This package provides a fast and scalable linear mixed-effects model (LMM) estimation algorithm for analysis of single-cell differential expression. The algorithm uses summary-level statistics and requires less computer memory to fit the LMM.

This package provides a method which uses the Cochran-Mantel-Haenszel test with significant pattern mining to detect intervals in binary genotype data which are significantly associated with a particular phenotype, while accounting for categorical covariates.

Computes the probability density function (pdf), cumulative distribution function (cdf), quantile function (qf) and generates random values (rg) for the following general models : mixture models, composite models, folded models, skewed symmetric models and arc tan models.

This package provides functions to read, process and analyse accelerometer data related to mechanical loading variables. This package is developed and tested for use with raw accelerometer data from triaxial ActiGraph <https://theactigraph.com> accelerometers.

Evaluating if values of vectors are within different open/closed intervals (`x %[]% c(a, b)`), or if two closed intervals overlap (`c(a1, b1) %[]o[]% c(a2, b2)`). Operators for negation and directional relations also implemented.

Create regression tables from generalized linear model(GLM), generalized estimating equation(GEE), generalized linear mixed-effects model(GLMM), Cox proportional hazards model, survey-weighted generalized linear model(svyglm) and survey-weighted Cox model results for publication.

Estimating the number of essential genes in a genome on the basis of data from a random transposon mutagenesis experiment, through the use of a Gibbs sampler. Lamichhane et al. (2003) <doi:10.1073/pnas.1231432100>.

Semissupervised model for geographical document classification (Watanabe 2018) <doi:10.1080/21670811.2017.1293487>. This package currently contains seed dictionaries in English, German, French, Spanish, Italian, Russian, Hebrew, Arabic, Turkish, Japanese and Chinese (Simplified and Traditional).

This package provides a system for calculating the minimum total sample size needed to achieve a prespecified power or the optimal allocation for each treatment group with a fixed total sample size to maximize the power.

Supports the modeling of ordinal random variables, like the outcomes of races, via Softmax regression, under the Harville <doi:10.1080/01621459.1973.10482425> and Henery <doi:10.1111/j.2517-6161.1981.tb01153.x> models.

Interact seamlessly with Open Target Genetics GraphQL endpoint to query and retrieve tidy data tables, facilitating the analysis of genetic data. For more information about the Open Target Genetics API (<https://genetics.opentargets.org/api>).

Facilitates analysis of paleontological sequences of trait values. Functions are provided to fit, using maximum likelihood, simple evolutionary models (including unbiased random walks, directional evolution,stasis, Ornstein-Uhlenbeck, covariate-tracking) and complex models (punctuation, mode shifts).

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) <doi:10.1016/j.vascn.2015.03.004>).

This package provides a shiny app that allows to access and use the INVEKOS API for field polygons in Austria. API documentation is available at <https://gis.lfrz.gv.at/api/geodata/i009501/ogc/features/v1/>.

An algorithm for identifying high-resolution driver elements for datasets from a high-definition reporter assay library. Xinchen Wang, Liang He, Sarah Goggin, Alham Saadat, Li Wang, Melina Claussnitzer, Manolis Kellis (2017) <doi:10.1101/193136>.

Secure handling of API keys can be difficult. This package provides secure convenience functions for entering / handling API keys and opening connections via inversion of control on those keys. Works seamlessly between production and developer environments.

This package provides a collection of recycled and modified R functions to aid in file manipulation, data exploration, wrangling, optimization, and object manipulation. Other functions aid in convenient data visualization, loop progression, software packaging, and installation.

The goal of this package will be to provide a simple interface for automatic machine learning that fits the tidymodels framework. The intention is to work for regression and classification problems with a simple verb framework.

Instance feature calculation and evolutionary instance generation for the traveling salesman problem. Also contains code to "morph" two TSP instances into each other. And the possibility to conveniently run a couple of solvers on TSP instances.

This package provides an htmlwidgets interface to VChart.js'. VChart', more than just a cross-platform charting library, but also an expressive data storyteller. VChart examples and documentation are available here: <https://www.visactor.io/vchart>.

Multi-caller variant analysis pipeline for targeted analysis sequencing (TAS) data. Features a modular, automated workflow that can start with raw reads and produces a user-friendly PDF summary and a spreadsheet containing consensus variant information.

Utility functions for visualization of expressionSet (or SummarizedExperiment) Bioconductor object, including spectral map, tsne and linear discriminant analysis. Static plot via the ggplot2 package or interactive via the ggvis or rbokeh packages are available.

Based on a large miRNA dilution study, this package provides tools to read in the raw amplification data and use these data to assess the performance of methods that estimate expression from the amplification curves.

The affyILM package is a preprocessing tool which estimates gene expression levels for Affymetrix Gene Chips. Input from physical chemistry is employed to first background subtract intensities before calculating concentrations on behal of the Langmuir model.