Calculate the maximal fat oxidation, the exercise intensity that elicits the maximal fat oxidation and the SIN model to represent the fat oxidation kinetics. Three variables can be obtained from the SIN model: dilatation, symmetry and translation. Examples of these methods can be found in Montes de Oca et al (2021) <doi:10.1080/17461391.2020.1788650> and Chenevière et al. (2009) <doi:10.1249/MSS.0b013e31819e2f91>.

Simulation, estimation, prediction procedure, and model identification methods for nonlinear time series analysis, including threshold autoregressive models, Markov-switching models, convolutional functional autoregressive models, nonlinearity tests, Kalman filters and various sequential Monte Carlo methods. More examples and details about this package can be found in the book "Nonlinear Time Series Analysis" by Ruey S. Tsay and Rong Chen, John Wiley & Sons, 2018 (ISBN: 978-1-119-26407-1).

This package provides tools for performing Transition Network Analysis (TNA) to study relational dynamics, including functions for building and plotting TNA models, calculating centrality measures, and identifying dominant events and patterns. TNA statistical techniques (e.g., bootstrapping and permutation tests) ensure the reliability of observed insights and confirm that identified dynamics are meaningful. See (Saqr et al., 2025) <doi:10.1145/3706468.3706513> for more details on TNA.

This package implements various independence tests for discrete, continuous, and infinite-dimensional data. The tests are based on a U-statistic permutation test, the USP of Berrett, Kontoyiannis and Samworth (2020) <arXiv:2001.05513>, and shown to be minimax rate optimal in a wide range of settings. As the permutation principle is used, all tests have exact, non-asymptotic Type I error control at the nominal level.

Compute the standard expected years of life lost (YLL), as developed by the Global Burden of Disease Study (Murray, C.J., Lopez, A.D. and World Health Organization, 1996). The YLL is based on comparing the age of death to an external standard life expectancy curve. It also computes the average YLL, which highlights premature causes of death and brings attention to preventable deaths (Aragon et al., 2008).

With this tool, a user should be able to quickly implement complex random effect models through simple C++ templates. The package combines CppAD (C++ automatic differentiation), Eigen (templated matrix-vector library) and CHOLMOD (sparse matrix routines available from R) to obtain an efficient implementation of the applied Laplace approximation with exact derivatives. Key features are: Automatic sparseness detection, parallelism through BLAS and parallel user templates.

The compound growth rate indicates the percentage change of a specific variable over a defined period. It is calculated using non-linear models, particularly the exponential model. To estimate the compound growth rates, the growth model is first converted to semilog form and then analyzed using Ordinary Least Squares (OLS) regression. This package has been developed using concept of Shankar et al. (2022)<doi:10.3389/fsufs.2023.1208898>.

Builds on the EMD package to provide additional tools for empirical mode decomposition (EMD) and Hilbert spectral analysis. It also implements the ensemble empirical decomposition (EEMD) and the complete ensemble empirical mode decomposition (CEEMD) methods to avoid mode mixing and intermittency problems found in EMD analysis. The package comes with several plotting methods that can be used to view intrinsic mode functions, the HHT spectrum, and the Fourier spectrum.

Analyse, plot, and tabulate antimicrobial minimum inhibitory concentration (MIC) data. Validate the results of an MIC experiment by comparing observed MIC values to a gold standard assay, in line with standards from the International Organization for Standardization (2021) <https://www.iso.org/standard/79377.html>. Perform MIC prediction from whole genome sequence data stored in the Pathosystems Resource Integration Center (2013) <doi:10.1093/nar/gkt1099> database or locally.

Market area models are used to analyze and predict store choices and market areas concerning retail and service locations. This package implements two market area models (Huff Model, Multiplicative Competitive Interaction Model) into R, while the emphases lie on 1.) fitting these models based on empirical data via OLS regression and nonlinear techniques and 2.) data preparation and processing (esp. interaction matrices and data preparation for the MCI Model).

Multiscale Graph Correlation (MGC) is a framework developed by Vogelstein et al. (2019) <DOI:10.7554/eLife.41690> that extends global correlation procedures to be multiscale; consequently, MGC tests typically require far fewer samples than existing methods for a wide variety of dependence structures and dimensionalities, while maintaining computational efficiency. Moreover, MGC provides a simple and elegant multiscale characterization of the potentially complex latent geometry underlying the relationship.

The goal of pak is to make package installation faster and more reliable. In particular, it performs all HTTP operations in parallel, so metadata resolution and package downloads are fast. Metadata and package files are cached on the local disk as well. pak has a dependency solver, so it finds version conflicts before performing the installation. This version of pak supports CRAN, Bioconductor and GitHub packages as well.

Pathway analysis based on p-values associated to genes from a genes expression analysis of interest. Utility functions enable to extract pathways from the Gene Ontology Biological Process (GOBP), Molecular Function (GOMF) and Cellular Component (GOCC), Kyoto Encyclopedia of Genes of Genomes (KEGG) and Reactome databases. Methodology, and helper functions to display the results as a table, barplot of pathway significance, Gene Ontology graph and pathway significance are available.

The mzR package provides a unified API to the common file formats and parsers available for mass spectrometry data. It comes with a wrapper for the ISB random access parser for mass spectrometry mzXML, mzData and mzML files. The package contains the original code written by the ISB, and a subset of the proteowizard library for mzML and mzIdentML. The netCDF reading code has previously been used in XCMS.

Fitting, cross-validating, and predicting with Bayesian Knowledge Tracing (BKT) models. It is designed for analyzing educational datasets to trace student knowledge over time. The package includes functions for fitting BKT models, evaluating their performance using various metrics, and making predictions on new data. It provides the similar functionality as the Python package pyBKT authored by Zachary A. Pardos (zp@berkeley.edu) at <https://github.com/CAHLR/pyBKT>.

This package provides a client for retrieving data and metadata from major central bank APIs. It supports access to the Bundesbank SDMX Web Service API (<https://www.bundesbank.de/en/statistics/time-series-databases/help-for-sdmx-web-service/web-service-interface-data>), the Swiss National Bank Data Portal (<https://data.snb.ch/en>), and the European Central Bank Data Portal API (<https://data.ecb.europa.eu/help/api/overview>).

Developed as a collaboration between Earth lab and the North Central Climate Adaptation Science Center to help users gain insights from available climate data. Includes tools and instructions for downloading climate data via a USGS API and then organizing those data for visualization and analysis that drive insight. Web interface for USGS API can be found at <http://thredds.northwestknowledge.net:8080/thredds/reacch_climate_CMIP5_aggregated_macav2_catalog.html>.

Numerical integration of cause-specific survival curves to arrive at cause-specific cumulative incidence functions, with three usage modes: 1) Convenient API for parametric survival regression followed by competing-risk analysis, 2) API for CFC, accepting user-specified survival functions in R, and 3) Same as 2, but accepting survival functions in C++. For mathematical details and software tutorial, see Mahani and Sharabiani (2019) <DOI:10.18637/jss.v089.i09>.

Intensity-duration-frequency (IDF) curves are a widely used analysis-tool in hydrology to assess extreme values of precipitation [e.g. Mailhot et al., 2007, <doi:10.1016/j.jhydrol.2007.09.019>]. The package IDF provides functions to estimate IDF parameters for given precipitation time series on the basis of a duration-dependent generalized extreme value distribution [Koutsoyiannis et al., 1998, <doi:10.1016/S0022-1694(98)00097-3>].

Psychometric analysis and scoring of judgment data using polytomous Item-Response Theory (IRT) models, as described in Myszkowski and Storme (2019) <doi:10.1037/aca0000225> and Myszkowski (2021) <doi:10.1037/aca0000287>. A function is used to automatically compare and select models, as well as to present a variety of model-based statistics. Plotting functions are used to present category curves, as well as information, reliability and standard error functions.

Includes some procedures for latent variable modeling with a particular focus on multilevel data. The LAM package contains mean and covariance structure modelling for multivariate normally distributed data (mlnormal(); Longford, 1987; <doi:10.1093/biomet/74.4.817>), a general Metropolis-Hastings algorithm (amh(); Roberts & Rosenthal, 2001, <doi:10.1214/ss/1015346320>) and penalized maximum likelihood estimation (pmle(); Cole, Chu & Greenland, 2014; <doi:10.1093/aje/kwt245>).

Machine learning estimator specifically optimized for predictive modeling of ordered non-numeric outcomes. ocf provides forest-based estimation of the conditional choice probabilities and the covariatesâ marginal effects. Under an "honesty" condition, the estimates are consistent and asymptotically normal and standard errors can be obtained by leveraging the weight-based representation of the random forest predictions. Please reference the use as Di Francesco (2025) <doi:10.1080/07474938.2024.2429596>.

Derives prediction rule ensembles (PREs). Largely follows the procedure for deriving PREs as described in Friedman & Popescu (2008; <DOI:10.1214/07-AOAS148>), with adjustments and improvements. The main function pre() derives prediction rule ensembles consisting of rules and/or linear terms for continuous, binary, count, multinomial, and multivariate continuous responses. Function gpe() derives generalized prediction ensembles, consisting of rules, hinge and linear functions of the predictor variables.

An implementation of the Partition Of variation (POV) method as developed by Dr. Thomas A Little <https://thomasalittleconsulting.com> in 1993 for the analysis of semiconductor data for hard drive manufacturing. POV is based on sequential sum of squares and is an exact method that explains all observed variation. It quantitates both the between and within factor variation effects and can quantitate the influence of both continuous and categorical factors.