DEsubs is a network-based systems biology package that extracts disease-perturbed subpathways within a pathway network as recorded by RNA-seq experiments. It contains an extensive and customizable framework covering a broad range of operation modes at all stages of the subpathway analysis, enabling a case-specific approach. The operation modes refer to the pathway network construction and processing, the subpathway extraction, visualization and enrichment analysis with regard to various biological and pharmacological features. Its capabilities render it a tool-guide for both the modeler and experimentalist for the identification of more robust systems-level biomarkers for complex diseases.

Implementing the Block Coordinate Ascent with One-Step Generalized Rosen (BCA1SG) algorithm on the semiparametric models for panel count data, interval-censored survival data, and degradation data. A comprehensive description of the BCA1SG algorithm can be found in Wang et al. (2020) <https://github.com/yudongstat/BCA1SG/blob/master/BCA1SG.pdf>. For details of the semiparametric models for panel count data, interval-censored survival data, and degradation data, please see Wellner and Zhang (2007) <doi:10.1214/009053607000000181>, Huang and Wellner (1997) <ISBN:978-0-387-94992-5>, and Wang and Xu (2010) <doi:10.1198/TECH.2009.08197>, respectively.

This package infers state-recorded gender categories from first names and dates of birth using historical datasets. By using these datasets instead of lists of male and female names, this package is able to more accurately infer the gender of a name, and it is able to report the probability that a name was male or female. GUIDELINES: This method must be used cautiously and responsibly. Please be sure to see the guidelines and warnings about usage in the README or the package documentation. See Blevins and Mullen (2015) <http://www.digitalhumanities.org/dhq/vol/9/3/000223/000223.html>.

This package provides regression for hierarchically ordered clinical outcomes via pairwise comparisons, using a covariate-adjusted Davidson (Bradley-Terry with ties) model with U-statistic sandwich standard errors. A hierarchy of outcomes (binary, ordinal, continuous, and time-to-event, with eligibility guards and tie margins) is defined; all pairs of subjects are scored lexicographically; and the resulting win / loss / tie data are analysed. Unadjusted win statistics (net benefit, win ratio, win odds), diagnostics, and a worked example based on outcomes after allogeneic stem cell transplant are also provided. The computational engine is written in C++ using Rcpp and RcppEigen'.

Error type I and Optimal critical values to test statistical hypothesis based on Neyman-Pearson Lemma and Likelihood ratio test based on random samples from several distributions. The families of distributions are Bernoulli, Exponential, Geometric, Inverse Normal, Normal, Gamma, Gumbel, Lognormal, Poisson, and Weibull. This package is an ideal resource to help with the teaching of Statistics. The main references for this package are Casella G. and Berger R. (2003,ISBN:0-534-24312-6 , "Statistical Inference. Second Edition", Duxbury Press) and Hogg, R., McKean, J., and Craig, A. (2019,ISBN:013468699, "Introduction to Mathematical Statistic. Eighth edition", Pearson).

Helps with the thoughtful saving, reading, and management of result files (using rds files). The core functions take a list of parameters that are used to generate a unique hash to save results under. Then, the same parameter list can be used to read those results back in. This is helpful to avoid clunky file naming when running a large number of simulations. Additionally, helper functions are available for compiling a flat file of parameters of saved results, monitoring result usage, and cleaning up unwanted or unused results. For more information, visit the indexr homepage <https://lharris421.github.io/indexr/>.

This package implements a methodology for the design and analysis of dose-response studies that combines aspects of multiple comparison procedures and modeling approaches (Bretz, Pinheiro and Branson, 2005, Biometrics 61, 738-748, <doi: 10.1111/j.1541-0420.2005.00344.x>). The package provides tools for the analysis of dose finding trials as well as a variety of tools necessary to plan a trial to be conducted with the MCP-Mod methodology. Please note: The MCPMod package will not be further developed, all future development of the MCP-Mod methodology will be done in the DoseFinding R-package.

Fits conditional naive Bayes survival models for right-censored outcomes using inverse-probability of censoring weighting. The package provides model fitting, prediction, resampling-based evaluation, cross-validation, hyper-parameter tuning, and permutation variable importance utilities for horizon-specific survival prediction. The model is the censored naive Bayes classifier of Wolfson et al. (2015) <doi:10.1002/sim.6526>, which combines the marginal Kaplan-Meier survivor function with horizon-specific class-conditional covariate densities and inverse-probability-of-censoring weights. Resampling evaluation uses the inverse-probability-of-censoring-weighted Brier score of Gerds and Schumacher (2006) <doi:10.1002/bimj.200610301>.

This package provides a novel method to implement cancer subtyping and subtype specific drug targets identification via non-negative matrix tri-factorization. To improve the interpretability, we introduce orthogonal constraint to the row coefficient matrix and column coefficient matrix. To meet the prior knowledge that each subtype should be strongly associated with few gene sets, we introduce sparsity constraint to the association sub-matrix. The average residue was introduced to evaluate the row and column cluster numbers. This is part of the work "Liver Cancer Analysis via Orthogonal Sparse Non-Negative Matrix Tri- Factorization" which will be submitted to BBRC.

This package provides functionality to fit a zero-inflated estimator for small area estimation. This estimator is a combines a linear mixed effects regression model and a logistic mixed effects regression model via a two-stage modeling approach. The estimator's mean squared error is estimated via a parametric bootstrap method. Chandra and others (2012, <doi:10.1080/03610918.2011.598991>) introduce and describe this estimator and mean squared error estimator. White and others (2024+, <doi:10.48550/arXiv.2402.03263>) describe the applicability of this estimator to estimation of forest attributes and further assess the estimator's properties.

This package performs turning point and inflection point tests for U-shaped and inverse U-shaped relationships in regression models. Implements the Sasabuchi (1980) test as extended by Lind and Mehlum (2010) with support for quadratic, cubic, log-quadratic, and inverse functional forms. Features include delta-method standard errors, Fieller confidence intervals, Simonsohn (2018) two-lines test, and parametric bootstrap. Designed for post-estimation analysis of linear models, panel models, and quantile regression. References: Lind and Mehlum (2010) <doi:10.1111/j.1468-0084.2009.00569.x>; Sasabuchi (1980); Fieller (1954) <doi:10.1111/j.2517-6161.1954.tb00159.x>.

This package provides a suite of utilities for working with the UK Biobank <https://www.ukbiobank.ac.uk/> Nuclear Magnetic Resonance spectroscopy (NMR) metabolomics data <https://biobank.ndph.ox.ac.uk/showcase/label.cgi?id=220>. Includes functions for extracting biomarkers from decoded UK Biobank field data, removing unwanted technical variation from biomarker concentrations, computing an extended set of lipid, fatty acid, and cholesterol fractions, and for re-deriving composite biomarkers and ratios after adjusting data for unwanted biological variation. For further details on methods see Ritchie SC et al. Sci Data (2023) <doi:10.1038/s41597-023-01949-y>.

This package implements a new RNA-Seq analysis method and integrates two modules: a basic model for pairwise comparison and a linear model for complex design. RNA-Seq quantifies gene expression with reads count, which usually consists of conditions (or treatments) and several replicates for each condition. This software infers differential expression directly by the counts difference between conditions. It assumes that the sum counts difference between conditions follow a negative binomial distribution. In addition, ABSSeq moderates the fold-changes by two steps: the expression level and gene-specific dispersion, that might facilitate the gene ranking by fold-change and visualization.

Geneset Ordinal Association Test Enrichment Analysis (GOATEA) provides a Shiny interface with interactive visualizations and utility functions for performing and exploring automated gene set enrichment analysis using the GOAT package. GOATEA is designed to support large-scale and user-friendly enrichment workflows across multiple gene lists and comparisons, with flexible plotting and output options. Visualizations pre-enrichment include interactive Volcano and UpSet (overlap) plots. Visualizations post-enrichment include interactive geneset dotplot, geneset treeplot, gene-effectsize heatmap, gene-geneset heatmap and STRING database of protein-protein-interactions network graph. GOAT reference: Frank Koopmans (2024) <doi:10.1038/s42003-024-06454-5>.

Defines and includes a set of class-based templates for developing and implementing data processing and analysis workflows, with a strong emphasis on statistics and machine learning. The templates can be used and where needed extended to wrap tools and methods from other packages into a common standardised structure to allow for effective and fast integration. Model objects can be combined into sequences, and sequences nested in iterators using overloaded operators to simplify and improve readability of the code. Ontology lookup has been integrated and implemented to provide standardised definitions for methods, inputs and outputs wrapped using the class-based templates.

Computed tomography (CT) imaging is a powerful tool for understanding the composition of sediment cores. This package streamlines and accelerates the analysis of CT data generated in the context of environmental science. Included are tools for processing raw DICOM images to characterize sediment composition (sand, peat, etc.). Root analyses are also enabled, including measures of external surface area and volumes for user-defined root size classes. For a detailed description of the application of computed tomography imaging for sediment characterization, see: Davey, E., C. Wigand, R. Johnson, K. Sundberg, J. Morris, and C. Roman. (2011) <DOI: 10.1890/10-2037.1>.

Implementations of the expected shortfall backtests of Bayer and Dimitriadis (2020) <doi:10.1093/jjfinec/nbaa013> as well as other well known backtests from the literature. Can be used to assess the correctness of forecasts of the expected shortfall risk measure which is e.g. used in the banking and finance industry for quantifying the market risk of investments. A special feature of the backtests of Bayer and Dimitriadis (2020) <doi:10.1093/jjfinec/nbaa013> is that they only require forecasts of the expected shortfall, which is in striking contrast to all other existing backtests, making them particularly attractive for practitioners.

The production of certified reference materials (CRMs) requires various statistical tests depending on the task and recorded data to ensure that reported values of CRMs are appropriate. Often these tests are performed according to the procedures described in ISO GUIDE 35:2017'. The eCerto package contains a Shiny app which provides functionality to load, process, report and backup data recorded during CRM production and facilitates following the recommended procedures. It is described in Lisec et al (2023) <doi:10.1007/s00216-023-05099-3> and can also be accessed online <https://apps.bam.de/shn00/eCerto/> without package installation.

Process automation of point cloud data derived from terrestrial-based technologies such as Terrestrial Laser Scanner (TLS) or Mobile Laser Scanner. FORTLS enables (i) detection of trees and estimation of tree-level attributes (e.g. diameters and heights), (ii) estimation of stand-level variables (e.g. density, basal area, mean and dominant height), (iii) computation of metrics related to important forest attributes estimated in Forest Inventories at stand-level, and (iv) optimization of plot design for combining TLS data and field measured data. Documentation about FORTLS is described in Molina-Valero et al. (2022, <doi:10.1016/j.envsoft.2022.105337>).

Cellular responses to perturbations are highly heterogeneous and depend largely on the initial state of cells. Connecting post-perturbation cells via cellular trajectories to untreated cells (e.g. by leveraging metabolic labeling information) enables exploitation of intercellular heterogeneity as a combined knock-down and overexpression screen to identify pathway modulators, termed Heterogeneity-seq (see Berg et al <doi:10.1101/2024.10.28.620481>). This package contains functions to generate cellular trajectories based on scSLAM-seq (single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labelling sequencing) time courses, functions to identify pathway modulators and to visualize the results.

Combine probabilistic forecasts using CRPS learning algorithms proposed in Berrisch, Ziel (2021) <doi:10.48550/arXiv.2102.00968> <doi:10.1016/j.jeconom.2021.11.008>. The package implements multiple online learning algorithms like Bernstein online aggregation; see Wintenberger (2014) <doi:10.48550/arXiv.1404.1356>. Quantile regression is also implemented for comparison purposes. Model parameters can be tuned automatically with respect to the loss of the forecast combination. Methods like predict(), update(), plot() and print() are available for convenience. This package utilizes the optim C++ library for numeric optimization <https://github.com/kthohr/optim>.

An R interface to the Open Data API of the Tribunal de Contas do Estado de Pernambuco (TCE-PE), the Court of Accounts of the State of Pernambuco, Brazil. Provides tidy, ready-to-use functions to query public data on revenues, expenditures, commitments, procurement, contracts, agreements, public works, legal processes, personnel and reference tables for all state and municipal government entities in Pernambuco. All results are returned as tibbles with column names converted to snake_case by default. Uses httr2 for HTTP requests and cli for user-friendly messages. See <https://sistemas.tcepe.tc.br/DadosAbertos/> for the API documentation.

This package provides a collection of functions useful in learning and practicing Item Response Theory (IRT), which can be combined into larger programs. It provides basic CTT analysis, a simple common interface to the estimation of item parameters in IRT models for binary responses with three different programs (ICL, BILOG-MG, and ltm), ability estimation (MLE, BME, EAP, WLE, plausible values), item and person fit statistics, scaling methods (MM, MS, Stocking-Lord, and the complete Hebaera method), and a rich array of parametric and non-parametric (kernel) plots. It estimates and plots Haberman's interaction model when all items are dichotomously scored.

Distributed Online Mean Tests is a powerful tool designed to efficiently process and analyze distributed datasets. It enables users to perform mean tests in an online, distributed manner, making it highly suitable for large-scale data analysis. By leveraging advanced computational techniques, Domean ensures robust and scalable solutions for statistical analysis, particularly in scenarios where data is dispersed across multiple nodes or sources. This package is ideal for researchers and practitioners working with high-dimensional data, providing a flexible and efficient framework for mean testing. The philosophy of Domean is described in Guo G.(2025) <doi:10.1016/j.physa.2024.130308>.