This package provides a collection of functions and classes which serve as the foundation for packages such as PharmacoGx and RadioGx. It was created to abstract shared functionality to increase ease of maintainability and reduce code repetition in current and future Gx suite programs. Major features include a CoreSet class, from which RadioSet and PharmacoSet are derived, along with get and set methods for each respective slot. Additional functions related to fitting and plotting dose response curves, quantifying statistical correlation and calculating AUC or SF are included.

The DHARMa package uses a simulation-based approach to create readily interpretable scaled (quantile) residuals for fitted (generalized) linear mixed models. Moreover, externally created simulations, e.g. posterior predictive simulations from Bayesian software such as JAGS, STAN, or BUGS can be processed as well. The resulting residuals are standardized to values between 0 and 1 and can be interpreted as intuitively as residuals from a linear regression. The package also provides a number of plot and test functions for typical model misspecification problems, such as over/underdispersion, zero-inflation, and residual spatial, phylogenetic and temporal autocorrelation.

Have you ever index sorted cells in a 96 or 384-well plate and then sequenced using Sanger sequencing? If so, you probably had some struggles to either check the electropherogram of each cell sequenced manually, or when you tried to identify which cell was sorted where after sequencing the plate. Scifer was developed to solve this issue by performing basic quality control of Sanger sequences and merging flow cytometry data from probed single-cell sorted B cells with sequencing data. scifer can export summary tables, fasta files, electropherograms for visual inspection, and generate reports.

Maleknia et al. (2020) <doi:10.1101/2020.01.13.905448>. A novel pathway enrichment analysis package based on Bayesian network to investigate the topology features of the pathways. firstly, 187 kyoto encyclopedia of genes and genomes (KEGG) human non-metabolic pathways which their cycles were eliminated by biological approach, enter in analysis as Bayesian network structures. The constructed Bayesian network were optimized by the Least Absolute Shrinkage Selector Operator (lasso) and the parameters were learned based on gene expression data. Finally, the impacted pathways were enriched by Fisherâ s Exact Test on significant parameters.

Gibbs sampling for Bayesian spatial blind source separation (BSP-BSS). BSP-BSS is designed for spatially dependent signals in high dimensional and large-scale data, such as neuroimaging. The method assumes the expectation of the observed images as a linear mixture of multiple sparse and piece-wise smooth latent source signals, and constructs a Bayesian nonparametric prior by thresholding Gaussian processes. Details can be found in our paper: Wu, B., Guo, Y., & Kang, J. (2024). Bayesian spatial blind source separation via the thresholded gaussian process. Journal of the American Statistical Association, 119(545), 422-433.

Interface to the ComexStat API <https://comexstat.mdic.gov.br/> from the Brazilian Ministry of Development, Industry, Trade and Services (MDIC). Provides access to detailed export and import data, including general trade statistics (1997-present), city-level data, historical data (1989-1996), and auxiliary tables with product codes (NCM - Nomenclatura Comum do Mercosul, NBM - Nomenclatura Brasileira de Mercadorias, HS - Harmonized System), countries, economic classifications (CGCE - Classificacao por Grandes Categorias Economicas, SITC - Standard International Trade Classification, ISIC - International Standard Industrial Classification), and other categories. Uses only httr2 for HTTP requests and cli for console messages.

The Ditwah storm began impacting Sri Lanka on 25 November 2025. Ditwah provides a collection of tidy, well-structured datasets to support storm data management, monitoring, and early warning applications in Sri Lanka. The publicly available data were converted to tidy data format for easy analysis. The package processes weather data, flood data and situation report data (families affected, etc.). The package also includes functions for analyzing river level progression and load dashboard visualizations to enhance situational awareness. This is also developed for educational purposes to support learning in data wrangling, visualization, and disaster analytics.

Calculates 15 different goodness of fit criteria. These are; standard deviation ratio (SDR), coefficient of variation (CV), relative root mean square error (RRMSE), Pearson's correlation coefficients (PC), root mean square error (RMSE), performance index (PI), mean error (ME), global relative approximation error (RAE), mean relative approximation error (MRAE), mean absolute percentage error (MAPE), mean absolute deviation (MAD), coefficient of determination (R-squared), adjusted coefficient of determination (adjusted R-squared), Akaike's information criterion (AIC), corrected Akaike's information criterion (CAIC), Mean Square Error (MSE), Bayesian Information Criterion (BIC) and Normalized Mean Square Error (NMSE).

This package provides easy access to tidy education finance data using Bellwether's methodology to combine NCES F-33 Survey, Census Bureau Small Area Income Poverty Estimates (SAIPE), community data from the ACS 5-Year Estimates, the Comparable Wage Index for Teachers (CWIFT) from NCES EDGE, and school district land area from U.S. Census Bureau Gazetteer Files. The package simplifies downloading, caching, and filtering education finance data by year and state, enabling researchers and analysts to explore K-12 education funding patterns, revenue sources, expenditure categories, and demographic factors across U.S. school districts.

Functions, data sets and shiny apps for "Epidemics: Models and Data in R" by Ottar N. Bjornstad (ISBN 978-3-319-97487-3) <https://www.springer.com/gp/book/9783319974866>. The package contains functions to study the S(E)IR model, spatial and age-structured SIR models; time-series SIR and chain-binomial stochastic models; catalytic disease models; coupled map lattice models of spatial transmission and network models for social spread of infection. The package is also an advanced quantitative companion to the coursera Epidemics Massive Online Open Course <https://www.coursera.org/learn/epidemics>.

This package provides a toolbox to make it easy to analyze plant disease epidemics. It provides a common framework for plant disease intensity data recorded over time and/or space. Implemented statistical methods are currently mainly focused on spatial pattern analysis (e.g., aggregation indices, Taylor and binary power laws, distribution fitting, SADIE and mapcomp methods). See Laurence V. Madden, Gareth Hughes, Franck van den Bosch (2007) <doi:10.1094/9780890545058> for further information on these methods. Several data sets that were mainly published in plant disease epidemiology literature are also included in this package.

It provides functions to generate operating characteristics and to calculate Sequential Conditional Probability Ratio Tests(SCPRT) efficacy and futility boundary values along with sample/event size of Multi-Arm Multi-Stage(MAMS) trials for different outcomes. The package is based on Jianrong Wu, Yimei Li, Liang Zhu (2023) <doi:10.1002/sim.9682>, Jianrong Wu, Yimei Li (2023) "Group Sequential Multi-Arm Multi-Stage Survival Trial Design with Treatment Selection"(Manuscript accepted for publication) and Jianrong Wu, Yimei Li, Shengping Yang (2023) "Group Sequential Multi-Arm Multi-Stage Trial Design with Ordinal Endpoints"(In preparation).

This package provides a wrapper for querying WISKI databases via the KiWIS REST API. WISKI is an SQL relational database used for the collection and storage of water data developed by KISTERS and KiWIS is a REST service that provides access to WISKI databases via HTTP requests (<https://www.kisters.eu/water-weather-and-environment/>). Contains a list of default databases (called hubs') and also allows users to provide their own KiWIS URL. Supports the entire query process- from metadata to specific time series values. All data is returned as tidy tibbles.

Various efficient and robust bootstrap methods are implemented for linear models with least squares estimation. Functions within this package allow users to create bootstrap sampling distributions for model parameters, test hypotheses about parameters, and visualize the bootstrap sampling or null distributions. Methods implemented for linear models include the wild bootstrap by Wu (1986) <doi:10.1214/aos/1176350142>, the residual and paired bootstraps by Efron (1979, ISBN:978-1-4612-4380-9), the delete-1 jackknife by Quenouille (1956) <doi:10.2307/2332914>, and the Bayesian bootstrap by Rubin (1981) <doi:10.1214/aos/1176345338>.

Advanced forecasting algorithms for long-term energy demand at the national or regional level. The methodology is based on Grandón et al. (2024) <doi:10.1016/j.apenergy.2023.122249>; Zimmermann & Ziel (2024) <doi:10.1016/j.apenergy.2025.125444>. Real-time data, including power demand, weather conditions, and macroeconomic indicators, are provided through automated API integration with various institutions. The modular approach maintains transparency on the various model selection processes and encompasses the ability to be adapted to individual needs. oRaklE tries to help facilitating robust decision-making in energy management and planning.

Implementations of the quantile slice sampler of Heiner et al. (2024+, in preparation) as well as other popular slice samplers are provided. Helper functions for specifying pseudo-target distributions are included, both for diagnostics and for tuning the quantile slice sampler. Other implemented methods include the generalized elliptical slice sampler of Nishihara et al. (2014)<https://jmlr.org/papers/v15/nishihara14a.html

Uses simulation to create prediction intervals for post-policy outcomes in interrupted time series (ITS) designs, following Miratrix (2020) <arXiv:2002.05746>. This package provides methods for fitting ITS models with lagged outcomes and variables to account for temporal dependencies. It then conducts inference via simulation, simulating a set of plausible counterfactual post-policy series to compare to the observed post-policy series. This package also provides methods to visualize such data, and also to incorporate seasonality models and smoothing and aggregation/summarization. This work partially funded by Arnold Ventures in collaboration with MDRC.

This package provides functions for the integrated analysis of protein-protein interaction networks and the detection of functional modules. Different datasets can be integrated into the network by assigning p-values of statistical tests to the nodes of the network. E.g. p-values obtained from the differential expression of the genes from an Affymetrix array are assigned to the nodes of the network. By fitting a beta-uniform mixture model and calculating scores from the p-values, overall scores of network regions can be calculated and an integer linear programming algorithm identifies the maximum scoring subnetwork.

This package provides a fast reimplementation of several density-based algorithms of the DBSCAN family. It includes the clustering algorithms DBSCAN (density-based spatial clustering of applications with noise) and hierarchical DBSCAN (HDBSCAN), the ordering algorithm ordering points to identify the clustering structure (OPTICS), shared nearest neighbor clustering, and the outlier detection algorithms local outlier factor (LOF) and global-local outlier score from hierarchies (GLOSH). The implementations use the kd-tree data structure for faster k-nearest neighbor search. An R interface to fast kNN and fixed-radius NN search is also provided.

Many tools for data analysis are not available in R, but are present in public repositories like conda. The Herper package provides a comprehensive set of functions to interact with the conda package managament system. With Herper users can install, manage and run conda packages from the comfort of their R session. Herper also provides an ad-hoc approach to handling external system requirements for R packages. For people developing packages with python conda dependencies we recommend using basilisk (https://bioconductor.org/packages/release/bioc/html/basilisk.html) to internally support these system requirments pre-hoc.

Here we present Link-HD, an approach to integrate heterogeneous datasets, as a generalization of STATIS-ACT (“Structuration des Tableaux A Trois Indices de la Statistique–Analyse Conjointe de Tableaux”), a family of methods to join and compare information from multiple subspaces. However, STATIS-ACT has some drawbacks since it only allows continuous data and it is unable to establish relationships between samples and features. In order to tackle these constraints, we incorporate multiple distance options and a linear regression based Biplot model in order to stablish relationships between observations and variable and perform variable selection.

Covariance measure tests for conditional independence testing against conditional covariance and nonlinear conditional mean alternatives. The package implements versions of the generalised covariance measure test (Shah and Peters, 2020, <doi:10.1214/19-aos1857>) and projected covariance measure test (Lundborg et al., 2023, <doi:10.1214/24-AOS2447>). The tram-GCM test, for censored responses, is implemented including the Cox model and survival forests (Kook et al., 2024, <doi:10.1080/01621459.2024.2395588>). Application examples to variable significance testing and modality selection can be found in Kook and Lundborg (2024, <doi:10.1093/bib/bbae475>).

This package provides a collection of tools that support data diagnosis, exploration, and transformation. Data diagnostics provides information and visualization of missing values, outliers, and unique and negative values to help you understand the distribution and quality of your data. Data exploration provides information and visualization of the descriptive statistics of univariate variables, normality tests and outliers, correlation of two variables, and the relationship between the target variable and predictor. Data transformation supports binning for categorizing continuous variables, imputes missing values and outliers, and resolves skewness. And it creates automated reports that support these three tasks.

Conducts sensitivity analyses for unmeasured confounding, selection bias, and measurement error (individually or in combination; VanderWeele & Ding (2017) <doi:10.7326/M16-2607>; Smith & VanderWeele (2019) <doi:10.1097/EDE.0000000000001032>; VanderWeele & Li (2019) <doi:10.1093/aje/kwz133>; Smith, Mathur, & VanderWeele (2021) <doi:10.1097/EDE.0000000000001380>). Also conducts sensitivity analyses for unmeasured confounding in meta-analyses (Mathur & VanderWeele (2020a) <doi:10.1080/01621459.2018.1529598>; Mathur & VanderWeele (2020b) <doi:10.1097/EDE.0000000000001180>) and for additive measures of effect modification (Mathur et al., <doi:10.1093/ije/dyac073>).