighting key nodes in the tree of life. Provides external taxonomy file support for trees with incomplete or missing taxonomic labels. Features real-time logging with timestamps, step tracking, and multiple log levels. Includes comprehensive input validation for tree and sequence file formats. Reduces a 60-line manual workflow to a single function call while preserving full compatibility with the ggtree'/'deeptime ecosystem. The visualization pipeline builds on ggtree Yu et al. (2017) <doi:10.1111/2041-210X.12628>, deeptime Gearty (2025) <doi:10.1080/20964471.2025.2537516>, and ape Paradis and Schliep (2019) <doi:10.1093/bioinformatics/bty633>.

This package provides gsubfn which is like gsub but can take a replacement function or certain other objects instead of the replacement string. Matches and back references are input to the replacement function and replaced by the function output. gsubfn can be used to split strings based on content rather than delimiters and for quasi-perl-style string interpolation. The package also has facilities for translating formulas to functions and allowing such formulas in function calls instead of functions.

The RISC-V Proxy Kernel, pk, is a lightweight application execution environment that can host statically-linked RISC-V ELF binaries. It is designed to support tethered RISC-V implementations with limited I/O capability and thus handles I/O-related system calls by proxying them to a host computer.

This package also contains the Berkeley Boot Loader, bbl, which is a supervisor execution environment for tethered RISC-V systems. It is designed to host the RISC-V Linux port.

Gene set analysis methods exist to combine SNP-level association p-values into gene sets, calculating a single association p-value for each gene set. This package implements two such methods that require only the calculated SNP p-values, the gene set(s) of interest, and a correlation matrix (if desired). One method (GLOSSI) requires independent SNPs and the other (VEGAS) can take into account correlation (LD) among the SNPs. Built-in plotting functions are available to help users visualize results.

nuCpos, a derivative of NuPoP, is an R package for prediction of nucleosome positions. nuCpos calculates local and whole nucleosomal histone binding affinity (HBA) scores for a given 147-bp sequence. Note: This package was designed to demonstrate the use of chemical maps in prediction. As the parental package NuPoP now provides chemical-map-based prediction, the function for dHMM-based prediction was removed from this package. nuCpos continues to provide functions for HBA calculation.