An algorithm for identifying high-resolution driver elements for datasets from a high-definition reporter assay library. Xinchen Wang, Liang He, Sarah Goggin, Alham Saadat, Li Wang, Melina Claussnitzer, Manolis Kellis (2017) <doi:10.1101/193136>.

Secure handling of API keys can be difficult. This package provides secure convenience functions for entering / handling API keys and opening connections via inversion of control on those keys. Works seamlessly between production and developer environments.

The goal of this package will be to provide a simple interface for automatic machine learning that fits the tidymodels framework. The intention is to work for regression and classification problems with a simple verb framework.

Instance feature calculation and evolutionary instance generation for the traveling salesman problem. Also contains code to "morph" two TSP instances into each other. And the possibility to conveniently run a couple of solvers on TSP instances.

Multi-caller variant analysis pipeline for targeted analysis sequencing (TAS) data. Features a modular, automated workflow that can start with raw reads and produces a user-friendly PDF summary and a spreadsheet containing consensus variant information.

This package provides an htmlwidgets interface to VChart.js'. VChart', more than just a cross-platform charting library, but also an expressive data storyteller. VChart examples and documentation are available here: <https://www.visactor.io/vchart>.

Utility functions for visualization of expressionSet (or SummarizedExperiment) Bioconductor object, including spectral map, tsne and linear discriminant analysis. Static plot via the ggplot2 package or interactive via the ggvis or rbokeh packages are available.

Based on a large miRNA dilution study, this package provides tools to read in the raw amplification data and use these data to assess the performance of methods that estimate expression from the amplification curves.

This package implements clustering of microarray gene expression profiles according to functional annotations. For each term genes are annotated to, splits into two subclasses are computed and a significance of the supporting gene set is determined.

The affyILM package is a preprocessing tool which estimates gene expression levels for Affymetrix Gene Chips. Input from physical chemistry is employed to first background subtract intensities before calculating concentrations on behal of the Langmuir model.

This package provides tools to obtain estimated marginal means (EMMs) for many linear, generalized linear, and mixed models. It can be used to compute contrasts or linear functions of EMMs, trends, and comparisons of slopes.

This package helps you to automate R package and project setup tasks that are otherwise performed manually. This includes setting up unit testing, test coverage, continuous integration, Git, GitHub integration, licenses, Rcpp, RStudio projects, and more.

This package implements the Subplex optimization algorithm. It solves unconstrained optimization problems using a simplex method on subspaces. The method is well suited for optimizing objective functions that are noisy or are discontinuous at the solution.

The rasdaemon daemon monitors platform RAS reports from Linux kernel trace events. These trace events are logged in /sys/kernel/debug/tracing and reported through standard log mechanisms like syslog.

This package provides a Ruby implementation of RFC5869: HKDF. The goal of HKDF is to take some source key material and generate suitable cryptographic keys from it.

Ridge regression due to Hoerl and Kennard (1970)<DOI:10.1080/00401706.1970.10488634> and generalized ridge regression due to Yang and Emura (2017)<DOI:10.1080/03610918.2016.1193195> with optimized tuning parameters. These ridge regression estimators (the HK estimator and the YE estimator) are computed by minimizing the cross-validated mean squared errors. Both the ridge and generalized ridge estimators are applicable for high-dimensional regressors (p>n), where p is the number of regressors, and n is the sample size.

The regression discontinuity (RD) design is a popular quasi-experimental design for causal inference and policy evaluation. The rdpower package provides tools to perform power, sample size and MDE calculations in RD designs: rdpower() calculates the power of an RD design, rdsampsi() calculates the required sample size to achieve a desired power and rdmde() calculates minimum detectable effects. See Cattaneo, Titiunik and Vazquez-Bare (2019) <https://rdpackages.github.io/references/Cattaneo-Titiunik-VazquezBare_2019_Stata.pdf> for further methodological details.

This package performs all steps in the credit scoring process. This package allows the user to follow all the necessary steps for building an effective scorecard. It provides the user functions for coarse binning of variables, Weights of Evidence (WOE) transformation, variable clustering, custom binning, visualization, and scaling of logistic regression coefficients. The results will generate a scorecard that can be used as an effective credit scoring tool to evaluate risk. For complete details on the credit scoring process, see Siddiqi (2005, ISBN:047175451X).

Non-linear transformations of data to better discover latent effects. Applies a sequence of three transformations (1) a Gaussianizing transformation, (2) a Z-score transformation, and (3) an outlier removal transformation. A publication describing the method has the following citation: Gregory J. Hunt, Mark A. Dane, James E. Korkola, Laura M. Heiser & Johann A. Gagnon-Bartsch (2020) "Automatic Transformation and Integration to Improve Visualization and Discovery of Latent Effects in Imaging Data", Journal of Computational and Graphical Statistics, <doi:10.1080/10618600.2020.1741379>.

Currently fully supports Enrichr, JASPAR, miEAA, PANTHER, Reactome, STRING, and UniProt! The goal of rbioapi is to provide a user-friendly and consistent interface to biological databases and services. In a way that insulates the user from the technicalities of using web services API and creates a unified and easy-to-use interface to biological and medical web services. This is an ongoing project; New databases and services will be added periodically. Feel free to suggest any databases or services you often use.

The aim of this package is to manipulate relational data models in R. It provides functions to create, modify and export data models in json format. It also allows importing models created with MySQL Workbench (<https://www.mysql.com/products/workbench/>). These functions are accessible through a graphical user interface made with shiny'. Constraints such as types, keys, uniqueness and mandatory fields are automatically checked and corrected when editing a model. Finally, real data can be confronted to a model to check their compatibility.

This package provides a Rust library for parsing and generating Intel HEX (or IHEX) objects. This format is commonly used for representing compiled program code and data to be loaded into a microcontroller, flash memory or ROM.

RTG Tools is a subset of RTG Core that includes several useful utilities for dealing with VCF files and sequence data. Probably the most interesting is the vcfeval command which performs sophisticated comparison of VCF files.

This is a legacy project, do not use it for new projects. Ruby 2.3 and later should make this obsolete. kgio provides non-blocking I/O methods for Ruby without raising exceptions on EAGAIN and EINPROGRESS.