Non-parametric clustering of joint pattern multi-genetic/epigenetic factors. This package contains functions designed to cluster subjects based on gene features including single nucleotide polymorphisms (SNPs), DNA methylation (CPG), gene expression (GE), and covariate data. The novel concept follows the general K-means (Hartigan and Wong (1979) <doi:10.2307/2346830> framework but uses weighted Euclidean distances across the gene features to cluster subjects. This approach is unique in that it attempts to capture all pairwise interactions in an effort to cluster based on their complex biological interactions.

The Linear Programming via Regularized Least Squares (LPPinv) is a two-stage estimation method that reformulates linear programs as structured least-squares problems. Based on the Convex Least Squares Programming (CLSP) framework, LPPinv solves linear inequality, equality, and bound constraints by (1) constructing a canonical constraint system and computing a pseudoinverse projection, followed by (2) a convex-programming correction stage to refine the solution under additional regularization (e.g., Lasso, Ridge, or Elastic Net). LPPinv is intended for underdetermined and ill-posed linear problems, for which standard solvers fail.

Compute spatially explicit land-use metrics for stream survey sites in GRASS GIS and R as an open-source implementation of IDW-PLUS (Inverse Distance Weighted Percent Land Use for Streams). The package includes functions for preprocessing digital elevation and streams data, and one function to compute all the spatially explicit land use metrics described in Peterson et al. (2011) <doi:10.1111/j.1365-2427.2010.02507.x> and previously implemented by Peterson and Pearse (2017) <doi:10.1111/1752-1688.12558> in ArcGIS-Python as IDW-PLUS.

This package provides functions for handling data from Bioconductor Affymetrix annotation data packages. It produces compact HTML and text reports including experimental data and URL links to many online databases. It allows searching of biological metadata using various criteria.

This package implements a model of per-position sequencing bias in high-throughput sequencing data using a simple Bayesian network, the structure and parameters of which are trained on a set of aligned reads and a reference genome sequence.

This is a package providing efficient operations for single cell ATAC-seq fragments and RNA counts matrices. It is interoperable with standard file formats, and introduces efficient bit-packed formats that allow large storage savings and increased read speeds.

The main function biclust() provides several algorithms to find biclusters in two-dimensional data, spectral, plaid model, xmotifs, and bimax. In addition, the package provides methods for data preprocessing (normalization and discretization), visualization, and validation of bicluster solutions.

This package provides an implementation of multiscale bootstrap resampling for assessing the uncertainty in hierarchical cluster analysis. It provides an AU (approximately unbiased) P-value as well as a BP (bootstrap probability) value for each cluster in a dendrogram.

The goal of this package is to generate an attractive and useful website from a source package. pkgdown converts your documentation, vignettes, README file, and more to HTML making it easy to share information about your package online.

This package contains several basic utility functions including: moving (rolling, running) window statistic functions, read/write for GIF and ENVI binary files, fast calculation of AUC, LogitBoost classifier, base64 encoder/decoder, round-off-error-free sum and cumsum, etc.

This is an extension of the testthat package that lets you add parameters to your unit tests. Parameterized unit tests are often easier to read and more reliable, since they follow the DNRY (do not repeat yourself) rule.

This package provides statistical tools for Bayesian structure learning in undirected graphical models for continuous, discrete, and mixed data. It uses a trans-dimensional Markov Chain Monte Carlo (MCMC) approach based on a continuous-time birth-death process.

This package implements the Differential Evolution algorithm. This algorithm is used for the global optimization of a real-valued function of a real-valued parameter vector. The implementation of DifferentialEvolution in DEoptim interfaces with C code for efficiency.

This package interacts with a suite of web services for chemical information. Sources include: Alan Wood's Compendium of Pesticide Common Names, Chemical Identifier Resolver, ChEBI, Chemical Translation Service, ChemSpider, ETOX, Flavornet, NIST Chemistry WebBook, OPSIN, PubChem, SRS, Wikidata.

Functions to help implement the extraction / subsetting / indexing function [ and replacement function [<- of custom matrix-like types (based on S3, S4, etc.), modeled as closely to the base matrix class as possible (with tests to prove it).

Common techinical complications such as clogging can result in spurious events and fluorescence intensity shifting, flowCut is designed to detect and remove technical artifacts from your data by removing segments that show statistical differences from other segments.

Bedgraph files generated by Bisulfite pipelines often come in various flavors. Critical downstream step requires summarization of these files into methylation/coverage matrices. This step of data aggregation is done by Methrix, including many other useful downstream functions.

This package provides a client for cryptocurrency exchange BitMEX <https://www.bitmex.com/> including the ability to obtain historic trade data and place, edit and cancel orders. BitMEX's Testnet and live API are both supported.

Preprocessing tools and biodiversity measures (species abundance, species richness, population heterogeneity and sensitivity) for analysing marine benthic data. See Van Loon et al. (2015) <doi:10.1016/j.seares.2015.05.002> for an application of these tools.

Data sets of the Spanish National Forest Inventory <https://www.miteco.gob.es/es/biodiversidad/servicios/banco-datos-naturaleza/informacion-disponible.html> are processed to compute tree metrics and statistics. Function metrics2Vol() controls most of the routines.

Posterior distribution in the Black-Litterman model is computed from a prior distribution given in the form of a time series of asset returns and a continuous distribution of views provided by the user as an external function.

An investigative tool designed to help users visualize correlations between variables in their datasets. This package aims to provide an easy and effective way to explore and visualize these correlations, making it easier to interpret and communicate results.

Converts any word, sentence or speech into Trump's infamous "covfefe" format. Reference: <https://www.nytimes.com/2017/05/31/us/politics/covfefe-trump-twitter.html>. Inspiration thanks to: <https://codegolf.stackexchange.com/questions/123685/covfefify-a-string>.

This package provides a programmatic interface to the Chromosome Counts Database (<https://ccdb.tau.ac.il/>), Rice et al. (2014) <doi:10.1111/nph.13191>. This package is part of the ROpenSci suite (<https://ropensci.org>).