This software is meant to be used for classification of images of cell-based assays for neuronal surface autoantibody detection or similar techniques. It takes imaging files as input and creates a composite score from these, that for example can be used to classify samples as negative or positive for a certain antibody-specificity. The reason for its name is that I during its creation have thought about the individual picture as an archielago where we with different filters control the water level as well as ground characteristica, thereby finding islands of interest.

markeR is an R package that provides a modular and extensible framework for the systematic evaluation of gene sets as phenotypic markers using transcriptomic data. The package is designed to support both quantitative analyses and visual exploration of gene set behaviour across experimental and clinical phenotypes. It implements multiple methods, including score-based and enrichment approaches, and also allows the exploration of expression behaviour of individual genes. In addition, users can assess the similarity of their own gene sets against established collections (e.g., those from MSigDB), facilitating biological interpretation.

For studying recurrent disease and death with competing risks, comparisons based on the well-known cumulative incidence function can be confounded by different prevalence rates of the competing events. Alternatively, comparisons of the conditional distribution of the survival time given the failure event type are more relevant for investigating the prognosis of different patterns of recurrence disease. This package implements a nonparametric estimator for the conditional cumulative incidence function and a nonparametric conditional bivariate cumulative incidence function for the bivariate gap times proposed in Huang et al. (2016) <doi:10.1111/biom.12494>.

API Client for the Climate Hazards Center CHIRPS and CHIRTS'. The CHIRPS data is a quasi-global (50°S â 50°N) high-resolution (0.05 arc-degrees) rainfall data set, which incorporates satellite imagery and in-situ station data to create gridded rainfall time series for trend analysis and seasonal drought monitoring. CHIRTS is a quasi-global (60°S â 70°N), high-resolution data set of daily maximum and minimum temperatures. For more details on CHIRPS and CHIRTS data please visit its official home page <https://www.chc.ucsb.edu/data>.

DataSHIELD is an infrastructure and series of R packages that enables the remote and non-disclosive analysis of sensitive research data. This package is the DataSHIELD interface implementation for Opal', which is the data integration application for biobanks by OBiBa'. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. Opal is such a central repository. It can import, process, validate, query, analyze, report, and export data. Opal is the reference implementation of the DataSHIELD infrastructure.

This package implements the Generalized Method of Wavelet Moments with Exogenous Inputs estimator (GMWMX) presented in Voirol, L., Xu, H., Zhang, Y., Insolia, L., Molinari, R. and Guerrier, S. (2024) <doi:10.48550/arXiv.2409.05160>. The GMWMX estimator allows to estimate functional and stochastic parameters of linear models with correlated residuals in presence of missing data. The gmwmx2 package provides functions to load and plot Global Navigation Satellite System (GNSS) data from the Nevada Geodetic Laboratory and functions to estimate linear model model with correlated residuals in presence of missing data.

This package provides statistical methods to check if a parametric family of conditional density functions fits to some given dataset of covariates and response variables. Different test statistics can be used to determine the goodness-of-fit of the assumed model, see Andrews (1997) <doi:10.2307/2171880>, Bierens & Wang (2012) <doi:10.1017/S0266466611000168>, Dikta & Scheer (2021) <doi:10.1007/978-3-030-73480-0> and Kremling & Dikta (2024) <doi:10.48550/arXiv.2409.20262>. As proposed in these papers, the corresponding p-values are approximated using a parametric bootstrap method.

Optimized for handling complex datasets in environmental and ecological research, this package offers functionality that is not fully met by general-purpose packages. It provides two key functions, summarize_data()', which summarizes datasets, and plot_means()', which creates plots with error bars. The plot_means() function incorporates error bars by default, allowing quick visualization of uncertainties, crucial in ecological studies. It also streamlines workflows for grouped datasets (e.g., by species or treatment), making it particularly user-friendly and reducing the complexity and time required for data summarization and visualization.

The official Trends in International Mathematics and Science Study (TIMSS) 2023 website provides Teacher Context Data Files for Grade 4 in RData format. However, the available data are presented solely as numerical values. This package transforms the numerical data into categorical variables, enabling clearer interpretation and reducing ambiguity in statistical analysis. The category labels are provided in Bahasa Indonesia. This initiative contributes to promoting the use of Bahasa Indonesia in programming, in line with its designation as one of the official languages of the United Nations. For more details see <https://timss2023.org/>.

This package provides functions for sample size estimation and simulation in clinical trials. Includes methods for selecting the best group using the Indifference-zone approach, as well as designs for non-inferiority, equivalence, and negative binomial models. For the sample size calculation for non-inferiority of vaccines, the approach is based on Fleming, Powers, and Huang (2021) <doi:10.1177/1740774520988244>. The Indifference-zone approach is based on Sobel and Huyett (1957) <doi:10.1002/j.1538-7305.1957.tb02411.x> and Bechhofer, Santner, and Goldsman (1995, ISBN:978-0-471-57427-9).

The R implementation of TIGER. TIGER integrates random forest algorithm into an innovative ensemble learning architecture. Benefiting from this advanced architecture, TIGER is resilient to outliers, free from model tuning and less likely to be affected by specific hyperparameters. TIGER supports targeted and untargeted metabolomics data and is competent to perform both intra- and inter-batch technical variation removal. TIGER can also be used for cross-kit adjustment to ensure data obtained from different analytical assays can be effectively combined and compared. Reference: Han S. et al. (2022) <doi:10.1093/bib/bbab535>.

This package takes a list of p-values resulting from the simultaneous testing of many hypotheses and estimates their q-values and local false discovery rate (FDR) values. The q-value of a test measures the proportion of false positives incurred when that particular test is called significant. The local FDR measures the posterior probability the null hypothesis is true given the test's p-value. Various plots are automatically generated, allowing one to make sensible significance cut-offs. The software can be applied to problems in genomics, brain imaging, astrophysics, and data mining.

SEMPLR computes transcription factor binding affinity scores for genomic positions and genetic variants. Scores are computed from SNP Effect Matrices (SEMs) produced by SEMpl. 223 pre-computed SEMs are included with the package or custom sets can be provided. Enrichment can be tested among sets of genomic positions to determine if transcription factor binding events occur more often than expected. Comparing binding affinity scores between alleles can reveal differences in transcription factor binding with genetic variation. This package also includes several visualization functions to view scores both on the motif and variant/position level.

Fits hidden Markov models to time-ordered sequences of curves, such as sample paths of stochastic processes or smoothed functional observations, without projecting the curves onto a finite basis. The emission functions are Onsager-Machlup functionals of Gaussian measures on function spaces, which allows for Brownian motion with drift, fractional Brownian motion, Ornstein-Uhlenbeck processes and non-parametric state means under a choice of Cameron-Martin norm. The Baum-Welch and Viterbi algorithms are implemented in C. Methods are described in Kashlak, Loliencar and Heo (2023) <https://jmlr.org/papers/v24/22-0685.html>.

This package implements regression models for bounded continuous data in the open interval (0,1) using the five-parameter Generalized Kumaraswamy distribution. Supports modeling all distribution parameters (alpha, beta, gamma, delta, lambda) as functions of predictors through various link functions. Provides efficient maximum likelihood estimation via Template Model Builder ('TMB'), offering comprehensive diagnostics, model comparison tools, and simulation methods. Particularly useful for analyzing proportions, rates, indices, and other bounded response data with complex distributional features not adequately captured by simpler models. Methods are described in Lopes and Bonat (2026) <doi:10.21105/joss.08991>.

This package provides a collection of sampling formulas for the unified neutral model of biogeography and biodiversity. Alongside the sampling formulas, it includes methods to perform maximum likelihood optimization of the sampling formulas, methods to generate data given the neutral model, and methods to estimate the expected species abundance distribution. Sampling formulas included in the GUILDS package are the Etienne Sampling Formula (Etienne 2005), the guild sampling formula, where guilds are assumed to differ in dispersal ability (Janzen et al. 2015), and the guilds sampling formula conditioned on guild size (Janzen et al. 2015).

Estimation methods for phase-type distribution (PH) and Markovian arrival process (MAP) from empirical data (point and grouped data) and density function. The tool is based on the following researches: Okamura et al. (2009) <doi:10.1109/TNET.2008.2008750>, Okamura and Dohi (2009) <doi:10.1109/QEST.2009.28>, Okamura et al. (2011) <doi:10.1016/j.peva.2011.04.001>, Okamura et al. (2013) <doi:10.1002/asmb.1919>, Horvath and Okamura (2013) <doi:10.1007/978-3-642-40725-3_10>, Okamura and Dohi (2016) <doi:10.15807/jorsj.59.72>.

This package implements a model-based clustering method for categorical life-course sequences relying on mixtures of exponential-distance models introduced by Murphy et al. (2021) <doi:10.1111/rssa.12712>. A range of flexible precision parameter settings corresponding to weighted generalisations of the Hamming distance metric are considered, along with the potential inclusion of a noise component. Gating covariates can be supplied in order to relate sequences to baseline characteristics and sampling weights are also accommodated. The models are fitted using the EM algorithm and tools for visualising the results are also provided.

Calculates D-, Ds-, A-, I- and L-optimal designs, weighted combinations of these via a Compound criterion, and KL-optimal designs for model discrimination, for non-linear single- and multi-factor models, via an implementation of the cocktail algorithm (Yu, 2011, <doi:10.1007/s11222-010-9183-2>). Multi-factor models use design variables x1, x2, â ¦ with a named-list design space; single-factor models remain backward compatible. Compares designs via their efficiency, augments any design with a controlled efficiency loss, and provides efficient rounding functions to convert approximate designs to exact ones.

This package provides generalized linear models for panel data, including pooled, fixed-effects, and random-effects estimators for continuous, binary, and count outcomes. Offers a unified interface for fitting and analysing panel regression models, with efficient computation for large datasets. Estimators and tests follow standard panel-data references, including Hausman (1978) <doi:10.2307/1913827>, Chamberlain (1980) <doi:10.2307/2297110>, Allison and Waterman (2002) <doi:10.1111/1467-9531.00117>, and Croissant and Millo (2008) <doi:10.18637/jss.v027.i02>. Core numerical routines are implemented using Rcpp', RcppArmadillo', and RcppParallel'.

Resources, tutorials, and code snippets dedicated to exploring the intersection of quantum computing and artificial intelligence (AI) in the context of analyzing Cluster of Differentiation 4 (CD4) lymphocytes and optimizing antiretroviral therapy (ART) for human immunodeficiency virus (HIV). With the emergence of quantum artificial intelligence and the development of small-scale quantum computers, there's an unprecedented opportunity to revolutionize the understanding of HIV dynamics and treatment strategies. This project leverages a quantum computer simulator, to explore these applications in quantum computing techniques, addressing the challenges in studying CD4 lymphocytes and enhancing ART efficacy.

Automatically fetch, transform and arrange subsets of multidimensional data sets (collections of files) stored in local and/or remote file systems or servers, using multicore capabilities where possible. This tool provides an interface to perceive a collection of data sets as a single large multidimensional data array, and enables the user to request for automatic retrieval, processing and arrangement of subsets of the large array. Wrapper functions to add support for custom file formats can be plugged in/out, making the tool suitable for any research field where large multidimensional data sets are involved.

This package provides a wrapper around Michel Scheffers's libassp (<https://libassp.sourceforge.net/>). The libassp (Advanced Speech Signal Processor) library aims at providing functionality for handling speech signal files in most common audio formats and for performing analyses common in phonetic science/speech science. This includes the calculation of formants, fundamental frequency, root mean square, auto correlation, a variety of spectral analyses, zero crossing rate, filtering etc. This wrapper provides R with a large subset of libassp's signal processing functions and provides them to the user in a (hopefully) user-friendly manner.

Facilitates the use of machine learning algorithms in classification and regression (including time series forecasting) tasks by presenting a short and coherent set of functions. Versions: 1.5.0 improved mparheuristic function (new hyperparameter heuristics); 1.4.9 / 1.4.8 improved help, several warning and error code fixes (more stable version, all examples run correctly); 1.4.7 - improved Importance function and examples, minor error fixes; 1.4.6 / 1.4.5 / 1.4.4 new automated machine learning (AutoML) and ensembles, via improved fit(), mining() and mparheuristic() functions, and new categorical preprocessing, via improved delevels() function; 1.4.3 new metrics (e.g., macro precision, explained variance), new "lssvm" model and improved mparheuristic() function; 1.4.2 new "NMAE" metric, "xgboost" and "cv.glmnet" models (16 classification and 18 regression models); 1.4.1 new tutorial and more robust version; 1.4 - new classification and regression models, with a total of 14 classification and 15 regression methods, including: Decision Trees, Neural Networks, Support Vector Machines, Random Forests, Bagging and Boosting; 1.3 and 1.3.1 - new classification and regression metrics; 1.2 - new input importance methods via improved Importance() function; 1.0 - first version.