This package provides tools for reading, parsing and visualizing simulation data stored in xvg'/'xpm file formats (commonly generated by GROMACS molecular dynamics software). Streamlines post-processing and analysis of molecular dynamics ('MD') simulation outputs, enabling efficient exploration of molecular stability and conformational changes. Supports import of trajectory metrics ('RMSD', energy, temperature) and creation of publication-ready visualizations through integration with ggplot2'.

Rygel is a home media solution (UPnP AV MediaServer and MediaRenderer) for GNOME that allows you to easily share audio, video, and pictures, and to control a media player on your home network.

Rygel achieves interoperability with other devices by trying to conform to the strict requirements of DLNA and by converting media on-the-fly to formats that client devices can handle.

It provides the density, distribution function, quantile function, random number generator, likelihood function, moments and Maximum Likelihood estimators for a given sample, all this for the three parameter Asymmetric Laplace Distribution defined in Koenker and Machado (1999). This is a special case of the skewed family of distributions available in Galarza et.al. (2017) <doi:10.1002/sta4.140> useful for quantile regression.

This package provides a tidy framework for automatic knowledge classification and visualization. Currently, the core functionality of the framework is mainly supported by modularity-based clustering (community detection) in keyword co-occurrence network, and focuses on co-word analysis of bibliometric research. However, the designed functions in akc are general, and could be extended to solve other tasks in text mining as well.

This package provides functions for computing the density and the log-likelihood function of closed-skew normal variates, and for generating random vectors sampled from this distribution. See Gonzalez-Farias, G., Dominguez-Molina, J., and Gupta, A. (2004). The closed skew normal distribution, Skew-elliptical distributions and their applications: a journey beyond normality, Chapman and Hall/CRC, Boca Raton, FL, pp. 25-42.

Splits data into Gaussian type clusters using the Cross-Entropy Clustering ('CEC') method. This method allows for the simultaneous use of various types of Gaussian mixture models, for performing the reduction of unnecessary clusters, and for discovering new clusters by splitting them. CEC is based on the work of Spurek, P. and Tabor, J. (2014) <doi:10.1016/j.patcog.2014.03.006>.

This package provides a flexible framework for calculating Elo ratings and resulting rankings of any two-team-per-matchup system (chess, sports leagues, Go', etc.). This implementation is capable of evaluating a variety of matchups, Elo rating updates, and win probabilities, all based on the basic Elo rating system. It also includes methods to benchmark performance, including logistic regression and Markov chain models.

Compute maximum likelihood estimators of parameters in a Gaussian factor model using the the matrix-free methodology described in Dai et al. (2020) <doi:10.1080/10618600.2019.1704296>. In contrast to the factanal() function from stats package, fad() can handle high-dimensional datasets where number of variables exceed the sample size and is also substantially faster than the EM algorithms.

This package implements the generalized integration model, which integrates individual-level data and summary statistics under a generalized linear model framework. It supports continuous and binary outcomes to be modeled by the linear and logistic regression models. For binary outcome, data can be sampled in prospective cohort studies or case-control studies. Described in Zhang et al. (2020)<doi:10.1093/biomet/asaa014>.

Implementation of Tyler, Critchley, Duembgen and Oja's (JRSS B, 2009, <doi:10.1111/j.1467-9868.2009.00706.x>) and Oja, Sirkia and Eriksson's (AJS, 2006, <https://www.ajs.or.at/index.php/ajs/article/view/vol35,%20no2%263%20-%207>) method of two different scatter matrices to obtain an invariant coordinate system or independent components, depending on the underlying assumptions.

This package provides methods and tools for model selection and multi-model inference (Burnham and Anderson (2002) <doi:10.1007/b97636>, among others). SUR (for parameter estimation), logit'/'probit (for binary classification), and VARMA (for time-series forecasting) are implemented. Evaluations are both in-sample and out-of-sample. It is designed to be efficient in terms of CPU usage and memory consumption.

Calculates the amplification efficiency and curves from real-time quantitative PCR (Polymerase Chain Reaction) data. Estimates the relative expression from PCR data using the double delta CT and the standard curve methods Livak & Schmittgen (2001) <doi:10.1006/meth.2001.1262>. Tests for statistical significance using two-group tests and linear regression Yuan et al. (2006) <doi: 10.1186/1471-2105-7-85>.

This package creates an S4 class "SSM" and defines functions for fitting smooth supersaturated models, a polynomial model with spline-like behaviour. Functions are defined for the computation of Sobol indices for sensitivity analysis and plotting the main effects using FANOVA methods. It also implements the estimation of the SSM metamodel error using a GP model with a variety of defined correlation functions.

TOP constructs a transferable model across gene expression platforms for prospective experiments. Such a transferable model can be trained to make predictions on independent validation data with an accuracy that is similar to a re-substituted model. The TOP procedure also has the flexibility to be adapted to suit the most common clinical response variables, including linear response, binomial and Cox PH models.

This package provides a framework to perform Non-negative Matrix Factorization (NMF). The package implements a set of already published algorithms and seeding methods, and provides a framework to test, develop and plug new or custom algorithms. Most of the built-in algorithms have been optimized in C++, and the main interface function provides an easy way of performing parallel computations on multicore machines.

Implementation of the web-based Practical Meta-Analysis Effect Size Calculator from David B. Wilson in R. Based on the input, the effect size can be returned as standardized mean difference, Cohen's f, Hedges' g, Pearson's r or Fisher's transformation z, odds ratio or log odds, or eta squared effect size.

This package provides the dyn class interfaces ts, irts, zoo and zooreg time series classes to lm, glm, loess, quantreg::rq, MASS::rlm, MCMCpack::MCMCregress(), quantreg::rq(), randomForest::randomForest() and other regression functions, allowing those functions to be used with time series including specifications that may contain lags, diffs and missing values.

Ragel compiles executable finite state machines from regular languages. Ragel targets C, C++, Obj-C, C#, D, Java, Go and Ruby. Ragel state machines can not only recognize byte sequences as regular expression machines do, but can also execute code at arbitrary points in the recognition of a regular language. Code embedding is done using inline operators that do not disrupt the regular language syntax.

s6-rc is a service manager for s6-based systems, i.e. a suite of programs that can start and stop services, both long-running daemons and one-time initialization scripts, in the proper order according to a dependency tree. It ensures that long-running daemons are supervised by the s6 infrastructure, and that one-time scripts are also run in a controlled environment.

This package provides a method for pattern discovery in weighted graphs as outlined in Thistlethwaite et al. (2021) <doi:10.1371/journal.pcbi.1008550>. Two use cases are achieved: 1) Given a weighted graph and a subset of its nodes, do the nodes show significant connectedness? 2) Given a weighted graph and two subsets of its nodes, are the subsets close neighbors or distant?

An interface to the Python InterpretML framework for fitting explainable boosting machines (EBMs); see Nori et al. (2019) <doi:10.48550/arXiv.1909.09223> for details. EBMs are a modern type of generalized additive model that use tree-based, cyclic gradient boosting with automatic interaction detection. They are often as accurate as state-of-the-art blackbox models while remaining completely interpretable.

Higher-order latent trait theory (item response theory). We implement the generalized partial credit model with a second-order latent trait structure. Latent regression can be done on the second-order latent trait. For a pre-print of the methods, see, "Latent Regression in Higher-Order Item Response Theory with the R Package hlt" <https://mkleinsa.github.io/doc/hlt_proof_draft_brmic.pdf>.

The book "Semiparametric Regression with R" by J. Harezlak, D. Ruppert & M.P. Wand (2018, Springer; ISBN: 978-1-4939-8851-8) makes use of datasets and scripts to explain semiparametric regression concepts. Each of the book's scripts are contained in this package as well as datasets that are not within other R packages. Functions that aid semiparametric regression analysis are also included.

Fit Gaussian Multinomial mixed-effects models for small area estimation: Model 1, with one random effect in each category of the response variable (Lopez-Vizcaino,E. et al., 2013) <doi:10.1177/1471082X13478873>; Model 2, introducing independent time effect; Model 3, introducing correlated time effect. mme calculates direct and parametric bootstrap MSE estimators (Lopez-Vizcaino,E et al., 2014) <doi:10.1111/rssa.12085>.