Calculates the amplification efficiency and curves from real-time quantitative PCR (Polymerase Chain Reaction) data. Estimates the relative expression from PCR data using the double delta CT and the standard curve methods Livak & Schmittgen (2001) <doi:10.1006/meth.2001.1262>. Tests for statistical significance using two-group tests and linear regression Yuan et al. (2006) <doi: 10.1186/1471-2105-7-85>.

This package creates an S4 class "SSM" and defines functions for fitting smooth supersaturated models, a polynomial model with spline-like behaviour. Functions are defined for the computation of Sobol indices for sensitivity analysis and plotting the main effects using FANOVA methods. It also implements the estimation of the SSM metamodel error using a GP model with a variety of defined correlation functions.

This package provides a framework to perform Non-negative Matrix Factorization (NMF). The package implements a set of already published algorithms and seeding methods, and provides a framework to test, develop and plug new or custom algorithms. Most of the built-in algorithms have been optimized in C++, and the main interface function provides an easy way of performing parallel computations on multicore machines.

This package provides the dyn class interfaces ts, irts, zoo and zooreg time series classes to lm, glm, loess, quantreg::rq, MASS::rlm, MCMCpack::MCMCregress(), quantreg::rq(), randomForest::randomForest() and other regression functions, allowing those functions to be used with time series including specifications that may contain lags, diffs and missing values.

Implementation of the web-based Practical Meta-Analysis Effect Size Calculator from David B. Wilson in R. Based on the input, the effect size can be returned as standardized mean difference, Cohen's f, Hedges' g, Pearson's r or Fisher's transformation z, odds ratio or log odds, or eta squared effect size.

Ragel compiles executable finite state machines from regular languages. Ragel targets C, C++, Obj-C, C#, D, Java, Go and Ruby. Ragel state machines can not only recognize byte sequences as regular expression machines do, but can also execute code at arbitrary points in the recognition of a regular language. Code embedding is done using inline operators that do not disrupt the regular language syntax.

s6-rc is a service manager for s6-based systems, i.e. a suite of programs that can start and stop services, both long-running daemons and one-time initialization scripts, in the proper order according to a dependency tree. It ensures that long-running daemons are supervised by the s6 infrastructure, and that one-time scripts are also run in a controlled environment.

This package provides a method for pattern discovery in weighted graphs as outlined in Thistlethwaite et al. (2021) <doi:10.1371/journal.pcbi.1008550>. Two use cases are achieved: 1) Given a weighted graph and a subset of its nodes, do the nodes show significant connectedness? 2) Given a weighted graph and two subsets of its nodes, are the subsets close neighbors or distant?

An interface to the Python InterpretML framework for fitting explainable boosting machines (EBMs); see Nori et al. (2019) <doi:10.48550/arXiv.1909.09223> for details. EBMs are a modern type of generalized additive model that use tree-based, cyclic gradient boosting with automatic interaction detection. They are often as accurate as state-of-the-art blackbox models while remaining completely interpretable.

The book "Semiparametric Regression with R" by J. Harezlak, D. Ruppert & M.P. Wand (2018, Springer; ISBN: 978-1-4939-8851-8) makes use of datasets and scripts to explain semiparametric regression concepts. Each of the book's scripts are contained in this package as well as datasets that are not within other R packages. Functions that aid semiparametric regression analysis are also included.

Higher-order latent trait theory (item response theory). We implement the generalized partial credit model with a second-order latent trait structure. Latent regression can be done on the second-order latent trait. For a pre-print of the methods, see, "Latent Regression in Higher-Order Item Response Theory with the R Package hlt" <https://mkleinsa.github.io/doc/hlt_proof_draft_brmic.pdf>.

Fit Gaussian Multinomial mixed-effects models for small area estimation: Model 1, with one random effect in each category of the response variable (Lopez-Vizcaino,E. et al., 2013) <doi:10.1177/1471082X13478873>; Model 2, introducing independent time effect; Model 3, introducing correlated time effect. mme calculates direct and parametric bootstrap MSE estimators (Lopez-Vizcaino,E et al., 2014) <doi:10.1111/rssa.12085>.

Processing Chlorophyll Fluorescence & P700 Absorbance data generated by WALZ hardware. Four models are provided for the regression of Pi curves, which can be compared with each other in order to select the most suitable model for the data set. Control plots ensure the successful verification of each regression. Bundled output of alpha, ETRmax, Ik etc. enables fast and reliable further processing of the data.

An extensive set of functions to perform Qualitative Comparative Analysis: crisp sets ('csQCA'), temporal ('tQCA'), multi-value ('mvQCA') and fuzzy sets ('fsQCA'), using a GUI - graphical user interface. QCA is a methodology that bridges the qualitative and quantitative divide in social science research. It uses a Boolean minimization algorithm, resulting in a minimal causal configuration associated with a given phenomenon.

The Simulation-based Sampling Protocol (SSP) is an R package designed to estimate sampling effort in studies of ecological communities. It is based on the concept of pseudo-multivariate standard error (MultSE) (Anderson & Santana-Garcon, 2015, <doi:10.1111/ele.12385>) and the simulation of ecological data. The theoretical background is described in Guerra-Castro et al. (2020, <doi:10.1111/ecog.05284>).

Transmission Ratio Distortion (TRD) is a genetic phenomenon where the two alleles from either parent are not transmitted to the offspring at the expected 1:1 ratio under Mendelian inheritance, leading to spurious signals in genetic association studies. Functions in this package are developed to account for this phenomenon using loglinear model and Transmission Disequilibrium Test (TDT). Some population information can also be calculated.

Empirical models for runoff, erosion, and phosphorus loss across a vegetated filter strip, given slope, soils, climate, and vegetation (Gall et al., 2018) <doi:10.1007/s00477-017-1505-x>. It also includes functions for deriving climate parameters from measured daily weather data, and for simulating rainfall. Models implemented include MUSLE (Williams, 1975) and APLE (Vadas et al., 2009 <doi:10.2134/jeq2008.0337>).

The base class VirtualArray is defined, which acts as a wrapper around lists allowing users to fold arbitrary sequential data into n-dimensional, R-style virtual arrays. The derived XArray class is defined to be used for homogeneous lists that contain a single class of objects. The RasterArray and SfArray classes enable the use of stacked spatial data instead of lists.

The msa package provides a unified R/Bioconductor interface to the multiple sequence alignment algorithms ClustalW, ClustalOmega, and Muscle. All three algorithms are integrated in the package, therefore, they do not depend on any external software tools and are available for all major platforms. The multiple sequence alignment algorithms are complemented by a function for pretty-printing multiple sequence alignments using the LaTeX package TeXshade.

This package implements latent Dirichlet allocation (LDA) and related models. This includes (but is not limited to) sLDA, corrLDA, and the mixed-membership stochastic blockmodel. Inference for all of these models is implemented via a fast collapsed Gibbs sampler written in C. Utility functions for reading/writing data typically used in topic models, as well as tools for examining posterior distributions are also included.

This package provides functions for fitting continuous-time Markov and hidden Markov multi-state models to longitudinal data. It was designed for processes observed at arbitrary times in continuous time (panel data) but some other observation schemes are supported. Both Markov transition rates and the hidden Markov output process can be modelled in terms of covariates, which may be constant or piecewise-constant in time.

This package provides a fast, lightweight, and vectorized base 64 engine to encode and decode character and raw vectors as well as files stored on disk. Common base 64 alphabets are supported out of the box including the standard, URL-safe, bcrypt, crypt, BinHex', and IMAP-modified UTF-7 alphabets. Custom engines can be created to support unique base 64 encoding and decoding needs.

Supervised learning using Boltzmann Bayes model inference, which extends naive Bayes model to include interactions. Enables classification of data into multiple response groups based on a large number of discrete predictors that can take factor values of heterogeneous levels. Either pseudo-likelihood or mean field inference can be used with L2 regularization, cross-validation, and prediction on new data. <doi:10.18637/jss.v101.i05>.

This package contains tools to build deep neural network with flexible users define loss function and probability models. Several applications included in this package are, 1) The (deepAFT) model, a deep neural network model for accelerated failure time (AFT) model for survival data. 2) The (deepGLM) model, a deep neural network model for generalized linear model (glm) for continuous, categorical and Poisson data.