This package provides a collection of data structures that represent volumetric brain imaging data. The focus is on basic data handling for 3D and 4D neuroimaging data. In addition, there are function to read and write NIFTI files and limited support for reading AFNI files.

This package provides a general framework for the application of cross-validation schemes to particular functions. By allowing arbitrary lists of results, origami accommodates a range of cross-validation applications. This implementation was first described by Coyle and Hejazi (2018) <doi:10.21105/joss.00512>.

Format and submit few-shot prompts to OpenAI's Large Language Models (LLMs). Designed to be particularly useful for text classification problems in the social sciences. Methods are described in Ornstein, Blasingame, and Truscott (2024) <https://joeornstein.github.io/publications/ornstein-blasingame-truscott.pdf>.

We provide new tools for the identification of prognostic and predictive biomarkers. For further details we refer the reader to the paper: Zhu et al. Identification of prognostic and predictive biomarkers in high-dimensional data with PPLasso. BMC Bioinformatics. 2023 Jan 23;24(1):25.

Prism <https://prismjs.com/> is a lightweight, extensible syntax highlighter, built with modern web standards in mind. This package provides server-side rendering in R using V8 such that no JavaScript library is required in the resulting HTML documents. Over 400 languages are supported.

Streamline the creation of Docker images with R packages and dependencies embedded. The pracpac package provides a usethis'-like interface to creating Dockerfiles with dependencies managed by renv'. The pracpac functionality is described in Nagraj and Turner (2023) <doi:10.48550/arXiv.2303.07876>.

This package provides functions to measure Alpha and Beta Proximity to Irreplaceability. The methods for Alpha and Beta irreplaceability were first described in: Baisero D., Schuster R. & Plumptre A.J. Redefining and Mapping Global Irreplaceability. Conservation Biology 2021;1-11. <doi:10.1111/cobi.13806>.

Use R to interface with the Charles Schwab Trade API <https://developer.schwab.com/>. Functions include authentication, trading, price requests, account information, and option chains. A user will need a Schwab brokerage account and Schwab Individual Developer app. See README for authentication process and examples.

Simulation tools for closed-loop simulation are provided for the MSEtool operating model to inform data-rich fisheries. SAMtool provides a conditioning model, assessment models of varying complexity with standardized reporting, model-based management procedures, and diagnostic tools for evaluating assessments inside closed-loop simulation.

Fits univariate and multivariate spatio-temporal random effects models for point-referenced data using Markov chain Monte Carlo (MCMC). Details are given in Finley, Banerjee, and Gelfand (2015) <doi:10.18637/jss.v063.i13> and Finley and Banerjee <doi:10.1016/j.envsoft.2019.104608>.

Multiple flavors of the Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model with a large choice of conditional distributions. Methods for specification, estimation, prediction, filtering, simulation, statistical testing and more. Represents a partial re-write and re-think of rugarch', making use of automatic differentiation for estimation.

This package provides a visualization for characterizing subgroups defined by a decision tree structure. The visualization simplifies the ability to interpret individual pathways to subgroups; each sub-plot describes the distribution of observations within individual terminal nodes and percentile ranges for the associated inner nodes.

Handling of vegetation data from different sources ( Turboveg 2.0 <https://www.synbiosys.alterra.nl/turboveg/>; the German national repository <https://www.vegetweb.de> and others. Taxonomic harmonization (given appropriate taxonomic lists, e.g. the German taxonomic standard list "GermanSL", <https://germansl.infinitenature.org>).

The package offers four network inference statistical models using Dynamic Bayesian Networks and Gibbs Variable Selection: a linear interaction model, two linear interaction models with added experimental noise (Gaussian and Student distributed) for the case where replicates are available and a non-linear interaction model.

Topological pathway analysis tool able to integrate multi-omics data. It finds survival-associated modules or significant modules for two-class analysis. This tool have two main methods: pathway tests and module tests. The latter method allows the user to dig inside the pathways itself.

The package is unified implementation of MeSH.db, MeSH.AOR.db, and MeSH.PCR.db and also is interface to construct Gene-MeSH package (MeSH.XXX.eg.db). loadMeSHDbiPkg import sqlite file and generate MeSH.XXX.eg.db.

Azimuth utilizes an annotated reference dataset. It automates the processing, analysis, and interpretation. This applies specifically to new single-cell RNA-seq or ATAC-seq experiments. Azimuth leverages a reference-based mapping pipeline that inputs accounts matrix and performs normalization, visualization, cell annotation, and differential expression.

Similarity Network Fusion takes multiple views of a network and fuses them together to construct an overall status matrix. The input to our algorithm can be feature vectors, pairwise distances, or pairwise similarities. The learned status matrix can then be used for retrieval, clustering, and classification.

cl-ratify is a collection of utilities to perform validation checks and parsing. The main intention of usage for this is in web-applications in order to check form inputs for correctness and automatically parse them into their proper representations or return meaningful errors.

This package provides a method for performing joint registration and functional principal component analysis for curves (functional data) that are generated from exponential family distributions. This mainly implements the algorithms described in Wrobel et al. (2019) <doi:10.1111/biom.12963> and further adapts them to potentially incomplete curves where (some) curves are not observed from the beginning and/or until the end of the common domain. Curve registration can be used to better understand patterns in functional data by separating curves into phase and amplitude variability. This software handles both binary and continuous functional data, and is especially applicable in accelerometry and wearable technology.

This package implements popular methods for matching in time-varying observational studies. Matching is difficult in this scenario because participants can be treated at different times which may have an influence on the outcomes. The core methods include: "Balanced Risk Set Matching" from Li, Propert, and Rosenbaum (2011) <doi:10.1198/016214501753208573> and "Propensity Score Matching with Time-Dependent Covariates" from Lu (2005) <doi:10.1111/j.1541-0420.2005.00356.x>. Some functions use the Gurobi optimization back-end to improve the optimization problem speed; the gurobi R package and associated software can be downloaded from <https://www.gurobi.com> after obtaining a license.

The package is the R-version of the C-based software \boldCASPAR (Kaderali,2006: \urlhttp://bioinformatics.oxfordjournals.org/content/22/12/1495). It is meant to help predict survival times in the presence of high-dimensional explanatory covariates. The model is a piecewise baseline hazard Cox regression model with an Lq-norm based prior that selects for the most important regression coefficients, and in turn the most relevant covariates for survival analysis. It was primarily tried on gene expression and aCGH data, but can be used on any other type of high-dimensional data and in disciplines other than biology and medicine.

Perform one-dimensional spline regression with automatic knot selection. This package uses a penalized approach to select the most relevant knots. B-splines of any degree can be fitted. More details in Goepp et al. (2018)', "Spline Regression with Automatic Knot Selection", <arXiv:1808.01770>.

This package contains functions for evaluating, analyzing, and fitting combined action dose response surfaces with the Bivariate Response to Additive Interacting Doses (BRAID) model of combined action, along with tools for implementing other combination analysis methods, including Bliss independence, combination index, and additional response surface methods.