Multiple flavors of the Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model with a large choice of conditional distributions. Methods for specification, estimation, prediction, filtering, simulation, statistical testing and more. Represents a partial re-write and re-think of rugarch', making use of automatic differentiation for estimation.

This package provides a visualization for characterizing subgroups defined by a decision tree structure. The visualization simplifies the ability to interpret individual pathways to subgroups; each sub-plot describes the distribution of observations within individual terminal nodes and percentile ranges for the associated inner nodes.

cl-ratify is a collection of utilities to perform validation checks and parsing. The main intention of usage for this is in web-applications in order to check form inputs for correctness and automatically parse them into their proper representations or return meaningful errors.

A tool for the river Wayland compositor which implements the "back-and-forth" functionality for tag switching which is common in similar desktops. Trying to focus a tag will focus it, unless it is already focused in which case the previously focused tags are focused again.

The package is the R-version of the C-based software \boldCASPAR (Kaderali,2006: \urlhttp://bioinformatics.oxfordjournals.org/content/22/12/1495). It is meant to help predict survival times in the presence of high-dimensional explanatory covariates. The model is a piecewise baseline hazard Cox regression model with an Lq-norm based prior that selects for the most important regression coefficients, and in turn the most relevant covariates for survival analysis. It was primarily tried on gene expression and aCGH data, but can be used on any other type of high-dimensional data and in disciplines other than biology and medicine.

This package implements popular methods for matching in time-varying observational studies. Matching is difficult in this scenario because participants can be treated at different times which may have an influence on the outcomes. The core methods include: "Balanced Risk Set Matching" from Li, Propert, and Rosenbaum (2011) <doi:10.1198/016214501753208573> and "Propensity Score Matching with Time-Dependent Covariates" from Lu (2005) <doi:10.1111/j.1541-0420.2005.00356.x>. Some functions use the Gurobi optimization back-end to improve the optimization problem speed; the gurobi R package and associated software can be downloaded from <https://www.gurobi.com> after obtaining a license.

The two main functions in the package are pairwiseAlignment and stringDist. The former solves (Needleman-Wunsch) global alignment, (Smith-Waterman) local alignment, and (ends-free) overlap alignment problems. The latter computes the Levenshtein edit distance or pairwise alignment score matrix for a set of strings.

This package provides a set of restricted permutation designs for freely exchangeable, line transects (time series), spatial grid designs and permutation of blocks (groups of samples). permute also allows split-plot designs, in which the whole-plots or split-plots or both can be freely exchangeable.

This package provides computationally efficient tools related to the multivariate normal and Student's t distributions. The main functionalities are: simulating multivariate random vectors, evaluating multivariate normal or Student's t densities and Mahalanobis distances. These tools are developed using C++ code and of the OpenMP API.

This package provides an R implementation of the Octave package signal, containing a variety of signal processing tools, such as signal generation and measurement, correlation and convolution, filtering, filter design, filter analysis and conversion, power spectrum analysis, system identification, decimation and sample rate change, and windowing.

Software to combine flow cytometry data that has been multiplexed into multiple tubes with common markers between them, by establishing common bins across tubes in terms of the common markers, then determining expression within each tube for each bin in terms of the tube-specific markers.

This package defines a custom landing page for an iSEE app interfacing with the Bioconductor ExperimentHub. The landing page allows users to browse the ExperimentHub, select a data set, download and cache it, and import it directly into a Bioconductor iSEE app.

MOGAMUN is a multi-objective genetic algorithm that identifies active modules in a multiplex biological network. This allows analyzing different biological networks at the same time. MOGAMUN is based on NSGA-II (Non-Dominated Sorting Genetic Algorithm, version II), which we adapted to work on networks.

Test for univariate and bivariate spatial patterns in spatial omics data with single-molecule resolution. The tests implemented allow for analysis of nested designs and are automatically calibrated to different biological specimens. Tests for aggregation, colocalization, gradients and vicinity to cell edge or centroid are provided.

The package disseminates mass spectrometry (MS)-based single-cell proteomics (SCP) datasets. The data were collected from published work and formatted using the `scp` data structure. The data sets contain quantitative information at spectrum, peptide and/or protein level for single cells or minute sample amounts.

Perform one-dimensional spline regression with automatic knot selection. This package uses a penalized approach to select the most relevant knots. B-splines of any degree can be fitted. More details in Goepp et al. (2018)', "Spline Regression with Automatic Knot Selection", <arXiv:1808.01770>.

Calculates the prices of European options based on the universal solution provided by Bakshi, Cao and Chen (1997) <doi:10.1111/j.1540-6261.1997.tb02749.x>. This solution considers stochastic volatility, stochastic interest and random jumps. Please cite their work if this package is used.

This package contains functions for evaluating, analyzing, and fitting combined action dose response surfaces with the Bivariate Response to Additive Interacting Doses (BRAID) model of combined action, along with tools for implementing other combination analysis methods, including Bliss independence, combination index, and additional response surface methods.

Implementation of the ageâ periodâ cohort models for claim development presented in Pittarello G, Hiabu M, Villegas A (2025) â Replicating and Extending Chainâ Ladder via an Ageâ Periodâ Cohort Structure on the Claim Development in a Runâ Off Triangleâ <doi:10.1080/10920277.2025.2496725>.

Clustered covariate regression enables estimation and inference in both linear and non-linear models with linear predictor functions even when the design matrix is column rank deficient. Routines in this package implement algorithms in Soale and Tsyawo (2019) <doi:10.13140/RG.2.2.32355.81441>.

Evaluation of the Carlson elliptic integrals and the incomplete elliptic integrals with complex arguments. The implementations use Carlson's algorithms <doi:10.1007/BF02198293>. Applications of elliptic integrals include probability distributions, geometry, physics, mechanics, electrodynamics, statistical mechanics, astronomy, geodesy, geodesics on conics, and magnetic field calculations.

Process command line arguments, as part of a data analysis workflow. command makes it easier to construct a workflow consisting of lots of small, self-contained scripts, all run from a Makefile or shell script. The aim is a workflow that is modular, transparent, and reliable.

DAGs With Omitted Objects Displayed (DAGWOOD) is a framework to help reveal key hidden assumptions in a causal DAG. This package provides an implementation of the DAGWOOD algorithm. Further description can be found in Haber et al (2022) <DOI:10.1016/j.annepidem.2022.01.001>.

This package provides functionality to infer trajectories from single-cell data, represent them into a common format, and adapt them. Other biological information can also be added, such as cellular grouping, RNA velocity and annotation. Saelens et al. (2019) <doi:10.1038/s41587-019-0071-9>.