Calculate Krippendorff's alpha for multi-valued data using the methods introduced by Krippendorff and Craggs (2016) <doi:10.1080/19312458.2016.1228863>. Nominal, ordinal, interval, and ratio data types are supported, with options to create bootstrapped estimates of alpha and/or parallelize calculations.

Computationally efficient functions to provide direct likelihood-based inference for partially-observed multivariate birth-death processes. Such processes range from a simple Yule model to the complex susceptible-infectious-removed model in disease dynamics. Efficient likelihood evaluation facilitates maximum likelihood estimation and Bayesian inference.

Retrieve data from the Our World in Data (OWID) Chart API <https://docs.owid.io/projects/etl/api/>. OWID provides public access to more than 5,000 charts focusing on global problems such as poverty, disease, hunger, climate change, war, existential risks, and inequality.

This package provides tools for modelling populations and demography using matrix projection models, with deterministic and stochastic model implementations. Includes population projection, indices of short- and long-term population size and growth, perturbation analysis, convergence to stability or stationarity, and diagnostic and manipulation tools.

This package provides a system enables cross study Analysis by extracting and filtering study data for control animals from CDISC SEND Study Repository. These data types are supported: Body Weights, Laboratory test results and Microscopic findings. These database types are supported: SQLite and Oracle'.

It fits scale mixture of skew-normal linear mixed models using either an expectationâ maximization (EM) type algorithm or its accelerated version (Damped Anderson Acceleration with Epsilon Monotonicity, DAAREM), including some possibilities for modeling the within-subject dependence <doi:10.18637/jss.v115.i07>.

Generate simulated datasets from an initial underlying distribution and apply transformations to obtain realistic data. Implements the NORTA (Normal-to-anything) approach from Cario and Nelson (1997) and other data generating mechanisms. Simple network visualization tools are provided to facilitate communicating the simulation setup.

Easily create alerts, notifications, modals, info tips and loading screens in Shiny'. Includes several options to customize alerts and notifications by including text, icons, images and buttons. When wrapped around a Shiny output, loading screen is automatically displayed while the output is being recalculated.

Swift and seamless Single Sign-On (SSO) integration. Designed for effortless compatibility with popular Single Sign-On providers like Google and Microsoft, it streamlines authentication, enhancing both user experience and application security. Elevate your shiny applications for a simplified, unified, and secure authentication process.

This package implements an algorithm for variable selection in high-dimensional linear regression using the "tilted correlation", a new way of measuring the contribution of each variable to the response which takes into account high correlations among the variables in a data-driven way.

Decoupled (e.g. separate averages) and censored (e.g. > 100 species) variables are continually reported by many well-established organizations (e.g. World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), World Bank, and various national censuses). The challenge therefore is to infer what the original data could have been given summarized information. We present an R package that reverse engineers decoupled and/or censored count data with two main functions. The cnbinom.pars function estimates the average and dispersion parameter of a censored univariate frequency table. The rec function reverse engineers summarized data into an uncensored bivariate table of probabilities.

Azimuth utilizes an annotated reference dataset. It automates the processing, analysis, and interpretation. This applies specifically to new single-cell RNA-seq or ATAC-seq experiments. Azimuth leverages a reference-based mapping pipeline that inputs accounts matrix and performs normalization, visualization, cell annotation, and differential expression.

Similarity Network Fusion takes multiple views of a network and fuses them together to construct an overall status matrix. The input to our algorithm can be feature vectors, pairwise distances, or pairwise similarities. The learned status matrix can then be used for retrieval, clustering, and classification.

The package offers four network inference statistical models using Dynamic Bayesian Networks and Gibbs Variable Selection: a linear interaction model, two linear interaction models with added experimental noise (Gaussian and Student distributed) for the case where replicates are available and a non-linear interaction model.

The package is unified implementation of MeSH.db, MeSH.AOR.db, and MeSH.PCR.db and also is interface to construct Gene-MeSH package (MeSH.XXX.eg.db). loadMeSHDbiPkg import sqlite file and generate MeSH.XXX.eg.db.

Topological pathway analysis tool able to integrate multi-omics data. It finds survival-associated modules or significant modules for two-class analysis. This tool have two main methods: pathway tests and module tests. The latter method allows the user to dig inside the pathways itself.

Scafari is a Shiny application designed for the analysis of single-cell DNA sequencing (scDNA-seq) data provided in .h5 file format. The analysis process is structured into the four key steps "Sequencing", "Panel", "Variants", and "Explore Variants". It supports various analyses and visualizations.

Create data that displays generative art when mapped into a ggplot2 plot. Functionality includes specialized data frame creation for geometric shapes, tools that define artistic color palettes, tools for geometrically transforming data, and other miscellaneous tools that are helpful when using ggplot2 for generative art.

This package provides a novel data-augmentation Markov chain Monte Carlo sampling algorithm to fit a progressive compartmental model of disease in a Bayesian framework Morsomme, R.N., Holloway, S.T., Ryser, M.D. and Xu J. (2024) <doi:10.48550/arXiv.2408.14625>.

Calculation of physical (e.g. aerodynamic conductance, surface temperature), and physiological (e.g. canopy conductance, water-use efficiency) ecosystem properties from eddy covariance data and accompanying meteorological measurements. Calculations assume the land surface to behave like a big-leaf and return bulk ecosystem/canopy variables.

This package implements the three-step workflow for robust analysis of change in two repeated measurements of continuous outcomes, described in Ning et al. (in press), "Robust estimation of the effect of an exposure on the change in a continuous outcome", BMC Medical Research Methodology.

For multiple testing. Computes estimates and confidence bounds for the False Discovery Proportion (FDP), the fraction of false positives among all rejected hypotheses. The methods in the package use permutations of the data. Doing so, they take into account the dependence structure in the data.

We aim to deal with the average treatment effect (ATE), where the data are subject to high-dimensionality and measurement error. This package primarily contains two functions, which are used to generate artificial data and estimate ATE with high-dimensional and error-prone data accommodated.

An implementation of Fan plots for cytometry data in ggplot2'. For reference see Britton, E.; Fisher, P. & J. Whitley (1998) The Inflation Report Projections: Understanding the Fan Chart <https://www.bankofengland.co.uk/quarterly-bulletin/1998/q1/the-inflation-report-projections-understanding-the-fan-chart>).